The network for 'positive regulation of actin filament bundle assembly' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of actin filament bundle assembly

Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles.

Homo sapiens
Name Description Probability Func Analog Organism
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 1.000
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.000
S100A6 S100 calcium binding protein A6 0.998
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.997
S100A8 S100 calcium binding protein A8 0.983
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.977
S100A11 S100 calcium binding protein A11 0.974
FN1 fibronectin 1 0.969
S100B S100 calcium binding protein B 0.968
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.959
RHOA ras homolog gene family, member A 0.951
S100A9 S100 calcium binding protein A9 0.899
S100A1 S100 calcium binding protein A1 0.890
ARHGAP1 Rho GTPase activating protein 1 0.832
EZR ezrin 0.824
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.815
ZYX zyxin 0.811
ANXA2 annexin A2 0.786
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.737
NCF2 neutrophil cytosolic factor 2 0.556
SPTAN1 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) 0.541
S100A4 S100 calcium binding protein A4 0.532
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.487
SCHIP1 schwannomin interacting protein 1 0.476
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.442
MSN moesin 0.441
HP haptoglobin 0.421
WIPF1 WAS/WASL interacting protein family, member 1 0.420
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.406
SORBS3 sorbin and SH3 domain containing 3 0.385
LGALS1 lectin, galactoside-binding, soluble, 1 0.374
SH3BGRL3 SH3 domain binding glutamic acid-rich protein like 3 0.331
FBLN1 fibulin 1 0.322
PALLD palladin, cytoskeletal associated protein 0.307
CTGF connective tissue growth factor 0.299
EMP3 epithelial membrane protein 3 0.298
PFN1 profilin 1 0.292
SPRY4 sprouty homolog 4 (Drosophila) 0.281
VCL vinculin 0.280
IQGAP1 IQ motif containing GTPase activating protein 1 0.274
A2M alpha-2-macroglobulin 0.270
RHOG ras homolog gene family, member G (rho G) 0.254
UBE2R2 ubiquitin-conjugating enzyme E2R 2 0.248
CD44 CD44 molecule (Indian blood group) 0.247
TMSB10 thymosin beta 10 0.244
AREG amphiregulin 0.219
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) 0.210
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.183
CFL1 cofilin 1 (non-muscle) 0.173
BAIAP2 BAI1-associated protein 2 0.139
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.123
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.119
CYR61 cysteine-rich, angiogenic inducer, 61 0.111
HTT huntingtin 0.111
ACTB actin, beta 0.110
FYN FYN oncogene related to SRC, FGR, YES 0.110
TAGLN2 transgelin 2 0.109
SPTBN1 spectrin, beta, non-erythrocytic 1 0.108
ALB albumin 0.107
WASF1 WAS protein family, member 1 0.103
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.101
AHNAK AHNAK nucleoprotein 0.099
MAP3K11 mitogen-activated protein kinase kinase kinase 11 0.097
DLG5 discs, large homolog 5 (Drosophila) 0.097
LMNA lamin A/C 0.094
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.091
TIMP1 TIMP metallopeptidase inhibitor 1 0.088
CAPG capping protein (actin filament), gelsolin-like 0.087
CDK11B cyclin-dependent kinase 11B 0.079
ANXA1 annexin A1 0.077
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like 0.076
ARRB1 arrestin, beta 1 0.076
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 0.071
S100A10 S100 calcium binding protein A10 0.071
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 0.070
SORBS2 sorbin and SH3 domain containing 2 0.069
LCAT lecithin-cholesterol acyltransferase 0.069
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.067
SMAD2 SMAD family member 2 0.067
LGALS3 lectin, galactoside-binding, soluble, 3 0.066
RAP1A RAP1A, member of RAS oncogene family 0.062
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 0.060
CTTN cortactin 0.060
FEM1B fem-1 homolog b (C. elegans) 0.059
APOC1 apolipoprotein C-I 0.059
BAK1 BCL2-antagonist/killer 1 0.057
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.057
ACTN1 actinin, alpha 1 0.057
FAT1 FAT tumor suppressor homolog 1 (Drosophila) 0.057
AMOTL2 angiomotin like 2 0.057
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.055
S100P S100 calcium binding protein P 0.054
HCK hemopoietic cell kinase 0.052
ITSN1 intersectin 1 (SH3 domain protein) 0.051
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.051
SH3RF3 SH3 domain containing ring finger 3 0.051
FLNA filamin A, alpha 0.050
JUP junction plakoglobin 0.050
INPPL1 inositol polyphosphate phosphatase-like 1 0.049
NCK1 NCK adaptor protein 1 0.049
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Cdc42 CG12530 gene product from transcript CG12530-RA 0.035
Rac1 CG2248 gene product from transcript CG2248-RA 0.020
par-1 CG8201 gene product from transcript CG8201-RA 0.018
Rho1 CG8416 gene product from transcript CG8416-RB 0.018
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.017
sqh spaghetti squash 0.014
Abl Abl tyrosine kinase 0.014
msn misshapen 0.013
Atg1 Autophagy-specific gene 1 0.012
milt milton 0.012
katanin-60 katanin 60 0.011
plexB plexin B 0.011
Ephrin CG1862 gene product from transcript CG1862-RA 0.011
drpr draper 0.011
Mtl Mig-2-like 0.011
up upheld 0.010
mbc myoblast city 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Ctnnb1 catenin (cadherin associated protein), beta 1 0.977
Apc adenomatosis polyposis coli 0.960
Rac1 RAS-related C3 botulinum substrate 1 0.954
Efnb2 ephrin B2 0.952
Ephb2 Eph receptor B2 0.906
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.703
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.673
Ephb3 Eph receptor B3 0.453
Gli3 GLI-Kruppel family member GLI3 0.446
Bcl2 B-cell leukemia/lymphoma 2 0.384
Efnb1 ephrin B1 0.379
Rarg retinoic acid receptor, gamma 0.361
Ptch1 patched homolog 1 0.355
Fgf18 fibroblast growth factor 18 0.348
Wnt3a wingless-related MMTV integration site 3A 0.328
Wnt4 wingless-related MMTV integration site 4 0.309
Gli2 GLI-Kruppel family member GLI2 0.280
Enah enabled homolog (Drosophila) 0.248
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.245
Epha4 Eph receptor A4 0.221
Lhx1 LIM homeobox protein 1 0.221
Fgfr2 fibroblast growth factor receptor 2 0.215
Actb actin, beta 0.201
Wdr1 WD repeat domain 1 0.169
Tbx2 T-box 2 0.168
Trp53 transformation related protein 53 0.159
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.150
Tead3 TEA domain family member 3 0.147
Hoxa13 homeobox A13 0.142
Nf1 neurofibromatosis 1 0.142
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.142
Trp73 transformation related protein 73 0.136
Vasp vasodilator-stimulated phosphoprotein 0.128
Mapkap1 mitogen-activated protein kinase associated protein 1 0.122
Pak1 p21 protein (Cdc42/Rac)-activated kinase 1 0.117
Rictor RPTOR independent companion of MTOR, complex 2 0.114
Prkar1a protein kinase, cAMP dependent regulatory, type I, alpha 0.114
Gata5 GATA binding protein 5 0.111
Wnt6 wingless-related MMTV integration site 6 0.110
Fgf10 fibroblast growth factor 10 0.106
Kl klotho 0.105
Pten phosphatase and tensin homolog 0.103
Zfp651 zinc finger protein 651 0.102
Amhr2 anti-Mullerian hormone type 2 receptor 0.101
Smad6 MAD homolog 6 (Drosophila) 0.095
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.093
Celsr2 cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila) 0.093
Efna4 ephrin A4 0.091
Bmp7 bone morphogenetic protein 7 0.091
Dnm1 dynamin 1 0.088
Rnd3 Rho family GTPase 3 0.088
Arhgap1 Rho GTPase activating protein 1 0.087
Vav2 vav 2 oncogene 0.082
Dmtf1 cyclin D binding myb-like transcription factor 1 0.080
Sox9 SRY-box containing gene 9 0.077
Lmx1a LIM homeobox transcription factor 1 alpha 0.076
Pnoc prepronociceptin 0.073
Hoxd13 homeobox D13 0.073
Dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.072
Unc5c unc-5 homolog C (C. elegans) 0.071
Lrp5 low density lipoprotein receptor-related protein 5 0.069
Kit kit oncogene 0.069
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.069
Bmpr1a bone morphogenetic protein receptor, type 1A 0.069
Kif5b kinesin family member 5B 0.069
Itga3 integrin alpha 3 0.068
Sult5a1 sulfotransferase family 5A, member 1 0.064
Rb1 retinoblastoma 1 0.063
Tmeff2 transmembrane protein with EGF-like and two follistatin-like domains 2 0.062
Rhoa ras homolog gene family, member A 0.061
Wipf1 WAS/WASL interacting protein family, member 1 0.058
Gli1 GLI-Kruppel family member GLI1 0.057
Npas1 neuronal PAS domain protein 1 0.055
Smurf2 SMAD specific E3 ubiquitin protein ligase 2 0.054
Anxa2 annexin A2 0.054
Sema5a sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.053
Sema3b sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.053
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.052
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.052
Irs1 insulin receptor substrate 1 0.051
Nckap1 NCK-associated protein 1 0.051
Hspb8 heat shock protein 8 0.051
Lhx9 LIM homeobox protein 9 0.051
Plxna1 plexin A1 0.051
Lepr leptin receptor 0.051
St8sia2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.050
Pou3f3 POU domain, class 3, transcription factor 3 0.050
Ret ret proto-oncogene 0.048
Braf Braf transforming gene 0.047
Mllt1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 0.047
Plxna3 plexin A3 0.046
Fzd8 frizzled homolog 8 (Drosophila) 0.046
Onecut1 one cut domain, family member 1 0.046
Ar androgen receptor 0.046
Slk STE20-like kinase (yeast) 0.046
Arpc4 actin related protein 2/3 complex, subunit 4 0.045
Jup junction plakoglobin 0.045
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.045
Cdc42ep1 CDC42 effector protein (Rho GTPase binding) 1 0.045
Cyr61 cysteine rich protein 61 0.044
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Rattus norvegicus
Name Description Probability Func Analog Organism
Tagln transgelin 0.034
Tubb5 tubulin, beta 5 0.017
Dag1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.017
Acta2 smooth muscle alpha-actin 0.016
Arf6 ADP-ribosylation factor 6 0.015
Anxa2 annexin A2 0.015
Myl9 myosin, light chain 9, regulatory 0.015
Cap1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.014
Efhd2 EF-hand domain family, member D2 0.014
Chrna4 cholinergic receptor, nicotinic, alpha 4 0.012
Clic4 chloride intracellular channel 4 0.011
Myh9 myosin, heavy chain 9, non-muscle 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism