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Danio rerio

18 genes annotated in zebrafish

definitive hemopoiesis

A second wave of blood cell production that, in vertebrates, generates long-term hemopoietic stem cells that continously provide erythroid, myeloid and lymphoid lineages throughout adulthood.

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In addition to gene-name show these genes:

Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "definitive hemopoiesis"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "definitive hemopoiesis" (in gray)

Name	Description	Probability	Func Analog Organism
runx1	runt-related transcription factor 1	0.967
hoxd4a	homeo box D4a	0.956
cmyb	transcription factor cmyb	0.934
haus3	HAUS augmin-like complex, subunit 3	0.779
hoxb4a	homeo box B4a	0.702	Mouse
isl1	islet1	0.611
znf574	zinc finger protein 574	0.482
hbbe3	hemoglobin beta embryonic-3	0.458
btk	Bruton agammaglobulinemia tyrosine kinase	0.408
pax2a	paired box gene 2a	0.387
otpb	orthopedia homolog b	0.385
ikzf1	IKAROS family zinc finger 1 (Ikaros)	0.373
hhex	hematopoietically expressed homeobox	0.369
lmo2	LIM domain only 2 (rhombotin-like 1)	0.362
tfr1a	transferrin receptor 1a	0.358
hoxa4a	homeo box A4a	0.324
atoh1b	atonal homolog 1b	0.308	Zebrafish
neurod4	neurogenic differentiation 4	0.300	Zebrafish
hoxb5b	homeo box B5b	0.253
sox9a	SRY-box containing gene 9a	0.253
hoxd10a	homeo box D10a	0.246
rpl22l1	ribosomal protein L22-like 1	0.236
hoxa3a	homeo box A3a	0.224
spi1l	spleen focus forming virus (SFFV) proviral integration oncogene spi1 like	0.219
hoxc4a	homeo box C4a	0.216
epor	erythropoietin receptor	0.215
pdcd2	programmed cell death 2	0.215
csf3r	colony stimulating factor 3 receptor (granulocyte)	0.202
mpx	myeloid-specific peroxidase	0.197
atoh1a	atonal homolog 1a	0.188	Zebrafish
LOC566708	FL cytokine receptor-like	0.173
mab21l2	mab-21-like 2	0.163
gata1a	GATA binding protein 1a	0.152	Human Mouse
wasa	Wiskott-Aldrich syndrome (eczema-thrombocytopenia) a	0.146
hey2	hairy/enhancer-of-split related with YRPW motif 2	0.139
eng2a	engrailed 2a	0.122
LOC100151531	zinc finger protein Gfi-1b-like	0.119
elavl3	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)	0.109
celsr3	cadherin, EGF LAG seven-pass G-type receptor 3	0.101
pou3f1	POU class 3 homeobox 1	0.095
metap2	methionyl aminopeptidase 2	0.093
epb4.1l4	erythrocyte protein band 4.1-like 4	0.093
hoxa10b	homeo box A10b	0.091
wasb	Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b	0.084
cpox	coproporphyrinogen oxidase	0.074
zeb2a	zinc finger E-box binding homeobox 2a	0.073
spaw	southpaw	0.073
ptf1a	pancreas specific transcription factor, 1a	0.072	Zebrafish
tp63	tumor protein p63	0.072	Zebrafish
six4b	sine oculis homeobox homolog 4b	0.072
hoxd3a	homeo box D3a	0.070
hoxc6a	homeo box C6a	0.067
hoxc9a	homeo box C9a	0.066
ppox	protoporphyrinogen oxidase	0.059
etv2	ets variant gene 2	0.058
myd88	myeloid differentiation primary response gene (88)	0.056
hbae1	hemoglobin alpha embryonic-1	0.056
apex1	APEX nuclease (multifunctional DNA repair enzyme) 1	0.054
