The network for 'endochondral bone morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

endochondral bone morphogenesis

The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone.

Homo sapiens
Name Description Probability Func Analog Organism
POU5F1 POU class 5 homeobox 1 0.981
TGFB1 transforming growth factor, beta 1 0.903
PAX3 paired box 3 0.900
ANGPT2 angiopoietin 2 0.718
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.640
NOTCH1 notch 1 0.635
SMAD7 SMAD family member 7 0.634
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.624
FYN FYN oncogene related to SRC, FGR, YES 0.540
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.481
NOTCH3 notch 3 0.432
COL4A1 collagen, type IV, alpha 1 0.392
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.368
COL6A1 collagen, type VI, alpha 1 0.359
ENG endoglin 0.346
BCAR1 breast cancer anti-estrogen resistance 1 0.339
POU3F2 POU class 3 homeobox 2 0.286
TGFB3 transforming growth factor, beta 3 0.264
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 0.256
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.249
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.241
EPOR erythropoietin receptor 0.205
APP amyloid beta (A4) precursor protein 0.204
FSTL1 follistatin-like 1 0.192
NRP1 neuropilin 1 0.189
JAG1 jagged 1 0.185
MSX1 msh homeobox 1 0.181
HDAC4 histone deacetylase 4 0.172
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 0.171
ANGPT1 angiopoietin 1 0.161
FN1 fibronectin 1 0.155
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0.153
MED25 mediator complex subunit 25 0.152
IGFBP3 insulin-like growth factor binding protein 3 0.149
SORBS3 sorbin and SH3 domain containing 3 0.143
ARID1A AT rich interactive domain 1A (SWI-like) 0.141
COL5A1 collagen, type V, alpha 1 0.136
INSR insulin receptor 0.134
BMP1 bone morphogenetic protein 1 0.133
TIMP2 TIMP metallopeptidase inhibitor 2 0.131
COL1A1 collagen, type I, alpha 1 0.127
COL11A2 collagen, type XI, alpha 2 0.126
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.125
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.120
FURIN furin (paired basic amino acid cleaving enzyme) 0.110
NID2 nidogen 2 (osteonidogen) 0.110
IL4R interleukin 4 receptor 0.107
RXRA retinoid X receptor, alpha 0.105
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.101
NOTCH2 notch 2 0.100
COL1A2 collagen, type I, alpha 2 0.098
PDGFA platelet-derived growth factor alpha polypeptide 0.094
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.092
NRP2 neuropilin 2 0.091
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.091
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.089
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.084
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.084
RXRB retinoid X receptor, beta 0.084
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.079
SOCS2 suppressor of cytokine signaling 2 0.079
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 0.077
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.077
GAB2 GRB2-associated binding protein 2 0.076
PGRMC1 progesterone receptor membrane component 1 0.076
LOX lysyl oxidase 0.075
MEF2A myocyte enhancer factor 2A 0.072
MMP16 matrix metallopeptidase 16 (membrane-inserted) 0.071
VEGFA vascular endothelial growth factor A 0.070
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.069
COL7A1 collagen, type VII, alpha 1 0.068
ESR1 estrogen receptor 1 0.068
PTPN2 protein tyrosine phosphatase, non-receptor type 2 0.067
DLL1 delta-like 1 (Drosophila) 0.066
HDAC9 histone deacetylase 9 0.065
HMGA2 high mobility group AT-hook 2 0.065
IGFBP5 insulin-like growth factor binding protein 5 0.064
TNK2 tyrosine kinase, non-receptor, 2 0.060
SOX11 SRY (sex determining region Y)-box 11 0.059
HIPK2 homeodomain interacting protein kinase 2 0.059
