IMP

Process View

Mus musculus

4 genes annotated in mouse

platelet derived growth factor receptor beta signaling pathway

A series of molecular signals initiated by the binding of a ligand to a beta-type platelet-derived growth factor receptor (PDGFbeta) on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "platelet derived growth factor receptor beta signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "platelet derived growth factor receptor beta signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
Csf1	colony stimulating factor 1 (macrophage)	0.813
Nos3	nitric oxide synthase 3, endothelial cell	0.797
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.754
Vegfa	vascular endothelial growth factor A	0.685
Tie1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.521
Kitl	kit ligand	0.457
Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.442
Pkd1	polycystic kidney disease 1 homolog	0.413
Cdh5	cadherin 5	0.374
Lrp1	low density lipoprotein receptor-related protein 1	0.272
Psen1	presenilin 1	0.237
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.217
Apoe	apolipoprotein E	0.208
Epas1	endothelial PAS domain protein 1	0.186
Ptprb	protein tyrosine phosphatase, receptor type, B	0.172
Mapk8ip1	mitogen-activated protein kinase 8 interacting protein 1	0.168
Arap3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.143
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.137	Mouse
Lyz2	lysozyme 2	0.132
Vegfc	vascular endothelial growth factor C	0.123
Tmem204	transmembrane protein 204	0.118
Foxc2	forkhead box C2	0.118
Eng	endoglin	0.118
Meox2	mesenchyme homeobox 2	0.116
She	src homology 2 domain-containing transforming protein E	0.113
C1qc	complement component 1, q subcomponent, C chain	0.111
Fgfr1	fibroblast growth factor receptor 1	0.110
Tek	endothelial-specific receptor tyrosine kinase	0.103
Tbx3	T-box 3	0.103
Notch2	Notch gene homolog 2 (Drosophila)	0.102
Cxcl12	chemokine (C-X-C motif) ligand 12	0.101
Stat3	signal transducer and activator of transcription 3	0.099
Col4a2	collagen, type IV, alpha 2	0.092
Flt1	FMS-like tyrosine kinase 1	0.087	Mouse
Tgfb1	transforming growth factor, beta 1	0.087
Bmp2	bone morphogenetic protein 2	0.085
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.081
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.081
Plcg1	phospholipase C, gamma 1	0.079
Runx2	runt related transcription factor 2	0.077
Pdgfb	platelet derived growth factor, B polypeptide	0.073	Human
Sox18	SRY-box containing gene 18	0.069
Apaf1	apoptotic peptidase activating factor 1	0.067
Col1a1	collagen, type I, alpha 1	0.065
Plxnd1	plexin D1	0.063
Ldlr	low density lipoprotein receptor	0.063
Cd93	CD93 antigen	0.062
Cbl	Casitas B-lineage lymphoma	0.062
Fyn	Fyn proto-oncogene	0.062
Stab1	stabilin 1	0.057
Esam	endothelial cell-specific adhesion molecule	0.052
Sox13	SRY-box containing gene 13	0.051
Grn	granulin	0.050
Cldn5	claudin 5	0.049
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.049
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.048
Esr1	estrogen receptor 1 (alpha)	0.048
Aplnr	apelin receptor	0.047
Ednrb	endothelin receptor type B	0.047
Zeb1	zinc finger E-box binding homeobox 1	0.046
Pecam1	platelet/endothelial cell adhesion molecule 1	0.046
Acvrl1	activin A receptor, type II-like 1	0.045
