IMP

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Mus musculus

13 genes annotated in mouse

type b pancreatic cell differentiation

The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "type b pancreatic cell differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "type b pancreatic cell differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
Shh	sonic hedgehog	1.000
Arntl	aryl hydrocarbon receptor nuclear translocator-like	0.994
Fgf8	fibroblast growth factor 8	0.993
Sox9	SRY-box containing gene 9	0.992
Pax2	paired box gene 2	0.987
Fgfr2	fibroblast growth factor receptor 2	0.982
Otx2	orthodenticle homolog 2 (Drosophila)	0.970
Gli3	GLI-Kruppel family member GLI3	0.956
Hand2	heart and neural crest derivatives expressed transcript 2	0.890
Hand1	heart and neural crest derivatives expressed transcript 1	0.831
Nog	noggin	0.813
Nkx2-2	NK2 transcription factor related, locus 2 (Drosophila)	0.806
Nkx6-1	NK6 homeobox 1	0.795	Zebrafish Rat
Lhx1	LIM homeobox protein 1	0.794
Wnt3a	wingless-related MMTV integration site 3A	0.788	Mouse
Per2	period homolog 2 (Drosophila)	0.786
Pitx2	paired-like homeodomain transcription factor 2	0.782
Pax8	paired box gene 8	0.756
Tbx1	T-box 1	0.753
Gli2	GLI-Kruppel family member GLI2	0.741
Hes1	hairy and enhancer of split 1 (Drosophila)	0.716
Cry1	cryptochrome 1 (photolyase-like)	0.713
Gata4	GATA binding protein 4	0.697	Mouse
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.662	Mouse
Clock	circadian locomotor output cycles kaput	0.656
Foxc1	forkhead box C1	0.603
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.570
Isl1	ISL1 transcription factor, LIM/homeodomain	0.564	Zebrafish
Bmp7	bone morphogenetic protein 7	0.536
Rarg	retinoic acid receptor, gamma	0.533
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.510
Fgf10	fibroblast growth factor 10	0.462
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.457
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.456
Gata6	GATA binding protein 6	0.447
Sox4	SRY-box containing gene 4	0.443
Foxc2	forkhead box C2	0.422
Pax3	paired box gene 3	0.420
Emx2	empty spiracles homolog 2 (Drosophila)	0.398
Bmp4	bone morphogenetic protein 4	0.397	Human
Foxa2	forkhead box A2	0.389
Tbx3	T-box 3	0.388
Gbx2	gastrulation brain homeobox 2	0.338
Fgfr1	fibroblast growth factor receptor 1	0.320
Fgf15	fibroblast growth factor 15	0.314
Lmx1b	LIM homeobox transcription factor 1 beta	0.309
Lhx3	LIM homeobox protein 3	0.276
Foxf1a	forkhead box F1a	0.257
Ctnnb1	catenin (cadherin associated protein), beta 1	0.254
Wnt1	wingless-related MMTV integration site 1	0.246	Mouse
Insm1	insulinoma-associated 1	0.244
Cry2	cryptochrome 2 (photolyase-like)	0.242
Eya1	eyes absent 1 homolog (Drosophila)	0.235
Ret	ret proto-oncogene	0.227
Pitx1	paired-like homeodomain transcription factor 1	0.214
Pdx1	pancreatic and duodenal homeobox 1	0.212	Human
Rarb	retinoic acid receptor, beta	0.206
Lmx1a	LIM homeobox transcription factor 1 alpha	0.202
Tcfap2a	transcription factor AP-2, alpha	0.192
Sox2	SRY-box containing gene 2	0.191
T	brachyury	0.191
Fgfr3	fibroblast growth factor receptor 3	0.191
Col2a1	collagen, type II, alpha 1	0.186
Chrd	chordin	0.183
Gdnf	glial cell line derived neurotrophic factor	0.180
Foxe1	forkhead box E1	0.176
Fgf3	fibroblast growth factor 3	0.172
Rara	retinoic acid receptor, alpha	0.172
Alx3	aristaless-like homeobox 3	0.169
Sim1	single-minded homolog 1 (Drosophila)	0.166
Tbx2	T-box 2	0.163
Rxra	retinoid X receptor alpha	0.157
Smad6	MAD homolog 6 (Drosophila)	0.145
Sox1	SRY-box containing gene 1	0.138
Msx1	homeobox, msh-like 1	0.135
Prrx1	paired related homeobox 1	0.134
Lhx5	LIM homeobox protein 5	0.134
Hoxa13	homeobox A13	0.133
Epha1	Eph receptor A1	0.130
Hes5	hairy and enhancer of split 5 (Drosophila)	0.125
Otx1	orthodenticle homolog 1 (Drosophila)	0.122
Emx1	empty spiracles homolog 1 (Drosophila)	0.121
Fgf18	fibroblast growth factor 18	0.120
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.111
Fgf17	fibroblast growth factor 17	0.109
Vax1	ventral anterior homeobox containing gene 1	0.108
Onecut1	one cut domain, family member 1	0.108
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.107
Sox11	SRY-box containing gene 11	0.102
Smo	smoothened homolog (Drosophila)	0.101
Sox3	SRY-box containing gene 3	0.101
Pcdh12	protocadherin 12	0.100
En1	engrailed 1	0.099
Nodal	nodal	0.091
Ptch1	patched homolog 1	0.088
Pou3f3	POU domain, class 3, transcription factor 3	0.085
Wnt2b	wingless related MMTV integration site 2b	0.083	Mouse
Hoxd11	homeobox D11	0.082
Hoxa4	homeobox A4	0.082
Wnt9a	wingless-type MMTV integration site 9A	0.080	Mouse
Mesp1	mesoderm posterior 1	0.076
Efna4	ephrin A4	0.073
Lepr	leptin receptor	0.071
Ccnd2	cyclin D2	0.070
Pax6	paired box gene 6	0.069
Nf1	neurofibromatosis 1	0.069
Tgfb2	transforming growth factor, beta 2	0.069
Foxf2	forkhead box F2	0.069
Sall3	sal-like 3 (Drosophila)	0.067
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.064
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.061
Arx	aristaless related homeobox	0.060
Dlx5	distal-less homeobox 5	0.059
Alx4	aristaless-like homeobox 4	0.058
Lef1	lymphoid enhancer binding factor 1	0.057
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.057
Zeb1	zinc finger E-box binding homeobox 1	0.055
Wnt10b	wingless related MMTV integration site 10b	0.054	Mouse
Meox2	mesenchyme homeobox 2	0.054
Barx1	BarH-like homeobox 1	0.054
Prrx2	paired related homeobox 2	0.053
Hnf1a	HNF1 homeobox A	0.053
Hoxa1	homeobox A1	0.052
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.051
Hmx3	H6 homeobox 3	0.050
Hoxa2	homeobox A2	0.048
Pou3f4	POU domain, class 3, transcription factor 4	0.047
Acvr1	activin A receptor, type 1	0.047
Neurog1	neurogenin 1	0.045
Npas2	neuronal PAS domain protein 2	0.045	Mouse
Otp	orthopedia homolog (Drosophila)	0.045
Axin2	axin2	0.045
Hes2	hairy and enhancer of split 2 (Drosophila)	0.044
Wnt5a	wingless-related MMTV integration site 5A	0.044
Adra2b	adrenergic receptor, alpha 2b	0.043
Kl	klotho	0.042
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.042
Chd7	chromodomain helicase DNA binding protein 7	0.042
Ahr	aryl-hydrocarbon receptor	0.040
Bmper	BMP-binding endothelial regulator	0.040
Npas1	neuronal PAS domain protein 1	0.039
Pitx3	paired-like homeodomain transcription factor 3	0.038
Zfpm2	zinc finger protein, multitype 2	0.038
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.035
Cdx1	caudal type homeobox 1	0.035
Twist2	twist homolog 2 (Drosophila)	0.035
Wnt4	wingless-related MMTV integration site 4	0.035	Mouse
Wnt6	wingless-related MMTV integration site 6	0.035	Mouse