PTPN9 protein tyrosine phosphatase, non-receptor type 9 0.058
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.057
EGR1 early growth response 1 0.057
MARCKSL1 MARCKS-like 1 0.057
HOXA10 homeobox A10 0.056
LIMK1 LIM domain kinase 1 0.056
MFAP2 microfibrillar-associated protein 2 0.055
COL2A1 collagen, type II, alpha 1 0.053
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 0.053
FBLN2 fibulin 2 0.052
C17orf28 chromosome 17 open reading frame 28 0.051
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.051
ZFYVE9 zinc finger, FYVE domain containing 9 0.050
RUNX1 runt-related transcription factor 1 0.050
FOXG1 forkhead box G1 0.048
COL6A2 collagen, type VI, alpha 2 0.046
DUSP7 dual specificity phosphatase 7 0.046
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.046
HDAC7 histone deacetylase 7 0.045
TGFBR1 transforming growth factor, beta receptor 1 0.045
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
gli2a GLI-Kruppel family member GLI2a 0.969
sox9a SRY-box containing gene 9a 0.967
wu:fv91b12 wu:fv91b12 0.913
foxi1 forkhead box I1 0.842
col5a1 procollagen, type V, alpha 1 0.782
sox10 SRY-box containing gene 10 0.655
efnb2a ephrin B2a 0.653
gdf6a growth differentiation factor 6a 0.591
bmp2b bone morphogenetic protein 2b 0.582
col1a2 collagen, type I, alpha 2 0.508
prdm1a PR domain containing 1a, with ZNF domain 0.501
jag1b jagged 1b 0.489
edn1 endothelin 1 0.474
shha sonic hedgehog a 0.359
raraa retinoic acid receptor, alpha a 0.319
col12a1 collagen, type XII, alpha 1 0.313
chrna1 cholinergic receptor, nicotinic, alpha polypeptide 1 0.282
lect1 leukocyte cell derived chemotaxin 1 0.268
notch1a notch homolog 1a 0.248
bmper BMP binding endothelial regulator 0.246
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.220
cmn calymmin 0.187
mdka midkine-related growth factor 0.185
col9a3 collagen, type IX, alpha 3 0.175
foxa2 forkhead box A2 0.169
nkx3.2 NK3 homeobox 2 0.154
tfe3b transcription factor binding to IGHM enhancer 3b 0.143
col5a2l collagen, type V, alpha 2-like 0.128
myod1 myogenic differentiation 1 0.119
twist2 twist2 0.106
ctgf connective tissue growth factor 0.103
dlx2a distal-less homeobox gene 2a 0.094
barx1 BarH-like homeobox 1 0.092
cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 0.088
pax7a paired box gene 7a 0.082
gbx2 gastrulation brain homeo box 2 0.071
lmo4a LIM domain only 4a 0.070
runx3 runt-related transcription factor 3 0.066
rerea arginine-glutamic acid dipeptide (RE) repeats a 0.065
bmp4 bone morphogenetic protein 4 0.062
itga5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.060
foxa3 forkhead box A3 0.056
tp63 tumor protein p63 0.056
eya1 eyes absent homolog 1 0.053
fgf3 fibroblast growth factor 3 0.052
pkd2 polycystic kidney disease 2 0.052
msxc muscle segment homeobox C 0.052
tbx5a T-box 5a 0.049
runx2a runt-related transcription factor 2a 0.049
col9a2 procollagen, type IX, alpha 2 0.047
dcn decorin 0.047
fgfr2 fibroblast growth factor receptor 2 0.043
foxi3b forkhead box I3b 0.043
foxc1a forkhead box C1a 0.043
cdx4 caudal type homeo box transcription factor 4 0.043
pxn paxillin 0.043
hoxa10b homeo box A10b 0.038
col1a1a collagen, type I, alpha 1a 0.037
sox2 SRY-box containing gene 2 0.036
ntla no tail a 0.036
foxa1 forkhead box A1 0.036
si:xx-bac7cse.2 si:xx-bac7cse.2 0.035
matn4 matrilin 4 0.035
ascl1a achaete-scute complex-like 1a (Drosophila) 0.035
dnmt4 DNA (cytosine-5-)-methyltransferase 4 0.034
cdon cell adhesion molecule-related/down-regulated by oncogenes 0.033
pcsk5b proprotein convertase subtilisin/kexin type 5b 0.032
hoxd12a homeo box D12a 0.032
neurog1 neurogenin 1 0.032
twist1b twist1b 0.031
hoxd10a homeo box D10a 0.030
otx2 orthodenticle homolog 2 0.030
cart1 cartilage paired-class homeoprotein 1 0.030
si:ch211-173b8.2 si:ch211-173b8.2 0.030
tfap2a transcription factor AP-2 alpha 0.029
tbx24 T-box 24 0.028
