IMP

Process View

Mus musculus

11 genes annotated in mouse

mesodermal cell fate specification

The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "mesodermal cell fate specification"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "mesodermal cell fate specification" (in gray)

Name	Description	Probability	Func Analog Organism
Shh	sonic hedgehog	1.000
Fgfr2	fibroblast growth factor receptor 2	1.000	Mouse
Bmp4	bone morphogenetic protein 4	0.999	Zebrafish
Gli3	GLI-Kruppel family member GLI3	0.999
Foxc1	forkhead box C1	0.991
Pax2	paired box gene 2	0.988
Pitx2	paired-like homeodomain transcription factor 2	0.986
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.982	Mouse
Ctnnb1	catenin (cadherin associated protein), beta 1	0.962
Pax3	paired box gene 3	0.946
Tbx1	T-box 1	0.944
Bmp7	bone morphogenetic protein 7	0.933	Mouse
Fgfr1	fibroblast growth factor receptor 1	0.930
Pbx1	pre B-cell leukemia transcription factor 1	0.917	Worm
Isl1	ISL1 transcription factor, LIM/homeodomain	0.907
Hoxa11	homeobox A11	0.895
Hoxd13	homeobox D13	0.894
Fgf8	fibroblast growth factor 8	0.891
Vangl2	vang-like 2 (van gogh, Drosophila)	0.887
Hand1	heart and neural crest derivatives expressed transcript 1	0.881
Sfrp2	secreted frizzled-related protein 2	0.878
Eya1	eyes absent 1 homolog (Drosophila)	0.820
Foxc2	forkhead box C2	0.815
Rarg	retinoic acid receptor, gamma	0.777
Jag1	jagged 1	0.767
Gdf5	growth differentiation factor 5	0.728	Mouse
Tgfbr2	transforming growth factor, beta receptor II	0.705	Mouse
Hoxd11	homeobox D11	0.613	Mouse
Hand2	heart and neural crest derivatives expressed transcript 2	0.604
Sox2	SRY-box containing gene 2	0.602	Mouse
Meox2	mesenchyme homeobox 2	0.592
Sox9	SRY-box containing gene 9	0.583	Mouse
Hoxa13	homeobox A13	0.580
Otx2	orthodenticle homolog 2 (Drosophila)	0.531
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.509
Gli2	GLI-Kruppel family member GLI2	0.501
Hoxa3	homeobox A3	0.496
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.494
Tcfap2a	transcription factor AP-2, alpha	0.487
Hoxa1	homeobox A1	0.469
Tgfb2	transforming growth factor, beta 2	0.466
Zeb1	zinc finger E-box binding homeobox 1	0.441
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.416
Gas1	growth arrest specific 1	0.397
Nodal	nodal	0.391
Eng	endoglin	0.355
Alx4	aristaless-like homeobox 4	0.354
Wnt3a	wingless-related MMTV integration site 3A	0.345	Human
Hes1	hairy and enhancer of split 1 (Drosophila)	0.339
Phox2b	paired-like homeobox 2b	0.333
Gsc	goosecoid homeobox	0.330
Dlx5	distal-less homeobox 5	0.319
Tbx15	T-box 15	0.319
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.310	Mouse Worm
Fgf10	fibroblast growth factor 10	0.297
Prrx1	paired related homeobox 1	0.287
Ntf3	neurotrophin 3	0.279
Smad6	MAD homolog 6 (Drosophila)	0.276
Msx2	homeobox, msh-like 2	0.273
Msx1	homeobox, msh-like 1	0.272
Gata4	GATA binding protein 4	0.271
Smo	smoothened homolog (Drosophila)	0.270
Psen1	presenilin 1	0.261
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.245
Pten	phosphatase and tensin homolog	0.242
Sox4	SRY-box containing gene 4	0.241	Mouse
Hoxa9	homeobox A9	0.238
Fgfr3	fibroblast growth factor receptor 3	0.229	Mouse
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.228
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.219	Human
Nog	noggin	0.217
Meis2	Meis homeobox 2	0.213	Worm
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.211
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.188
