IMP

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Mus musculus

5 genes annotated in mouse

endocardial cushion to mesenchymal transition

A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "endocardial cushion to mesenchymal transition"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "endocardial cushion to mesenchymal transition" (in gray)

Name	Description	Probability	Func Analog Organism
Efnb2	ephrin B2	0.999	Mouse
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.999
Gata4	GATA binding protein 4	0.999
Gli3	GLI-Kruppel family member GLI3	0.998
Neurod1	neurogenic differentiation 1	0.997	Mouse
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.997
Foxc2	forkhead box C2	0.997
Foxc1	forkhead box C1	0.994
Shh	sonic hedgehog	0.991
Hand2	heart and neural crest derivatives expressed transcript 2	0.990	Mouse
Tgfb2	transforming growth factor, beta 2	0.989
Msx1	homeobox, msh-like 1	0.989
Ntf3	neurotrophin 3	0.983
Ephb2	Eph receptor B2	0.978
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.969
Hand1	heart and neural crest derivatives expressed transcript 1	0.966	Mouse
Isl1	ISL1 transcription factor, LIM/homeodomain	0.954
Pitx2	paired-like homeodomain transcription factor 2	0.949
Sox9	SRY-box containing gene 9	0.921
Fgf8	fibroblast growth factor 8	0.905
Pax6	paired box gene 6	0.901
Pax3	paired box gene 3	0.882
Tcfap2a	transcription factor AP-2, alpha	0.880
Prrx1	paired related homeobox 1	0.869
Efna2	ephrin A2	0.865	Mouse
Nhlh1	nescient helix loop helix 1	0.864	Mouse
Jag1	jagged 1	0.857
Otx2	orthodenticle homolog 2 (Drosophila)	0.827
Tbx1	T-box 1	0.711
Gli2	GLI-Kruppel family member GLI2	0.701
Gbx2	gastrulation brain homeobox 2	0.656
Gpr50	G-protein-coupled receptor 50	0.626
Ptf1a	pancreas specific transcription factor, 1a	0.605	Mouse
Dlx2	distal-less homeobox 2	0.579
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.514
Sox11	SRY-box containing gene 11	0.445
Hoxa1	homeobox A1	0.444
Neurog2	neurogenin 2	0.438	Mouse
Hey1	hairy/enhancer-of-split related with YRPW motif 1	0.423
En1	engrailed 1	0.398
Mecom	MDS1 and EVI1 complex locus	0.398
Zfpm2	zinc finger protein, multitype 2	0.376
Prrx2	paired related homeobox 2	0.351
Gsc	goosecoid homeobox	0.319
Ebf3	early B-cell factor 3	0.309
Foxg1	forkhead box G1	0.302
Adam19	a disintegrin and metallopeptidase domain 19 (meltrin beta)	0.280
Gata6	GATA binding protein 6	0.269
Bnc1	basonuclin 1	0.260
Foxd2	forkhead box D2	0.260
Dlx5	distal-less homeobox 5	0.256
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.255
Twist2	twist homolog 2 (Drosophila)	0.248	Mouse
Insm1	insulinoma-associated 1	0.237
Onecut1	one cut domain, family member 1	0.231
Ebf2	early B-cell factor 2	0.217
Hoxd3	homeobox D3	0.216
Eya1	eyes absent 1 homolog (Drosophila)	0.209
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.206
Dock1	dedicator of cytokinesis 1	0.205
Hoxa2	homeobox A2	0.193
Cxcr4	chemokine (C-X-C motif) receptor 4	0.177
Lhx3	LIM homeobox protein 3	0.166
Smo	smoothened homolog (Drosophila)	0.165
Epha4	Eph receptor A4	0.160
Lhx5	LIM homeobox protein 5	0.157
