IMP

Process View

Mus musculus

10 genes annotated in mouse

heart valve formation

The developmental process pertaining to the initial formation of a heart valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "heart valve formation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "heart valve formation" (in gray)

Name	Description	Probability	Func Analog Organism
Gata4	GATA binding protein 4	0.999
Hand2	heart and neural crest derivatives expressed transcript 2	0.999	Mouse
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.998
Shh	sonic hedgehog	0.996
Tbx3	T-box 3	0.993	Mouse
Gli3	GLI-Kruppel family member GLI3	0.984
Pitx2	paired-like homeodomain transcription factor 2	0.983
Efnb2	ephrin B2	0.975	Mouse
Pax3	paired box gene 3	0.969
Hoxa1	homeobox A1	0.965
Fgfr2	fibroblast growth factor receptor 2	0.958
Fgf8	fibroblast growth factor 8	0.957
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.950
Sox9	SRY-box containing gene 9	0.944
Smad6	MAD homolog 6 (Drosophila)	0.914	Mouse
Pitx1	paired-like homeodomain transcription factor 1	0.900
Otx2	orthodenticle homolog 2 (Drosophila)	0.887
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.853
Foxc2	forkhead box C2	0.839
Jag1	jagged 1	0.830
Smad4	MAD homolog 4 (Drosophila)	0.789
Hand1	heart and neural crest derivatives expressed transcript 1	0.739	Mouse
Bmp4	bone morphogenetic protein 4	0.733
Msx1	homeobox, msh-like 1	0.720
Tcfap2a	transcription factor AP-2, alpha	0.688
Isl1	ISL1 transcription factor, LIM/homeodomain	0.622
Sox2	SRY-box containing gene 2	0.608	Mouse
Foxg1	forkhead box G1	0.567
Tgfb2	transforming growth factor, beta 2	0.563
Gata6	GATA binding protein 6	0.539	Mouse
Neurod1	neurogenic differentiation 1	0.441	Mouse
Efna2	ephrin A2	0.421	Mouse
Fgf10	fibroblast growth factor 10	0.409
Msx2	homeobox, msh-like 2	0.382
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.374
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.371
Eya1	eyes absent 1 homolog (Drosophila)	0.357
Foxc1	forkhead box C1	0.310
Gata1	GATA binding protein 1	0.306	Mouse
Sox11	SRY-box containing gene 11	0.304	Mouse
Snai1	snail homolog 1 (Drosophila)	0.302
Ntf3	neurotrophin 3	0.294
Pax2	paired box gene 2	0.281
Hes1	hairy and enhancer of split 1 (Drosophila)	0.279
Dll4	delta-like 4 (Drosophila)	0.277
Meox2	mesenchyme homeobox 2	0.276
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.274
Hey1	hairy/enhancer-of-split related with YRPW motif 1	0.273
Smad3	MAD homolog 3 (Drosophila)	0.253	Mouse
Rxra	retinoid X receptor alpha	0.240
Gbx2	gastrulation brain homeobox 2	0.238
Zic3	zinc finger protein of the cerebellum 3	0.234
Prrx1	paired related homeobox 1	0.231
Gli2	GLI-Kruppel family member GLI2	0.231
Hoxd13	homeobox D13	0.226
Alx3	aristaless-like homeobox 3	0.222
Dlx5	distal-less homeobox 5	0.220
Ctnnb1	catenin (cadherin associated protein), beta 1	0.219
Chd7	chromodomain helicase DNA binding protein 7	0.215
Lef1	lymphoid enhancer binding factor 1	0.205
Alx4	aristaless-like homeobox 4	0.184
Pax6	paired box gene 6	0.182
Ephb2	Eph receptor B2	0.181
Hoxa13	homeobox A13	0.174
Tal1	T-cell acute lymphocytic leukemia 1	0.165	Mouse
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.159
Sox7	SRY-box containing gene 7	0.157	Mouse
Nos3	nitric oxide synthase 3, endothelial cell	0.147
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.147
Runx2	runt related transcription factor 2	0.141
Zeb1	zinc finger E-box binding homeobox 1	0.139
She	src homology 2 domain-containing transforming protein E	0.135
Smad1	MAD homolog 1 (Drosophila)	0.130	Mouse
Gata5	GATA binding protein 5	0.129	Mouse
Apc	adenomatosis polyposis coli	0.127
Neurog2	neurogenin 2	0.123	Mouse
Tbx2	T-box 2	0.120	Mouse
En1	engrailed 1	0.116
Gsc	goosecoid homeobox	0.114
Mecom	MDS1 and EVI1 complex locus	0.106
Zfpm2	zinc finger protein, multitype 2	0.105	Mouse
Gpr50	G-protein-coupled receptor 50	0.100
Fgf3	fibroblast growth factor 3	0.098
Tbx5	T-box 5	0.096	Zebrafish Mouse
Sall4	sal-like 4 (Drosophila)	0.091
Shox2	short stature homeobox 2	0.089
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.088
Hoxa2	homeobox A2	0.086
Nog	noggin	0.084
Atoh7	atonal homolog 7 (Drosophila)	0.084	Mouse
Tbx1	T-box 1	0.080	Mouse
Tcf15	transcription factor 15	0.079	Mouse
Efnb1	ephrin B1	0.076	Mouse
Trp63	transformation related protein 63	0.072
Hoxd1	homeobox D1	0.068
Axin1	axin 1	0.066
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.063
Vangl2	vang-like 2 (van gogh, Drosophila)	0.062
Uncx	UNC homeobox	0.060
T	brachyury	0.060	Mouse
Col22a1	collagen, type XXII, alpha 1	0.059
Notch3	Notch gene homolog 3 (Drosophila)	0.056
Dock1	dedicator of cytokinesis 1	0.055
Hoxb1	homeobox B1	0.055
Nynrin	NYN domain and retroviral integrase containing	0.055
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.055
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.053
Erbb2ip	Erbb2 interacting protein	0.053
Sox18	SRY-box containing gene 18	0.052	Mouse
Pou5f1	POU domain, class 5, transcription factor 1	0.051
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.051
Pou4f2	POU domain, class 4, transcription factor 2	0.050
Col13a1	collagen, type XIII, alpha 1	0.050
Col2a1	collagen, type II, alpha 1	0.048
Hoxa10	homeobox A10	0.048
Dll1	delta-like 1 (Drosophila)	0.047
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.047
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.045
Klf3	Kruppel-like factor 3 (basic)	0.045
Nodal	nodal	0.044
Irx3	Iroquois related homeobox 3 (Drosophila)	0.043
Bnc1	basonuclin 1	0.043
Alx1	ALX homeobox 1	0.042
Robo3	roundabout homolog 3 (Drosophila)	0.042
Insm1	insulinoma-associated 1	0.041
Vegfa	vascular endothelial growth factor A	0.041
Neurog3	neurogenin 3	0.039	Mouse
En2	engrailed 2	0.039
Pou3f3	POU domain, class 3, transcription factor 3	0.037
Gja4	gap junction protein, alpha 4	0.037
Ebf3	early B-cell factor 3	0.037
Mesp1	mesoderm posterior 1	0.037
Sall3	sal-like 3 (Drosophila)	0.036
Bmp7	bone morphogenetic protein 7	0.036
Lmx1a	LIM homeobox transcription factor 1 alpha	0.036
Tlx3	T-cell leukemia, homeobox 3	0.035
Hesx1	homeobox gene expressed in ES cells	0.035
Foxd2	forkhead box D2	0.035
Fgfr1	fibroblast growth factor receptor 1	0.035
Ptf1a	pancreas specific transcription factor, 1a	0.034	Mouse
Fgfr3	fibroblast growth factor receptor 3	0.034
Hoxc4	homeobox C4	0.034
Smo	smoothened homolog (Drosophila)	0.034
Bdnf	brain derived neurotrophic factor	0.034
Neurod4	neurogenic differentiation 4	0.034	Mouse
Hoxa11	homeobox A11	0.033
Pcdh12	protocadherin 12	0.033
Cbfa2t3	core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)	0.033
Dlx1	distal-less homeobox 1	0.032
Eda	ectodysplasin-A	0.032
Nf1	neurofibromatosis 1	0.031
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.031
Hoxb4	homeobox B4	0.031
Prrx2	paired related homeobox 2	0.030
Onecut1	one cut domain, family member 1	0.030
Wt1	Wilms tumor 1 homolog	0.030
Tal2	T-cell acute lymphocytic leukemia 2	0.030	Mouse
Pax9	paired box gene 9	0.029
Hba-x	hemoglobin X, alpha-like embryonic chain in Hba complex	0.029
Ighmbp2	immunoglobulin mu binding protein 2	0.029
Tbx4	T-box 4	0.029	Mouse
Gata2	GATA binding protein 2	0.028	Zebrafish Mouse
Hoxa4	homeobox A4	0.028
Axin2	axin2	0.027
Gja1	gap junction protein, alpha 1	0.027
Rarb	retinoic acid receptor, beta	0.027
Hmga2	high mobility group AT-hook 2	0.026
Tcfap2c	transcription factor AP-2, gamma	0.025
Aplnr	apelin receptor	0.025
Tbx20	T-box 20	0.025
Wnt6	wingless-related MMTV integration site 6	0.025
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.025
Dlx2	distal-less homeobox 2	0.025
Gdnf	glial cell line derived neurotrophic factor	0.024
Fhl3	four and a half LIM domains 3	0.023
Lrp6	low density lipoprotein receptor-related protein 6	0.023
Btbd17	BTB (POZ) domain containing 17	0.023
Gpc3	glypican 3	0.023
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.023
Efs	embryonal Fyn-associated substrate	0.023
Plac1	placental specific protein 1	0.022
Pax1	paired box gene 1	0.022
Zic1	zinc finger protein of the cerebellum 1	0.022
Lmx1b	LIM homeobox transcription factor 1 beta	0.022
Arap3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.021
Nck2	non-catalytic region of tyrosine kinase adaptor protein 2	0.021
Tead4	TEA domain family member 4	0.021
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.021
Gata3	GATA binding protein 3	0.020	Mouse
Homer3	homer homolog 3 (Drosophila)	0.020
Nkd1	naked cuticle 1 homolog (Drosophila)	0.020
Mn1	meningioma 1	0.020
Hoxb6	homeobox B6	0.020
Sox4	SRY-box containing gene 4	0.020	Mouse
Hes5	hairy and enhancer of split 5 (Drosophila)	0.020
Twist2	twist homolog 2 (Drosophila)	0.020	Mouse
Pbx1	pre B-cell leukemia transcription factor 1	0.019
Lhx5	LIM homeobox protein 5	0.019
Hoxb13	homeobox B13	0.019
Foxh1	forkhead box H1	0.019
Hoxc8	homeobox C8	0.017
Fgf4	fibroblast growth factor 4	0.017
Myl7	myosin, light polypeptide 7, regulatory	0.017
Foxf1a	forkhead box F1a	0.017
Nkx3-2	NK3 homeobox 2	0.017
Acvr1	activin A receptor, type 1	0.017
Hoxd11	homeobox D11	0.017
Dab1	disabled homolog 1 (Drosophila)	0.017
Pou4f3	POU domain, class 4, transcription factor 3	0.017
Sox1	SRY-box containing gene 1	0.017
Foxf2	forkhead box F2	0.016
Nrk	Nik related kinase	0.016
Adcy4	adenylate cyclase 4	0.016
Rnf2	ring finger protein 2	0.016
Cdx2	caudal type homeobox 2	0.016
Hoxd4	homeobox D4	0.016
Tcf21	transcription factor 21	0.016
Kdr	kinase insert domain protein receptor	0.015
Epha4	Eph receptor A4	0.015
Prph2	peripherin 2	0.015
Hhex	hematopoietically expressed homeobox	0.015
Ptch1	patched homolog 1	0.015
Cldn5	claudin 5	0.015
S1pr4	sphingosine-1-phosphate receptor 4	0.015
Irx4	Iroquois related homeobox 4 (Drosophila)	0.015
Foxd1	forkhead box D1	0.014
Hmx3	H6 homeobox 3	0.014
Notch2	Notch gene homolog 2 (Drosophila)	0.014
Etv4	ets variant gene 4 (E1A enhancer binding protein, E1AF)	0.014
Hbb-bh1	hemoglobin Z, beta-like embryonic chain	0.014
a	nonagouti	0.014
Hoxd3	homeobox D3	0.014
Hoxb5	homeobox B5	0.013
Hif1a	hypoxia inducible factor 1, alpha subunit	0.013
Myf5	myogenic factor 5	0.013
Pthlh	parathyroid hormone-like peptide	0.013
Obsl1	obscurin-like 1	0.013
Prox1	prospero-related homeobox 1	0.013
Lrp5	low density lipoprotein receptor-related protein 5	0.013
Cdh5	cadherin 5	0.013
Tie1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.013
Igf2bp1	insulin-like growth factor 2 mRNA binding protein 1	0.013
Lhx6	LIM homeobox protein 6	0.013
Dlk1	delta-like 1 homolog (Drosophila)	0.013
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.012
Kcnk3	potassium channel, subfamily K, member 3	0.012
Hoxc6	homeobox C6	0.012
Sim2	single-minded homolog 2 (Drosophila)	0.012
Wnt11	wingless-related MMTV integration site 11	0.012
Lhx9	LIM homeobox protein 9	0.012
Pdx1	pancreatic and duodenal homeobox 1	0.012
Fgf18	fibroblast growth factor 18	0.012
Krt14	keratin 14	0.012
Rgnef	Rho-guanine nucleotide exchange factor	0.012
Lhx3	LIM homeobox protein 3	0.011
Hbb-y	hemoglobin Y, beta-like embryonic chain	0.011
Has2	hyaluronan synthase 2	0.011
Evx1	even skipped homeotic gene 1 homolog	0.011
Hoxd12	homeobox D12	0.011
Fbn2	fibrillin 2	0.011
Gdf11	growth differentiation factor 11	0.011
Atoh8	atonal homolog 8 (Drosophila)	0.011
Igf2bp2	insulin-like growth factor 2 mRNA binding protein 2	0.011
Emx1	empty spiracles homolog 1 (Drosophila)	0.011
Epha5	Eph receptor A5	0.011
Hoxa3	homeobox A3	0.010
Foxa2	forkhead box A2	0.010
Six5	sine oculis-related homeobox 5 homolog (Drosophila)	0.010
Hoxb2	homeobox B2	0.010
Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.010
Gja5	gap junction protein, alpha 5	0.010
Tgif2	TGFB-induced factor homeobox 2	0.010
Nhlh1	nescient helix loop helix 1	0.010	Mouse
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.010
Sox17	SRY-box containing gene 17	0.010	Mouse
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.010
Cd160	CD160 antigen	0.010