IMP

Process View

Mus musculus

2 genes annotated in mouse

neuropilin signaling pathway

A series of molecular signals initiated by the binding of an extracellular ligand to an neuropilin protein on the surface of a target cell, followed by transmission of the signal, and ending with regulation of a downstream cellular process, e.g. transcription.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "neuropilin signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "neuropilin signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
Plxnd1	plexin D1	0.973
Kdr	kinase insert domain protein receptor	0.933
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.898
Ednra	endothelin receptor type A	0.840
Nos3	nitric oxide synthase 3, endothelial cell	0.798
Ece1	endothelin converting enzyme 1	0.701
Flt4	FMS-like tyrosine kinase 4	0.572
Flt1	FMS-like tyrosine kinase 1	0.545
Cd151	CD151 antigen	0.531
Acvr1	activin A receptor, type 1	0.449
Notch2	Notch gene homolog 2 (Drosophila)	0.420
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.236
Mkl2	MKL/myocardin-like 2	0.223
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.211
Fgf8	fibroblast growth factor 8	0.134
Tgfbr2	transforming growth factor, beta receptor II	0.120
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.113
Rxra	retinoid X receptor alpha	0.109
Fzd4	frizzled homolog 4 (Drosophila)	0.102
Cdh5	cadherin 5	0.097
Jag1	jagged 1	0.093
Lepr	leptin receptor	0.092
Lmna	lamin A	0.090
Gaa	glucosidase, alpha, acid	0.085
Egln1	EGL nine homolog 1 (C. elegans)	0.081
Nfib	nuclear factor I/B	0.076
Pecam1	platelet/endothelial cell adhesion molecule 1	0.069
Eng	endoglin	0.069
Itga3	integrin alpha 3	0.069
Wwtr1	WW domain containing transcription regulator 1	0.064
Bcl2	B-cell leukemia/lymphoma 2	0.063
Ptprb	protein tyrosine phosphatase, receptor type, B	0.060
Fgfr1	fibroblast growth factor receptor 1	0.060
Gata6	GATA binding protein 6	0.057
Hbegf	heparin-binding EGF-like growth factor	0.057
Tspan12	tetraspanin 12	0.054
Hoxa1	homeobox A1	0.050
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.050
Atp2a2	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	0.049
Sema3f	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	0.048
Lama4	laminin, alpha 4	0.048
Foxc2	forkhead box C2	0.047
Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.047
Bmp4	bone morphogenetic protein 4	0.046
Vhl	von Hippel-Lindau tumor suppressor	0.045
Plxna1	plexin A1	0.044
Tgfb2	transforming growth factor, beta 2	0.043
Ptgs2	prostaglandin-endoperoxide synthase 2	0.041
Plvap	plasmalemma vesicle associated protein	0.040
Thbd	thrombomodulin	0.040
Apbb2	amyloid beta (A4) precursor protein-binding, family B, member 2	0.040
Ripply3	ripply3 homolog (zebrafish)	0.040
Pdgfc	platelet-derived growth factor, C polypeptide	0.039
Ptk2	PTK2 protein tyrosine kinase 2	0.039
Wt1	Wilms tumor 1 homolog	0.039
Apoe	apolipoprotein E	0.038
Htra1	HtrA serine peptidase 1	0.038
Hoxa3	homeobox A3	0.038
Fbln1	fibulin 1	0.036
Lama5	laminin, alpha 5	0.036
Cd93	CD93 antigen	0.035
Rarb	retinoic acid receptor, beta	0.034
Col4a3	collagen, type IV, alpha 3	0.033
Lamb1	laminin B1	0.033
Ccm2	cerebral cavernous malformation 2 homolog (human)	0.033
Fgfr2	fibroblast growth factor receptor 2	0.032
Bcar1	breast cancer anti-estrogen resistance 1	0.031
Id1	inhibitor of DNA binding 1	0.029
Nos1	nitric oxide synthase 1, neuronal	0.028
Ptov1	prostate tumor over expressed gene 1	0.028
Ehd4	EH-domain containing 4	0.028
Rara	retinoic acid receptor, alpha	0.028
Fli1	Friend leukemia integration 1	0.027
Stab1	stabilin 1	0.027
Ltbp1	latent transforming growth factor beta binding protein 1	0.027
Epas1	endothelial PAS domain protein 1	0.027
Yap1	yes-associated protein 1	0.026
Klf7	Kruppel-like factor 7 (ubiquitous)	0.026
Elk3	ELK3, member of ETS oncogene family	0.025
Cldn5	claudin 5	0.025
Plcg1	phospholipase C, gamma 1	0.024
Myadm	myeloid-associated differentiation marker	0.024
Sox7	SRY-box containing gene 7	0.024
Tcf4	transcription factor 4	0.022
Lrp1	low density lipoprotein receptor-related protein 1	0.022
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.022
Aplnr	apelin receptor	0.022
Ldb2	LIM domain binding 2	0.021
Nov	nephroblastoma overexpressed gene	0.020
Cav1	caveolin 1, caveolae protein	0.020
Rarg	retinoic acid receptor, gamma	0.020
Tek	endothelial-specific receptor tyrosine kinase	0.020
Sox18	SRY-box containing gene 18	0.020
Aldoa	aldolase A, fructose-bisphosphate	0.020
