The network for 'long term synaptic potentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

long term synaptic potentiation

A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse.

Homo sapiens
Name Description Probability Func Analog Organism
SNAP23 synaptosomal-associated protein, 23kDa 0.978
SNAP25 synaptosomal-associated protein, 25kDa 0.883
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 0.847
MAPT microtubule-associated protein tau 0.844
VAMP3 vesicle-associated membrane protein 3 (cellubrevin) 0.836
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.785
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.713
CRH corticotropin releasing hormone 0.679
CRHR1 corticotropin releasing hormone receptor 1 0.679
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha 0.661
FYN FYN oncogene related to SRC, FGR, YES 0.638
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.604
STX1A syntaxin 1A (brain) 0.525
ITSN1 intersectin 1 (SH3 domain protein) 0.496
VAC14 Vac14 homolog (S. cerevisiae) 0.410
ZNF71 zinc finger protein 71 0.403
SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.390
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.382
NUMB numb homolog (Drosophila) 0.361
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.334
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.324
ADORA2A adenosine A2a receptor 0.318
HIPK2 homeodomain interacting protein kinase 2 0.309
EGR3 early growth response 3 0.292
PPP1R9B protein phosphatase 1, regulatory (inhibitor) subunit 9B 0.252
ADRB2 adrenergic, beta-2-, receptor, surface 0.244
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.233
LRRK2 leucine-rich repeat kinase 2 0.232
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.229
SYT1 synaptotagmin I 0.189
TNRC6C trinucleotide repeat containing 6C 0.185
NTF4 neurotrophin 4 0.146
DUSP23 dual specificity phosphatase 23 0.141
DLG4 discs, large homolog 4 (Drosophila) 0.136
SNCAIP synuclein, alpha interacting protein 0.131
APP amyloid beta (A4) precursor protein 0.121
PABPC1 poly(A) binding protein, cytoplasmic 1 0.119
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.117
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.117
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.117
IER2 immediate early response 2 0.116
DNM1 dynamin 1 0.113
PRRT2 proline-rich transmembrane protein 2 0.108
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.107
KIAA0408 KIAA0408 0.104
SNAI1 snail homolog 1 (Drosophila) 0.103
PARD6G par-6 partitioning defective 6 homolog gamma (C. elegans) 0.100
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.097
CPLX1 complexin 1 0.095
SYN1 synapsin I 0.095
KSR1 kinase suppressor of ras 1 0.095
CCDC115 coiled-coil domain containing 115 0.095
PRKCE protein kinase C, epsilon 0.087
DLGAP2 discs, large (Drosophila) homolog-associated protein 2 0.086
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 0.085
GSK3B glycogen synthase kinase 3 beta 0.085
SRCIN1 SRC kinase signaling inhibitor 1 0.082
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 0.080
FOS FBJ murine osteosarcoma viral oncogene homolog 0.077
MATK megakaryocyte-associated tyrosine kinase 0.077
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.075
PDCD6IP programmed cell death 6 interacting protein 0.070
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.069
EGR2 early growth response 2 0.069
TPPP tubulin polymerization promoting protein 0.068
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.068
PARD6B par-6 partitioning defective 6 homolog beta (C. elegans) 0.067
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.063
UBXN2A UBX domain protein 2A 0.063
PRDX1 peroxiredoxin 1 0.062
RTN4 reticulon 4 0.062
BAI1 brain-specific angiogenesis inhibitor 1 0.061
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.059
NSF N-ethylmaleimide-sensitive factor 0.054
SYN2 synapsin II 0.052
VAMP8 vesicle-associated membrane protein 8 (endobrevin) 0.051
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.050
SOD1 superoxide dismutase 1, soluble 0.049
SOS1 son of sevenless homolog 1 (Drosophila) 0.047
LNX1 ligand of numb-protein X 1 0.045
HSPA1B heat shock 70kDa protein 1B 0.045
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.044
DCAF7 DDB1 and CUL4 associated factor 7 0.044
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.044
EP300 E1A binding protein p300 0.044
NRXN1 neurexin 1 0.044
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 0.043
KCNA1 potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) 0.043