Ptch1	patched homolog 1	0.044
Adcy4	adenylate cyclase 4	0.043
Tyrobp	TYRO protein tyrosine kinase binding protein	0.042
Ctnnb1	catenin (cadherin associated protein), beta 1	0.039
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.039
Mertk	c-mer proto-oncogene tyrosine kinase	0.038
Rasip1	Ras interacting protein 1	0.037
Gja4	gap junction protein, alpha 4	0.037
Vwf	Von Willebrand factor homolog	0.036
Ltbp3	latent transforming growth factor beta binding protein 3	0.036
S1pr3	sphingosine-1-phosphate receptor 3	0.036
Tgfbr2	transforming growth factor, beta receptor II	0.035
Robo4	roundabout homolog 4 (Drosophila)	0.035
Plvap	plasmalemma vesicle associated protein	0.035
Apc	adenomatosis polyposis coli	0.035
Npc1	Niemann Pick type C1	0.034
Podxl	podocalyxin-like	0.034
Slc6a20b	solute carrier family 6 (neurotransmitter transporter), member 20B	0.034
Gnai2	guanine nucleotide binding protein (G protein), alpha inhibiting 2	0.033
Ncoa3	nuclear receptor coactivator 3	0.033
Il6st	interleukin 6 signal transducer	0.033
Tcirg1	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3	0.031
Col4a3	collagen, type IV, alpha 3	0.031
Cyp19a1	cytochrome P450, family 19, subfamily a, polypeptide 1	0.031
Bcl2	B-cell leukemia/lymphoma 2	0.030
Kdr	kinase insert domain protein receptor	0.030	Mouse
Lepr	leptin receptor	0.030
Fgfr3	fibroblast growth factor receptor 3	0.030
Itgb5	integrin beta 5	0.030
Ldb2	LIM domain binding 2	0.030
Itga3	integrin alpha 3	0.029
Pparg	peroxisome proliferator activated receptor gamma	0.029
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.029
Ushbp1	Usher syndrome 1C binding protein 1	0.028
Dab2	disabled homolog 2 (Drosophila)	0.028
Anpep	alanyl (membrane) aminopeptidase	0.027
Hlx	H2.0-like homeobox	0.027
Arid5b	AT rich interactive domain 5B (MRF1-like)	0.027
Gsk3b	glycogen synthase kinase 3 beta	0.027
Sgpl1	sphingosine phosphate lyase 1	0.027
Sertad2	SERTA domain containing 2	0.026
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.026
Tiparp	TCDD-inducible poly(ADP-ribose) polymerase	0.025
Thbd	thrombomodulin	0.025
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.025
Gpx3	glutathione peroxidase 3	0.025
Egfl7	EGF-like domain 7	0.025
Lrp4	low density lipoprotein receptor-related protein 4	0.024	Mouse
Tbx2	T-box 2	0.024
Klf15	Kruppel-like factor 15	0.024
Sox7	SRY-box containing gene 7	0.024
Tinagl1	tubulointerstitial nephritis antigen-like 1	0.023
Tenc1	tensin like C1 domain-containing phosphatase	0.023
Lama5	laminin, alpha 5	0.023
Jak2	Janus kinase 2	0.023
Axin1	axin 1	0.023
Gucy1b3	guanylate cyclase 1, soluble, beta 3	0.023
Tnks1bp1	tankyrase 1 binding protein 1	0.023
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.023
Col4a1	collagen, type IV, alpha 1	0.023
Mitf	microphthalmia-associated transcription factor	0.022
Gas1	growth arrest specific 1	0.022
Phex	phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)	0.022
Emcn	endomucin	0.022
Ramp2	receptor (calcitonin) activity modifying protein 2	0.021
Heg1	HEG homolog 1 (zebrafish)	0.021
Crtc3	CREB regulated transcription coactivator 3	0.021
Bmp4	bone morphogenetic protein 4	0.021
Pltp	phospholipid transfer protein	0.021
Shank3	SH3/ankyrin domain gene 3	0.020
Cacnb2	calcium channel, voltage-dependent, beta 2 subunit	0.020
