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Process View

Danio rerio

7 genes annotated in zebrafish

regulation of cartilage development

Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of cartilage development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of cartilage development" (in gray)

Name	Description	Probability	Func Analog Organism
tbx1	T-box 1	0.755
bmp2b	bone morphogenetic protein 2b	0.476	Human Mouse
runx2b	runt-related transcription factor 2b	0.441	Mouse
rarga	retinoic acid receptor gamma a	0.386	Mouse
hapln1a	hyaluronan and proteoglycan link protein 1a	0.211
fgf3	fibroblast growth factor 3	0.204
tbx16	T-box gene 16	0.182
fgf10a	fibroblast growth factor 10a	0.173
runx2a	runt-related transcription factor 2a	0.135	Mouse
twist3	twist3	0.132
gpr126	G protein-coupled receptor 126	0.124
col2a1a	collagen type II, alpha-1a	0.124
flh	floating head	0.121
sox9a	SRY-box containing gene 9a	0.117	Human Zebrafish Mouse
bmper	BMP binding endothelial regulator	0.105
shha	sonic hedgehog a	0.102
tgfbi	transforming growth factor, beta-induced	0.098
rarab	retinoic acid receptor, alpha b	0.096	Mouse
s1pr2	sphingosine-1-phosphate receptor 2	0.092
ndr2	nodal-related 2	0.090
prdm1a	PR domain containing 1a, with ZNF domain	0.086
zic3	zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)	0.084
fgfrl1b	fibroblast growth factor receptor-like 1b	0.084
chd	chordin	0.082
fgfr1a	fibroblast growth factor receptor 1a	0.079
cx30.3	connexin 30.3	0.076
hand2	heart and neural crest derivatives expressed transcript 2	0.070
gsc	goosecoid	0.070
hoxa13b	homeo box A13b	0.069
lft1	lefty1	0.068
osr1	odd-skipped related 1 (Drosophila)	0.065
cyp26b1	cytochrome P450, family 26, subfamily b, polypeptide 1	0.064
gli2a	GLI-Kruppel family member GLI2a	0.061	Mouse
dlx4a	distal-less homeobox gene 4a	0.056
snai1b	snail homolog 1b (Drosophila)	0.053
prrx1a	paired related homeobox 1a	0.053
bmp2a	bone morphogenetic protein 2a	0.051	Human Mouse
twist1a	twist1a	0.050
wu:fv91b12	wu:fv91b12	0.050
sox2	SRY-box containing gene 2	0.049	Zebrafish
rxrbb	retinoid x receptor, beta b	0.049
col10a1	collagen, type X, alpha 1	0.049
gdf6a	growth differentiation factor 6a	0.048
dlx2a	distal-less homeobox gene 2a	0.046
hoxa11b	homeo box A11b	0.045	Mouse
msxc	muscle segment homeobox C	0.045
hoxd10a	homeo box D10a	0.044
hoxd12a	homeo box D12a	0.043
si:ch211-173b8.2	si:ch211-173b8.2	0.043
hoxa9b	homeo box A9b	0.041
hoxd13a	homeo box D13a	0.041
foxa3	forkhead box A3	0.041
jag1b	jagged 1b	0.040
fgf4	fibroblast growth factor 4	0.038
sec24d	SEC24 family, member D (S. cerevisiae)	0.037
pax9	paired box gene 9	0.037
dact2	dapper homolog 2, antagonist of beta-catenin (xenopus)	0.035
wnt5b	wingless-type MMTV integration site family, member 5b	0.034	Mouse
spry2	sprouty homolog 2	0.034
sall4	sal-like 4 (Drosophila)	0.034
hoxa10b	homeo box A10b	0.034
ptch1	patched 1	0.033
col1a1a	collagen, type I, alpha 1a	0.033
foxi1	forkhead box I1	0.033
ets1a	v-ets erythroblastosis virus E26 oncogene homolog 1a	0.030
dlx5a	distal-less homeobox gene 5a	0.030
spns2	spinster homolog 2 (Drosophila)	0.029
loxl3b	lysyl oxidase-like 3b	0.029
ctgf	connective tissue growth factor	0.029	Mouse
znf703	zinc finger protein 703	0.028
fn1	fibronectin 1	0.028
sparc	secreted acidic cysteine rich glycoprotein	0.028
tcf12	transcription factor 12	0.027
fgfr2	fibroblast growth factor receptor 2	0.027
kita	kit receptor a	0.027
hsp47	heat shock protein 47	0.027
ptch2	patched 2	0.026
zic1	zic family member 1 (odd-paired homolog, Drosophila)	0.026
loxl2b	lysyl oxidase-like 2b	0.026
twist2	twist2	0.025
efnb1	ephrin B1	0.025
shhb	sonic hedgehog b	0.025	Zebrafish
ldb2a	LIM-domain binding factor 2a	0.024
