IMP

Process View

Mus musculus

1 genes annotated in mouse

Multi-species View

regulation of heart looping

GO:1901207

Any process that modulates the frequency, rate or extent of heart looping.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in mouse Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of heart looping"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of heart looping" (in gray)

Name	Description	Probability	Func Analog Organism
Shh	sonic hedgehog	0.996
Pitx2	paired-like homeodomain transcription factor 2	0.995
Fgfr2	fibroblast growth factor receptor 2	0.991
Tcfap2a	transcription factor AP-2, alpha	0.990
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.972
Hoxa1	homeobox A1	0.947
Eya1	eyes absent 1 homolog (Drosophila)	0.941
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.932
Pitx1	paired-like homeodomain transcription factor 1	0.930
Foxg1	forkhead box G1	0.925
Prrx1	paired related homeobox 1	0.886
Scn5a	sodium channel, voltage-gated, type V, alpha	0.874
Foxc2	forkhead box C2	0.857
Pax2	paired box gene 2	0.832
Tbx3	T-box 3	0.813	Mouse
Msx1	homeobox, msh-like 1	0.801
Pax3	paired box gene 3	0.794
Foxc1	forkhead box C1	0.759
Gli3	GLI-Kruppel family member GLI3	0.744
Dlx5	distal-less homeobox 5	0.717
Fgf8	fibroblast growth factor 8	0.712
Fgf10	fibroblast growth factor 10	0.702
Bmp4	bone morphogenetic protein 4	0.681
Hand2	heart and neural crest derivatives expressed transcript 2	0.673
Otx2	orthodenticle homolog 2 (Drosophila)	0.658
Jag1	jagged 1	0.617
Sox9	SRY-box containing gene 9	0.610
Chd7	chromodomain helicase DNA binding protein 7	0.583
Vangl2	vang-like 2 (van gogh, Drosophila)	0.526
Hand1	heart and neural crest derivatives expressed transcript 1	0.474
Chrd	chordin	0.404
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.367
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.347
Gbx2	gastrulation brain homeobox 2	0.328
Zeb1	zinc finger E-box binding homeobox 1	0.318
Sox2	SRY-box containing gene 2	0.308
Ntf3	neurotrophin 3	0.288
Gsc	goosecoid homeobox	0.276
Fgfr1	fibroblast growth factor receptor 1	0.259
Hoxa3	homeobox A3	0.235
Sall4	sal-like 4 (Drosophila)	0.220
Hoxa2	homeobox A2	0.211
Lef1	lymphoid enhancer binding factor 1	0.195
Zic3	zinc finger protein of the cerebellum 3	0.191
Lrp6	low density lipoprotein receptor-related protein 6	0.191
Efnb2	ephrin B2	0.190
Fgfr3	fibroblast growth factor receptor 3	0.174
Tbx5	T-box 5	0.174	Mouse
Tbx1	T-box 1	0.171	Mouse
Vegfa	vascular endothelial growth factor A	0.160
Rarg	retinoic acid receptor, gamma	0.157
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.152
Tbx4	T-box 4	0.150	Mouse
Runx2	runt related transcription factor 2	0.142
Msx2	homeobox, msh-like 2	0.141
Isl1	ISL1 transcription factor, LIM/homeodomain	0.139
Gata3	GATA binding protein 3	0.134
Pax9	paired box gene 9	0.133
Rarb	retinoic acid receptor, beta	0.133
Tcf21	transcription factor 21	0.132
Wt1	Wilms tumor 1 homolog	0.126
Smo	smoothened homolog (Drosophila)	0.119
Ednra	endothelin receptor type A	0.108
Dlx2	distal-less homeobox 2	0.105
Alx1	ALX homeobox 1	0.104
Wnt3a	wingless-related MMTV integration site 3A	0.100
Tgfb2	transforming growth factor, beta 2	0.100
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.097
Gja5	gap junction protein, alpha 5	0.089
Lmx1a	LIM homeobox transcription factor 1 alpha	0.083
Bmp7	bone morphogenetic protein 7	0.082
Trp63	transformation related protein 63	0.079
Rxra	retinoid X receptor alpha	0.078
Bmp5	bone morphogenetic protein 5	0.075
Prrx2	paired related homeobox 2	0.074
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.067
Hoxa13	homeobox A13	0.067
Gata4	GATA binding protein 4	0.066
Nodal	nodal	0.066
Smad6	MAD homolog 6 (Drosophila)	0.066
Mecom	MDS1 and EVI1 complex locus	0.065
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.064
Ighmbp2	immunoglobulin mu binding protein 2	0.063
Pou5f1	POU domain, class 5, transcription factor 1	0.061
Hoxb3	homeobox B3	0.058
Pbx1	pre B-cell leukemia transcription factor 1	0.056
Meox2	mesenchyme homeobox 2	0.056
Nanog	Nanog homeobox	0.056
Gata6	GATA binding protein 6	0.055
Gli2	GLI-Kruppel family member GLI2	0.055
Ece1	endothelin converting enzyme 1	0.054
Otx1	orthodenticle homolog 1 (Drosophila)	0.050
Twist2	twist homolog 2 (Drosophila)	0.044
Nog	noggin	0.044
Acvr1	activin A receptor, type 1	0.039
Alx4	aristaless-like homeobox 4	0.039
Shox2	short stature homeobox 2	0.037
Bdnf	brain derived neurotrophic factor	0.037
Fgf3	fibroblast growth factor 3	0.036
Dll4	delta-like 4 (Drosophila)	0.035
Hoxa10	homeobox A10	0.035
Gata5	GATA binding protein 5	0.035
Mn1	meningioma 1	0.033
Wnt5a	wingless-related MMTV integration site 5A	0.033
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.033
Rnf2	ring finger protein 2	0.032
Myf5	myogenic factor 5	0.032
Hoxa11	homeobox A11	0.032
Foxh1	forkhead box H1	0.031
Emx2	empty spiracles homolog 2 (Drosophila)	0.031
Tbx2	T-box 2	0.030
Foxf1a	forkhead box F1a	0.030
Hmx3	H6 homeobox 3	0.030
Lrp5	low density lipoprotein receptor-related protein 5	0.029
Ebf3	early B-cell factor 3	0.028
Irx3	Iroquois related homeobox 3 (Drosophila)	0.028
Hoxd1	homeobox D1	0.027
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.027
Gata2	GATA binding protein 2	0.027
Col13a1	collagen, type XIII, alpha 1	0.027
En1	engrailed 1	0.027
Hoxd3	homeobox D3	0.026
Nkx3-2	NK3 homeobox 2	0.026
Rag2	recombination activating gene 2	0.025
Capn6	calpain 6	0.025
Hoxd11	homeobox D11	0.025
Sox11	SRY-box containing gene 11	0.024
Dlx6	distal-less homeobox 6	0.024
T	brachyury	0.023	Mouse
Notch1	Notch gene homolog 1 (Drosophila)	0.022
Msc	musculin	0.022
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.022
Hoxb4	homeobox B4	0.022
Mesp1	mesoderm posterior 1	0.021
Rara	retinoic acid receptor, alpha	0.021
Myog	myogenin	0.021
Pax1	paired box gene 1	0.020
Noto	notochord homolog (Xenopus laevis)	0.020
Egfr	epidermal growth factor receptor	0.020
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.019
Bnc1	basonuclin 1	0.019
Eda	ectodysplasin-A	0.019
Ptk7	PTK7 protein tyrosine kinase 7	0.018
Alx3	aristaless-like homeobox 3	0.018
Runx3	runt related transcription factor 3	0.018
Hoxb1	homeobox B1	0.018
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.017
Prdm6	PR domain containing 6	0.017
Tlx3	T-cell leukemia, homeobox 3	0.017
Sall1	sal-like 1 (Drosophila)	0.017
Nfatc4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	0.017
Hoxb2	homeobox B2	0.017
Hoxb6	homeobox B6	0.017
Lhx1	LIM homeobox protein 1	0.016
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.016
Hoxd9	homeobox D9	0.016
Bmp2	bone morphogenetic protein 2	0.016
Foxa2	forkhead box A2	0.016
Ctnnb1	catenin (cadherin associated protein), beta 1	0.016
Cxadr	coxsackie virus and adenovirus receptor	0.016
Tcfcp2l1	transcription factor CP2-like 1	0.016
Hspb7	heat shock protein family, member 7 (cardiovascular)	0.016
Foxf2	forkhead box F2	0.016
Wnt1	wingless-related MMTV integration site 1	0.016
Zfpm2	zinc finger protein, multitype 2	0.016
Myf6	myogenic factor 6	0.016
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.016
Pcdh12	protocadherin 12	0.015
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.015
Hoxa4	homeobox A4	0.015
Axin2	axin2	0.015
Hoxd13	homeobox D13	0.014
Zbtb46	zinc finger and BTB domain containing 46	0.014
Gpr182	G protein-coupled receptor 182	0.014
Tbx20	T-box 20	0.014	Mouse
Foxa1	forkhead box A1	0.013
Hoxb5	homeobox B5	0.013
Neurog2	neurogenin 2	0.013
Satb2	special AT-rich sequence binding protein 2	0.013
Pou4f2	POU domain, class 4, transcription factor 2	0.013
Foxi1	forkhead box I1	0.013
Hes1	hairy and enhancer of split 1 (Drosophila)	0.013
Fgfrl1	fibroblast growth factor receptor-like 1	0.013
Hesx1	homeobox gene expressed in ES cells	0.013
Nkx2-1	NK2 homeobox 1	0.013
Hoxc8	homeobox C8	0.013
Dll1	delta-like 1 (Drosophila)	0.013
Fgf18	fibroblast growth factor 18	0.013
Hoxa9	homeobox A9	0.013
Ripply3	ripply3 homolog (zebrafish)	0.013
Hoxd8	homeobox D8	0.012
Tal1	T-cell acute lymphocytic leukemia 1	0.012
Sox7	SRY-box containing gene 7	0.012
Zic1	zinc finger protein of the cerebellum 1	0.012
Dlx1	distal-less homeobox 1	0.012
Apc	adenomatosis polyposis coli	0.012
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.012
Myl7	myosin, light polypeptide 7, regulatory	0.012
Nr0b1	nuclear receptor subfamily 0, group B, member 1	0.012
Gimap7	GTPase, IMAP family member 7	0.012
Foxi3	forkhead box I3	0.012
Irx5	Iroquois related homeobox 5 (Drosophila)	0.011
Foxd3	forkhead box D3	0.011
Dnahc5	dynein, axonemal, heavy chain 5	0.011
Lrp2	low density lipoprotein receptor-related protein 2	0.011
She	src homology 2 domain-containing transforming protein E	0.011
Nf1	neurofibromatosis 1	0.011
Hoxc4	homeobox C4	0.011
Hoxd10	homeobox D10	0.011
Acvr2b	activin receptor IIB	0.011
Cox4i2	cytochrome c oxidase subunit IV isoform 2	0.011
Lmx1b	LIM homeobox transcription factor 1 beta	0.011
Atoh8	atonal homolog 8 (Drosophila)	0.011
Snai1	snail homolog 1 (Drosophila)	0.011
Npr3	natriuretic peptide receptor 3	0.011
Gdf3	growth differentiation factor 3	0.011
Smpd3	sphingomyelin phosphodiesterase 3, neutral	0.011
St8sia2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.011
Osr1	odd-skipped related 1 (Drosophila)	0.011
Pcdh18	protocadherin 18	0.011
Cdh9	cadherin 9	0.011
Hey1	hairy/enhancer-of-split related with YRPW motif 1	0.011
Sox17	SRY-box containing gene 17	0.011
Notch2	Notch gene homolog 2 (Drosophila)	0.011
Prx	periaxin	0.011
Gpc3	glypican 3	0.011
BC020535	cDNA sequence BC020535	0.011
Zfp503	zinc finger protein 503	0.010
Boc	biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein	0.010
Mks1	Meckel syndrome, type 1	0.010
Cdx2	caudal type homeobox 2	0.010
Rybp	RING1 and YY1 binding protein	0.010
Myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	0.010
Tbx6	T-box 6	0.010	Mouse
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.010
Efnb1	ephrin B1	0.010
Cd8b1	CD8 antigen, beta chain 1	0.010
Emx1	empty spiracles homolog 1 (Drosophila)	0.010
Efna2	ephrin A2	0.010
Ptch1	patched homolog 1	0.010
Bcl6	B-cell leukemia/lymphoma 6	0.010
Col4a3	collagen, type IV, alpha 3	0.010