foxi3a forkhead box I3a 0.028
pax6a paired box gene 6a 0.028
rbp4 retinol binding protein 4, plasma 0.028
rlbp1a retinaldehyde binding protein 1a 0.028
crestin crestin 0.027
grhl1 grainyhead-like 1 (Drosophila) 0.026
foxb1.1 forkhead box B1.1 0.026
ptch2 patched 2 0.026
fn1 fibronectin 1 0.025
hapln1a hyaluronan and proteoglycan link protein 1a 0.025
pax7b paired box gene 7b 0.025
rxrab retinoid x receptor, alpha b 0.024
ehd2 EH-domain containing 2 0.024
dld deltaD 0.023
notch3 notch homolog 3 0.022
sparc secreted acidic cysteine rich glycoprotein 0.022
fgfrl1a fibroblast growth factor receptor-like 1a 0.022
gpr126 G protein-coupled receptor 126 0.022
fgf8b fibroblast growth factor 8 b 0.022
kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 0.022
hoxd13a homeo box D13a 0.022
mgp matrix Gla protein 0.022
zgc:85866 zgc:85866 0.021
hand2 heart and neural crest derivatives expressed transcript 2 0.021
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Col1a1 collagen, type I, alpha 1 1.000
Shh sonic hedgehog 0.999
Hand1 heart and neural crest derivatives expressed transcript 1 0.997
Hand2 heart and neural crest derivatives expressed transcript 2 0.996
Fgf8 fibroblast growth factor 8 0.996
Fgfr2 fibroblast growth factor receptor 2 0.995
Prrx1 paired related homeobox 1 0.991
Gli3 GLI-Kruppel family member GLI3 0.989
Fgfr1 fibroblast growth factor receptor 1 0.984
Pax3 paired box gene 3 0.982
Fgfr3 fibroblast growth factor receptor 3 0.979
Foxc1 forkhead box C1 0.979
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.977
Gli2 GLI-Kruppel family member GLI2 0.976
Tgfb2 transforming growth factor, beta 2 0.974
Prrx2 paired related homeobox 2 0.969
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.969
Runx2 runt related transcription factor 2 0.962
Mrc2 mannose receptor, C type 2 0.957
Tgfbr2 transforming growth factor, beta receptor II 0.941
Smo smoothened homolog (Drosophila) 0.937
Fbn1 fibrillin 1 0.920
Hoxd11 homeobox D11 0.904
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.903
Thra thyroid hormone receptor alpha 0.902
Sox9 SRY-box containing gene 9 0.892
Pax2 paired box gene 2 0.891
Rara retinoic acid receptor, alpha 0.878
Pten phosphatase and tensin homolog 0.872
Hoxa11 homeobox A11 0.871
Rarg retinoic acid receptor, gamma 0.867
Eya1 eyes absent 1 homolog (Drosophila) 0.858
Acvr1 activin A receptor, type 1 0.854
Nos3 nitric oxide synthase 3, endothelial cell 0.849
Hoxd13 homeobox D13 0.847
Smad3 MAD homolog 3 (Drosophila) 0.847
Otx2 orthodenticle homolog 2 (Drosophila) 0.844
Pkd1 polycystic kidney disease 1 homolog 0.838
Col1a2 collagen, type I, alpha 2 0.810
Gdf3 growth differentiation factor 3 0.809
Ctnnb1 catenin (cadherin associated protein), beta 1 0.809
Vegfa vascular endothelial growth factor A 0.808
En1 engrailed 1 0.807
Nodal nodal 0.799
Tcfap2a transcription factor AP-2, alpha 0.797
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.796
Apc adenomatosis polyposis coli 0.785
Col11a1 collagen, type XI, alpha 1 0.785
Snai1 snail homolog 1 (Drosophila) 0.778
Col2a1 collagen, type II, alpha 1 0.775
Trp53 transformation related protein 53 0.761
Hoxa1 homeobox A1 0.753
Lhx1 LIM homeobox protein 1 0.749
Chrd chordin 0.714
Meox2 mesenchyme homeobox 2 0.709
Msx1 homeobox, msh-like 1 0.692
Tgfb1 transforming growth factor, beta 1 0.692
Egr2 early growth response 2 0.651
Isl1 ISL1 transcription factor, LIM/homeodomain 0.641
Msx2 homeobox, msh-like 2 0.638
Tbx15 T-box 15 0.637
Gdf5 growth differentiation factor 5 0.630
Bmpr1a bone morphogenetic protein receptor, type 1A 0.626
Zic3 zinc finger protein of the cerebellum 3 0.601
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.593
Pitx2 paired-like homeodomain transcription factor 2 0.565
Bmp4 bone morphogenetic protein 4 0.564
Gata4 GATA binding protein 4 0.556
