IMP

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Danio rerio

2 genes annotated in zebrafish

Multi-species View

negative regulation of heart contraction

GO:0045822

Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of heart contraction"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of heart contraction" (in gray)

Name	Description	Probability	Func Analog Organism
atp1a1a.2	ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide	0.974	Mouse
atp1b1b	ATPase, Na+/K+ transporting, beta 1b polypeptide	0.745
cmyb	transcription factor cmyb	0.622
pvalb8	parvalbumin 8	0.597
tbx20	T-box 20	0.579
kita	kit receptor a	0.523
myl7	myosin, light polypeptide 7, regulatory	0.515
atp1b1a	ATPase, Na+/K+ transporting, beta 1a polypeptide	0.436
tie1	endothelium-specific receptor tyrosine kinase 1	0.378
atp1a1	ATPase, Na+/K+ transporting, alpha 1 polypeptide	0.367	Mouse
tnnt2a	troponin T2a, cardiac	0.366
sparc	secreted acidic cysteine rich glycoprotein	0.365
cmlc1	cardiac myosin light chain-1	0.348
cldnh	claudin h	0.329
tbx1	T-box 1	0.283
gpr126	G protein-coupled receptor 126	0.261
anxa11a	annexin A11a	0.216
atp1a1a.3	ATPase, Na+/K+ transporting, alpha 1a.3 polypeptide	0.205	Mouse
atp1a2a	ATPase, Na+/K+ transporting, alpha 2a polypeptide	0.181	Mouse
agr2	anterior gradient homolog 2 (Xenopus laevis)	0.180
atp2a2a	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2a	0.144	Mouse
ins	preproinsulin	0.144
myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	0.129
tbx5b	T-box 5b	0.129
foxi3a	forkhead box I3a	0.127
vmhc	ventricular myosin heavy chain	0.127
slc12a3	solute carrier family 12 (sodium/chloride transporters), member 3	0.115
anxa11b	annexin A11b	0.108
igfbp3	insulin-like growth factor binding protein 3	0.100
actn2	actinin, alpha 2	0.098
cdh17	cadherin 17, LI cadherin (liver-intestine)	0.097
atp1a1a.4	ATPase, Na+/K+ transporting, alpha 1a.4 polypeptide	0.089	Mouse
kdrl	kinase insert domain receptor like	0.083
gata1a	GATA binding protein 1a	0.082
trpm7	transient receptor potential cation channel, subfamily M, member 7	0.080
snd1	staphylococcal nuclease domain containing 1	0.073
notch1b	notch homolog 1b	0.069
mef2ca	myocyte enhancer factor 2ca	0.068
tnnc1a	troponin C type 1a (slow)	0.067
tpm4	tropomyosin 4	0.062
s1pr2	sphingosine-1-phosphate receptor 2	0.061
dusp5	dual specificity phosphatase 5	0.059
atp6v1al	ATPase, H+ transporting, lysosomal V1 subunit A, like	0.058
edn1	endothelin 1	0.058
synpo2lb	synaptopodin 2-like b	0.058
flot1b	flotillin 1b	0.055
sox7	SRY-box containing gene 7	0.050
hpca	hippocalcin	0.049
spock3	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3	0.048
cdh5	cadherin 5	0.048
nkx2.5	NK2 transcription factor related 5	0.048
aqp8a.1	aquaporin 8a, tandem duplicate 1	0.045
hbbe1.1	hemoglobin beta embryonic-1.1	0.044
gata5	GATA-binding protein 5	0.043
has3	hyaluronan synthase 3	0.041
eml2	echinoderm microtubule associated protein like 2	0.041
calm1b	calmodulin 1b	0.041
mybpc3	myosin binding protein C, cardiac	0.041
six2a	sine oculis-related homeobox 2a	0.041
lama4	laminin, alpha 4	0.040
zgc:55418	zgc:55418	0.040
cbfb	core-binding factor, beta subunit	0.039
xirp1	xin actin-binding repeat containing 1	0.038
plcg1	phospholipase C, gamma 1	0.038
si:dkeyp-104h9.6	si:dkeyp-104h9.6	0.038
tbx5a	T-box 5a	0.038
slc12a2	solute carrier family 12 (potassium/chloride transporters), member 2	0.037
etf1	eukaryotic translation termination factor 1	0.037
nppa	natriuretic peptide precursor A	0.037
tbx18	T-box 18	0.036
pcdh10a	protocadherin 10a	0.035
hspb7	heat shock protein family, alpha-crystallin-related, b7	0.035
