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Process View

Mus musculus

9 genes annotated in mouse

neuron fate determination

The process in which a cell becomes capable of differentiating autonomously into a neuron regardless of its environment; upon determination, the cell fate cannot be reversed.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "neuron fate determination"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "neuron fate determination" (in gray)

Name	Description	Probability	Func Analog Organism
Otx2	orthodenticle homolog 2 (Drosophila)	1.000
Shh	sonic hedgehog	1.000
Fgf8	fibroblast growth factor 8	0.999
Pax2	paired box gene 2	0.998
Gli3	GLI-Kruppel family member GLI3	0.997
Hand2	heart and neural crest derivatives expressed transcript 2	0.995	Mouse
Foxc1	forkhead box C1	0.994	Mouse
Foxc2	forkhead box C2	0.993	Mouse
Pax3	paired box gene 3	0.986
Emx1	empty spiracles homolog 1 (Drosophila)	0.984
Nog	noggin	0.982
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.981
Pitx2	paired-like homeodomain transcription factor 2	0.974
Pax6	paired box gene 6	0.960
Gata4	GATA binding protein 4	0.958
Pax8	paired box gene 8	0.943
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.928
En1	engrailed 1	0.878
Lhx1	LIM homeobox protein 1	0.855
Tbx1	T-box 1	0.850
Lmx1a	LIM homeobox transcription factor 1 alpha	0.842
Msx1	homeobox, msh-like 1	0.806
Sox9	SRY-box containing gene 9	0.789
Foxa2	forkhead box A2	0.785	Mouse
Hand1	heart and neural crest derivatives expressed transcript 1	0.784	Mouse
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.775	Mouse
Gli2	GLI-Kruppel family member GLI2	0.770
Lhx3	LIM homeobox protein 3	0.761
Lmx1b	LIM homeobox transcription factor 1 beta	0.759
Gbx2	gastrulation brain homeobox 2	0.758
Wnt3a	wingless-related MMTV integration site 3A	0.741	Mouse
Neurog2	neurogenin 2	0.718	Mouse
Jag1	jagged 1	0.712
Hoxd3	homeobox D3	0.685
Wnt4	wingless-related MMTV integration site 4	0.678	Mouse
Isl1	ISL1 transcription factor, LIM/homeodomain	0.666
Sox2	SRY-box containing gene 2	0.648
Emx2	empty spiracles homolog 2 (Drosophila)	0.610
T	brachyury	0.610
Eya1	eyes absent 1 homolog (Drosophila)	0.571
Tlx3	T-cell leukemia, homeobox 3	0.571
Neurog1	neurogenin 1	0.569	Mouse
Rarg	retinoic acid receptor, gamma	0.553
Vax1	ventral anterior homeobox containing gene 1	0.548
Lhx5	LIM homeobox protein 5	0.523
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.518
Neurod1	neurogenic differentiation 1	0.517	Mouse
Hoxa1	homeobox A1	0.493
Gdnf	glial cell line derived neurotrophic factor	0.489
Sox3	SRY-box containing gene 3	0.474
Bmp4	bone morphogenetic protein 4	0.469
Foxb1	forkhead box B1	0.466
Cdc42	cell division cycle 42 homolog (S. cerevisiae)	0.459
Tcfap2a	transcription factor AP-2, alpha	0.430
Wnt6	wingless-related MMTV integration site 6	0.411	Mouse
Foxg1	forkhead box G1	0.409
Prrx2	paired related homeobox 2	0.384
Hes5	hairy and enhancer of split 5 (Drosophila)	0.357
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.336