Snai1	snail homolog 1 (Drosophila)	0.156
Msx2	homeobox, msh-like 2	0.154
Sox2	SRY-box containing gene 2	0.151
Neurod4	neurogenic differentiation 4	0.150	Mouse
Twist1	twist homolog 1 (Drosophila)	0.137
Dlx1	distal-less homeobox 1	0.131
Hes5	hairy and enhancer of split 5 (Drosophila)	0.128
Pdx1	pancreatic and duodenal homeobox 1	0.120
Zic1	zinc finger protein of the cerebellum 1	0.113
Uncx	UNC homeobox	0.106
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.105
Hoxd13	homeobox D13	0.104
Dlk1	delta-like 1 homolog (Drosophila)	0.103
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.103
Prox1	prospero-related homeobox 1	0.096
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.096
Tlx3	T-cell leukemia, homeobox 3	0.095
Hoxc4	homeobox C4	0.093
Magel2	melanoma antigen, family L, 2	0.092
Hoxb1	homeobox B1	0.091
Bmp7	bone morphogenetic protein 7	0.089
Hoxc6	homeobox C6	0.086
Pax1	paired box gene 1	0.086
Hoxd1	homeobox D1	0.084
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.084
Gata1	GATA binding protein 1	0.083
Hba-x	hemoglobin X, alpha-like embryonic chain in Hba complex	0.081
Hoxc8	homeobox C8	0.079
Fbn2	fibrillin 2	0.077
Tbx5	T-box 5	0.076
Nkx3-2	NK3 homeobox 2	0.074
Prph	peripherin	0.074
Tbx20	T-box 20	0.074
Hoxa10	homeobox A10	0.072
Efnb1	ephrin B1	0.071	Mouse
Sim2	single-minded homolog 2 (Drosophila)	0.067
Neurog3	neurogenin 3	0.066	Mouse
Pitx1	paired-like homeodomain transcription factor 1	0.065
Notch1	Notch gene homolog 1 (Drosophila)	0.065
Pou3f2	POU domain, class 3, transcription factor 2	0.062
Efs	embryonal Fyn-associated substrate	0.062
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.060
Zeb1	zinc finger E-box binding homeobox 1	0.060
Shox2	short stature homeobox 2	0.059
Pax9	paired box gene 9	0.059
Myog	myogenin	0.059
Runx1t1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.056
Dcc	deleted in colorectal carcinoma	0.056
Hoxc5	homeobox C5	0.055
Has2	hyaluronan synthase 2	0.053
Alx3	aristaless-like homeobox 3	0.053
Emx1	empty spiracles homolog 1 (Drosophila)	0.052
Fgfr2	fibroblast growth factor receptor 2	0.051
Atoh1	atonal homolog 1 (Drosophila)	0.051	Mouse
Col22a1	collagen, type XXII, alpha 1	0.051
Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.051
Ednra	endothelin receptor type A	0.049
Odz2	odd Oz/ten-m homolog 2 (Drosophila)	0.048
Sall3	sal-like 3 (Drosophila)	0.047
Ephb3	Eph receptor B3	0.047
Col2a1	collagen, type II, alpha 1	0.046
Col11a1	collagen, type XI, alpha 1	0.046
Efnb3	ephrin B3	0.045	Mouse
Lhx6	LIM homeobox protein 6	0.045
Tcf15	transcription factor 15	0.044	Mouse
Meox1	mesenchyme homeobox 1	0.043
Kcnj11	potassium inwardly rectifying channel, subfamily J, member 11	0.043
Hoxa3	homeobox A3	0.042
Pou4f2	POU domain, class 4, transcription factor 2	0.042
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.040
Pitx3	paired-like homeodomain transcription factor 3	0.039
Foxd1	forkhead box D1	0.039
Runx2	runt related transcription factor 2	0.039
Ptgir	prostaglandin I receptor (IP)	0.037
Myod1	myogenic differentiation 1	0.037
Gdf11	growth differentiation factor 11	0.037
