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Danio rerio

3 genes annotated in zebrafish

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

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Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "complement activation" (in gray)

Name	Description	Probability	Func Analog Organism
c3b	complement component c3b	0.721
zgc:103710	zgc:103710	0.621
zgc:92533	zgc:92533	0.361
adipoql	adiponectin, C1Q and collagen domain containing, like	0.261	Zebrafish
proc	protein C (inactivator of coagulation factors Va and VIIIa)	0.260
krt8	keratin 8	0.244
cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.229
nr1h5	nuclear receptor subfamily 1, group H, member 5	0.197
rhag	Rhesus blood group-associated glycoprotein	0.172
vwf	von Willebrand factor	0.140
zgc:92061	zgc:92061	0.139
adipor2	adiponectin receptor 2	0.135
c1qb	complement component 1, q subcomponent, B chain	0.118
calcr	calcitonin receptor	0.112
cps1	carbamoyl-phosphate synthase 1, mitochondrial	0.098
grn1	granulin 1	0.093
slc34a2a	solute carrier family 34 (sodium phosphate), member 2a	0.093
rnasel1	ribonuclease like 1	0.084
klf2b	Kruppel-like factor 2b	0.083
sdprb	serum deprivation response b	0.079
lipc	lipase, hepatic	0.075
ela2	elastase 2	0.074
s1pr3	sphingosine-1-phosphate receptor 3	0.072
LOC100330224	fatty acid binding protein 1b-like	0.071
LOC566708	FL cytokine receptor-like	0.069
pcsk9	proprotein convertase subtilisin/kexin type 9	0.067
LOC100149056	pannexin-3-like	0.065
zgc:113516	zgc:113516	0.061
otc	ornithine carbamoyltransferase	0.060
shbg	sex hormone binding globulin	0.060
LOC560602	novel protein similar to vertebrate solute carrier family 2 (facilitated glucose transporter), member 6 (SLC2A6)	0.058
zgc:194131	zgc:194131	0.053
rdh1	retinol dehydrogenase 1	0.051
ahsg	alpha-2-HS-glycoprotein	0.051
crfb7	cytokine receptor family member b7	0.050
wu:fi14a03	wu:fi14a03	0.049
pcsk7	proprotein convertase subtilisin/kexin type 7	0.048
cd209	CD209 molecule	0.047
cecr1b	cat eye syndrome chromosome region, candidate 1b	0.046
c1qa	complement component 1, q subcomponent, A chain	0.045
f7	coagulation factor VII	0.045
adipoql2	adiponectin, C1Q and collagen domain containing, like 2	0.044	Zebrafish
LOC100003330	melanocortin-2 receptor accessory protein 2-like	0.044
adrb2b	adrenergic receptor, beta 2b	0.042
agxta	alanine-glyoxylate aminotransferase a	0.042
slc2a13	solute carrier family 2 (facilitated glucose transporter), member 13	0.039
polr3gla	polymerase (RNA) III (DNA directed) polypeptide G like a	0.037
slc4a4b	solute carrier family 4, sodium bicarbonate cotransporter, member 4b	0.037
cfhl2	complement factor H like 2	0.036	Mouse
cd40	CD40 antigen	0.036
LOC100003535	prostaglandin E2 receptor subtype EP1-like protein	0.036
slc12a10.2	solute carrier family 12 (sodium/potassium/chloride transporters), member 10.2	0.036
c1qc	complement component 1, q subcomponent, C chain	0.036
pglyrp5	peptidoglycan recognition protein 5	0.035
ighm	immunoglobulin heavy constant mu and immunoglobulin heavy constant mu	0.035
cfhl3	complement factor H like 3	0.035
gmfg	glia maturation factor, gamma	0.035