Msx2	homeobox, msh-like 2	0.332
Wnt1	wingless-related MMTV integration site 1	0.307
Pitx3	paired-like homeodomain transcription factor 3	0.306
Tgfb2	transforming growth factor, beta 2	0.299
Fgf10	fibroblast growth factor 10	0.290
Hoxd11	homeobox D11	0.289
Hoxa10	homeobox A10	0.279
Onecut1	one cut domain, family member 1	0.261
Dlx5	distal-less homeobox 5	0.260
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.252
Ctnnb1	catenin (cadherin associated protein), beta 1	0.252
Pdx1	pancreatic and duodenal homeobox 1	0.243
Meox2	mesenchyme homeobox 2	0.241
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.237
Wnt7a	wingless-related MMTV integration site 7A	0.237	Mouse
Hoxa13	homeobox A13	0.222
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.220
Nkx2-1	NK2 homeobox 1	0.217	Mouse
Pitx1	paired-like homeodomain transcription factor 1	0.215
Hmx1	H6 homeobox 1	0.209
Otx1	orthodenticle homolog 1 (Drosophila)	0.207	Mouse
Foxd3	forkhead box D3	0.203	Mouse
Fgfr2	fibroblast growth factor receptor 2	0.198
Gsc	goosecoid homeobox	0.198
Col22a1	collagen, type XXII, alpha 1	0.194
Fgf15	fibroblast growth factor 15	0.186
Hes1	hairy and enhancer of split 1 (Drosophila)	0.182
Nkx6-1	NK6 homeobox 1	0.175
Fgf4	fibroblast growth factor 4	0.172
Hoxd13	homeobox D13	0.172
Efnb2	ephrin B2	0.172
Hmx3	H6 homeobox 3	0.170
Nodal	nodal	0.166
Twist2	twist homolog 2 (Drosophila)	0.163	Mouse
Foxd2	forkhead box D2	0.161	Mouse
Insm1	insulinoma-associated 1	0.160
Sox11	SRY-box containing gene 11	0.155
Pax9	paired box gene 9	0.145
Neurod4	neurogenic differentiation 4	0.143	Mouse
Snai1	snail homolog 1 (Drosophila)	0.141
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.140
Cyp26a1	cytochrome P450, family 26, subfamily a, polypeptide 1	0.140
Hoxa11	homeobox A11	0.135
Zic1	zinc finger protein of the cerebellum 1	0.134
Amhr2	anti-Mullerian hormone type 2 receptor	0.134
Evx2	even skipped homeotic gene 2 homolog	0.130
Gata6	GATA binding protein 6	0.129
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.126
Uncx	UNC homeobox	0.126
Sim2	single-minded homolog 2 (Drosophila)	0.123
Nhlh1	nescient helix loop helix 1	0.119	Mouse
Sox1	SRY-box containing gene 1	0.118
Tlx2	T-cell leukemia, homeobox 2	0.117
Mesp1	mesoderm posterior 1	0.116
Ptf1a	pancreas specific transcription factor, 1a	0.115	Mouse
Hoxa3	homeobox A3	0.114
Foxf2	forkhead box F2	0.112
Ntf3	neurotrophin 3	0.111
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.110
Prrx1	paired related homeobox 1	0.109
Fgf3	fibroblast growth factor 3	0.108
Smo	smoothened homolog (Drosophila)	0.107
Pou3f3	POU domain, class 3, transcription factor 3	0.107
Rarb	retinoic acid receptor, beta	0.106
Gnrhr	gonadotropin releasing hormone receptor	0.105
Fgfr1	fibroblast growth factor receptor 1	0.104
Cdx1	caudal type homeobox 1	0.102
Arx	aristaless related homeobox	0.100
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.100
Mnx1	motor neuron and pancreas homeobox 1	0.095
Kiss1	KiSS-1 metastasis-suppressor	0.094
Hoxa4	homeobox A4	0.091
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.090
Amh	anti-Mullerian hormone	0.089
Pou4f2	POU domain, class 4, transcription factor 2	0.089
Hoxc6	homeobox C6	0.083
Hes3	hairy and enhancer of split 3 (Drosophila)	0.080	Mouse
Dlx2	distal-less homeobox 2	0.079
Pthlh	parathyroid hormone-like peptide	0.077
Alx4	aristaless-like homeobox 4	0.076
Gpr50	G-protein-coupled receptor 50	0.075
Hoxd1	homeobox D1	0.074
Foxe1	forkhead box E1	0.072	Mouse
Atoh1	atonal homolog 1 (Drosophila)	0.072
Gli1	GLI-Kruppel family member GLI1	0.070
Hoxa2	homeobox A2	0.068
Zic2	zinc finger protein of the cerebellum 2	0.067
Hoxc5	homeobox C5	0.067
Tal2	T-cell acute lymphocytic leukemia 2	0.063	Mouse
Meox1	mesenchyme homeobox 1	0.063
Matn3	matrilin 3	0.063
Nkx3-2	NK3 homeobox 2	0.059	Mouse
Twist1	twist homolog 1 (Drosophila)	0.059	Mouse
Wnt2b	wingless related MMTV integration site 2b	0.058	Mouse
Tbx2	T-box 2	0.057
Neurog3	neurogenin 3	0.057	Mouse
Fgf17	fibroblast growth factor 17	0.053
Igfbpl1	insulin-like growth factor binding protein-like 1	0.053
Hoxd9	homeobox D9	0.052
Olfr70	olfactory receptor 70	0.048
Emid2	EMI domain containing 2	0.047
Tbx3	T-box 3	0.047
Gata1	GATA binding protein 1	0.046
Hoxb5	homeobox B5	0.046
Bmp7	bone morphogenetic protein 7	0.046
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.045	Fly
Rara	retinoic acid receptor, alpha	0.044
Sox7	SRY-box containing gene 7	0.042
Pax7	paired box gene 7	0.042
Hoxa5	homeobox A5	0.042
Tcfap2c	transcription factor AP-2, gamma	0.042
Foxe3	forkhead box E3	0.042	Mouse
Skor1	SKI family transcriptional corepressor 1	0.042
Dlx1	distal-less homeobox 1	0.041
Cldn3	claudin 3	0.040
Chrd	chordin	0.040
Rax	retina and anterior neural fold homeobox	0.039
Bnc1	basonuclin 1	0.039
Otp	orthopedia homolog (Drosophila)	0.039
Col13a1	collagen, type XIII, alpha 1	0.039
Smad6	MAD homolog 6 (Drosophila)	0.039
Pou3f2	POU domain, class 3, transcription factor 2	0.039
Ihh	Indian hedgehog	0.038
Hey1	hairy/enhancer-of-split related with YRPW motif 1	0.038	Fly
Chd7	chromodomain helicase DNA binding protein 7	0.037
Adra2b	adrenergic receptor, alpha 2b	0.037
Sox4	SRY-box containing gene 4	0.037
Ednra	endothelin receptor type A	0.037
Atoh7	atonal homolog 7 (Drosophila)	0.036	Mouse
Hesx1	homeobox gene expressed in ES cells	0.036
Rac1	RAS-related C3 botulinum substrate 1	0.036	Mouse
Efna2	ephrin A2	0.035
Sox14	SRY-box containing gene 14	0.034
Fes	feline sarcoma oncogene	0.034
Hes2	hairy and enhancer of split 2 (Drosophila)	0.033	Mouse
Lhb	luteinizing hormone beta	0.033
Lhx9	LIM homeobox protein 9	0.033
Ascl2	achaete-scute complex homolog 2 (Drosophila)	0.033
Pcdh12	protocadherin 12	0.032
Hoxb6	homeobox B6	0.032
Zic3	zinc finger protein of the cerebellum 3	0.032
Pak1	p21 protein (Cdc42/Rac)-activated kinase 1	0.032
Tbx15	T-box 15	0.032
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.032	Mouse
Rprm	reprimo, TP53 dependent G2 arrest mediator candidate	0.032
Fzd10	frizzled homolog 10 (Drosophila)	0.031
Foxa1	forkhead box A1	0.031	Mouse