Fzd2	frizzled homolog 2 (Drosophila)	0.036
Smad6	MAD homolog 6 (Drosophila)	0.036
Lmo1	LIM domain only 1	0.034
Nog	noggin	0.034
Mab21l2	mab-21-like 2 (C. elegans)	0.034
Gja1	gap junction protein, alpha 1	0.033
Srrm4	serine/arginine repetitive matrix 4	0.033
Bmp4	bone morphogenetic protein 4	0.032
Sox7	SRY-box containing gene 7	0.032
Alx4	aristaless-like homeobox 4	0.030
Dlx6	distal-less homeobox 6	0.030
Lmx1b	LIM homeobox transcription factor 1 beta	0.030
Pax2	paired box gene 2	0.029
Hmga2	high mobility group AT-hook 2	0.029
Mesp1	mesoderm posterior 1	0.029
Obsl1	obscurin-like 1	0.029
Igf2	insulin-like growth factor 2	0.028
Slc4a1	solute carrier family 4 (anion exchanger), member 1	0.028
Rprm	reprimo, TP53 dependent G2 arrest mediator candidate	0.027
Emid2	EMI domain containing 2	0.027
Gfra3	glial cell line derived neurotrophic factor family receptor alpha 3	0.027
Kcne1l	potassium voltage-gated channel, Isk-related family, member 1-like, pseudogene	0.027
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.027
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.026
Tbx3	T-box 3	0.026
Nck2	non-catalytic region of tyrosine kinase adaptor protein 2	0.025
Arx	aristaless related homeobox	0.025
Wnt6	wingless-related MMTV integration site 6	0.025
Tead3	TEA domain family member 3	0.024
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.024
Zic2	zinc finger protein of the cerebellum 2	0.024
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.024
Hoxb7	homeobox B7	0.024
Cel	carboxyl ester lipase	0.024
Irx3	Iroquois related homeobox 3 (Drosophila)	0.023
St8sia2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.023
Glra1	glycine receptor, alpha 1 subunit	0.023
Capn6	calpain 6	0.022
Lhx9	LIM homeobox protein 9	0.022
Col13a1	collagen, type XIII, alpha 1	0.022
Ptx3	pentraxin related gene	0.022
Eda	ectodysplasin-A	0.022
Cbfa2t3	core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)	0.022
Tal2	T-cell acute lymphocytic leukemia 2	0.021	Mouse
Dab1	disabled homolog 1 (Drosophila)	0.021
En2	engrailed 2	0.021
Mnx1	motor neuron and pancreas homeobox 1	0.021
Hoxa4	homeobox A4	0.021
Hes1	hairy and enhancer of split 1 (Drosophila)	0.021
Heyl	hairy/enhancer-of-split related with YRPW motif-like	0.021	Mouse
Pou4f3	POU domain, class 4, transcription factor 3	0.021
Madcam1	mucosal vascular addressin cell adhesion molecule 1	0.021
Irx4	Iroquois related homeobox 4 (Drosophila)	0.020
Neurod2	neurogenic differentiation 2	0.020	Mouse
Meox2	mesenchyme homeobox 2	0.020
Gas1	growth arrest specific 1	0.020
Ptk7	PTK7 protein tyrosine kinase 7	0.019
Efna1	ephrin A1	0.019
Cdh3	cadherin 3	0.019
Rarb	retinoic acid receptor, beta	0.019
Msi1	Musashi homolog 1(Drosophila)	0.019
Sox4	SRY-box containing gene 4	0.019
Unc5c	unc-5 homolog C (C. elegans)	0.019
Igfbpl1	insulin-like growth factor binding protein-like 1	0.019
Efna3	ephrin A3	0.018	Mouse
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.018
Tcfap2c	transcription factor AP-2, gamma	0.018
Hif3a	hypoxia inducible factor 3, alpha subunit	0.018
Cbln1	cerebellin 1 precursor protein	0.018