f2r	coagulation factor II (thrombin) receptor	0.053
alas2	aminolevulinate, delta-, synthetase 2	0.051
atoh1c	atonal homolog 1c	0.050	Zebrafish
nkx2.1b	NK2 homeobox 1b	0.050
fli1b	friend leukemia integration 1b	0.048
LOC100150924	DNA polymerase subunit gamma-1-like	0.047
rpl23a	ribosomal protein L23a	0.046
nolc1	nucleolar and coiled-body phosphoprotein 1	0.046
drl	draculin	0.046
rpl36a	ribosomal protein L36A	0.044
e2f7	E2F transcription factor 7	0.044
fev	FEV (ETS oncogene family)	0.043
olig2	oligodendrocyte lineage transcription factor 2	0.042
prmt5	protein arginine methyltransferase 5	0.040
ctr9	Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.040
lyz	lysozyme	0.038
slc17a6b	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6b	0.038
hoxa13b	homeo box A13b	0.038
dlx4b	distal-less homeobox gene 4b	0.038
fgfr3	fibroblast growth factor receptor 3	0.037
slc17a7	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7	0.037
pitx2	paired-like homeodomain transcription factor 2	0.036
dbx1b	developing brain homeobox 1b	0.034
zic1	zic family member 1 (odd-paired homolog, Drosophila)	0.034
aldoca	aldolase C, fructose-bisphosphate, a	0.033
insm1b	insulinoma-associated 1b	0.033
foxg1a	forkhead box G1a	0.032
tbl3	transducin (beta)-like 3	0.032
hoxa11b	homeo box A11b	0.032
twist1a	twist1a	0.031	Zebrafish
itga2b	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)	0.031
pea3	ETS-domain transcription factor pea3	0.031
barhl2	BarH-like 2	0.030
rps24	ribosomal protein S24	0.030
mcm7	MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)	0.029
ptpn9a	protein tyrosine phosphatase, non-receptor type 9, a	0.029
rx2	retinal homeobox gene 2	0.028
hs3st1l2	heparan sulfate (glucosamine) 3-O-sulfotransferase 1-like 2	0.028
tie2	endothelium-specific receptor tyrosine kinase 2	0.028
spry2	sprouty homolog 2	0.028
foxa1	forkhead box A1	0.028
zgc:123327	zgc:123327	0.028	Zebrafish
cenph	centromere protein H	0.027
prox1	prospero-related homeobox gene 1	0.027
elk4	ELK4, ETS-domain protein	0.027
hoxa5a	homeo box A5a	0.026
spi1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.026
chst11	carbohydrate (chondroitin 4) sulfotransferase 11	0.026
tbr1b	T-box, brain, 1b	0.025
gabra1	gamma-aminobutyric acid (GABA) A receptor, alpha 1	0.025
rpl38	ribosomal protein L38	0.025
mef2cb	myocyte enhancer factor 2cb	0.025
tnc	tenascin C	0.025
foxl1	forkhead box L1	0.025
stab2	stabilin 2	0.024
mpll	myeloproliferative leukemia virus oncogene, like	0.024
slit1a	slit homolog 1a (Drosophila)	0.024
zgc:195154	zgc:195154	0.024
msh2	mutS homolog 2 (E. coli)	0.024
bmper	BMP binding endothelial regulator	0.023
pou3f2	POU class 3 homeobox 2	0.023
vhl	von Hippel-Lindau tumor suppressor	0.023
zgc:92868	zgc:92868	0.023
gypc	glycophorin C (Gerbich blood group)	0.023
nkx2.7	NK2 transcription factor related 7	0.023
rac2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	0.022
sae1	SUMO1 activating enzyme subunit 1	0.022
grem2	gremlin 2, cysteine knot superfamily	0.022
myl7	myosin, light polypeptide 7, regulatory	0.022
per3	period homolog 3 (Drosophila)	0.022