Foxd2	forkhead box D2	0.182
Hoxa5	homeobox A5	0.178
Gata3	GATA binding protein 3	0.174
Tbx2	T-box 2	0.171
Vegfa	vascular endothelial growth factor A	0.170
Cdh5	cadherin 5	0.168
Efnb2	ephrin B2	0.168
Prrx2	paired related homeobox 2	0.165
Tbx6	T-box 6	0.165
Barx1	BarH-like homeobox 1	0.161
Sox11	SRY-box containing gene 11	0.154	Mouse
Apc	adenomatosis polyposis coli	0.141
Fgf3	fibroblast growth factor 3	0.140
Lef1	lymphoid enhancer binding factor 1	0.137
Rarb	retinoic acid receptor, beta	0.136
Nos3	nitric oxide synthase 3, endothelial cell	0.135
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.133
Smad3	MAD homolog 3 (Drosophila)	0.117
Hoxa2	homeobox A2	0.115
Ret	ret proto-oncogene	0.107
Lhx1	LIM homeobox protein 1	0.107
Lmx1a	LIM homeobox transcription factor 1 alpha	0.102
Gbx2	gastrulation brain homeobox 2	0.092
Acvr1	activin A receptor, type 1	0.088	Mouse
Kif3a	kinesin family member 3A	0.087
Tcf21	transcription factor 21	0.084
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.080
Pitx1	paired-like homeodomain transcription factor 1	0.079
Tbx3	T-box 3	0.072
Wnt5a	wingless-related MMTV integration site 5A	0.070
T	brachyury	0.069
Col2a1	collagen, type II, alpha 1	0.069
Rara	retinoic acid receptor, alpha	0.065
Ptch1	patched homolog 1	0.065
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.063
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.063	Mouse
Alx3	aristaless-like homeobox 3	0.062
Nkx2-1	NK2 homeobox 1	0.059
Foxf1a	forkhead box F1a	0.059
Pou3f3	POU domain, class 3, transcription factor 3	0.057
En1	engrailed 1	0.057
Gpc3	glypican 3	0.056
Chd7	chromodomain helicase DNA binding protein 7	0.054
Pitx3	paired-like homeodomain transcription factor 3	0.053
Bcl2	B-cell leukemia/lymphoma 2	0.051
Hoxc4	homeobox C4	0.050
Etv4	ets variant gene 4 (E1A enhancer binding protein, E1AF)	0.050	Mouse
Sox7	SRY-box containing gene 7	0.049	Mouse
Zfp503	zinc finger protein 503	0.048
Foxa2	forkhead box A2	0.044
Efna4	ephrin A4	0.044
Zic3	zinc finger protein of the cerebellum 3	0.043
Hmx3	H6 homeobox 3	0.043	Worm
Trp53	transformation related protein 53	0.042
Nf1	neurofibromatosis 1	0.042
Gdf9	growth differentiation factor 9	0.042
Foxh1	forkhead box H1	0.041	Zebrafish
Hoxd9	homeobox D9	0.041
Runx2	runt related transcription factor 2	0.041
Hoxd12	homeobox D12	0.041
Dnahc11	dynein, axonemal, heavy chain 11	0.039
Gata6	GATA binding protein 6	0.039
Hoxa10	homeobox A10	0.038
Notch2	Notch gene homolog 2 (Drosophila)	0.038
Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.038
Smad4	MAD homolog 4 (Drosophila)	0.038
Pkd1	polycystic kidney disease 1 homolog	0.036
Meis1	Meis homeobox 1	0.036	Worm
She	src homology 2 domain-containing transforming protein E	0.036
Foxg1	forkhead box G1	0.035
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.034
Dll3	delta-like 3 (Drosophila)	0.034
Pax1	paired box gene 1	0.032	Mouse
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.032
Dll1	delta-like 1 (Drosophila)	0.030
Fgf15	fibroblast growth factor 15	0.030
Nkx2-4	NK2 transcription factor related, locus 4 (Drosophila)	0.029
Ebf3	early B-cell factor 3	0.028
Adra2b	adrenergic receptor, alpha 2b	0.028
Wnt1	wingless-related MMTV integration site 1	0.028
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.028
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.027
Hesx1	homeobox gene expressed in ES cells	0.027
Gdnf	glial cell line derived neurotrophic factor	0.026
Twist1	twist homolog 1 (Drosophila)	0.025	Worm
Btbd17	BTB (POZ) domain containing 17	0.025
Wnt6	wingless-related MMTV integration site 6	0.025
Tcf15	transcription factor 15	0.025
Lrp2	low density lipoprotein receptor-related protein 2	0.024
Tcfap2c	transcription factor AP-2, gamma	0.024
Hoxb3	homeobox B3	0.024
Notch3	Notch gene homolog 3 (Drosophila)	0.023
Npr3	natriuretic peptide receptor 3	0.023
Efna2	ephrin A2	0.023
Lrp6	low density lipoprotein receptor-related protein 6	0.022
Wnt4	wingless-related MMTV integration site 4	0.022
Epas1	endothelial PAS domain protein 1	0.022
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.021
Foxf2	forkhead box F2	0.021
Lfng	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.020
Uncx	UNC homeobox	0.020
Pax6	paired box gene 6	0.020
Egfr	epidermal growth factor receptor	0.019
Nr2f1	nuclear receptor subfamily 2, group F, member 1	0.019
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.019
Thbd	thrombomodulin	0.018
Rxra	retinoid X receptor alpha	0.018
Vax1	ventral anterior homeobox containing gene 1	0.018
Igf2bp1	insulin-like growth factor 2 mRNA binding protein 1	0.017
Sox3	SRY-box containing gene 3	0.017	Mouse
Crebbp	CREB binding protein	0.017
Fgf9	fibroblast growth factor 9	0.017
Hoxb4	homeobox B4	0.016
Adam17	a disintegrin and metallopeptidase domain 17	0.015
Lmx1b	LIM homeobox transcription factor 1 beta	0.015
Mks1	Meckel syndrome, type 1	0.015
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.015
Fgf5	fibroblast growth factor 5	0.015
Ednra	endothelin receptor type A	0.014
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.014
Cxcl12	chemokine (C-X-C motif) ligand 12	0.014
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.014
Gdf6	growth differentiation factor 6	0.014	Mouse
Foxj1	forkhead box J1	0.014
Gli1	GLI-Kruppel family member GLI1	0.014
Efs	embryonal Fyn-associated substrate	0.014
Sharpin	SHANK-associated RH domain interacting protein	0.013
Smad7	MAD homolog 7 (Drosophila)	0.013
Chrd	chordin	0.013
Nfia	nuclear factor I/A	0.013
Fzd4	frizzled homolog 4 (Drosophila)	0.013
Evx1	even skipped homeotic gene 1 homolog	0.013
Tgfbr3	transforming growth factor, beta receptor III	0.012
Adcy4	adenylate cyclase 4	0.012
Klf4	Kruppel-like factor 4 (gut)	0.012
Hoxb5	homeobox B5	0.012
Foxb1	forkhead box B1	0.012
Hoxb13	homeobox B13	0.012
Kiss1	KiSS-1 metastasis-suppressor	0.012
Tead3	TEA domain family member 3	0.011
Hoxb6	homeobox B6	0.011
Dach1	dachshund 1 (Drosophila)	0.011
Barx2	BarH-like homeobox 2	0.011
Eda	ectodysplasin-A	0.011
Hist1h1t	histone cluster 1, H1t	0.011
Neurog1	neurogenin 1	0.011
Atoh7	atonal homolog 7 (Drosophila)	0.011
Atp7a	ATPase, Cu++ transporting, alpha polypeptide	0.011
Pthlh	parathyroid hormone-like peptide	0.011
Ikzf1	IKAROS family zinc finger 1	0.011
Hoxb9	homeobox B9	0.011
Fgf17	fibroblast growth factor 17	0.011
Nkx6-1	NK6 homeobox 1	0.011
Sfrp1	secreted frizzled-related protein 1	0.011	Mouse
Rspo1	R-spondin homolog (Xenopus laevis)	0.011
Sox17	SRY-box containing gene 17	0.011
Nfib	nuclear factor I/B	0.011
Capn6	calpain 6	0.010
Cilp2	cartilage intermediate layer protein 2	0.010
Zfhx3	zinc finger homeobox 3	0.010
Emid2	EMI domain containing 2	0.010
Hdac7	histone deacetylase 7	0.010
Lhx3	LIM homeobox protein 3	0.010
Ebf2	early B-cell factor 2	0.010
Socs5	suppressor of cytokine signaling 5	0.010
Neurog2	neurogenin 2	0.010
Bmp6	bone morphogenetic protein 6	0.010	Mouse
Edar	ectodysplasin-A receptor	0.010
Pknox1	Pbx/knotted 1 homeobox	0.010