sfrp1b	secreted frizzled-related protein 1b	0.035
rhcgl1	Rhesus blood group, C glycoprotein, like 1	0.034
igfbp6a	insulin-like growth factor binding protein 6a	0.034
ass1	argininosuccinate synthetase 1	0.034
si:dkey-76b14.4	si:dkey-76b14.4	0.033
cldni	claudin i	0.032
ptger4b	prostaglandin E receptor 4 (subtype EP4) b	0.031
LOC100151049	lysosomal-associated protein transmembrane 5	0.031
cfb	complement factor B	0.030
grna	granulin a	0.030
pcsk1	proprotein convertase subtilisin/kexin type 1	0.029
aqp12	aquaporin 12	0.029
foxi3a	forkhead box I3a	0.029
ftcd	formiminotransferase cyclodeaminase	0.028
ppl	periplakin	0.028
zgc:153921	zgc:153921	0.028
si:dkey-223d9.2	si:dkey-223d9.2	0.027
dspa	desmoplakin a	0.027
foxp3a	forkhead box P3a	0.027
LOC100005232	Gig2-like protein DreD	0.027
ppp4cb	protein phosphatase 4 (formerly X), catalytic subunit b	0.027
cx32.3	connexin 32.3	0.026
cd40lg	CD40 ligand	0.026
cfdl	complement factor D (adipsin) like	0.026
upp2	uridine phosphorylase 2	0.025
masp2	mannan-binding lectin serine peptidase 2	0.025	Mouse
slc12a10.1	solute carrier family 12 (sodium/potassium/chloride transporters), member 10.1	0.025
wnt8a	wingless-type MMTV integration site family, member 8a	0.025
zgc:112992	zgc:112992	0.024
stat1b	signal transducer and activator of transcription 1b	0.024
pkz	protein kinase containing Z-DNA binding domains	0.024
sb:eu1555	sb:eu1555	0.024
zgc:92406	zgc:92406	0.024
ugt5c3	UDP glucuronosyltransferase 5 family, polypeptide C3	0.024
pkp1	plakophilin 1	0.024
adipor1a	adiponectin receptor 1a	0.023
f5	coagulation factor V	0.023
notum3	notum 3	0.023
krt4	keratin 4	0.023
pmp22b	peripheral myelin protein 22b	0.023
ca15a	carbonic anhydrase XV a	0.022
itln3	intelectin 3	0.022
ptger2b	prostaglandin E receptor 2b (subtype EP2)	0.022
si:dkeyp-22b2.3	si:dkeyp-22b2.3	0.022
slc2a1b	solute carrier family 2 (facilitated glucose transporter), member 1b	0.022
upb1	ureidopropionase, beta	0.022
mep1a.2	meprin A, alpha.2	0.022
si:ch211-140f21.1	si:ch211-140f21.1	0.021
col6a2	collagen, type VI, alpha 2	0.021
zgc:161979	zgc:161979	0.021
anxa1c	annexin A1c	0.021
LOC100000934	hypothetical protein LOC100000934	0.021
LOC100005283	Gig2-like protein DreE	0.021
adal	adenosine deaminase-like	0.020
mep1b	meprin A, beta	0.020
si:dkeyp-55c8.3	si:dkeyp-55c8.3	0.020
elovl2	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2	0.020
pcsk5b	proprotein convertase subtilisin/kexin type 5b	0.020
dsg2	desmoglein 2	0.020
zgc:153941	zgc:153941	0.020
LOC567441	interferon-induced protein with tetratricopeptide repeats 5-like	0.020
wu:fb80a07	wu:fb80a07	0.020
aqp9b	aquaporin 9b	0.020
LOC794786	interferon-induced protein with tetratricopeptide repeats 1-like	0.019
npy7r	neuropeptide Y receptor Y7	0.019
pglyrp6	peptidoglycan recognition protein 6	0.019
slc8a4a	solute carrier family 8 (sodium/calcium exchanger), member 4a	0.019
ticam1	toll-like receptor adaptor molecule 1	0.019
si:dkeyp-50f5.1	si:dkeyp-50f5.1	0.019
casrl	calcium-sensing receptor, like	0.019
si:ch211-223p9.1	si:ch211-223p9.1	0.019
cxc46	CXC chemokine 46	0.019
kctd15a	potassium channel tetramerisation domain containing 15a	0.019
bfb	complement component bfb	0.019
cxcr3.2	chemokine (C-X-C motif) receptor 3.2	0.019
anxa1a	annexin A1a	0.019
cfhl1	complement factor H like 1	0.018	Mouse
psmb9a	proteasome (prosome, macropain) subunit, beta type, 9a	0.018
foxi3b	forkhead box I3b	0.018
b2m	beta-2-microglobulin	0.018
mstna	myostatin a	0.018
eif2ak2	eukaryotic translation initiation factor 2-alpha kinase 2	0.018
tiparp	TCDD-inducible poly(ADP-ribose) polymerase	0.018
ugt2a1	UDP glucuronosyltransferase 2 family, polypeptide A1	0.018
sult1st3	sulfotransferase family 1, cytosolic sulfotransferase 3	0.018
LOC555482	tachykinin receptor 3-like	0.018
nitr5	novel immune-type receptor 5 and immune-type receptor 5-like	0.018
slc5a8l	solute carrier family 5 (iodide transporter), member 8-like	0.018
tacc2	transforming, acidic coiled-coil containing protein 2	0.017
LOC795096	hypothetical protein LOC795096	0.017
scn2b	sodium channel, voltage-gated, type II, beta	0.017
apob	apolipoprotein B	0.017
krt18	keratin 18	0.017
illr3	immune-related, lectin-like receptor 3	0.017
zgc:64051	zgc:64051	0.017
slc25a14	solute carrier family 25 (mitochondrial carrier, brain), member 14	0.017
slc16a1	solute carrier family 16 (monocarboxylic acid transporters), member 1	0.017
crfb13	cytokine receptor family member b13	0.017
itgb1a	integrin, beta 1a	0.017
LOC793458	peptide Y-like	0.017
dsc2l	desmocollin 2 like	0.016
zgc:123282	zgc:123282	0.016
slc9a3.2	solute carrier family 9 (sodium/hydrogen exchanger), member 3.2	0.016
slco3a1	solute carrier organic anion transporter family, member 3A1	0.016
LOC569142	ectonucleoside triphosphate diphosphohydrolase 2-like	0.016
s1pr5a	sphingosine-1-phosphate receptor 5a	0.016
defbl3	defensin, beta-like 3	0.016
pcsk2	proprotein convertase subtilisin/kexin type 2	0.016
ugt5f1	UDP glucuronosyltransferase 5 family, polypeptide F1	0.016
adrb1	adrenergic receptor, beta 1	0.015
jun	jun proto-oncogene	0.015
mbtps1	membrane-bound transcription factor protease, site 1	0.015
slco2b1	solute carrier organic anion transporter family, member 2B1	0.015
entpd2a.1	ectonucleoside triphosphate diphosphohydrolase 2 a.1	0.015
klf2a	Kruppel-like factor 2a	0.015
il17a/f2	interleukin 17a/f2	0.015
zgc:152778	zgc:152778	0.015
tlr9	toll-like receptor 9	0.015
cd74	CD74 molecule, major histocompatibility complex, class II invariant chain	0.015
arg2	arginase, type II	0.015
aqp3b	aquaporin 3b	0.015
gnrhr4	gonadotropin releasing hormone receptor 4	0.015
ucp3	uncoupling protein 3	0.015
ugt5b1	UDP glucuronosyltransferase 5 family, polypeptide B1	0.015
zgc:136614	zgc:136614	0.015
ldlr	low density lipoprotein receptor	0.015
ifit2	interferon-induced protein with tetratricopeptide repeats 2	0.014
rfc2	replication factor C (activator 1) 2	0.014
ada	adenosine deaminase	0.014
jak2a	Janus kinase 2a	0.014
ugt5c2	UDP glucuronosyltransferase 5 family, polypeptide C2	0.014
col7a1l	collagen type VII alpha 1-like	0.014
tufm	Tu translation elongation factor, mitochondrial	0.014
tnfrsf18	tumor necrosis factor receptor superfamily, member 18	0.014
nos2a	nitric oxide synthase 2a, inducible	0.014
abcg2b	ATP-binding cassette, sub-family G (WHITE), member 2b	0.014
pygl	phosphorylase, glycogen; liver (Hers disease, glycogen storage disease type VI)	0.014
sat1a	spermidine/spermine N1-acetyltransferase 1a	0.014
itk	IL2-inducible T-cell kinase	0.014
ugt2b6	UDP glucuronosyltransferase 2 family, polypeptide B6	0.014
rasl11b	RAS-like, family 11, member B	0.014
asl	argininosuccinate lyase	0.013
zgc:92880	zgc:92880	0.013
fah	fumarylacetoacetate hydrolase (fumarylacetoacetase)	0.013
ugt1b7	UDP glucuronosyltransferase 1 family, polypeptide B7	0.013
aqp1a.2	aquaporin 1a, tandem duplicate 2	0.013
neu3.5	Neu3.5	0.013
tbx21	T-box 21	0.013
srd5a2a	steroid-5-alpha-reductase, alpha polypeptide 2a	0.013
ptprc	protein tyrosine phosphatase, receptor type, C	0.013
si:ch211-69i14.7	si:ch211-69i14.7	0.013
LOC100333520	hypothetical protein LOC100333520	0.013
ugt5g1	UDP glucuronosyltransferase 5 family, polypeptide G1	0.013
si:ch211-287j19.6	si:ch211-287j19.6	0.013
tlr2	toll-like receptor 2	0.013
mhc2dcb	major histocompatibility complex class II DCB gene	0.013
creb3l3	cAMP responsive element binding protein 3-like 3	0.013
si:dkey-21e7.2	si:dkey-21e7.2	0.013
illr1	immune-related, lectin-like receptor 1	0.013
zgc:174888	zgc:174888	0.013
vdrb	vitamin D receptor b	0.013
il22	interleukin 22	0.013
LOC794635	complement C4-like	0.013
sipa1l1	signal-induced proliferation-associated 1 like 1	0.013
ftsj	FtsJ homolog 3 (E. coli)	0.013
LOC100359374	BCL-WAV	0.013
nitr13	novel immune-type receptor 13	0.013
si:dkey-236e20.6	si:dkey-236e20.6	0.013
atp6v1a	ATPase, H+ transporting, lysosomal V1 subunit A	0.013
phf20b	PHD finger protein 20, b	0.013
polr2d	polymerase (RNA) II (DNA directed) polypeptide D	0.012
ugt5a2	UDP glucuronosyltransferase 5 family, polypeptide A2	0.012
ugt2b1	UDP glucuronosyltransferase 2 family, polypeptide B1	0.012
fabp10b	fatty acid binding protein 10b, liver basic	0.012
pygma	phosphorylase, glycogen (muscle) A	0.012
plaua	plasminogen activator, urokinase a	0.012
lta	lymphotoxin alpha (TNF superfamily, member 1)	0.012
tas1r3	taste receptor, type 1, member 3	0.012
camsap1l1	calmodulin regulated spectrin-associated protein 1-like 1	0.012
LOC560057	prostaglandin E receptor 4, subtype EP4-like	0.012
slco5a1	solute carrier organic anion transporter family, member 5A1	0.012
ptger1b	prostaglandin E receptor 1, subtype EP1b	0.012
zgc:100919	zgc:100919	0.012
gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	0.012
si:dkey-27i16.2	si:dkey-27i16.2	0.012
col1a1b	collagen, type I, alpha 1b	0.012
pglyrp2	peptidoglycan recognition protein 2	0.012
cfh	complement factor H	0.012
gtpbp3	GTP binding protein 3	0.012
hes2.2	hairy and enhancer of split 2.2	0.012
tnfa	tumor necrosis factor a (TNF superfamily, member 2)	0.012
accn2a	amiloride-sensitive cation channel 2 a	0.012
LOC100331195	putative interleukin-17 receptor E-like	0.012
cd247l	CD247 antigen like	0.012
s100a10b	S100 calcium binding protein A10b	0.012
sb:cb592	sb:cb592	0.012
cp	ceruloplasmin	0.012
s100b	S100 calcium binding protein, beta (neural)	0.012
si:ch211-222f23.6	si:ch211-222f23.6	0.012
si:dkey-14k9.3	si:dkey-14k9.3	0.012
gys2	glycogen synthase 2	0.012
cyp4t8	cytochrome P450, family 4, subfamily T, polypeptide 8	0.012
cx52.9	connexin 52.9	0.011
nitr9	novel immune-type receptor 9	0.011
zgc:123207	zgc:123207	0.011
slc15a4	solute carrier family 15, member 4	0.011
zgc:92467	zgc:92467	0.011
slc4a11	solute carrier family 4, sodium borate transporter, member 11	0.011
tlr1	toll-like receptor 1	0.011
ercc4	excision repair cross-complementing rodent repair deficiency, complementation group 4	0.011
ccr7	chemokine (C-C motif) receptor 7	0.011
zgc:103580	zgc:103580	0.011
cyp2aa1	cytochrome P450, family 2, subfamily AA, polypeptide 1	0.011
abp1	amiloride binding protein 1 (amine oxidase (copper-containing))	0.011
nme3	non-metastatic cells 3, protein expressed in	0.011
slc6a19b	solute carrier family 6 (neurotransmitter transporter), member 19b	0.011
zap70	zeta-chain (TCR) associated protein kinase	0.011
c3c	complement component c3c	0.011	Human
zgc:110377	zgc:110377	0.011
xpa	xeroderma pigmentosum, complementation group A	0.011
opn1mw3	opsin 1 (cone pigments), medium-wave-sensitive, 3	0.011
inppl1a	inositol polyphosphate phosphatase-like 1a	0.011
slc2a9l1	solute carrier family 2 (facilitated glucose transporter), member 9-like 1	0.011
itgb1b.1	integrin, beta 1b.1	0.011
nitr8	novel immune-type receptor 8	0.011
mhc1uba	major histocompatibility complex class I UBA gene	0.011
tnfb	tumor necrosis factor b (TNF superfamily, member 2)	0.011
mkrn2	makorin, ring finger protein, 2	0.011
cd4-4	cd4-4 protein	0.011
LOC100005504	Gig2-like protein DreL	0.011
efna1a	ephrin A1a	0.011
f13a1	coagulation factor XIII, A1 polypeptide	0.011
zgc:113383	zgc:113383	0.011
zgc:195195	zgc:195195	0.011
rbp7b	retinol binding protein 7b, cellular	0.011
zgc:101810	zgc:101810	0.011
si:dkeyp-113d7.7	si:dkeyp-113d7.7	0.011
slc8a2a	solute carrier family 8 (sodium-calcium exchanger), member 2a	0.011
cacna1ba	calcium channel, voltage-dependent, N type, alpha 1B subunit, a	0.010
atp7b	ATPase, Cu++ transporting, beta polypeptide (Wilson disease)	0.010
tas2r200.1	taste receptor, type 2, member 200.1	0.010
rbp2b	retinol binding protein 2b, cellular	0.010
LOC559147	novel protein similar to vertebrate hairy and enhancer of split 2 (Drosophila) (HES2)	0.010
si:dkey-13i19.7	si:dkey-13i19.7	0.010
LOC100536988	Gig2-like protein DreQ	0.010
zgc:103559	zgc:103559	0.010
si:ch211-77g15.32	si:ch211-77g15.32	0.010
ca4a	carbonic anhydrase IV a	0.010
lgals2a	lectin, galactoside-binding, soluble, 2a	0.010
hlxb9la	homeo box HB9 like a	0.010
LOC557722	similar to transient receptor potential cation channel, subfamily M, member 5	0.010
LOC100334492	ectonucleoside triphosphate diphosphohydrolase 5-like	0.010
egf	epidermal growth factor	0.010
ywhai	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide	0.010
npy2r	neuropeptide Y receptor Y2	0.010
tpm2	tropomyosin 2 (beta)	0.010
LOC572344	hypothetical protein LOC572344	0.010
zgc:153978	zgc:153978	0.010
rgrb	retinal G protein coupled receptor b	0.010
LOC560066	similar to vitellogenin	0.010
LOC790901	glucose-dependent insulinotropic polypeptide	0.010
cygb1	cytoglobin 1	0.010
fcer1g	Fc receptor, IgE, high affinity I, gamma polypeptide	0.010
sprn2	shadow of prion protein 2	0.010
itln1	intelectin 1	0.010
map1lc3b	microtubule-associated protein 1 light chain 3 beta	0.010
zgc:92806	zgc:92806	0.010