Alx3 aristaless-like homeobox 3 0.553
Alx4 aristaless-like homeobox 4 0.551
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.550
Twist1 twist homolog 1 (Drosophila) 0.538
Neurod1 neurogenic differentiation 1 0.537
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.526
Bmp7 bone morphogenetic protein 7 0.525
Col5a1 collagen, type V, alpha 1 0.519
Col3a1 collagen, type III, alpha 1 0.510
Gdnf glial cell line derived neurotrophic factor 0.509
Foxc2 forkhead box C2 0.502
Pax8 paired box gene 8 0.501
Pbx1 pre B-cell leukemia transcription factor 1 0.496
Robo3 roundabout homolog 3 (Drosophila) 0.487
Grem1 gremlin 1 0.487
Emid2 EMI domain containing 2 0.486
Twist2 twist homolog 2 (Drosophila) 0.474
Tbx2 T-box 2 0.471
Dlx5 distal-less homeobox 5 0.444
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.441
Hes1 hairy and enhancer of split 1 (Drosophila) 0.441
Smad7 MAD homolog 7 (Drosophila) 0.425
Gbx2 gastrulation brain homeobox 2 0.423
Wt1 Wilms tumor 1 homolog 0.421
Wnt6 wingless-related MMTV integration site 6 0.411
Neurog3 neurogenin 3 0.408
Gsc goosecoid homeobox 0.405
Lox lysyl oxidase 0.398
Smad6 MAD homolog 6 (Drosophila) 0.388
Col6a2 collagen, type VI, alpha 2 0.384
Dlx1 distal-less homeobox 1 0.376
Neurog2 neurogenin 2 0.375
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Rattus norvegicus
Name Description Probability Func Analog Organism
Col1a1 collagen, type I, alpha 1 0.998
Col1a2 collagen, type I, alpha 2 0.996
Col3a1 collagen, type III, alpha 1 0.986
Col5a1 collagen, type V, alpha 1 0.883
Col5a2 collagen, type V, alpha 2 0.785
Postn periostin, osteoblast specific factor 0.385
Fstl1 follistatin-like 1 0.311
Col12a1 collagen, type XII, alpha 1 0.254
Fbn1 fibrillin 1 0.246
Sparc secreted protein, acidic, cysteine-rich (osteonectin) 0.226
Bgn biglycan 0.209
Eln elastin 0.145
Loxl1 lysyl oxidase-like 1 0.139
Col15a1 collagen, type XV, alpha 1 0.114
Lum lumican 0.097
Pcolce procollagen C-endopeptidase enhancer 0.092
Ccdc80 coiled-coil domain containing 80 0.089
Col6a2 collagen, type VI, alpha 2 0.077
Dab2 disabled homolog 2 (Drosophila) 0.066
Col4a1 collagen, type IV, alpha 1 0.044
Mfap4 microfibrillar-associated protein 4 0.042
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.037
Pxdn peroxidasin homolog (Drosophila) 0.035
Emcn endomucin 0.034
Fn1 fibronectin 1 0.033
Nid2 nidogen 2 0.031
Elk3 ELK3, ETS-domain protein 0.027
Col4a2 collagen, type IV, alpha 2 0.025
Myl9 myosin, light chain 9, regulatory 0.023
Cyyr1 cysteine/tyrosine-rich 1 0.022
Col14a1 collagen, type XIV, alpha 1 0.021
Fgfr2 fibroblast growth factor receptor 2 0.019
Plxnd1 plexin D1 0.019
Lamc1 laminin, gamma 1 0.018
Crtap cartilage associated protein 0.017
Col4a5 collagen, type IV, alpha 5 0.017
Acan aggrecan 0.017
Aspn asporin 0.016
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.016
Kdr kinase insert domain receptor 0.015
LOC686539 similar to immunoglobulin superfamily containing leucine-rich repeat 0.015
Lect1 leukocyte cell derived chemotaxin 1 0.014
Fkbp10 FK506 binding protein 10 0.014
Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.013
RGD1310423 similar to hypothetical protein FLJ31737 0.013
Lef1 lymphoid enhancer binding factor 1 0.013
Lama2 laminin, alpha 2 0.013
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.013
Chad chondroadherin 0.011
Arhgef15 Rho guanine nucleotide exchange factor (GEF) 15 0.011
RGD1565043 similar to Rho guanine nucleotide exchange factor (GEF) 10 0.011
Mia melanoma inhibitory activity 0.011
Shox2 short stature homeobox 2 0.011
Enpep glutamyl aminopeptidase 0.010
Prrx1 paired related homeobox 1 0.010
Lox lysyl oxidase 0.010
Stard8 StAR-related lipid transfer (START) domain containing 8 0.010
Aebp1 AE binding protein 1 0.010
Sod3 superoxide dismutase 3, extracellular 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism