IMP

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Mus musculus

2 genes annotated in mouse

vegf activated neuropilin signaling pathway

A series of molecular signals initiated by the binding of vascular endothelial growth factor (VEGF) to a neuropilin protein on the surface of a target cell, followed by transmission of the signal, and ending with regulation of a downstream cellular process, e.g. transcription.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "vegf activated neuropilin signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "vegf activated neuropilin signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
Plxnd1	plexin D1	0.995
Kdr	kinase insert domain protein receptor	0.979
Nrp1	neuropilin 1	0.957
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.947
Nos3	nitric oxide synthase 3, endothelial cell	0.901
Flt1	FMS-like tyrosine kinase 1	0.826
Ednra	endothelin receptor type A	0.823
Flt4	FMS-like tyrosine kinase 4	0.712
Vegfa	vascular endothelial growth factor A	0.705
Ece1	endothelin converting enzyme 1	0.674
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.479
Acvr1	activin A receptor, type 1	0.397
Ptprb	protein tyrosine phosphatase, receptor type, B	0.311
Mkl2	MKL/myocardin-like 2	0.281
Cd151	CD151 antigen	0.235
Eng	endoglin	0.226
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.207
Apbb2	amyloid beta (A4) precursor protein-binding, family B, member 2	0.189
Epas1	endothelial PAS domain protein 1	0.187
Itga3	integrin alpha 3	0.147
Gaa	glucosidase, alpha, acid	0.136
Ptk2	PTK2 protein tyrosine kinase 2	0.125
Atp2a2	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	0.113
Plxna1	plexin A1	0.104
Ilk	integrin linked kinase	0.099
Cdh5	cadherin 5	0.098
Fzd4	frizzled homolog 4 (Drosophila)	0.098
Tcf4	transcription factor 4	0.096
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.092
Lama4	laminin, alpha 4	0.092
Egln1	EGL nine homolog 1 (C. elegans)	0.086
Col1a1	collagen, type I, alpha 1	0.083
Hbegf	heparin-binding EGF-like growth factor	0.078
Id1	inhibitor of DNA binding 1	0.075
Bcar1	breast cancer anti-estrogen resistance 1	0.072
Lepr	leptin receptor	0.070
Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.065
Ripply3	ripply3 homolog (zebrafish)	0.065
Ldb2	LIM domain binding 2	0.063
Pdgfc	platelet-derived growth factor, C polypeptide	0.063
Tspan12	tetraspanin 12	0.063
Apoe	apolipoprotein E	0.062
Emcn	endomucin	0.061
Cav1	caveolin 1, caveolae protein	0.061
Tgfbr2	transforming growth factor, beta receptor II	0.060
Pdgfa	platelet derived growth factor, alpha	0.059	Mouse
Cd93	CD93 antigen	0.053
Plcg1	phospholipase C, gamma 1	0.052
Pecam1	platelet/endothelial cell adhesion molecule 1	0.050
Lrp1	low density lipoprotein receptor-related protein 1	0.050
Lama5	laminin, alpha 5	0.049
Nfib	nuclear factor I/B	0.048
Ltbp1	latent transforming growth factor beta binding protein 1	0.048
Bcl2	B-cell leukemia/lymphoma 2	0.048
Ccm2	cerebral cavernous malformation 2 homolog (human)	0.047
Tek	endothelial-specific receptor tyrosine kinase	0.046
Ptgs2	prostaglandin-endoperoxide synthase 2	0.046
Aes	amino-terminal enhancer of split	0.045
Lamb1	laminin B1	0.045
Thbd	thrombomodulin	0.045
Fbln1	fibulin 1	0.045
Myadm	myeloid-associated differentiation marker	0.043
Gata6	GATA binding protein 6	0.042
Sox7	SRY-box containing gene 7	0.042
Wwtr1	WW domain containing transcription regulator 1	0.041
Phlda3	pleckstrin homology-like domain, family A, member 3	0.040
Rdh10	retinol dehydrogenase 10 (all-trans)	0.039
Vhl	von Hippel-Lindau tumor suppressor	0.039
Sema3f	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	0.039
Tie1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.038
Aplnr	apelin receptor	0.038
Pltp	phospholipid transfer protein	0.038
Phldb2	pleckstrin homology-like domain, family B, member 2	0.037
Tspan9	tetraspanin 9	0.037
Col4a2	collagen, type IV, alpha 2	0.036
Fli1	Friend leukemia integration 1	0.035