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.031
Alx3	aristaless-like homeobox 3	0.031
Myf5	myogenic factor 5	0.030
Heyl	hairy/enhancer-of-split related with YRPW motif-like	0.030	Fly
Hlx	H2.0-like homeobox	0.030
Irx1	Iroquois related homeobox 1 (Drosophila)	0.030
Foxn4	forkhead box N4	0.029
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.029
Lhcgr	luteinizing hormone/choriogonadotropin receptor	0.028
Nobox	NOBOX oogenesis homeobox	0.028
Myod1	myogenic differentiation 1	0.028
Foxl2	forkhead box L2	0.028	Mouse
BC057022	cDNA sequence BC057022	0.028
Sall3	sal-like 3 (Drosophila)	0.028
Wnt3	wingless-related MMTV integration site 3	0.028	Mouse
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.027
Myog	myogenin	0.026
Hoxb2	homeobox B2	0.026
Mecom	MDS1 and EVI1 complex locus	0.026
Gdf11	growth differentiation factor 11	0.025
Hoxb9	homeobox B9	0.025
Pou4f3	POU domain, class 4, transcription factor 3	0.025
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.025
Omp	olfactory marker protein	0.025
Dmrt3	doublesex and mab-3 related transcription factor 3	0.025
Hoxd12	homeobox D12	0.025
Hoxb13	homeobox B13	0.024
Irx6	Iroquois related homeobox 6 (Drosophila)	0.023
Shox2	short stature homeobox 2	0.023
Nrtn	neurturin	0.023
Barhl1	BarH-like 1 (Drosophila)	0.023
Il11	interleukin 11	0.023
Foxf1a	forkhead box F1a	0.023
Etv4	ets variant gene 4 (E1A enhancer binding protein, E1AF)	0.022
Cldn5	claudin 5	0.022
Wnt9a	wingless-type MMTV integration site 9A	0.022	Mouse
Eya4	eyes absent 4 homolog (Drosophila)	0.022
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.021
Pax1	paired box gene 1	0.021
Efna4	ephrin A4	0.021
Pou3f4	POU domain, class 3, transcription factor 4	0.021
Fgf18	fibroblast growth factor 18	0.021
Bdnf	brain derived neurotrophic factor	0.021
Prph2	peripherin 2	0.020
Acan	aggrecan	0.020
Slc32a1	solute carrier family 32 (GABA vesicular transporter), member 1	0.020
Phox2b	paired-like homeobox 2b	0.019
Hoxb1	homeobox B1	0.019
Nkx2-2	NK2 transcription factor related, locus 2 (Drosophila)	0.019
Adra2a	adrenergic receptor, alpha 2a	0.019
Zeb1	zinc finger E-box binding homeobox 1	0.019
Ebf3	early B-cell factor 3	0.019
Hic1	hypermethylated in cancer 1	0.019
Hsd11b2	hydroxysteroid 11-beta dehydrogenase 2	0.019
Gpr27	G protein-coupled receptor 27	0.019
Sall4	sal-like 4 (Drosophila)	0.019
Hoxc8	homeobox C8	0.018
Tal1	T-cell acute lymphocytic leukemia 1	0.018	Mouse
Tead3	TEA domain family member 3	0.018
Lyl1	lymphoblastomic leukemia 1	0.018	Mouse
Matn4	matrilin 4	0.018
Gjb4	gap junction protein, beta 4	0.018
Evx1	even skipped homeotic gene 1 homolog	0.018
Ntn3	netrin 3	0.018
Vsx2	visual system homeobox 2	0.018
Tbx5	T-box 5	0.018
Bhlha9	basic helix-loop-helix family, member a9	0.018
Tcf15	transcription factor 15	0.017	Mouse
Hnf4a	hepatic nuclear factor 4, alpha	0.017
Pou3f1	POU domain, class 3, transcription factor 1	0.017
Barx1	BarH-like homeobox 1	0.017
En2	engrailed 2	0.017
Zfp703	zinc finger protein 703	0.017
Tcf21	transcription factor 21	0.017