Egfr	epidermal growth factor receptor	0.018
Tal1	T-cell acute lymphocytic leukemia 1	0.018	Mouse
Notch3	Notch gene homolog 3 (Drosophila)	0.017
Tbx15	T-box 15	0.017
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.017
Sim1	single-minded homolog 1 (Drosophila)	0.017
Etv4	ets variant gene 4 (E1A enhancer binding protein, E1AF)	0.017
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.017
Krt2	keratin 2	0.017
Wnt7a	wingless-related MMTV integration site 7A	0.017
Nppa	natriuretic peptide type A	0.016
Fgf10	fibroblast growth factor 10	0.016
Eya4	eyes absent 4 homolog (Drosophila)	0.016
Fgf15	fibroblast growth factor 15	0.016
Hoxa13	homeobox A13	0.015
Ncan	neurocan	0.015
Epha5	Eph receptor A5	0.015
Nrk	Nik related kinase	0.015
Sox1	SRY-box containing gene 1	0.015
Nkx2-2	NK2 transcription factor related, locus 2 (Drosophila)	0.015
Fgr	Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog	0.015
Matn3	matrilin 3	0.015
Kcnj5	potassium inwardly-rectifying channel, subfamily J, member 5	0.014
Epha3	Eph receptor A3	0.014
Nkx6-1	NK6 homeobox 1	0.014
Mn1	meningioma 1	0.014
Zic4	zinc finger protein of the cerebellum 4	0.014
Gjb5	gap junction protein, beta 5	0.014
Irx1	Iroquois related homeobox 1 (Drosophila)	0.014
Foxd3	forkhead box D3	0.014
She	src homology 2 domain-containing transforming protein E	0.014
Foxd4	forkhead box D4	0.013
Hic1	hypermethylated in cancer 1	0.013
Cachd1	cache domain containing 1	0.013
Hoxd11	homeobox D11	0.013
Adra2a	adrenergic receptor, alpha 2a	0.013
Krt14	keratin 14	0.013
Dcx	doublecortin	0.013
Odz4	odd Oz/ten-m homolog 4 (Drosophila)	0.012
Cdx1	caudal type homeobox 1	0.012
Hbb-bh1	hemoglobin Z, beta-like embryonic chain	0.012
Tbr1	T-box brain gene 1	0.012
Col9a1	collagen, type IX, alpha 1	0.012
Foxb1	forkhead box B1	0.012
Cited1	Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1	0.012
Cxcr7	chemokine (C-X-C motif) receptor 7	0.012
Kcnd3	potassium voltage-gated channel, Shal-related family, member 3	0.012
Ikzf4	IKAROS family zinc finger 4	0.012
Igf2bp2	insulin-like growth factor 2 mRNA binding protein 2	0.012
Tcf3	transcription factor 3	0.011
T	brachyury	0.011
Pbx1	pre B-cell leukemia transcription factor 1	0.011
Chrd	chordin	0.011
1700065I17Rik	RIKEN cDNA 1700065I17 gene	0.011
Gpc3	glypican 3	0.011
Gdnf	glial cell line derived neurotrophic factor	0.011
Bcl6b	B-cell CLL/lymphoma 6, member B	0.011
Tlx2	T-cell leukemia, homeobox 2	0.011
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.011
Chrna7	cholinergic receptor, nicotinic, alpha polypeptide 7	0.011
Hoxb5	homeobox B5	0.011
Apcdd1	adenomatosis polyposis coli down-regulated 1	0.011
Nynrin	NYN domain and retroviral integrase containing	0.011
Hoxb6	homeobox B6	0.011
Chrna3	cholinergic receptor, nicotinic, alpha polypeptide 3	0.011
Hmx3	H6 homeobox 3	0.010
Cntn2	contactin 2	0.010
Hbb-y	hemoglobin Y, beta-like embryonic chain	0.010
Pou3f4	POU domain, class 3, transcription factor 4	0.010
Kiss1	KiSS-1 metastasis-suppressor	0.010
Foxh1	forkhead box H1	0.010
Neurog1	neurogenin 1	0.010	Mouse
Celf4	CUGBP, Elav-like family member 4	0.010