Nid1	nidogen 1	0.020
Src	Rous sarcoma oncogene	0.020
Gja1	gap junction protein, alpha 1	0.019
Glg1	golgi apparatus protein 1	0.019
Mmrn2	multimerin 2	0.019
Gpr116	G protein-coupled receptor 116	0.019
Cdh1	cadherin 1	0.019
C1qb	complement component 1, q subcomponent, beta polypeptide	0.018
Hdac7	histone deacetylase 7	0.018
P2ry6	pyrimidinergic receptor P2Y, G-protein coupled, 6	0.018
Apln	apelin	0.018
Wwc2	WW, C2 and coiled-coil domain containing 2	0.017
Kctd10	potassium channel tetramerisation domain containing 10	0.017
Figf	c-fos induced growth factor	0.017
Pdgfc	platelet-derived growth factor, C polypeptide	0.017
X99384	cDNA sequence X99384	0.017
Agtr2	angiotensin II receptor, type 2	0.017
Smo	smoothened homolog (Drosophila)	0.017
Cntn3	contactin 3	0.017
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.017
Sox17	SRY-box containing gene 17	0.017
Pvrl2	poliovirus receptor-related 2	0.017
Caskin2	CASK-interacting protein 2	0.017
Apbb2	amyloid beta (A4) precursor protein-binding, family B, member 2	0.017
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.016
Zfhx3	zinc finger homeobox 3	0.016
Sirpa	signal-regulatory protein alpha	0.016
Sorbs3	sorbin and SH3 domain containing 3	0.016
Mas1	MAS1 oncogene	0.016
Fgd5	FYVE, RhoGEF and PH domain containing 5	0.016
Tmem150a	transmembrane protein 150A	0.016
Myh9	myosin, heavy polypeptide 9, non-muscle	0.016
Notch1	Notch gene homolog 1 (Drosophila)	0.016
Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	0.016
Prkd1	protein kinase D1	0.016
Tgfb2	transforming growth factor, beta 2	0.016
Nav1	neuron navigator 1	0.016
Icam2	intercellular adhesion molecule 2	0.015
Ptprf	protein tyrosine phosphatase, receptor type, F	0.015
Lamb2	laminin, beta 2	0.015
Eltd1	EGF, latrophilin seven transmembrane domain containing 1	0.015
Rasa3	RAS p21 protein activator 3	0.015
Schip1	schwannomin interacting protein 1	0.015
Sipa1l2	signal-induced proliferation-associated 1 like 2	0.015
Vangl2	vang-like 2 (van gogh, Drosophila)	0.015
Folr1	folate receptor 1 (adult)	0.015
C1qa	complement component 1, q subcomponent, alpha polypeptide	0.014
Foxp3	forkhead box P3	0.014
Col4a4	collagen, type IV, alpha 4	0.014
Card10	caspase recruitment domain family, member 10	0.014
Sdc3	syndecan 3	0.014
Lcat	lecithin cholesterol acyltransferase	0.014
Tln1	talin 1	0.014
Ikzf1	IKAROS family zinc finger 1	0.014
D730048I06Rik	RIKEN cDNA D730048I06 gene	0.014
Bmp7	bone morphogenetic protein 7	0.014
Kifc3	kinesin family member C3	0.014
Myo9b	myosin IXb	0.014
Nrp1	neuropilin 1	0.014
Bcl6b	B-cell CLL/lymphoma 6, member B	0.013
0610009D07Rik	RIKEN cDNA 0610009D07 gene	0.013
App	amyloid beta (A4) precursor protein	0.013
Plekho1	pleckstrin homology domain containing, family O member 1	0.013
Mesdc2	mesoderm development candidate 2	0.013
Kit	kit oncogene	0.013	Mouse
Ncor2	nuclear receptor co-repressor 2	0.013
Ptpn21	protein tyrosine phosphatase, non-receptor type 21	0.013
Jup	junction plakoglobin	0.013
Inpp5d	inositol polyphosphate-5-phosphatase D	0.013
Cotl1	coactosin-like 1 (Dictyostelium)	0.013
Crebbp	CREB binding protein	0.013
Bex6	brain expressed gene 6	0.013
Trim3	tripartite motif-containing 3	0.013
Stard8	START domain containing 8	0.013
Pxn	paxillin	0.013
Rab11fip5	RAB11 family interacting protein 5 (class I)	0.013