boc	brother of CDO	0.024
pcdh18a	protocadherin 18a	0.023
dlx3b	distal-less homeobox gene 3b	0.023
spon2a	spondin 2a, extracellular matrix protein	0.022
mab21l2	mab-21-like 2	0.021
hoxa11a	homeo box A11a	0.021
prrx1b	paired related homeobox 1b	0.021
frem3	Fras1 related extracellular matrix 3	0.021
barx1	BarH-like homeobox 1	0.020
srf	serum response factor	0.020
rxraa	retinoid X receptor, alpha a	0.020
sh3gl1b	SH3-domain GRB2-like 1b	0.020
bmp4	bone morphogenetic protein 4	0.020	Human Mouse
hoxb5a	homeo box B5a	0.020
sp7	Sp7 transcription factor	0.019
dkk1b	dickkopf 1b	0.019
admp	anti-dorsalizing morphogenic protein	0.019
inka1a	induced in neural crest by AP2, 1a	0.019
sox32	SRY-box containing gene 32	0.019
fgfrl1a	fibroblast growth factor receptor-like 1a	0.018
dhrs3a	dehydrogenase/reductase (SDR family) member 3a	0.018
hdac4	histone deacetylase 4	0.018
tll1	tolloid-like 1	0.018
LOC100000500	sclerostin-like	0.018
wnt4a	wingless-type MMTV integration site family, member 4a	0.017
klf4	Kruppel-like factor 4	0.016
tcf7l2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.016
notch2	notch homolog 2	0.016
rxrba	retinoid x receptor, beta a	0.016
ripk2	receptor-interacting serine-threonine kinase 2	0.015
brd4	bromodomain containing 4	0.015
hoxd11a	homeo box D11a	0.015	Mouse
hoxa2b	homeo box A2b	0.015
pcdh8	protocadherin 8	0.015
tgfb1a	transforming growth factor, beta 1a	0.015	Mouse
pitx2	paired-like homeodomain transcription factor 2	0.015
rxrga	retinoid x receptor, gamma a	0.015
bmpr1aa	bone morphogenetic protein receptor, type 1aa	0.015
id1	inhibitor of DNA binding 1	0.015
sox11b	SRY-box containing gene 11b	0.014
fgfr4	fibroblast growth factor receptor 4	0.014
pde10a	phosphodiesterase 10A	0.014
acvr1b	activin A receptor, type IB	0.014
jag2	jagged 2	0.014
LOC100334210	growth/differentiation factor 5-like	0.014
bambia	BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a	0.014
id:ibd2573	id:ibd2573	0.014
emx3	empty spiracles homeobox 3	0.014
tbx5a	T-box 5a	0.014
col27a1a	collagen, type XXVII, alpha 1a	0.013
fli1a	friend leukemia integration 1a	0.013
col5a1	procollagen, type V, alpha 1	0.013
etv5a	ets variant 5a	0.013
crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.013
cd99l2	CD99 antigen-like 2	0.013
msxd	muscle segment homeobox D	0.013
spry4	sprouty (Drosophila) homolog 4	0.013
si:xx-bac7cse.2	si:xx-bac7cse.2	0.013
igfbp3	insulin-like growth factor binding protein 3	0.013
msxe	muscle segment homeobox E	0.013
zic2a	zic family member 2 (odd-paired homolog, Drosophila), a	0.013
six1a	sine oculis homeobox homolog 1a	0.013
npnt	nephronectin	0.013
hoxa9a	homeo box A9a	0.013
smad7	MAD, mothers against decapentaplegic homolog 7 (Drosophila)	0.012
zgc:136878	zgc:136878	0.012
hoxc9a	homeo box C9a	0.012
six4b	sine oculis homeobox homolog 4b	0.012
lmo4a	LIM domain only 4a	0.012
msxb	muscle segment homeobox B	0.012
lect1	leukocyte cell derived chemotaxin 1	0.012
cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.012
vent	ventral expressed homeobox	0.012
rspo3	R-spondin 3 homolog (Xenopus laevis)	0.012
six4a	sine oculis homeobox homolog 4a	0.012
plod1a	procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a	0.012
nt5e	5'-nucleotidase, ecto (CD73)	0.011
smo	smoothened homolog (Drosophila)	0.011
gpc4	glypican 4	0.011
dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.011
twist1b	twist1b	0.011
si:ch211-212m21.5	si:ch211-212m21.5	0.011
chpf	chondroitin polymerizing factor	0.011
sfrp1a	secreted frizzled-related protein 1a	0.011
fzd8a	frizzled homolog 8a	0.011
angpt1	angiopoietin 1	0.011
col8a1a	collagen, type VIII, alpha 1a	0.010
smad3a	MAD homolog 3a (Drosophila)	0.010	Mouse
tgfb2	transforming growth factor, beta 2	0.010	Mouse