oep	one-eyed pinhead	0.035
mdh1a	malate dehydrogenase 1a, NAD (soluble)	0.035
krt15	keratin 15	0.035
si:ch73-60e21.1	si:ch73-60e21.1	0.034
bcl2l1	bcl2-like 1	0.034
atp1a3b	ATPase, Na+/K+ transporting, alpha 3b polypeptide	0.033
anxa2b	annexin A2b	0.033
arg2	arginase, type II	0.033
tmem88a	transmembrane protein 88 a	0.033
rgs4	regulator of G-protein signalling 4	0.032
smyhc1	slow myosin heavy chain 1	0.032
podxl	podocalyxin-like	0.032
LOC100000433	hypothetical LOC100000433	0.032
mpp2b	membrane protein, palmitoylated 2b (MAGUK p55 subfamily member 2b)	0.031
ppargc1al	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha like	0.031
gpia	glucose phosphate isomerase a	0.030
dlx4a	distal-less homeobox gene 4a	0.030
hey2	hairy/enhancer-of-split related with YRPW motif 2	0.029
wnt2bb	wingless-type MMTV integration site family, member 2Bb	0.029
zgc:56376	zgc:56376	0.029
mpx	myeloid-specific peroxidase	0.029
ogdh	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	0.028
ugdh	UDP-glucose dehydrogenase	0.027
mef2a	myocyte enhancer factor 2a	0.027
rbp4	retinol binding protein 4, plasma	0.027
cav1	caveolin 1	0.027
eef2l2	eukaryotic translation elongation factor 2, like 2	0.027
mib	mind bomb	0.027
rbm24a	RNA binding motif protein 24a	0.027
atp6ap2	ATPase, H+ transporting, lysosomal accessory protein 2	0.026
fhl2a	four and a half LIM domains 2a	0.026
mknk2b	MAP kinase-interacting serine/threonine kinase 2b	0.026
ache	acetylcholinesterase	0.026
zgc:194131	zgc:194131	0.025
ca2	carbonic anhydrase II	0.025
mef2d	myocyte enhancer factor 2d	0.025
si:ch211-15d5.5	si:ch211-15d5.5	0.025
erg	v-ets erythroblastosis virus E26 oncogene like (avian)	0.025
ltbp3	latent transforming growth factor beta binding protein 3	0.025
pax9	paired box gene 9	0.025
fgf10a	fibroblast growth factor 10a	0.025
hadha	hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase, alpha subunit	0.024
ucp2	uncoupling protein 2	0.024
cpne1	copine I	0.024
calb2b	calbindin 2b, (calretinin)	0.023
uap1l1	UDP-N-acteylglucosamine pyrophosphorylase 1, like 1	0.023
rap1b	RAS related protein 1b	0.023
ndufv1	NADH dehydrogenase (ubiquinone) flavoprotein 1	0.023
aldh1a2	aldehyde dehydrogenase 1 family, member A2	0.023
ehd1	EH-domain containing 1	0.023
ptch1	patched 1	0.022
atoh8	atonal homolog 8	0.022
atp6v1c1b	ATPase, H+ transporting, lysosomal, V1 subunit C, isoform 1b	0.022
si:ch211-184m19.1	si:ch211-184m19.1	0.022
ppargc1b	peroxisome proliferative activated receptor, gamma, coactivator 1, beta	0.022
hk1	hexokinase 1	0.022
yrk	Yes-related kinase	0.022
fhla	four and a half LIM domains a	0.022
si:dkeyp-51c11.1	si:dkeyp-51c11.1	0.022
anxa13	annexin A13	0.022
timp2a	tissue inhibitor of metalloproteinase 2a	0.021
fabp2	fatty acid binding protein 2, intestinal	0.021
epas1b	endothelial PAS domain protein 1b	0.021
plekha7	pleckstrin homology domain containing, family A member 7	0.021
foxi3b	forkhead box I3b	0.021
lrrc6	leucine rich repeat containing 6	0.020
hdlbp	high density lipoprotein-binding protein (vigilin)	0.020
cyp3a65	cytochrome P450, family 3, subfamily A, polypeptide 65	0.020
cabp1	calcium binding protein 1	0.020
esama	endothelial cell adhesion molecule a	0.020
ttna	titin a	0.020
kcnj1	potassium inwardly-rectifying channel, subfamily J, member 1	0.020
si:dkey-222f8.3	si:dkey-222f8.3	0.020
desma	desmin a	0.019
acta2	actin, alpha 2, smooth muscle, aorta	0.019
appb	amyloid beta (A4) precursor protein b	0.019
cry1a	cryptochrome 1a	0.019
LOC553527	hypothetical protein LOC553527	0.019
mbp	myelin basic protein	0.019
cyp1a	cytochrome P450, family 1, subfamily A	0.019