Col4a3	collagen, type IV, alpha 3	0.035
Lmna	lamin A	0.035
Zfhx3	zinc finger homeobox 3	0.035
Sema3a	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	0.035
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.033
Sox18	SRY-box containing gene 18	0.033
Plxna2	plexin A2	0.033
Acvrl1	activin A receptor, type II-like 1	0.032
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.032
Slc27a1	solute carrier family 27 (fatty acid transporter), member 1	0.031
Dock4	dedicator of cytokinesis 4	0.031
Fgf8	fibroblast growth factor 8	0.031
Rxra	retinoid X receptor alpha	0.031
She	src homology 2 domain-containing transforming protein E	0.031
Pcolce	procollagen C-endopeptidase enhancer protein	0.030
Ehd4	EH-domain containing 4	0.030
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.030
Ren1	renin 1 structural	0.029
Wt1	Wilms tumor 1 homolog	0.029
Cxcl12	chemokine (C-X-C motif) ligand 12	0.028
Myl9	myosin, light polypeptide 9, regulatory	0.027
Pfkm	phosphofructokinase, muscle	0.027
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.026
S1pr3	sphingosine-1-phosphate receptor 3	0.026
Naalad2	N-acetylated alpha-linked acidic dipeptidase 2	0.026
Agtr1a	angiotensin II receptor, type 1a	0.026
Ptov1	prostate tumor over expressed gene 1	0.026
Cldn5	claudin 5	0.025
Itgb5	integrin beta 5	0.025
Ptprm	protein tyrosine phosphatase, receptor type, M	0.024
Adrb1	adrenergic receptor, beta 1	0.024
Plvap	plasmalemma vesicle associated protein	0.023
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.023
Nenf	neuron derived neurotrophic factor	0.022
Ramp2	receptor (calcitonin) activity modifying protein 2	0.022
Mesp1	mesoderm posterior 1	0.022
P4ha2	procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha II polypeptide	0.022
Nav1	neuron navigator 1	0.022
Spry4	sprouty homolog 4 (Drosophila)	0.022
Cacna1c	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.022
Emp2	epithelial membrane protein 2	0.021
Lamc1	laminin, gamma 1	0.021
Wwc2	WW, C2 and coiled-coil domain containing 2	0.021
Colec12	collectin sub-family member 12	0.021
Pparg	peroxisome proliferator activated receptor gamma	0.020
Prkg2	protein kinase, cGMP-dependent, type II	0.020
Fgd5	FYVE, RhoGEF and PH domain containing 5	0.020
Ikbip	IKBKB interacting protein	0.020
Prkci	protein kinase C, iota	0.020
Smad6	MAD homolog 6 (Drosophila)	0.020
Cd34	CD34 antigen	0.020
Podxl	podocalyxin-like	0.019
Tmem204	transmembrane protein 204	0.019
Edn1	endothelin 1	0.019
Ghr	growth hormone receptor	0.018
Cacnb2	calcium channel, voltage-dependent, beta 2 subunit	0.018
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.018
Ddr2	discoidin domain receptor family, member 2	0.018
Src	Rous sarcoma oncogene	0.018
F2r	coagulation factor II (thrombin) receptor	0.018
Notch2	Notch gene homolog 2 (Drosophila)	0.018
Bmp4	bone morphogenetic protein 4	0.018
Extl3	exostoses (multiple)-like 3	0.018
Rasgrp3	RAS, guanyl releasing protein 3	0.018
Fkbp9	FK506 binding protein 9	0.018
Ptgfrn	prostaglandin F2 receptor negative regulator	0.018
Sema6d	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	0.018
Mcam	melanoma cell adhesion molecule	0.018
Dag1	dystroglycan 1	0.018
Large	like-glycosyltransferase	0.018
Pvr	poliovirus receptor	0.017
Nfix	nuclear factor I/X	0.017
Gng11	guanine nucleotide binding protein (G protein), gamma 11	0.017
Lhfp	lipoma HMGIC fusion partner	0.017
Mas1	MAS1 oncogene	0.017
Krtap3-3	keratin associated protein 3-3	0.017
Fn1	fibronectin 1	0.017
Sdc3	syndecan 3	0.017
Tgfb2	transforming growth factor, beta 2	0.017
Jag1	jagged 1	0.016
Rasip1	Ras interacting protein 1	0.016
Snai2	snail homolog 2 (Drosophila)	0.016
Ndn	necdin	0.016
Itga1	integrin alpha 1	0.016
Nf1	neurofibromatosis 1	0.016
Fam69b	family with sequence similarity 69, member B	0.016
Clec14a	C-type lectin domain family 14, member a	0.016
Esam	endothelial cell-specific adhesion molecule	0.016
Adam22	a disintegrin and metallopeptidase domain 22	0.016
