IMP
Process View
tumor necrosis factor biosynthetic process
The chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "tumor necrosis factor biosynthetic process"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Ikzf1 | IKAROS family zinc finger 1 | 0.877 | ||
| Nfkb2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 | 0.859 | ||
| Clec4n | C-type lectin domain family 4, member n | 0.772 | Mouse | |
| Ccr6 | chemokine (C-C motif) receptor 6 | 0.723 | Mouse | |
| Cd19 | CD19 antigen | 0.707 | ||
| Nfkb1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 | 0.618 | ||
| Relb | avian reticuloendotheliosis viral (v-rel) oncogene related B | 0.551 | ||
| Cd79a | CD79A antigen (immunoglobulin-associated alpha) | 0.481 | ||
| Clec4d | C-type lectin domain family 4, member d | 0.442 | Mouse | |
| Fcrla | Fc receptor-like A | 0.348 | Mouse | |
| Map3k14 | mitogen-activated protein kinase kinase kinase 14 | 0.337 | ||
| Icos | inducible T-cell co-stimulator | 0.323 | ||
| Rela | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 0.308 | ||
| Xcr1 | chemokine (C motif) receptor 1 | 0.295 | Mouse | |
| Cd40 | CD40 antigen | 0.256 | ||
| Fcer1g | Fc receptor, IgE, high affinity I, gamma polypeptide | 0.251 | ||
| Blk | B lymphoid kinase | 0.225 | ||
| Csf3r | colony stimulating factor 3 receptor (granulocyte) | 0.213 | ||
| Ptprc | protein tyrosine phosphatase, receptor type, C | 0.204 | ||
| Cd44 | CD44 antigen | 0.180 | ||
| Ccr1 | chemokine (C-C motif) receptor 1 | 0.177 | Mouse | |
| Lyz2 | lysozyme 2 | 0.168 | ||
| Cd14 | CD14 antigen | 0.145 | ||
| Tnfrsf1a | tumor necrosis factor receptor superfamily, member 1a | 0.141 | ||
| Ccr7 | chemokine (C-C motif) receptor 7 | 0.133 | Mouse | |
| Ccl2 | chemokine (C-C motif) ligand 2 | 0.128 | ||
| Ms4a1 | membrane-spanning 4-domains, subfamily A, member 1 | 0.121 | ||
| Klrk1 | killer cell lectin-like receptor subfamily K, member 1 | 0.118 | ||
| Ccr5 | chemokine (C-C motif) receptor 5 | 0.117 | Mouse | |
| Fcer2a | Fc receptor, IgE, low affinity II, alpha polypeptide | 0.112 | Mouse | |
| Klrg1 | killer cell lectin-like receptor subfamily G, member 1 | 0.107 | ||
| Il1b | interleukin 1 beta | 0.106 | ||
| Klra2 | killer cell lectin-like receptor, subfamily A, member 2 | 0.103 | ||
| Ccr3 | chemokine (C-C motif) receptor 3 | 0.103 | Mouse | |
| Btk | Bruton agammaglobulinemia tyrosine kinase | 0.101 | ||
| Pik3cg | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 0.095 | ||
| Ccr2 | chemokine (C-C motif) receptor 2 | 0.091 | ||
| Cd22 | CD22 antigen | 0.084 | ||
| Cd7 | CD7 antigen | 0.083 | ||
| P2rx7 | purinergic receptor P2X, ligand-gated ion channel, 7 | 0.082 | ||
| Ifng | interferon gamma | 0.082 | ||
| Cxcr5 | chemokine (C-X-C motif) receptor 5 | 0.081 | Mouse | |
| Il10 | interleukin 10 | 0.077 | ||
| Vpreb3 | pre-B lymphocyte gene 3 | 0.075 | ||
| Klrd1 | killer cell lectin-like receptor, subfamily D, member 1 | 0.074 | ||
| Spib | Spi-B transcription factor (Spi-1/PU.1 related) | 0.073 | ||
| Cd209a | CD209a antigen | 0.072 | Mouse | |
| Tlr2 | toll-like receptor 2 | 0.070 | ||
| Cr2 | complement receptor 2 | 0.068 | ||
| H2-Ob | histocompatibility 2, O region beta locus | 0.067 | ||
| Clec4e | C-type lectin domain family 4, member e | 0.064 | Mouse | |
| Fpr2 | formyl peptide receptor 2 | 0.064 | ||
| Sfpi1 | SFFV proviral integration 1 | 0.063 | ||
| C3 | complement component 3 | 0.062 | ||
| Lair1 | leukocyte-associated Ig-like receptor 1 | 0.061 | ||
| Fgr | Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog | 0.061 | ||
| Clec7a | C-type lectin domain family 7, member a | 0.058 | ||
| Selp | selectin, platelet | 0.055 | ||
| Cybb | cytochrome b-245, beta polypeptide | 0.055 | ||
| Fgd3 | FYVE, RhoGEF and PH domain containing 3 | 0.055 | ||
| C3ar1 | complement component 3a receptor 1 | 0.055 | ||
| AF251705 | cDNA sequence AF251705 | 0.052 | ||
| Cd300ld | CD300 molecule-like family member d | 0.052 | ||
| Cryab | crystallin, alpha B | 0.052 | Mouse | |
| Cd180 | CD180 antigen | 0.052 | Mouse | |
| Ciita | class II transactivator | 0.051 | ||
| Mmp8 | matrix metallopeptidase 8 | 0.051 | ||
| Itgam | integrin alpha M | 0.051 | ||
| Pou2af1 | POU domain, class 2, associating factor 1 | 0.051 | ||
| Ncr1 | natural cytotoxicity triggering receptor 1 | 0.050 | ||
| S1pr4 | sphingosine-1-phosphate receptor 4 | 0.050 | ||
| Tnf | tumor necrosis factor | 0.049 | ||
| Clec4b1 | C-type lectin domain family 4, member b1 | 0.046 | Mouse | |
| Myd88 | myeloid differentiation primary response gene 88 | 0.046 | ||
| Ms4a4c | membrane-spanning 4-domains, subfamily A, member 4C | 0.045 | ||
| Emr1 | EGF-like module containing, mucin-like, hormone receptor-like sequence 1 | 0.044 | ||
| Cdkn1a | cyclin-dependent kinase inhibitor 1A (P21) | 0.044 | ||
| Nphp4 | nephronophthisis 4 (juvenile) homolog (human) | 0.043 | ||
| Itgal | integrin alpha L | 0.042 | ||
| Igh | immunoglobulin heavy chain complex | 0.042 | ||
| Sell | selectin, lymphocyte | 0.042 | ||
| Nkx2-3 | NK2 transcription factor related, locus 3 (Drosophila) | 0.041 | ||
| Msr1 | macrophage scavenger receptor 1 | 0.041 | ||
| Lta | lymphotoxin A | 0.039 | ||
| Abcg3 | ATP-binding cassette, sub-family G (WHITE), member 3 | 0.038 | ||
| Tlr8 | toll-like receptor 8 | 0.036 | Mouse | |
| Clec4a2 | C-type lectin domain family 4, member a2 | 0.036 | Mouse | |
| Folr2 | folate receptor 2 (fetal) | 0.036 | ||
| Ccl3 | chemokine (C-C motif) ligand 3 | 0.035 | ||
| Il18rap | interleukin 18 receptor accessory protein | 0.035 | ||
| Nos2 | nitric oxide synthase 2, inducible | 0.033 | ||
| Fpr1 | formyl peptide receptor 1 | 0.033 | ||
| Cd209d | CD209d antigen | 0.033 | Mouse | |
| Klrb1b | killer cell lectin-like receptor subfamily B member 1B | 0.032 | ||
| Tlr7 | toll-like receptor 7 | 0.031 | ||
| Klra9 | killer cell lectin-like receptor subfamily A, member 9 | 0.031 | ||
| Pyhin1 | pyrin and HIN domain family, member 1 | 0.031 | ||
| Klra5 | killer cell lectin-like receptor, subfamily A, member 5 | 0.029 | ||
| Ear2 | eosinophil-associated, ribonuclease A family, member 2 | 0.029 | ||
| Emr4 | EGF-like module containing, mucin-like, hormone receptor-like sequence 4 | 0.029 | ||
| Pla2g2d | phospholipase A2, group IID | 0.028 | ||
| Cxcl13 | chemokine (C-X-C motif) ligand 13 | 0.028 | ||
| Pik3cd | phosphatidylinositol 3-kinase catalytic delta polypeptide | 0.027 | ||
| Il12a | interleukin 12a | 0.027 | ||
| Cd209b | CD209b antigen | 0.027 | ||
| Fcgr4 | Fc receptor, IgG, low affinity IV | 0.027 | ||
| Gpr132 | G protein-coupled receptor 132 | 0.026 | ||
| Cyld | cylindromatosis (turban tumor syndrome) | 0.026 | ||
| Birc3 | baculoviral IAP repeat-containing 3 | 0.026 | ||
| Tnfsf14 | tumor necrosis factor (ligand) superfamily, member 14 | 0.025 | ||
| Mc5r | melanocortin 5 receptor | 0.025 | ||
| Trem3 | triggering receptor expressed on myeloid cells 3 | 0.025 | ||
| Tbxas1 | thromboxane A synthase 1, platelet | 0.023 | ||
| Ccl24 | chemokine (C-C motif) ligand 24 | 0.022 | ||
| Runx1 | runt related transcription factor 1 | 0.022 | ||
| Itgax | integrin alpha X | 0.022 | ||
| Tnfrsf13c | tumor necrosis factor receptor superfamily, member 13c | 0.022 | ||
| Pilrb1 | paired immunoglobin-like type 2 receptor beta 1 | 0.022 | ||
| Stat3 | signal transducer and activator of transcription 3 | 0.021 | ||
| Bcl6 | B-cell leukemia/lymphoma 6 | 0.021 | ||
| Igk | immunoglobulin kappa chain complex | 0.021 | ||
| Clec5a | C-type lectin domain family 5, member a | 0.021 | ||
| Mgl2 | macrophage galactose N-acetyl-galactosamine specific lectin 2 | 0.021 | ||
| Slamf6 | SLAM family member 6 | 0.021 | ||
| Prg3 | proteoglycan 3 | 0.021 | ||
| Il27ra | interleukin 27 receptor, alpha | 0.021 | ||
| Sit1 | suppression inducing transmembrane adaptor 1 | 0.020 | ||
| Icam1 | intercellular adhesion molecule 1 | 0.020 | ||
| C5ar1 | complement component 5a receptor 1 | 0.019 | ||
| Serpinb7 | serine (or cysteine) peptidase inhibitor, clade B, member 7 | 0.019 | ||
| Fcrl1 | Fc receptor-like 1 | 0.019 | ||
| Fasl | Fas ligand (TNF superfamily, member 6) | 0.018 | ||
| Tnfrsf17 | tumor necrosis factor receptor superfamily, member 17 | 0.018 | ||
| Klra17 | killer cell lectin-like receptor, subfamily A, member 17 | 0.018 | ||
| Siglecg | sialic acid binding Ig-like lectin G | 0.018 | ||
| Pilra | paired immunoglobin-like type 2 receptor alpha | 0.018 | ||
| Gzma | granzyme A | 0.017 | ||
| Gimap7 | GTPase, IMAP family member 7 | 0.017 | ||
| Cd33 | CD33 antigen | 0.017 | ||
| Cysltr1 | cysteinyl leukotriene receptor 1 | 0.017 | ||
| Efna1 | ephrin A1 | 0.017 | ||
| Prdm1 | PR domain containing 1, with ZNF domain | 0.016 | ||
| Fpr3 | formyl peptide receptor 3 | 0.016 | ||
| Nckap1l | NCK associated protein 1 like | 0.016 | ||
| Sykb | spleen tyrosine kinase | 0.016 | ||
| Bag3 | BCL2-associated athanogene 3 | 0.015 | ||
| Prf1 | perforin 1 (pore forming protein) | 0.015 | ||
| Clec2i | C-type lectin domain family 2, member i | 0.015 | ||
| Ccl9 | chemokine (C-C motif) ligand 9 | 0.015 | ||
| Lilrb4 | leukocyte immunoglobulin-like receptor, subfamily B, member 4 | 0.015 | ||
| Ms4a6d | membrane-spanning 4-domains, subfamily A, member 6D | 0.015 | ||
| Marco | macrophage receptor with collagenous structure | 0.015 | ||
| Cd207 | CD207 antigen | 0.015 | Mouse | |
| Cd209f | CD209f antigen | 0.014 | ||
| Havcr2 | hepatitis A virus cellular receptor 2 | 0.014 | ||
| Ms4a6c | membrane-spanning 4-domains, subfamily A, member 6C | 0.014 | ||
| Il18r1 | interleukin 18 receptor 1 | 0.013 | ||
| Siglec1 | sialic acid binding Ig-like lectin 1, sialoadhesin | 0.013 | ||
| Mefv | Mediterranean fever | 0.013 | ||
| Il1rn | interleukin 1 receptor antagonist | 0.013 | ||
| Tnfrsf13b | tumor necrosis factor receptor superfamily, member 13b | 0.013 | ||
| H2-M9 | histocompatibility 2, M region locus 9 | 0.013 | ||
| Elane | elastase, neutrophil expressed | 0.013 | ||
| Flt3 | FMS-like tyrosine kinase 3 | 0.012 | ||
| Apoe | apolipoprotein E | 0.012 | ||
| Ccl6 | chemokine (C-C motif) ligand 6 | 0.012 | ||
| Gdf9 | growth differentiation factor 9 | 0.012 | ||
| Ltb | lymphotoxin B | 0.012 | ||
| Cd96 | CD96 antigen | 0.012 | ||
| H2-DMb2 | histocompatibility 2, class II, locus Mb2 | 0.012 | ||
| Vnn3 | vanin 3 | 0.012 | ||
| Gpr33 | G protein-coupled receptor 33 | 0.012 | ||
| Spn | sialophorin | 0.012 | ||
| Stab2 | stabilin 2 | 0.011 | ||
| Gsn | gelsolin | 0.011 | ||
| Card9 | caspase recruitment domain family, member 9 | 0.011 | ||
| Casp4 | caspase 4, apoptosis-related cysteine peptidase | 0.011 | ||
| Il4ra | interleukin 4 receptor, alpha | 0.011 | ||
| Ifngr1 | interferon gamma receptor 1 | 0.011 | ||
| Ms4a7 | membrane-spanning 4-domains, subfamily A, member 7 | 0.011 | ||
| Cd79b | CD79B antigen | 0.011 | ||
| Il1f9 | interleukin 1 family, member 9 | 0.011 | ||
| 2210010C04Rik | RIKEN cDNA 2210010C04 gene | 0.011 | ||
| Mmp9 | matrix metallopeptidase 9 | 0.011 | ||
| Trem1 | triggering receptor expressed on myeloid cells 1 | 0.011 | ||
| Cd6 | CD6 antigen | 0.011 | ||
| Cnr2 | cannabinoid receptor 2 (macrophage) | 0.011 | ||
| Gzmk | granzyme K | 0.011 | ||
| Rgr | retinal G protein coupled receptor | 0.011 | ||
| Bex6 | brain expressed gene 6 | 0.011 | ||
| Olfr140 | olfactory receptor 140 | 0.010 | ||
| Cmah | cytidine monophospho-N-acetylneuraminic acid hydroxylase | 0.010 | ||
| Oosp1 | oocyte secreted protein 1 | 0.010 | ||
| Lyn | Yamaguchi sarcoma viral (v-yes-1) oncogene homolog | 0.010 | ||
| Tlr6 | toll-like receptor 6 | 0.010 | Mouse | |
| Pcdh12 | protocadherin 12 | 0.010 | ||
| Cmklr1 | chemokine-like receptor 1 | 0.010 |