hsp90b1	heat shock protein 90, beta (grp94), member 1	0.019
laptm4a	lysosomal-associated protein transmembrane 4 alpha	0.019
tpi1b	triosephosphate isomerase 1b	0.019
pvalb7	parvalbumin 7	0.018
mef2cb	myocyte enhancer factor 2cb	0.018
sgk1	serum/glucocorticoid regulated kinase 1	0.018
me2	malic enzyme 2, NAD(+)-dependent, mitochondrial	0.018
pck1	phosphoenolpyruvate carboxykinase 1 (soluble)	0.018
etv2	ets variant gene 2	0.018
fev	FEV (ETS oncogene family)	0.018
mpp5a	membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a)	0.018
fbp1b	fructose-1,6-bisphosphatase 1b	0.018
gfi1.1	growth factor independent 1.1	0.018
tagln2	transgelin 2	0.017
adcyap1b	adenylate cyclase activating polypeptide 1b	0.017
esrrd	estrogen-related receptor delta	0.017
smyd1b	SET and MYND domain containing 1b	0.017
eif3jb	eukaryotic translation initiation factor 3, subunit Jb	0.017
tgfb3	transforming growth factor, beta 3	0.017
lcp1	lymphocyte cytosolic plastin 1	0.017
ldb3a	LIM-domain binding factor 3a	0.017
slc15a2	solute carrier family 15 (H+/peptide transporter), member 2	0.017
wu:fq26c12	wu:fq26c12	0.017
bcdo2l	beta-carotene 15, 15-dioxygenase 2, like	0.017
si:ch1073-463l14.2	si:ch1073-463l14.2	0.017
id2b	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, b	0.016
dmrt2a	doublesex and mab-3 related transcription factor 2a	0.016
dnaja	DnaJ (Hsp40) homolog, subfamily A member	0.016
foxo3b	forkhead box O3b	0.016
lama1	laminin, alpha 1	0.016
tal1	T-cell acute lymphocytic leukemia 1	0.016
dub	duboraya	0.016
wu:fj39b01	wu:fj39b01	0.016
zgc:152873	zgc:152873	0.016
ilk	integrin linked kinase	0.016
avpl	arginine vasopressin-like	0.015
dusp2	dual specificity phosphatase 2	0.015
mpz	myelin protein zero	0.015
cntn1a	contactin 1a	0.015
gadd45aa	growth arrest and DNA-damage-inducible, alpha, a	0.015
rhcgb	Rhesus blood group, C glycoprotein b	0.015
got2b	glutamic-oxaloacetic transaminase 2b, mitochondrial (aspartate aminotransferase 2)	0.015
pck2	phosphoenolpyruvate carboxykinase 2 (mitochondrial)	0.015
gapdh	glyceraldehyde-3-phosphate dehydrogenase	0.015
hapln3	hyaluronan and proteoglycan link protein 3	0.015
matn1	matrilin 1	0.015
lrpprc	leucine-rich PPR-motif containing	0.015
sec61al2	Sec61 alpha like 2	0.015
wu:fb15e04	wu:fb15e04	0.015
aldocb	aldolase C, fructose-bisphosphate, b	0.015
ndrg1	N-myc downstream regulated gene 1	0.015
ndufa4	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4	0.015
dap	death associated protein	0.015
cldn1	claudin 1	0.014
ptk2.2	protein tyrosine kinase 2b	0.014
dixdc1a	DIX domain containing 1a	0.014
mical3	flavoprotein oxidoreductase MICAL3	0.014
hand2	heart and neural crest derivatives expressed transcript 2	0.014
tnni1b	troponin I, skeletal, slow b	0.014
ldha	lactate dehydrogenase A4	0.014
casz1	castor zinc finger 1	0.014
eno1	enolase 1, (alpha)	0.014
ecrg4a	esophageal cancer related gene 4a	0.014
epas1a	endothelial PAS domain protein 1a	0.014
sox4b	SRY-box containing gene 4b	0.014
im:6903943	im:6903943	0.014
jag1b	jagged 1b	0.014
gcga	glucagon a and glucagon a-like	0.014
loxl2b	lysyl oxidase-like 2b	0.014
ahcyl1	S-adenosylhomocysteine hydrolase-like 1	0.014
crip2	cysteine-rich protein 2	0.014
ucp3	uncoupling protein 3	0.014
itgb3b	integrin beta 3b	0.014
snx1	sorting nexin 1	0.013
hm13	histocompatibility (minor) 13	0.013
cldnc	claudin c	0.013
hbbe3	hemoglobin beta embryonic-3	0.013
cyp3c1	cytochrome P450, family 3, subfamily c, polypeptide 1	0.013
slc16a1	solute carrier family 16 (monocarboxylic acid transporters), member 1	0.013
ccdc80	coiled-coil domain containing 80	0.013
copb1	coatomer protein complex, subunit beta 1	0.013
clic1	chloride intracellular channel 1	0.013
slc8a1a	solute carrier family 8 (sodium/calcium exchanger), member 1a	0.013
syt4	synaptotagmin IV	0.013
ca8	carbonic anhydrase VIII	0.013
rab11al	RAB11a, member RAS oncogene family, like	0.013
ndufb4	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4	0.013
mapk12	mitogen-activated protein kinase 12	0.013
ftcd	formiminotransferase cyclodeaminase	0.013
zgc:85746	zgc:85746	0.013
zgc:63734	zgc:63734	0.013
lyz	lysozyme	0.013
krml2.2	Kreisler (mouse) maf-related leucine zipper homolog 2.2	0.012
ndrg4	N-myc downstream regulated gene 4	0.012
tdh	L-threonine dehydrogenase	0.012
apoea	apolipoprotein Ea	0.012
ivd	isovaleryl Coenzyme A dehydrogenase	0.012
gclc	glutamate-cysteine ligase, catalytic subunit	0.012
zgc:110586	zgc:110586	0.012
cyp4t8	cytochrome P450, family 4, subfamily T, polypeptide 8	0.012
sst2	somatostatin 2	0.012
rpn1	ribophorin I	0.012
maf	v-maf musculoaponeurotic fibrosarcoma (avian) oncogene homolog	0.012
arap3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.012
aldh6a1	aldehyde dehydrogenase 6 family, member A1	0.012
mxra8a	matrix-remodelling associated 8a	0.012
mmp13a	matrix metalloproteinase 13a	0.012
pabpc1b	poly A binding protein, cytoplasmic 1 b	0.012
pgd	phosphogluconate hydrogenase	0.012
pdcd6	programmed cell death 6	0.012
gapdhs	glyceraldehyde-3-phosphate dehydrogenase, spermatogenic	0.012
hbae1	hemoglobin alpha embryonic-1	0.011
mafl	v-maf musculoaponeurotic fibrosarcoma (avian) oncogene family, protein L	0.011
col12a1	collagen, type XII, alpha 1	0.011
atp6v1f	ATPase, H+ transporting, V1 subunit F	0.011
runx3	runt-related transcription factor 3	0.011
si:dkeyp-113d7.4	si:dkeyp-113d7.4	0.011
aco2	aconitase 2, mitochondrial	0.011
pax7b	paired box gene 7b	0.011
stmn1b	stathmin 1b	0.011
tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.011
mat2a	methionine adenosyltransferase II, alpha	0.011
c10orf11	c10orf11 homolog (H. sapiens)	0.011
zgc:92533	zgc:92533	0.011
cx39.9	connexin 39.9	0.011
adipor2	adiponectin receptor 2	0.011
sepw1	selenoprotein W, 1	0.011
prkcea	protein kinase C, epsilon a	0.011
zgc:77123	zgc:77123	0.011
mrc1a	mannose receptor, C type 1a	0.011
clptm1	cleft lip and palate associated transmembrane protein 1	0.011
apobec2a	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2a	0.011
atp1b2b	ATPase, Na+/K+ transporting, beta 2b polypeptide	0.011
gata6	GATA-binding protein 6	0.011
tpst1	tyrosylprotein sulfotransferase 1	0.011
spi1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.011
plp1b	proteolipid protein 1b	0.011
zgc:63938	zgc:63938	0.011
plxnd1	plexin D1	0.011
fli1a	friend leukemia integration 1a	0.011
abca5	ATP-binding cassette, sub-family A (ABC1), member 5	0.011
hig1	hypoxia induced gene 1	0.011
wnt2ba	wingless-type MMTV integration site family, member 2Ba	0.011
eya4	eyes absent homolog 4 (Drosophila)	0.011
jun	jun proto-oncogene	0.010
frem1a	Fras1 related extracellular matrix 1a	0.010
st6galnac	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase	0.010
igfbp5a	insulin-like growth factor binding protein 5a	0.010
bscv	bscv (C20orf3) homolog	0.010
slc31a1	solute carrier family 31 (copper transporters), member 1	0.010
cldna	claudin a	0.010
syt11a	synaptotagmin XIa	0.010
slc22a7b	solute carrier family 22 (organic anion transporter), member 7b	0.010
sepp1b	selenoprotein P, plasma, 1b	0.010
zgc:101724	zgc:101724	0.010
mt2	metallothionein 2	0.010
hspa9	heat shock protein 9	0.010
slc11a2	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	0.010
dct	dopachrome tautomerase	0.010