Sox7	SRY-box containing gene 7	0.034
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.034
Fzd8	frizzled homolog 8 (Drosophila)	0.034
Col22a1	collagen, type XXII, alpha 1	0.033
Gli1	GLI-Kruppel family member GLI1	0.033
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.033
Foxd3	forkhead box D3	0.032
Bmp2	bone morphogenetic protein 2	0.032
Uncx	UNC homeobox	0.032
Hoxb4	homeobox B4	0.032
Tal1	T-cell acute lymphocytic leukemia 1	0.031
Tcf21	transcription factor 21	0.031
Igfbpl1	insulin-like growth factor binding protein-like 1	0.031
Ihh	Indian hedgehog	0.029
Adra2a	adrenergic receptor, alpha 2a	0.029
Foxd2	forkhead box D2	0.028
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.028
Trp63	transformation related protein 63	0.028
Foxa1	forkhead box A1	0.027
Fzd4	frizzled homolog 4 (Drosophila)	0.027
Neurog3	neurogenin 3	0.026
Foxb1	forkhead box B1	0.026
Pnoc	prepronociceptin	0.026
Hoxa10	homeobox A10	0.026
Hoxd13	homeobox D13	0.025
Myl7	myosin, light polypeptide 7, regulatory	0.025
Msx3	homeobox, msh-like 3	0.025
Nkx2-4	NK2 transcription factor related, locus 4 (Drosophila)	0.025	Mouse
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.025
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.025
Cdx2	caudal type homeobox 2	0.025
Scn5a	sodium channel, voltage-gated, type V, alpha	0.024
Hsd11b2	hydroxysteroid 11-beta dehydrogenase 2	0.024
Gpc3	glypican 3	0.024
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.024
Hoxd3	homeobox D3	0.024
Vangl2	vang-like 2 (van gogh, Drosophila)	0.023
Hoxb5	homeobox B5	0.023
Btbd17	BTB (POZ) domain containing 17	0.023
Sfrp5	secreted frizzled-related sequence protein 5	0.023
Foxi3	forkhead box I3	0.023
Ptf1a	pancreas specific transcription factor, 1a	0.022
Amhr2	anti-Mullerian hormone type 2 receptor	0.022
Hoxa5	homeobox A5	0.022
Sct	secretin	0.022
Adra1b	adrenergic receptor, alpha 1b	0.021
Fzd10	frizzled homolog 10 (Drosophila)	0.021
Sox17	SRY-box containing gene 17	0.021
Hoxb6	homeobox B6	0.020
Atoh7	atonal homolog 7 (Drosophila)	0.020
Scube1	signal peptide, CUB domain, EGF-like 1	0.020
a	nonagouti	0.020
Prdm6	PR domain containing 6	0.020
Ccnd1	cyclin D1	0.020
Col13a1	collagen, type XIII, alpha 1	0.020
Wnt5b	wingless-related MMTV integration site 5B	0.020	Mouse
Zfp771	zinc finger protein 771	0.020
Sim2	single-minded homolog 2 (Drosophila)	0.019
Hoxd12	homeobox D12	0.019
Hoxc9	homeobox C9	0.019
Tbx5	T-box 5	0.019
Foxb2	forkhead box B2	0.019
Crybb2	crystallin, beta B2	0.018
Slc32a1	solute carrier family 32 (GABA vesicular transporter), member 1	0.018
Pax9	paired box gene 9	0.018
Barhl1	BarH-like 1 (Drosophila)	0.018
Fzd1	frizzled homolog 1 (Drosophila)	0.018
Pou3f2	POU domain, class 3, transcription factor 2	0.017
Nobox	NOBOX oogenesis homeobox	0.017
Dlx1	distal-less homeobox 1	0.017
Sh3pxd2a	SH3 and PX domains 2A	0.017
Lbx1	ladybird homeobox homolog 1 (Drosophila)	0.016
Neurod1	neurogenic differentiation 1	0.016
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.016
Apc	adenomatosis polyposis coli	0.016
Fgfrl1	fibroblast growth factor receptor-like 1	0.016
Fgf9	fibroblast growth factor 9	0.016
Plac1	placental specific protein 1	0.016
Tgfbr3	transforming growth factor, beta receptor III	0.016
Rb1	retinoblastoma 1	0.016
Gata3	GATA binding protein 3	0.016	Mouse
