IMP

Process View

Mus musculus

1 genes annotated in mouse

regulation of activation of jak2 kinase activity

Any process that modulates the frequency or rate of activation of JAK2 protein. The activation of JAK2 protein is the process of introducing a phosphate group to a tyrosine residue of a JAK2 (Janus Activated Kinase 2) protein, thereby activating it.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of activation of jak2 kinase activity"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of activation of jak2 kinase activity" (in gray)

Name	Description	Probability	Func Analog Organism
Lepr	leptin receptor	1.000
Jak2	Janus kinase 2	0.977
Ren1	renin 1 structural	0.956
Agtr1a	angiotensin II receptor, type 1a	0.950
Cish	cytokine inducible SH2-containing protein	0.896	Mouse
Umod	uromodulin	0.793
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.747
Tgfb1	transforming growth factor, beta 1	0.727
Stat3	signal transducer and activator of transcription 3	0.684
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.635
Il6st	interleukin 6 signal transducer	0.560
Vav2	vav 2 oncogene	0.535
Pim1	proviral integration site 1	0.403
Stat5a	signal transducer and activator of transcription 5A	0.372
Ptgs2	prostaglandin-endoperoxide synthase 2	0.362
Socs2	suppressor of cytokine signaling 2	0.338	Mouse
Plcg1	phospholipase C, gamma 1	0.266
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.264
Foxp3	forkhead box P3	0.264
Tnf	tumor necrosis factor	0.259
Cul5	cullin 5	0.257
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.256
Vdr	vitamin D receptor	0.252
Smad3	MAD homolog 3 (Drosophila)	0.204
Egfr	epidermal growth factor receptor	0.162
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.149
Vav3	vav 3 oncogene	0.138
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.129
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.118
Slc12a1	solute carrier family 12, member 1	0.093
Rag1	recombination activating gene 1	0.087
Adamts1	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1	0.080
Gcgr	glucagon receptor	0.079
Gdf15	growth differentiation factor 15	0.077
Vegfa	vascular endothelial growth factor A	0.074
Spred1	sprouty protein with EVH-1 domain 1, related sequence	0.070
Foxn1	forkhead box N1	0.070
Egr1	early growth response 1	0.060
B4galt1	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1	0.058
Socs3	suppressor of cytokine signaling 3	0.058	Mouse
Itga1	integrin alpha 1	0.057
Skil	SKI-like	0.054
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.051
Nos3	nitric oxide synthase 3, endothelial cell	0.048
Nos2	nitric oxide synthase 2, inducible	0.047
Stat5b	signal transducer and activator of transcription 5B	0.046
Fosl2	fos-like antigen 2	0.045
Rapgef3	Rap guanine nucleotide exchange factor (GEF) 3	0.044
Junb	Jun-B oncogene	0.044
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.044
Irs1	insulin receptor substrate 1	0.041
Ptpn12	protein tyrosine phosphatase, non-receptor type 12	0.041
Cd44	CD44 antigen	0.040
Pdcd1	programmed cell death 1	0.037
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.036
Col4a3	collagen, type IV, alpha 3	0.036
Fas	Fas (TNF receptor superfamily member 6)	0.036
Insr	insulin receptor	0.035
Bdkrb2	bradykinin receptor, beta 2	0.035
Foxa3	forkhead box A3	0.034
Aqp2	aquaporin 2	0.034
Pim2	proviral integration site 2	0.031
Bcl2	B-cell leukemia/lymphoma 2	0.030
Wnk4	WNK lysine deficient protein kinase 4	0.030
Arrdc3	arrestin domain containing 3	0.030
Kit	kit oncogene	0.030
Fgf21	fibroblast growth factor 21	0.030
Maff	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)	0.029
Rora	RAR-related orphan receptor alpha	0.029
Rxra	retinoid X receptor alpha	0.028
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.027
Il6	interleukin 6	0.026
Rel	reticuloendotheliosis oncogene	0.026
Clcnka	chloride channel Ka	0.026
Mefv	Mediterranean fever	0.024
Lcat	lecithin cholesterol acyltransferase	0.022
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.022
Cdhr5	cadherin-related family member 5	0.021
Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	0.021
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.021
Csf2	colony stimulating factor 2 (granulocyte-macrophage)	0.021
G0s2	G0/G1 switch gene 2	0.021
Mapk8	mitogen-activated protein kinase 8	0.021
Il10	interleukin 10	0.021
Socs6	suppressor of cytokine signaling 6	0.020	Mouse
Irs2	insulin receptor substrate 2	0.020
Tgfbr1	transforming growth factor, beta receptor I	0.020
Tead3	TEA domain family member 3	0.020
Mib1	mindbomb homolog 1 (Drosophila)	0.020
Adora2a	adenosine A2a receptor	0.019
Sim1	single-minded homolog 1 (Drosophila)	0.019
Slc14a2	solute carrier family 14 (urea transporter), member 2	0.018
Wt1	Wilms tumor 1 homolog	0.018
Prkci	protein kinase C, iota	0.018
Arid5b	AT rich interactive domain 5B (MRF1-like)	0.018
Pnpla2	patatin-like phospholipase domain containing 2	0.017
Trp53	transformation related protein 53	0.017
S1pr1	sphingosine-1-phosphate receptor 1	0.017
Tnfsf9	tumor necrosis factor (ligand) superfamily, member 9	0.017
Apoa4	apolipoprotein A-IV	0.017
Akr1b7	aldo-keto reductase family 1, member B7	0.017
Rps6ka3	ribosomal protein S6 kinase polypeptide 3	0.016
Ppargc1a	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	0.016
Adra1b	adrenergic receptor, alpha 1b	0.015
Egr2	early growth response 2	0.015
Foxf1a	forkhead box F1a	0.015
Nr3c2	nuclear receptor subfamily 3, group C, member 2	0.015
Ptpn2	protein tyrosine phosphatase, non-receptor type 2	0.015
Dusp1	dual specificity phosphatase 1	0.015
Nfil3	nuclear factor, interleukin 3, regulated	0.015
Vhl	von Hippel-Lindau tumor suppressor	0.015
Cyld	cylindromatosis (turban tumor syndrome)	0.014
Sctr	secretin receptor	0.014
Zap70	zeta-chain (TCR) associated protein kinase	0.013
Il12b	interleukin 12b	0.013
Usp25	ubiquitin specific peptidase 25	0.013
Hipk3	homeodomain interacting protein kinase 3	0.013
Igf2bp2	insulin-like growth factor 2 mRNA binding protein 2	0.013
Dusp2	dual specificity phosphatase 2	0.013
Pcsk4	proprotein convertase subtilisin/kexin type 4	0.013
Chmp1b	chromatin modifying protein 1B	0.013
Il2rb	interleukin 2 receptor, beta chain	0.013
Dpysl2	dihydropyrimidinase-like 2	0.013
Sirt1	sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)	0.013
Gab2	growth factor receptor bound protein 2-associated protein 2	0.013
Batf	basic leucine zipper transcription factor, ATF-like	0.012
Stk40	serine/threonine kinase 40	0.012
Sertad1	SERTA domain containing 1	0.012
Nr0b2	nuclear receptor subfamily 0, group B, member 2	0.012
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.012
Purb	purine rich element binding protein B	0.012
Braf	Braf transforming gene	0.012
Nf1	neurofibromatosis 1	0.012
Sct	secretin	0.011
Klf10	Kruppel-like factor 10	0.011
Rap2c	RAP2C, member of RAS oncogene family	0.011
Atp2a2	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	0.011
Prkaa1	protein kinase, AMP-activated, alpha 1 catalytic subunit	0.011
Hamp	hepcidin antimicrobial peptide	0.011
Il12rb1	interleukin 12 receptor, beta 1	0.011
Cpe	carboxypeptidase E	0.010
Btg2	B-cell translocation gene 2, anti-proliferative	0.010
Habp2	hyaluronic acid binding protein 2	0.010
Serpinc1	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	0.010
Kl	klotho	0.010
Rap2a	RAS related protein 2a	0.010
Socs7	suppressor of cytokine signaling 7	0.010	Mouse
Plscr1	phospholipid scramblase 1	0.010
Apoa1	apolipoprotein A-I	0.010
Gck	glucokinase	0.010
Jak3	Janus kinase 3	0.010
Tbxa2r	thromboxane A2 receptor	0.010
Ubtd2	ubiquitin domain containing 2	0.010