Smad6	MAD homolog 6 (Drosophila)	0.019
Pltp	phospholipid transfer protein	0.019
Pax3	paired box gene 3	0.019
Tie1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.019
Plxna2	plexin A2	0.019
Agtr1a	angiotensin II receptor, type 1a	0.019
Neurod1	neurogenic differentiation 1	0.018
Vegfa	vascular endothelial growth factor A	0.018
F2r	coagulation factor II (thrombin) receptor	0.018
Meox2	mesenchyme homeobox 2	0.018
Aes	amino-terminal enhancer of split	0.018
Rrm2b	ribonucleotide reductase M2 B (TP53 inducible)	0.018
Pvr	poliovirus receptor	0.017
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.017
Bcl6b	B-cell CLL/lymphoma 6, member B	0.017
Fn1	fibronectin 1	0.017
Krtap3-3	keratin associated protein 3-3	0.017
Dock4	dedicator of cytokinesis 4	0.017
Gata4	GATA binding protein 4	0.017
Phlda3	pleckstrin homology-like domain, family A, member 3	0.017
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.017
P4ha2	procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha II polypeptide	0.017
Rasgrp3	RAS, guanyl releasing protein 3	0.016
Sema3a	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	0.016
Gja1	gap junction protein, alpha 1	0.016
She	src homology 2 domain-containing transforming protein E	0.016
Prkci	protein kinase C, iota	0.016
Wwc2	WW, C2 and coiled-coil domain containing 2	0.016
Adrb1	adrenergic receptor, beta 1	0.016
Hapln1	hyaluronan and proteoglycan link protein 1	0.016
Large	like-glycosyltransferase	0.015
Ehd3	EH-domain containing 3	0.015
Edn1	endothelin 1	0.015
Ptprm	protein tyrosine phosphatase, receptor type, M	0.015
Spry4	sprouty homolog 4 (Drosophila)	0.014
Phldb2	pleckstrin homology-like domain, family B, member 2	0.014
Pygb	brain glycogen phosphorylase	0.014
Arap3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.014
Tspan9	tetraspanin 9	0.014
Lamc1	laminin, gamma 1	0.014
Egfr	epidermal growth factor receptor	0.014
Sema6d	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	0.013
Tcf21	transcription factor 21	0.013
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.013
Tcfap2a	transcription factor AP-2, alpha	0.013
Ldlr	low density lipoprotein receptor	0.013
Ren1	renin 1 structural	0.013
Pparg	peroxisome proliferator activated receptor gamma	0.013
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.013
Ilk	integrin linked kinase	0.013
Cacna1c	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.013
Nf1	neurofibromatosis 1	0.013
Prkg2	protein kinase, cGMP-dependent, type II	0.013
Itga5	integrin alpha 5 (fibronectin receptor alpha)	0.013
Acvrl1	activin A receptor, type II-like 1	0.013
Cxcl12	chemokine (C-X-C motif) ligand 12	0.013
Prkd1	protein kinase D1	0.013
Ghr	growth hormone receptor	0.012
Amotl1	angiomotin-like 1	0.012
Angpt2	angiopoietin 2	0.012
Rasip1	Ras interacting protein 1	0.012
Tcte2	t-complex-associated testis expressed 2	0.012
Tmem204	transmembrane protein 204	0.012
Extl3	exostoses (multiple)-like 3	0.012
Snta1	syntrophin, acidic 1	0.012
Dpep1	dipeptidase 1 (renal)	0.012
Fosl2	fos-like antigen 2	0.012
Nav1	neuron navigator 1	0.012
Tbx1	T-box 1	0.012
Nid1	nidogen 1	0.012
Isl1	ISL1 transcription factor, LIM/homeodomain	0.012
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.012
Myo1e	myosin IE	0.012
Tgfb1	transforming growth factor, beta 1	0.012
Tmem109	transmembrane protein 109	0.012
Serpine1	serine (or cysteine) peptidase inhibitor, clade E, member 1	0.012
Podxl	podocalyxin-like	0.011
Hlx	H2.0-like homeobox	0.011
Smo	smoothened homolog (Drosophila)	0.011
Apbb1	amyloid beta (A4) precursor protein-binding, family B, member 1	0.011
Gys1	glycogen synthase 1, muscle	0.011
Hgf	hepatocyte growth factor	0.011
Itgb5	integrin beta 5	0.011
Gja4	gap junction protein, alpha 4	0.011
Dag1	dystroglycan 1	0.011
Ereg	epiregulin	0.011
Sipa1l2	signal-induced proliferation-associated 1 like 2	0.011
Gcnt2	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme	0.011
Col4a2	collagen, type IV, alpha 2	0.011
Pdgfa	platelet derived growth factor, alpha	0.011	Mouse
Itm2c	integral membrane protein 2C	0.010
Zfhx3	zinc finger homeobox 3	0.010
Sox4	SRY-box containing gene 4	0.010
Emp2	epithelial membrane protein 2	0.010
Hand2	heart and neural crest derivatives expressed transcript 2	0.010
Dbndd2	dysbindin (dystrobrevin binding protein 1) domain containing 2	0.010
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.010
Cyr61	cysteine rich protein 61	0.010
Dmd	dystrophin, muscular dystrophy	0.010
Nfic	nuclear factor I/C	0.010
Ikbip	IKBKB interacting protein	0.010