IMP

Process View

Mus musculus

4 genes annotated in mouse

rhombomere 5 development

The process whose specific outcome is the progression of rhombomere 5 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "rhombomere 5 development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "rhombomere 5 development" (in gray)

Name	Description	Probability	Func Analog Organism
Pax2	paired box gene 2	1.000
Hoxa1	homeobox A1	1.000
Hoxa2	homeobox A2	1.000	Mouse
Gbx2	gastrulation brain homeobox 2	0.998
Tbx1	T-box 1	0.995
Eya1	eyes absent 1 homolog (Drosophila)	0.992
Egr2	early growth response 2	0.984
Hoxa3	homeobox A3	0.980
Hoxb2	homeobox B2	0.969	Mouse
Otx1	orthodenticle homolog 1 (Drosophila)	0.965
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.965
Hoxb1	homeobox B1	0.962
Otx2	orthodenticle homolog 2 (Drosophila)	0.949
Gata3	GATA binding protein 3	0.939
Isl1	ISL1 transcription factor, LIM/homeodomain	0.939
Jag1	jagged 1	0.920
Lmx1a	LIM homeobox transcription factor 1 alpha	0.892
Hoxd3	homeobox D3	0.887
Tbx10	T-box 10	0.840
Shh	sonic hedgehog	0.827
Phox2b	paired-like homeobox 2b	0.759
Emx2	empty spiracles homolog 2 (Drosophila)	0.739
Hmx3	H6 homeobox 3	0.735
Foxg1	forkhead box G1	0.705
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.681
Hoxb3	homeobox B3	0.656
Fgf8	fibroblast growth factor 8	0.645	Zebrafish
Gdnf	glial cell line derived neurotrophic factor	0.615
Ntf3	neurotrophin 3	0.615
Lhx1	LIM homeobox protein 1	0.579
Nab2	Ngfi-A binding protein 2	0.578
Bdnf	brain derived neurotrophic factor	0.533
Junb	Jun-B oncogene	0.530
Ptgs2	prostaglandin-endoperoxide synthase 2	0.475
Tcfap2a	transcription factor AP-2, alpha	0.455
Hand2	heart and neural crest derivatives expressed transcript 2	0.441
Dlx5	distal-less homeobox 5	0.435
Foxc2	forkhead box C2	0.415
En1	engrailed 1	0.414
Col4a3	collagen, type IV, alpha 3	0.375
Fos	FBJ osteosarcoma oncogene	0.364
Rarb	retinoic acid receptor, beta	0.353
Rara	retinoic acid receptor, alpha	0.350
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.338
Fgf3	fibroblast growth factor 3	0.316	Zebrafish
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.312
Nrg1	neuregulin 1	0.299
Hoxb6	homeobox B6	0.295
Ednra	endothelin receptor type A	0.292
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.291
Hoxb5	homeobox B5	0.287
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.287
Chd7	chromodomain helicase DNA binding protein 7	0.278
Fgf10	fibroblast growth factor 10	0.260
Hoxc8	homeobox C8	0.243
Vegfa	vascular endothelial growth factor A	0.242
Hoxa4	homeobox A4	0.229
Wnt1	wingless-related MMTV integration site 1	0.229
Lhx9	LIM homeobox protein 9	0.223
Serpine1	serine (or cysteine) peptidase inhibitor, clade E, member 1	0.222
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.215
Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	0.202
Fosb	FBJ osteosarcoma oncogene B	0.202
Zfp36	zinc finger protein 36	0.191
Hmx2	H6 homeobox 2	0.190
Gsc	goosecoid homeobox	0.189
Hoxb4	homeobox B4	0.157
Hoxc4	homeobox C4	0.154
Fosl2	fos-like antigen 2	0.154
Jun	Jun oncogene	0.151
Nr4a1	nuclear receptor subfamily 4, group A, member 1	0.145
Pax8	paired box gene 8	0.144
Chrd	chordin	0.139
Pax3	paired box gene 3	0.137
Foxc1	forkhead box C1	0.135
Lmx1b	LIM homeobox transcription factor 1 beta	0.128
Bnc1	basonuclin 1	0.124
Hmx1	H6 homeobox 1	0.124
Msx1	homeobox, msh-like 1	0.107
Kiss1	KiSS-1 metastasis-suppressor	0.104
Mesp1	mesoderm posterior 1	0.103
Pitx2	paired-like homeodomain transcription factor 2	0.103
Neurog1	neurogenin 1	0.102
Atf3	activating transcription factor 3	0.099
Pou4f2	POU domain, class 4, transcription factor 2	0.099
Dlx2	distal-less homeobox 2	0.098
Hoxd11	homeobox D11	0.097
Sall3	sal-like 3 (Drosophila)	0.095
Pitx1	paired-like homeodomain transcription factor 1	0.090
Hoxb9	homeobox B9	0.090
Hoxa9	homeobox A9	0.089
Zic2	zinc finger protein of the cerebellum 2	0.085
Cyp26a1	cytochrome P450, family 26, subfamily a, polypeptide 1	0.084
Foxd2	forkhead box D2	0.078
Foxi1	forkhead box I1	0.077
Hoxa11	homeobox A11	0.076
Hes5	hairy and enhancer of split 5 (Drosophila)	0.074
Tcf21	transcription factor 21	0.073
Pbx1	pre B-cell leukemia transcription factor 1	0.072
Dusp1	dual specificity phosphatase 1	0.069
Wnt6	wingless-related MMTV integration site 6	0.069
Foxi3	forkhead box I3	0.068
Sox2	SRY-box containing gene 2	0.067
Btg2	B-cell translocation gene 2, anti-proliferative	0.067
Mecom	MDS1 and EVI1 complex locus	0.065
Tbx2	T-box 2	0.059
Hoxd1	homeobox D1	0.059	Mouse
Nog	noggin	0.059
Maff	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)	0.059	Mouse
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.057
Nab1	Ngfi-A binding protein 1	0.057
Hoxd9	homeobox D9	0.057
Col13a1	collagen, type XIII, alpha 1	0.056
Hoxd4	homeobox D4	0.056
Pvr	poliovirus receptor	0.055
Pax6	paired box gene 6	0.055
Itga3	integrin alpha 3	0.054
Hoxd8	homeobox D8	0.054
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.053
Epha2	Eph receptor A2	0.052
Alx4	aristaless-like homeobox 4	0.051
Osr1	odd-skipped related 1 (Drosophila)	0.051
Klf4	Kruppel-like factor 4 (gut)	0.051
Atoh7	atonal homolog 7 (Drosophila)	0.050
Umod	uromodulin	0.049
Erbb4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.049
Prrx1	paired related homeobox 1	0.049
Hoxb8	homeobox B8	0.048
Ribc2	RIB43A domain with coiled-coils 2	0.048
Zic3	zinc finger protein of the cerebellum 3	0.046
Fgf15	fibroblast growth factor 15	0.046
Msx2	homeobox, msh-like 2	0.046
Ripply3	ripply3 homolog (zebrafish)	0.045
Foxa2	forkhead box A2	0.044
Prph2	peripherin 2	0.044
Hoxa5	homeobox A5	0.043
Gata6	GATA binding protein 6	0.043
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.042
Egr1	early growth response 1	0.042	Mouse
Phlda2	pleckstrin homology-like domain, family A, member 2	0.042
Sim2	single-minded homolog 2 (Drosophila)	0.041
Hoxa7	homeobox A7	0.040
Vax1	ventral anterior homeobox containing gene 1	0.040
Pou4f3	POU domain, class 4, transcription factor 3	0.039
Hoxd10	homeobox D10	0.039
Hbegf	heparin-binding EGF-like growth factor	0.038
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.038
Zfp503	zinc finger protein 503	0.037
Fshr	follicle stimulating hormone receptor	0.036
Lhx3	LIM homeobox protein 3	0.036
Kcne1	potassium voltage-gated channel, Isk-related subfamily, member 1	0.036
Hoxa10	homeobox A10	0.036
Pou3f3	POU domain, class 3, transcription factor 3	0.036
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.036
Pim1	proviral integration site 1	0.036
Adora2b	adenosine A2b receptor	0.036
Robo3	roundabout homolog 3 (Drosophila)	0.035
Nkx3-2	NK3 homeobox 2	0.035
Bhlhe40	basic helix-loop-helix family, member e40	0.035
Ppp1r15a	protein phosphatase 1, regulatory (inhibitor) subunit 15A	0.034
Csrnp1	cysteine-serine-rich nuclear protein 1	0.034
Hes1	hairy and enhancer of split 1 (Drosophila)	0.034
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.034
Ier3	immediate early response 3	0.033
Gfra3	glial cell line derived neurotrophic factor family receptor alpha 3	0.033
En2	engrailed 2	0.033
Nphs2	nephrosis 2 homolog, podocin (human)	0.032
Hmga2	high mobility group AT-hook 2	0.032
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.032
Vangl2	vang-like 2 (van gogh, Drosophila)	0.032
Wt1	Wilms tumor 1 homolog	0.031	Mouse
Ren1	renin 1 structural	0.031
T	brachyury	0.030
Neurog2	neurogenin 2	0.030
Prrx2	paired related homeobox 2	0.029
Dlx1	distal-less homeobox 1	0.028
Foxa1	forkhead box A1	0.027
Hoxc6	homeobox C6	0.027
Gfra1	glial cell line derived neurotrophic factor family receptor alpha 1	0.027
Tchh	trichohyalin	0.027
Hsd11b2	hydroxysteroid 11-beta dehydrogenase 2	0.027
Cyr61	cysteine rich protein 61	0.027
Ier2	immediate early response 2	0.027
Rarg	retinoic acid receptor, gamma	0.027
Socs3	suppressor of cytokine signaling 3	0.026
Hand1	heart and neural crest derivatives expressed transcript 1	0.026
Afp	alpha fetoprotein	0.026
Igf2bp2	insulin-like growth factor 2 mRNA binding protein 2	0.026
Irs2	insulin receptor substrate 2	0.025
Lhx5	LIM homeobox protein 5	0.024
Ntf5	neurotrophin 5	0.024
Wnt9b	wingless-type MMTV integration site 9B	0.024
Lef1	lymphoid enhancer binding factor 1	0.024
Bcl2	B-cell leukemia/lymphoma 2	0.024
Wnt3	wingless-related MMTV integration site 3	0.024
Ar	androgen receptor	0.023
Sox3	SRY-box containing gene 3	0.023
Emx1	empty spiracles homolog 1 (Drosophila)	0.023
Myf5	myogenic factor 5	0.022
Cga	glycoprotein hormones, alpha subunit	0.022
Cldn8	claudin 8	0.022
Adrb1	adrenergic receptor, beta 1	0.022
Foxa3	forkhead box A3	0.021
Smo	smoothened homolog (Drosophila)	0.021
Btbd17	BTB (POZ) domain containing 17	0.021
Ihh	Indian hedgehog	0.021
Ece1	endothelin converting enzyme 1	0.021
Irx1	Iroquois related homeobox 1 (Drosophila)	0.021
Dusp9	dual specificity phosphatase 9	0.021
Wnt5b	wingless-related MMTV integration site 5B	0.021
Nrtn	neurturin	0.020
Nfkbiz	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.020
Pitx3	paired-like homeodomain transcription factor 3	0.020
Bmp4	bone morphogenetic protein 4	0.020
Pdx1	pancreatic and duodenal homeobox 1	0.019
Snai1	snail homolog 1 (Drosophila)	0.019
Lrp2	low density lipoprotein receptor-related protein 2	0.019
Pou3f1	POU domain, class 3, transcription factor 1	0.019
Pax9	paired box gene 9	0.019
Vstm2b	V-set and transmembrane domain containing 2B	0.019
Phox2a	paired-like homeobox 2a	0.019
Lepr	leptin receptor	0.019
Wnt9a	wingless-type MMTV integration site 9A	0.018
Cdx1	caudal type homeobox 1	0.018
Ier5l	immediate early response 5-like	0.018
Slc26a4	solute carrier family 26, member 4	0.018
Etv2	ets variant gene 2	0.018
Otp	orthopedia homolog (Drosophila)	0.017
Dkk2	dickkopf homolog 2 (Xenopus laevis)	0.017
Cckar	cholecystokinin A receptor	0.017
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.017
Myo1e	myosin IE	0.017
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.017
Gadd45b	growth arrest and DNA-damage-inducible 45 beta	0.016
Tcf15	transcription factor 15	0.016
Efna2	ephrin A2	0.016
Tnfrsf12a	tumor necrosis factor receptor superfamily, member 12a	0.016
Efna5	ephrin A5	0.016
Tshz1	teashirt zinc finger family member 1	0.016
Hoxc5	homeobox C5	0.016
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.016
Prm1	protamine 1	0.016
Ntrk3	neurotrophic tyrosine kinase, receptor, type 3	0.016
Cyp26c1	cytochrome P450, family 26, subfamily c, polypeptide 1	0.016
Masp1	mannan-binding lectin serine peptidase 1	0.016
Errfi1	ERBB receptor feedback inhibitor 1	0.016
Amh	anti-Mullerian hormone	0.015
Slc7a2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	0.015
Foxb1	forkhead box B1	0.015
Il6	interleukin 6	0.015
Nodal	nodal	0.015
Fgfr2	fibroblast growth factor receptor 2	0.015
Fgf17	fibroblast growth factor 17	0.015
Cdh6	cadherin 6	0.015
Htr1f	5-hydroxytryptamine (serotonin) receptor 1F	0.015
Matn3	matrilin 3	0.015
BC024139	cDNA sequence BC024139	0.015
Gdf15	growth differentiation factor 15	0.015
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.015
Wnt3a	wingless-related MMTV integration site 3A	0.015
Plk3	polo-like kinase 3 (Drosophila)	0.015
Gjb5	gap junction protein, beta 5	0.015
Prkg2	protein kinase, cGMP-dependent, type II	0.015
Col4a4	collagen, type IV, alpha 4	0.015
Vgll2	vestigial like 2 homolog (Drosophila)	0.015
Lhx8	LIM homeobox protein 8	0.014
Kremen2	kringle containing transmembrane protein 2	0.014
Sox1	SRY-box containing gene 1	0.014
Cabp7	calcium binding protein 7	0.014
Lgr5	leucine rich repeat containing G protein coupled receptor 5	0.014
Kif12	kinesin family member 12	0.014
Sox11	SRY-box containing gene 11	0.014
Ptk7	PTK7 protein tyrosine kinase 7	0.014
Foxl2	forkhead box L2	0.014
Spry4	sprouty homolog 4 (Drosophila)	0.014
Ikzf2	IKAROS family zinc finger 2	0.014
Bdkrb2	bradykinin receptor, beta 2	0.014
Evx1	even skipped homeotic gene 1 homolog	0.014
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.013
Mkl2	MKL/myocardin-like 2	0.013
Uncx	UNC homeobox	0.013
Greb1	gene regulated by estrogen in breast cancer protein	0.013
Gli3	GLI-Kruppel family member GLI3	0.013
Hoxb13	homeobox B13	0.013
Crb2	crumbs homolog 2 (Drosophila)	0.013
Tlx3	T-cell leukemia, homeobox 3	0.013
Mll2	myeloid/lymphoid or mixed-lineage leukemia 2	0.013
Gata4	GATA binding protein 4	0.013
Areg	amphiregulin	0.013
Aqp2	aquaporin 2	0.013
Foxd1	forkhead box D1	0.013
Hoxd13	homeobox D13	0.013
Ahr	aryl-hydrocarbon receptor	0.013
Nkx6-1	NK6 homeobox 1	0.013
Agrp	agouti related protein	0.013
Slc6a4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	0.013
Rxra	retinoid X receptor alpha	0.013
Adra2b	adrenergic receptor, alpha 2b	0.013
Lama1	laminin, alpha 1	0.013
Nhedc2	Na+/H+ exchanger domain containing 2	0.013
Tcof1	Treacher Collins Franceschetti syndrome 1, homolog	0.013
Cxcl1	chemokine (C-X-C motif) ligand 1	0.013
Myog	myogenin	0.012
Rgs9bp	regulator of G-protein signalling 9 binding protein	0.012
Kiss1r	KISS1 receptor	0.012
Dlx6	distal-less homeobox 6	0.012
Rdh10	retinol dehydrogenase 10 (all-trans)	0.012
Gata2	GATA binding protein 2	0.012
Pou3f4	POU domain, class 3, transcription factor 4	0.012
Per1	period homolog 1 (Drosophila)	0.012
Nr2e1	nuclear receptor subfamily 2, group E, member 1	0.012
Col25a1	collagen, type XXV, alpha 1	0.012
Meis1	Meis homeobox 1	0.012
Papln	papilin, proteoglycan-like sulfated glycoprotein	0.012
Twist1	twist homolog 1 (Drosophila)	0.012
Crtac1	cartilage acidic protein 1	0.012
Ctf1	cardiotrophin 1	0.012
Amhr2	anti-Mullerian hormone type 2 receptor	0.012
Stag3	stromal antigen 3	0.012
Edn1	endothelin 1	0.011
Adra2a	adrenergic receptor, alpha 2a	0.011
Fgf6	fibroblast growth factor 6	0.011
Amn	amnionless	0.011
Glra1	glycine receptor, alpha 1 subunit	0.011
Efna4	ephrin A4	0.011
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.011
Nrk	Nik related kinase	0.011
Sp5	trans-acting transcription factor 5	0.011
Slc32a1	solute carrier family 32 (GABA vesicular transporter), member 1	0.011
Pim3	proviral integration site 3	0.011
Cxcl2	chemokine (C-X-C motif) ligand 2	0.011
Ddx4	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4	0.011
Smad6	MAD homolog 6 (Drosophila)	0.011
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.011
Eya4	eyes absent 4 homolog (Drosophila)	0.011
Foxf1a	forkhead box F1a	0.011
Cd151	CD151 antigen	0.011
Apoa1	apolipoprotein A-I	0.011
Dmrta2	doublesex and mab-3 related transcription factor like family A2	0.011
Dusp5	dual specificity phosphatase 5	0.011
Hs3st6	heparan sulfate (glucosamine) 3-O-sulfotransferase 6	0.011
Gjd3	gap junction protein, delta 3	0.011
Agtr2	angiotensin II receptor, type 2	0.011
Phlda1	pleckstrin homology-like domain, family A, member 1	0.011
Cftr	cystic fibrosis transmembrane conductance regulator homolog	0.011
Iqcd	IQ motif containing D	0.011
Ovol2	ovo-like 2 (Drosophila)	0.011
Cdh16	cadherin 16	0.011
Lhb	luteinizing hormone beta	0.011
Agtr1a	angiotensin II receptor, type 1a	0.011
Nfil3	nuclear factor, interleukin 3, regulated	0.011
Epha1	Eph receptor A1	0.011
Zic1	zinc finger protein of the cerebellum 1	0.011
Gja3	gap junction protein, alpha 3	0.011
Pias2	protein inhibitor of activated STAT 2	0.011
Gal	galanin	0.010
Nxnl2	nucleoredoxin-like 2	0.010
Mip	major intrinsic protein of eye lens fiber	0.010
Tmem28	transmembrane protein 28	0.010
Tnfrsf25	tumor necrosis factor receptor superfamily, member 25	0.010
Gpr182	G protein-coupled receptor 182	0.010
Sim1	single-minded homolog 1 (Drosophila)	0.010
Onecut1	one cut domain, family member 1	0.010
Nkx2-4	NK2 transcription factor related, locus 4 (Drosophila)	0.010
Lpar3	lysophosphatidic acid receptor 3	0.010
Bmp2	bone morphogenetic protein 2	0.010