tbx1	T-box 1	0.022
LOC100536439	parathyroid hormone-related protein-like	0.022
adora2aa	adenosine A2a receptor a	0.022
il6r	interleukin 6 receptor	0.022
nr2e1	nuclear receptor subfamily 2, group E, member 1	0.021
neurod6a	neurogenic differentiation 6a	0.021
diaph2	diaphanous homolog 2 (Drosophila)	0.021
egfl7	EGF-like-domain, multiple 7	0.021
cmlc1	cardiac myosin light chain-1	0.021
syt9a	synaptotagmin IXa	0.021
zgc:158363	zgc:158363	0.020
hoxb1b	homeo box B1b	0.020
hbae3	hemoglobin alpha embryonic-3	0.020
gfi1.1	growth factor independent 1.1	0.020
flt4	fms-related tyrosine kinase 4	0.020
grhl1	grainyhead-like 1 (Drosophila)	0.020
chrna6	cholinergic receptor, nicotinic, alpha 6	0.020
hoxa9b	homeo box A9b	0.019	Mouse
hoxc6b	homeo box C6b	0.019
nol6	nucleolar protein family 6 (RNA-associated)	0.019
znfl2a	zinc finger-like gene 2a	0.019
dab2	disabled homolog 2 (Drosophila)	0.019
barx1	BarH-like homeobox 1	0.019
dlx3b	distal-less homeobox gene 3b	0.019
il7r	interleukin 7 receptor	0.019
dlx4a	distal-less homeobox gene 4a	0.019
mef2d	myocyte enhancer factor 2d	0.018
ptprf	protein tyrosine phosphatase, receptor type, F	0.018
nfatc4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	0.018
vegfc	vascular endothelial growth factor c	0.018
hoxb10a	homeo box B10a	0.018
bmp2a	bone morphogenetic protein 2a	0.018
polr3b	polymerase (RNA) III (DNA directed) polypeptide B	0.017
zgc:158345	zgc:158345	0.017
meis3	myeloid ecotropic viral integration site 3	0.017	Zebrafish
msh6	mutS homolog 6 (E. coli)	0.017
dacha	dachshund a	0.017
fstl5	follistatin-like 5 and follistatin-like 5	0.017
ighz2	immunoglobulin heavy constant zeta2	0.017
zfpm1	zinc finger protein, multitype 1	0.017	Human Mouse
tfeb	transcription factor EB	0.016
ptrfb	polymerase I and transcript release factor b	0.016
hbbe1.1	hemoglobin beta embryonic-1.1	0.016
mettl2a	methyltransferase like 2A	0.016
nr2f2	nuclear receptor subfamily 2, group F, member 2	0.016
sec61g	Sec61 gamma subunit	0.016
nek8	NIMA (never in mitosis gene a)-related kinase 8	0.016
nkx2.9	NK2 transcription factor related, locus 9 (Drosophila)	0.016
lhx2a	LIM homeobox 2a	0.016
ddt	D-dopachrome tautomerase	0.016
trpa1b	transient receptor potential cation channel, subfamily A, member 1b	0.015
tal1	T-cell acute lymphocytic leukemia 1	0.015
hoxd9a	homeo box D9a	0.015
tyrp1b	tyrosinase-related protein 1b	0.015
olig4	oligodendrocyte transcription factor 4	0.015
metrn	meteorin, glial cell differentiation regulator	0.015
elavl4	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)	0.015
ascl1b	achaete-scute complex-like 1b (Drosophila)	0.015
gata4	GATA-binding protein 4	0.015
hoxb5a	homeo box B5a	0.015
fzd9b	frizzled homolog 9b	0.015
si:ch211-195h23.3	si:ch211-195h23.3	0.015
wu:fl55e11	wu:fl55e11	0.014
fzd10	frizzled homolog 10	0.014
lhx1a	LIM homeobox 1a	0.014
klf4	Kruppel-like factor 4	0.014
ddx46	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46	0.014
hoxb8b	homeo box B8b	0.014
olig3	oligodendrocyte transcription factor 3	0.014
six2a	sine oculis-related homeobox 2a	0.014
ctcf	CCCTC-binding factor (zinc finger protein)	0.014
foxn4	forkhead box N4	0.014
irf8	interferon regulatory factor 8	0.013
dip2c	DIP2 disco-interacting protein 2 homolog C (Drosophila)	0.013
gabpa	GA-binding protein transcription factor, alpha subunit	0.013
cadm3	cell adhesion molecule 3	0.013
her2	hairy-related 2	0.013
hoxb8a	homeo box B8a	0.013
bms1l	BMS1-like, ribosome assembly protein (yeast)	0.013
LOC568230	similar to CHD3	0.013
gdnf	glial cell derived neurotrophic factor	0.013
rag1	recombination activating gene 1	0.013
prox1b	prospero-related homeobox gene 1b	0.013
zgc:73189	zgc:73189	0.013
mpeg1	macrophage expressed 1	0.013
nola1	nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs)	0.013
trim2a	tripartite motif-containing 2a	0.013
LOC100149834	cdc2-related kinase, arginine/serine-rich-like	0.012
slit2	slit (Drosophila) homolog 2	0.012
cd74	CD74 molecule, major histocompatibility complex, class II invariant chain	0.012
zgc:162468	zgc:162468 and hypothetical protein LOC798890	0.012
eya3	eyes absent homolog 3	0.012
slc1a3b	solute carrier family 1 (glial high affinity glutamate transporter), member 3b	0.012
LOC565256	similar to Metabotropic glutamate receptor 3 precursor (mGluR3)	0.012
hs6st1b	heparan sulfate 6-O-sulfotransferase 1b	0.012
smchd1	structural maintenance of chromosomes flexible hinge domain containing 1	0.012
tbx5b	T-box 5b	0.012
hoxb3a	homeo box B3a	0.012	Mouse
boc	brother of CDO	0.012
sulf1	sulfatase 1	0.012
nol10	nucleolar protein 10	0.012
irx4b	iroquois homeobox protein 4b	0.012
hoxb6b	homeo box B6b	0.012
srrt	serrate RNA effector molecule homolog (Arabidopsis)	0.012
gng3	guanine nucleotide binding protein (G protein), gamma 3	0.012
tprb	translocated promoter region b (to activated MET oncogene)	0.012
si:ch211-246m6.5	si:ch211-246m6.5	0.012
si:dkeyp-15g12.1	si:dkeyp-15g12.1	0.012
nkx2.5	NK2 transcription factor related 5	0.012
dhrs3a	dehydrogenase/reductase (SDR family) member 3a	0.011
dla	deltaA	0.011
rela	v-rel reticuloendotheliosis viral oncogene homolog A	0.011
dbx1a	developing brain homeobox 1a	0.011
pax6a	paired box gene 6a	0.011
eif4h	eukaryotic translation initiation factor 4h	0.011
xylt1	xylosyltransferase 1	0.011
atoh8	atonal homolog 8	0.011
wdr74	WD repeat domain 74	0.011
zbtb4	zinc finger and BTB domain containing 4	0.011
tshz1	teashirt family zinc finger 1	0.011
zgc:92745	zgc:92745	0.011
fgfr4	fibroblast growth factor receptor 4	0.011
hmbsb	hydroxymethylbilane synthase, b	0.011
crlf1b	cytokine receptor-like factor 1b	0.011
fancc	Fanconi anemia, complementation group C	0.011
il6st	interleukin 6 signal transducer	0.011	Zebrafish
gro2	groucho 2	0.011
tmsb	thymosin, beta	0.011
mybl2	myeloblastosis oncogene-like 2	0.011	Zebrafish
rpl11	ribosomal protein L11	0.010
eef2a.1	eukaryotic translation elongation factor 2a, tandem duplicate 1	0.010
npm4	nucleophosmin/nucleoplasmin, 4	0.010
hoxb6a	homeo box B6a	0.010
hoxc5a	homeo box C5a	0.010
arfip2a	ADP-ribosylation factor interacting protein 2a	0.010
atpif1	ATPase inhibitory factor 1	0.010
zgc:66382	zgc:66382	0.010
fsta	follistatin a	0.010
plxnd1	plexin D1	0.010