Tgfb1i1	transforming growth factor beta 1 induced transcript 1	0.016
Gja4	gap junction protein, alpha 4	0.015
Ar	androgen receptor	0.015
Cdh11	cadherin 11	0.015
Ldlr	low density lipoprotein receptor	0.015
Ppap2b	phosphatidic acid phosphatase type 2B	0.015
Itm2c	integral membrane protein 2C	0.015
Elk3	ELK3, member of ETS oncogene family	0.015
Myo1e	myosin IE	0.015
Sox17	SRY-box containing gene 17	0.015
Fat4	FAT tumor suppressor homolog 4 (Drosophila)	0.015
Ttl	tubulin tyrosine ligase	0.015
Arap3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.014
Nr2f2	nuclear receptor subfamily 2, group F, member 2	0.014
Nrp2	neuropilin 2	0.014	Mouse
Homer1	homer homolog 1 (Drosophila)	0.014
Scn7a	sodium channel, voltage-gated, type VII, alpha	0.014
Mtch1	mitochondrial carrier homolog 1 (C. elegans)	0.014
Pdgfb	platelet derived growth factor, B polypeptide	0.014	Mouse
Olfm1	olfactomedin 1	0.013
Rarb	retinoic acid receptor, beta	0.013
Fam198b	family with sequence similarity 198, member B	0.013
Efnb2	ephrin B2	0.013
Tcf21	transcription factor 21	0.013
Ptp4a3	protein tyrosine phosphatase 4a3	0.013
Rras	Harvey rat sarcoma oncogene, subgroup R	0.013
Mest	mesoderm specific transcript	0.013
Pmepa1	prostate transmembrane protein, androgen induced 1	0.013
Phlda1	pleckstrin homology-like domain, family A, member 1	0.013
Fstl3	follistatin-like 3	0.013
Gjc1	gap junction protein, gamma 1	0.013
Zeb2	zinc finger E-box binding homeobox 2	0.013
Antxr2	anthrax toxin receptor 2	0.013
Pea15a	phosphoprotein enriched in astrocytes 15A	0.013
Nfic	nuclear factor I/C	0.013
Rbpms	RNA binding protein gene with multiple splicing	0.012
Pfkl	phosphofructokinase, liver, B-type	0.012
Cd81	CD81 antigen	0.012
Col4a1	collagen, type IV, alpha 1	0.012
Serpine1	serine (or cysteine) peptidase inhibitor, clade E, member 1	0.012
Npy2r	neuropeptide Y receptor Y2	0.012
Sept4	septin 4	0.012
Prkd1	protein kinase D1	0.012
Tgfb1	transforming growth factor, beta 1	0.012
Nos1	nitric oxide synthase 1, neuronal	0.012
Dmd	dystrophin, muscular dystrophy	0.012
Gnb4	guanine nucleotide binding protein (G protein), beta 4	0.012
Amotl1	angiomotin-like 1	0.012
Stard8	START domain containing 8	0.012
Pcbp4	poly(rC) binding protein 4	0.012
Itga5	integrin alpha 5 (fibronectin receptor alpha)	0.012
Gys1	glycogen synthase 1, muscle	0.012
Fgf7	fibroblast growth factor 7	0.012
Pdc	phosducin	0.012
Dlc1	deleted in liver cancer 1	0.012
Pfkfb2	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	0.012
Dapk2	death-associated protein kinase 2	0.012
Crtap	cartilage associated protein	0.012
Rbms3	RNA binding motif, single stranded interacting protein	0.012
Hlx	H2.0-like homeobox	0.012
Pls3	plastin 3 (T-isoform)	0.012
Cryab	crystallin, alpha B	0.012
Ehd3	EH-domain containing 3	0.011
Mid2	midline 2	0.011
Ptprg	protein tyrosine phosphatase, receptor type, G	0.011
Slit2	slit homolog 2 (Drosophila)	0.011
Mmrn2	multimerin 2	0.011
Mid1	midline 1	0.011
Arhgap29	Rho GTPase activating protein 29	0.011
Lamb2	laminin, beta 2	0.011
Fermt2	fermitin family homolog 2 (Drosophila)	0.011
Wnt5a	wingless-related MMTV integration site 5A	0.011
Ckb	creatine kinase, brain	0.011
Fam20c	family with sequence similarity 20, member C	0.011
Tmbim1	transmembrane BAX inhibitor motif containing 1	0.011
Sox4	SRY-box containing gene 4	0.011
Nov	nephroblastoma overexpressed gene	0.011
Gpr56	G protein-coupled receptor 56	0.011
Pkd2	polycystic kidney disease 2	0.010
Armcx2	armadillo repeat containing, X-linked 2	0.010
Dpysl2	dihydropyrimidinase-like 2	0.010
Irs1	insulin receptor substrate 1	0.010
Npdc1	neural proliferation, differentiation and control gene 1	0.010
Ercc1	excision repair cross-complementing rodent repair deficiency, complementation group 1	0.010
Slc17a1	solute carrier family 17 (sodium phosphate), member 1	0.010
Cfh	complement component factor h	0.010
Gja1	gap junction protein, alpha 1	0.010
Htra1	HtrA serine peptidase 1	0.010
Camk1	calcium/calmodulin-dependent protein kinase I	0.010