Klra17	killer cell lectin-like receptor, subfamily A, member 17	0.012
Ptgs1	prostaglandin-endoperoxide synthase 1	0.012
Slco6c1	solute carrier organic anion transporter family, member 6c1	0.012
Gli3	GLI-Kruppel family member GLI3	0.012
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.012
Prss12	protease, serine, 12 neurotrypsin (motopsin)	0.012
Jun	Jun oncogene	0.012
Ly86	lymphocyte antigen 86	0.012
Pdcl2	phosducin-like 2	0.012
Bcar1	breast cancer anti-estrogen resistance 1	0.012
Itga8	integrin alpha 8	0.012
Plekhh1	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	0.012
Pcdh12	protocadherin 12	0.012
H2-Aa	histocompatibility 2, class II antigen A, alpha	0.012
Sox11	SRY-box containing gene 11	0.012
Fbln1	fibulin 1	0.012
Vat1	vesicle amine transport protein 1 homolog (T californica)	0.012
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.012
Gaa	glucosidase, alpha, acid	0.012
Leprel2	leprecan-like 2	0.012
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.011
Efnb1	ephrin B1	0.011
Kank3	KN motif and ankyrin repeat domains 3	0.011
Scarb1	scavenger receptor class B, member 1	0.011
Pkdcc	protein kinase domain containing, cytoplasmic	0.011
Nab2	Ngfi-A binding protein 2	0.011
Igfbp4	insulin-like growth factor binding protein 4	0.011
Hnrpdl	heterogeneous nuclear ribonucleoprotein D-like	0.011
Gcet2	germinal center expressed transcript 2	0.011
Nhsl2	NHS-like 2	0.011
Adrb1	adrenergic receptor, beta 1	0.011
Sept4	septin 4	0.011
Gata2	GATA binding protein 2	0.011
Nrp2	neuropilin 2	0.011
Efnb2	ephrin B2	0.011
Unc93b1	unc-93 homolog B1 (C. elegans)	0.011
Tcf7l2	transcription factor 7-like 2, T-cell specific, HMG-box	0.011
Itpkb	inositol 1,4,5-trisphosphate 3-kinase B	0.011
Phldb1	pleckstrin homology-like domain, family B, member 1	0.011
Notch3	Notch gene homolog 3 (Drosophila)	0.011
Gpr182	G protein-coupled receptor 182	0.011
Pet2	plasmacytoma expressed transcript 2	0.011
Tbc1d2b	TBC1 domain family, member 2B	0.011
Pkd2	polycystic kidney disease 2	0.011
Dnttip2	deoxynucleotidyltransferase, terminal, interacting protein 2	0.011
Olfr74	olfactory receptor 74	0.011
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.011
Ddx4	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4	0.011
Lrp6	low density lipoprotein receptor-related protein 6	0.011	Mouse
Bmp5	bone morphogenetic protein 5	0.011
BC028528	cDNA sequence BC028528	0.010
Pld4	phospholipase D family, member 4	0.010
Csf2	colony stimulating factor 2 (granulocyte-macrophage)	0.010
Grb7	growth factor receptor bound protein 7	0.010
Cubn	cubilin (intrinsic factor-cobalamin receptor)	0.010
Umod	uromodulin	0.010
Dnajb5	DnaJ (Hsp40) homolog, subfamily B, member 5	0.010
Emr1	EGF-like module containing, mucin-like, hormone receptor-like sequence 1	0.010
Smtn	smoothelin	0.010
Phlda1	pleckstrin homology-like domain, family A, member 1	0.010
Lrp5	low density lipoprotein receptor-related protein 5	0.010	Mouse
Plekha1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	0.010
Dennd5a	DENN/MADD domain containing 5A	0.010
Fam171a1	family with sequence similarity 171, member A1	0.010
Kif3a	kinesin family member 3A	0.010
Tmed11	transmembrane emp24 protein transport domain containing	0.010
Plod3	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3	0.010