Bik	BCL2-interacting killer	0.017
Hoxa7	homeobox A7	0.017
Gpsm3	G-protein signalling modulator 3 (AGS3-like, C. elegans)	0.016
Grm2	glutamate receptor, metabotropic 2	0.016
Zfpm2	zinc finger protein, multitype 2	0.016
Pyy	peptide YY	0.016
Hs3st3b1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1	0.016
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.016
Vstm2b	V-set and transmembrane domain containing 2B	0.015
Nfatc1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.015
Rxra	retinoid X receptor alpha	0.015
Fzd2	frizzled homolog 2 (Drosophila)	0.015
Wnt8a	wingless-related MMTV integration site 8A	0.015	Mouse
Sftpb	surfactant associated protein B	0.015
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.015
Hba-x	hemoglobin X, alpha-like embryonic chain in Hba complex	0.015
Ret	ret proto-oncogene	0.015
Btbd17	BTB (POZ) domain containing 17	0.015
Hoxb7	homeobox B7	0.014
Sox21	SRY-box containing gene 21	0.014
Ptk7	PTK7 protein tyrosine kinase 7	0.014
Vgll2	vestigial like 2 homolog (Drosophila)	0.014
Etv2	ets variant gene 2	0.014
Wnt10b	wingless related MMTV integration site 10b	0.014	Mouse
Zfp771	zinc finger protein 771	0.014
Isl2	insulin related protein 2 (islet 2)	0.014
Foxb2	forkhead box B2	0.014	Mouse
Nkx2-9	NK2 transcription factor related, locus 9 (Drosophila)	0.013	Mouse
Lbx2	ladybird homeobox homolog 2 (Drosophila)	0.013	Mouse
Wnt5b	wingless-related MMTV integration site 5B	0.013	Mouse
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.013
Tcl1	T-cell lymphoma breakpoint 1	0.013
Gja3	gap junction protein, alpha 3	0.013
Fgf16	fibroblast growth factor 16	0.013
Cdx2	caudal type homeobox 2	0.013
Nxph4	neurexophilin 4	0.013
Crlf1	cytokine receptor-like factor 1	0.013
Foxd1	forkhead box D1	0.012	Mouse
Edn3	endothelin 3	0.012
Gsx2	GS homeobox 2	0.012
Socs1	suppressor of cytokine signaling 1	0.012
Foxh1	forkhead box H1	0.012
Hmga2	high mobility group AT-hook 2	0.012
Fzd8	frizzled homolog 8 (Drosophila)	0.012
Sox17	SRY-box containing gene 17	0.012
Hmx2	H6 homeobox 2	0.012
Scrt2	scratch homolog 2, zinc finger protein (Drosophila)	0.012
Tbxa2r	thromboxane A2 receptor	0.012
Fgf6	fibroblast growth factor 6	0.011
Sox10	SRY-box containing gene 10	0.011
Irx3	Iroquois related homeobox 3 (Drosophila)	0.011
Klk4	kallikrein related-peptidase 4 (prostase, enamel matrix, prostate)	0.011
Fgf5	fibroblast growth factor 5	0.011
Nr2e1	nuclear receptor subfamily 2, group E, member 1	0.011
Aplnr	apelin receptor	0.011
Lef1	lymphoid enhancer binding factor 1	0.011
Cel	carboxyl ester lipase	0.011
Fshr	follicle stimulating hormone receptor	0.011
Gipc3	GIPC PDZ domain containing family, member 3	0.011
Lhx6	LIM homeobox protein 6	0.011
Lhx4	LIM homeobox protein 4	0.011
Slc16a8	solute carrier family 16 (monocarboxylic acid transporters), member 8	0.010
Fev	FEV (ETS oncogene family)	0.010
Htr1b	5-hydroxytryptamine (serotonin) receptor 1B	0.010
Ptch2	patched homolog 2	0.010
Lefty1	left right determination factor 1	0.010
Gas1	growth arrest specific 1	0.010