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Process View

Mus musculus

5 genes annotated in mouse

notochord formation

The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "notochord formation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "notochord formation" (in gray)

Name	Description	Probability	Func Analog Organism
Efnb2	ephrin B2	1.000	Mouse
Shh	sonic hedgehog	1.000
Pitx2	paired-like homeodomain transcription factor 2	1.000
Fgfr2	fibroblast growth factor receptor 2	1.000
Gli3	GLI-Kruppel family member GLI3	1.000
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.999
Jag1	jagged 1	0.999
Vangl2	vang-like 2 (van gogh, Drosophila)	0.998
Tbx3	T-box 3	0.998	Mouse
Gata4	GATA binding protein 4	0.997
Foxc1	forkhead box C1	0.995
Pax2	paired box gene 2	0.994
Foxg1	forkhead box G1	0.992
Foxc2	forkhead box C2	0.992
Hoxa1	homeobox A1	0.990
Epha4	Eph receptor A4	0.977	Mouse
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.967
Pax3	paired box gene 3	0.965
Fgf8	fibroblast growth factor 8	0.964
Eya1	eyes absent 1 homolog (Drosophila)	0.954
Ephb2	Eph receptor B2	0.954	Mouse
Pitx1	paired-like homeodomain transcription factor 1	0.946
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.944
Bmp4	bone morphogenetic protein 4	0.936
Chd7	chromodomain helicase DNA binding protein 7	0.936
Ntf3	neurotrophin 3	0.925
Tcfap2a	transcription factor AP-2, alpha	0.878
Nodal	nodal	0.876
Sox2	SRY-box containing gene 2	0.872
Efnb1	ephrin B1	0.871	Mouse
Otx2	orthodenticle homolog 2 (Drosophila)	0.869
Sox9	SRY-box containing gene 9	0.850
Fgf10	fibroblast growth factor 10	0.846
Tgfb2	transforming growth factor, beta 2	0.845
Gata5	GATA binding protein 5	0.736
Dlx5	distal-less homeobox 5	0.725
Zic3	zinc finger protein of the cerebellum 3	0.624
Smad6	MAD homolog 6 (Drosophila)	0.619
Isl1	ISL1 transcription factor, LIM/homeodomain	0.619
Chrd	chordin	0.559
Atoh7	atonal homolog 7 (Drosophila)	0.540
Hand1	heart and neural crest derivatives expressed transcript 1	0.521
Tbx1	T-box 1	0.516	Mouse
Sox11	SRY-box containing gene 11	0.500
Lhx1	LIM homeobox protein 1	0.472
Hand2	heart and neural crest derivatives expressed transcript 2	0.467
Fgfr3	fibroblast growth factor receptor 3	0.444
Gata6	GATA binding protein 6	0.443
Gli2	GLI-Kruppel family member GLI2	0.429
Zfpm2	zinc finger protein, multitype 2	0.385
Wt1	Wilms tumor 1 homolog	0.382
Gbx2	gastrulation brain homeobox 2	0.371
Notch1	Notch gene homolog 1 (Drosophila)	0.347
Rarg	retinoic acid receptor, gamma	0.345
Nog	noggin	0.316
Smo	smoothened homolog (Drosophila)	0.314
Ptk7	PTK7 protein tyrosine kinase 7	0.311
Prrx1	paired related homeobox 1	0.304
Pbx1	pre B-cell leukemia transcription factor 1	0.291
Msx2	homeobox, msh-like 2	0.291
Zeb1	zinc finger E-box binding homeobox 1	0.282
Wnt5a	wingless-related MMTV integration site 5A	0.259
Ephb3	Eph receptor B3	0.254	Mouse
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.254
Irx3	Iroquois related homeobox 3 (Drosophila)	0.241
Msx1	homeobox, msh-like 1	0.238
Prph2	peripherin 2	0.236
Lrp6	low density lipoprotein receptor-related protein 6	0.232
Efna1	ephrin A1	0.211
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.211
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.183
Foxj1	forkhead box J1	0.176
Hes1	hairy and enhancer of split 1 (Drosophila)	0.153
Pax6	paired box gene 6	0.151
Dock1	dedicator of cytokinesis 1	0.144
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.143
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.139
Bdnf	brain derived neurotrophic factor	0.139
Hoxa2	homeobox A2	0.135
Rxra	retinoid X receptor alpha	0.134
Col2a1	collagen, type II, alpha 1	0.134
Alx1	ALX homeobox 1	0.126
Dnahc11	dynein, axonemal, heavy chain 11	0.122
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.117
Ret	ret proto-oncogene	0.114
Bmp7	bone morphogenetic protein 7	0.113
Klf3	Kruppel-like factor 3 (basic)	0.109
Tbx6	T-box 6	0.107	Mouse
Pou5f1	POU domain, class 5, transcription factor 1	0.101
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.098
Rarb	retinoic acid receptor, beta	0.097
Gja5	gap junction protein, alpha 5	0.092
Fgfr1	fibroblast growth factor receptor 1	0.092
Dll4	delta-like 4 (Drosophila)	0.091
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.091
Sox4	SRY-box containing gene 4	0.091
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.090
Alx4	aristaless-like homeobox 4	0.090
Bnc1	basonuclin 1	0.089
Lhx9	LIM homeobox protein 9	0.085
Trp63	transformation related protein 63	0.082
Lrp5	low density lipoprotein receptor-related protein 5	0.081
Cxadr	coxsackie virus and adenovirus receptor	0.081
Col13a1	collagen, type XIII, alpha 1	0.080
Hey1	hairy/enhancer-of-split related with YRPW motif 1	0.080
Dlx1	distal-less homeobox 1	0.076
Itga3	integrin alpha 3	0.076
Adam19	a disintegrin and metallopeptidase domain 19 (meltrin beta)	0.075
Noto	notochord homolog (Xenopus laevis)	0.074	Zebrafish
Runx1t1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.070
Mks1	Meckel syndrome, type 1	0.068
Pax1	paired box gene 1	0.067
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.067
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.067
Gsc	goosecoid homeobox	0.066
Snai1	snail homolog 1 (Drosophila)	0.066
Tead2	TEA domain family member 2	0.054
Ptch1	patched homolog 1	0.054
Scn5a	sodium channel, voltage-gated, type V, alpha	0.053
St8sia2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.053
Sall4	sal-like 4 (Drosophila)	0.053
Hoxa13	homeobox A13	0.052
Nck2	non-catalytic region of tyrosine kinase adaptor protein 2	0.052
Emx2	empty spiracles homolog 2 (Drosophila)	0.052
Sema3f	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	0.051
Hoxb1	homeobox B1	0.051
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.049
Tcf21	transcription factor 21	0.048
Nf1	neurofibromatosis 1	0.048
Tead1	TEA domain family member 1	0.046
Efna4	ephrin A4	0.046
Shox2	short stature homeobox 2	0.045
Efna2	ephrin A2	0.044	Mouse
Hoxa3	homeobox A3	0.043
Ighmbp2	immunoglobulin mu binding protein 2	0.043
Prox1	prospero-related homeobox 1	0.042
Foxa2	forkhead box A2	0.040
Fzd8	frizzled homolog 8 (Drosophila)	0.040
Npr3	natriuretic peptide receptor 3	0.039
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.037
Otx1	orthodenticle homolog 1 (Drosophila)	0.037
Kif3a	kinesin family member 3A	0.036
Hoxb4	homeobox B4	0.035
Plxna3	plexin A3	0.035
Bmp5	bone morphogenetic protein 5	0.034
Tlx3	T-cell leukemia, homeobox 3	0.034
Sh3rf1	SH3 domain containing ring finger 1	0.034
Hes5	hairy and enhancer of split 5 (Drosophila)	0.034
Fzd2	frizzled homolog 2 (Drosophila)	0.032
Efna3	ephrin A3	0.032	Mouse
Twist2	twist homolog 2 (Drosophila)	0.031
Lef1	lymphoid enhancer binding factor 1	0.031
Ihh	Indian hedgehog	0.030
Grip1	glutamate receptor interacting protein 1	0.030
Fign	fidgetin	0.029
Gata3	GATA binding protein 3	0.029
Pou4f2	POU domain, class 4, transcription factor 2	0.027
Pcdh1	protocadherin 1	0.027
Dll1	delta-like 1 (Drosophila)	0.027
Fzd3	frizzled homolog 3 (Drosophila)	0.027
Ikzf4	IKAROS family zinc finger 4	0.026
Mmp15	matrix metallopeptidase 15	0.026
T	brachyury	0.026
Nynrin	NYN domain and retroviral integrase containing	0.026
Spry4	sprouty homolog 4 (Drosophila)	0.026
Pard3	par-3 (partitioning defective 3) homolog (C. elegans)	0.025
Klf12	Kruppel-like factor 12	0.025
Tbx4	T-box 4	0.025	Mouse
Ephb4	Eph receptor B4	0.025	Mouse
Egfr	epidermal growth factor receptor	0.024
Runx2	runt related transcription factor 2	0.023
Hoxb3	homeobox B3	0.023
Capn6	calpain 6	0.023
Mesp1	mesoderm posterior 1	0.023
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.022
C77370	expressed sequence C77370	0.022
Six5	sine oculis-related homeobox 5 homolog (Drosophila)	0.022
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.022
Pax9	paired box gene 9	0.021
Foxd1	forkhead box D1	0.021
Lmx1a	LIM homeobox transcription factor 1 alpha	0.021
Hapln1	hyaluronan and proteoglycan link protein 1	0.021
Lmx1b	LIM homeobox transcription factor 1 beta	0.020
Wnt3a	wingless-related MMTV integration site 3A	0.020
Efs	embryonal Fyn-associated substrate	0.020
Cbx2	chromobox homolog 2 (Drosophila Pc class)	0.019
Foxa1	forkhead box A1	0.019
Acvr2b	activin receptor IIB	0.019
Vegfa	vascular endothelial growth factor A	0.019
Hoxd1	homeobox D1	0.019
Cdh10	cadherin 10	0.018
Zfp703	zinc finger protein 703	0.018
Efna5	ephrin A5	0.018	Mouse
Cdx1	caudal type homeobox 1	0.017
Ryr3	ryanodine receptor 3	0.017
Hoxd13	homeobox D13	0.017
Neurog2	neurogenin 2	0.017
Padi3	peptidyl arginine deiminase, type III	0.017
Tpbg	trophoblast glycoprotein	0.017
Tbx2	T-box 2	0.017	Mouse
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.017
Zfhx4	zinc finger homeodomain 4	0.017
Gpc3	glypican 3	0.017
Tead3	TEA domain family member 3	0.017
Neurod6	neurogenic differentiation 6	0.017
Uncx	UNC homeobox	0.016
Rgnef	Rho-guanine nucleotide exchange factor	0.016
Eda	ectodysplasin-A	0.016
Hesx1	homeobox gene expressed in ES cells	0.016
Apc	adenomatosis polyposis coli	0.015
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.015
Erbb4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.015
Has2	hyaluronan synthase 2	0.015
Fbn2	fibrillin 2	0.015
Rai1	retinoic acid induced 1	0.015
Cachd1	cache domain containing 1	0.015
Cux2	cut-like homeobox 2	0.015
Pou3f3	POU domain, class 3, transcription factor 3	0.015
Hs3st3a1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1	0.015
Boc	biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein	0.014
Nanog	Nanog homeobox	0.014
Fzd6	frizzled homolog 6 (Drosophila)	0.014
Rnf2	ring finger protein 2	0.014
Tbx5	T-box 5	0.014	Mouse
Hoxb13	homeobox B13	0.014
Lhx5	LIM homeobox protein 5	0.014
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.014
Osr1	odd-skipped related 1 (Drosophila)	0.013
En2	engrailed 2	0.013
Sema5a	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	0.013
Wnt5b	wingless-related MMTV integration site 5B	0.013
Magi1	membrane associated guanylate kinase, WW and PDZ domain containing 1	0.013
Foxh1	forkhead box H1	0.013	Zebrafish
Flt4	FMS-like tyrosine kinase 4	0.013
Cdh4	cadherin 4	0.013
Slc27a3	solute carrier family 27 (fatty acid transporter), member 3	0.013
Tcfap2c	transcription factor AP-2, gamma	0.013
Tcfcp2l1	transcription factor CP2-like 1	0.013
Fgf3	fibroblast growth factor 3	0.013
Ift88	intraflagellar transport 88 homolog (Chlamydomonas)	0.012
Axin2	axin2	0.012
Arhgef15	Rho guanine nucleotide exchange factor (GEF) 15	0.012
Foxf2	forkhead box F2	0.012
Celsr1	cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)	0.012
Jup	junction plakoglobin	0.012
Ctnnd2	catenin (cadherin associated protein), delta 2	0.012
Sall1	sal-like 1 (Drosophila)	0.012
Sox3	SRY-box containing gene 3	0.011
Nkx3-1	NK-3 transcription factor, locus 1 (Drosophila)	0.011
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.011
Emx1	empty spiracles homolog 1 (Drosophila)	0.011
Hoxc4	homeobox C4	0.011
Tead4	TEA domain family member 4	0.011
Nfia	nuclear factor I/A	0.011
Myl7	myosin, light polypeptide 7, regulatory	0.011
Emid2	EMI domain containing 2	0.011
Tcf7l2	transcription factor 7-like 2, T-cell specific, HMG-box	0.010
Insm1	insulinoma-associated 1	0.010
Apbh	androgen-binding protein eta	0.010
Kalrn	kalirin, RhoGEF kinase	0.010
Cdh9	cadherin 9	0.010
Etv4	ets variant gene 4 (E1A enhancer binding protein, E1AF)	0.010
Wnt3	wingless-related MMTV integration site 3	0.010
Celf4	CUGBP, Elav-like family member 4	0.010
Gpr12	G-protein coupled receptor 12	0.010
Cdc42ep1	CDC42 effector protein (Rho GTPase binding) 1	0.010