Vegfa	vascular endothelial growth factor A	0.016
Atp7b	ATPase, Cu++ transporting, beta polypeptide	0.015
Zfpm1	zinc finger protein, multitype 1	0.015
Emp2	epithelial membrane protein 2	0.015
Zbtb7c	zinc finger and BTB domain containing 7C	0.015
Atoh8	atonal homolog 8 (Drosophila)	0.015
Hoxa11	homeobox A11	0.015
BC021891	cDNA sequence BC021891	0.015
Sycn	syncollin	0.015
Neurog2	neurogenin 2	0.015
Rax	retina and anterior neural fold homeobox	0.014
Hbb-bh1	hemoglobin Z, beta-like embryonic chain	0.014
Gpr27	G protein-coupled receptor 27	0.014
Tbx19	T-box 19	0.014
Ephb2	Eph receptor B2	0.014
Sall4	sal-like 4 (Drosophila)	0.014
Fzd6	frizzled homolog 6 (Drosophila)	0.014
Mxd1	MAX dimerization protein 1	0.014
Barx2	BarH-like homeobox 2	0.013
Slc16a8	solute carrier family 16 (monocarboxylic acid transporters), member 8	0.013
Pou3f1	POU domain, class 3, transcription factor 1	0.013
Ager	advanced glycosylation end product-specific receptor	0.013
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.013	Mouse
Ywhaq	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.013
Apoa1	apolipoprotein A-I	0.013
1700080E11Rik	RIKEN cDNA 1700080E11 gene	0.013
Shox2	short stature homeobox 2	0.013
Slc34a2	solute carrier family 34 (sodium phosphate), member 2	0.013
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.013
Fgf5	fibroblast growth factor 5	0.013
Fgf4	fibroblast growth factor 4	0.013
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.012
Bmp5	bone morphogenetic protein 5	0.012	Human
Hoxb3	homeobox B3	0.012
Hba-x	hemoglobin X, alpha-like embryonic chain in Hba complex	0.012
Foxe3	forkhead box E3	0.012
Bnc1	basonuclin 1	0.012
Gfra1	glial cell line derived neurotrophic factor family receptor alpha 1	0.012
Dll1	delta-like 1 (Drosophila)	0.012
Art5	ADP-ribosyltransferase 5	0.012
Pten	phosphatase and tensin homolog	0.012
Gsc	goosecoid homeobox	0.012
Fzd7	frizzled homolog 7 (Drosophila)	0.012
Nrk	Nik related kinase	0.011
Bmp8b	bone morphogenetic protein 8b	0.011
Akp3	alkaline phosphatase 3, intestine, not Mn requiring	0.011
Fst	follistatin	0.011
Fgfr4	fibroblast growth factor receptor 4	0.011
Lama1	laminin, alpha 1	0.011
Dlx6	distal-less homeobox 6	0.011
Per1	period homolog 1 (Drosophila)	0.011
Amh	anti-Mullerian hormone	0.011
Bcl2	B-cell leukemia/lymphoma 2	0.011
Gipc3	GIPC PDZ domain containing family, member 3	0.011
Ntf3	neurotrophin 3	0.011
Smpd3	sphingomyelin phosphodiesterase 3, neutral	0.011
Wnt3	wingless-related MMTV integration site 3	0.011	Mouse
Avpr1b	arginine vasopressin receptor 1B	0.011
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.011
Foxl2	forkhead box L2	0.011
Efnb2	ephrin B2	0.011
Stra8	stimulated by retinoic acid gene 8	0.011
Nkx3-2	NK3 homeobox 2	0.011	Mouse
Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	0.011
Ptger1	prostaglandin E receptor 1 (subtype EP1)	0.010
Gpr50	G-protein-coupled receptor 50	0.010
Emid2	EMI domain containing 2	0.010
Pbx1	pre B-cell leukemia transcription factor 1	0.010
Dnase1l2	deoxyribonuclease 1-like 2	0.010
Skor1	SKI family transcriptional corepressor 1	0.010
Ednra	endothelin receptor type A	0.010
Zic1	zinc finger protein of the cerebellum 1	0.010
Hoxd9	homeobox D9	0.010
Lhx6	LIM homeobox protein 6	0.010
Wnt11	wingless-related MMTV integration site 11	0.010	Mouse