KCNB1 potassium voltage-gated channel, Shab-related subfamily, member 1 0.043
HDAC4 histone deacetylase 4 0.040
F11R F11 receptor 0.040
STX11 syntaxin 11 0.039
BMI1 BMI1 polycomb ring finger oncogene 0.037
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.037
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O 0.037
TRDMT1 tRNA aspartic acid methyltransferase 1 0.037
ACAN aggrecan 0.037
STX5 syntaxin 5 0.037
STXBP1 syntaxin binding protein 1 0.037
PARD3 par-3 partitioning defective 3 homolog (C. elegans) 0.037
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 1.000
Emx1 empty spiracles homolog 1 (Drosophila) 1.000
Dlg4 discs, large homolog 4 (Drosophila) 1.000
Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) 1.000
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.998
Snap25 synaptosomal-associated protein 25 0.994
Drd2 dopamine receptor D2 0.993
Camk2a calcium/calmodulin-dependent protein kinase II alpha 0.993
Nos1 nitric oxide synthase 1, neuronal 0.985
Dlgap1 discs, large (Drosophila) homolog-associated protein 1 0.933
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.930
Kcnma1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 0.913
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.899
Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) 0.879
Stx1a syntaxin 1A (brain) 0.875
Nefl neurofilament, light polypeptide 0.875
Grm1 glutamate receptor, metabotropic 1 0.864
Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 0.863
Bsn bassoon 0.833
Ina internexin neuronal intermediate filament protein, alpha 0.828
Bdnf brain derived neurotrophic factor 0.777
Prkcc protein kinase C, gamma 0.769
Pparg peroxisome proliferator activated receptor gamma 0.765
Dlg2 discs, large homolog 2 (Drosophila) 0.759
Syt2 synaptotagmin II 0.732
Plcg1 phospholipase C, gamma 1 0.728
Adrb1 adrenergic receptor, beta 1 0.708
Syp synaptophysin 0.707
Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 0.706
Ptgs2 prostaglandin-endoperoxide synthase 2 0.688
Kcna1 potassium voltage-gated channel, shaker-related subfamily, member 1 0.669
Lep leptin 0.658
Lepr leptin receptor 0.654
Shc3 src homology 2 domain-containing transforming protein C3 0.646
Nsf N-ethylmaleimide sensitive fusion protein 0.626
Esr1 estrogen receptor 1 (alpha) 0.615
Stxbp5 syntaxin binding protein 5 (tomosyn) 0.610
Kl klotho 0.582
Prkce protein kinase C, epsilon 0.571
Npy2r neuropeptide Y receptor Y2 0.557
Cacng2 calcium channel, voltage-dependent, gamma subunit 2 0.550
Sstr4 somatostatin receptor 4 0.534
Ar androgen receptor 0.502
Thbs1 thrombospondin 1 0.498
Adcy1 adenylate cyclase 1 0.471
Pgr progesterone receptor 0.461
Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit 0.458
Lrp1 low density lipoprotein receptor-related protein 1 0.451
Lyst lysosomal trafficking regulator 0.439
Grid1 glutamate receptor, ionotropic, delta 1 0.437
Drd1a dopamine receptor D1A 0.425
Adrb3 adrenergic receptor, beta 3 0.421
Pnpla2 patatin-like phospholipase domain containing 2 0.399
Cit citron 0.398
Mtap2 microtubule-associated protein 2 0.385
Gabrb3 gamma-aminobutyric acid (GABA) A receptor, subunit beta 3 0.381
Cplx1 complexin 1 0.373
Gria2 glutamate receptor, ionotropic, AMPA2 (alpha 2) 0.371
Chrm1 cholinergic receptor, muscarinic 1, CNS 0.365
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.364
Arc activity regulated cytoskeletal-associated protein 0.359
Dnm1 dynamin 1 0.332
Kcna2 potassium voltage-gated channel, shaker-related subfamily, member 2 0.327
Sstr3 somatostatin receptor 3 0.325
Sult4a1 sulfotransferase family 4A, member 1 0.315
Nf1 neurofibromatosis 1 0.306
Homer1 homer homolog 1 (Drosophila) 0.303
Shank3 SH3/ankyrin domain gene 3 0.298
ND6 NADH dehydrogenase subunit 6 0.269
Kcna4 potassium voltage-gated channel, shaker-related subfamily, member 4 0.269
Syn2 synapsin II 0.265
Gabra2 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2 0.264
Dcx doublecortin 0.264
Rab27a RAB27A, member RAS oncogene family 0.257
En1 engrailed 1 0.251
Napb N-ethylmaleimide sensitive fusion protein attachment protein beta 0.249
Pax6 paired box gene 6 0.231
Cyr61 cysteine rich protein 61 0.230
Htr7 5-hydroxytryptamine (serotonin) receptor 7 0.223
Vamp2 vesicle-associated membrane protein 2 0.223
Ptpn5 protein tyrosine phosphatase, non-receptor type 5 0.223
Trp53 transformation related protein 53 0.218
Hpca hippocalcin 0.216
Paip2b poly(A) binding protein interacting protein 2B 0.214
Des desmin 0.209
Fgf4 fibroblast growth factor 4 0.205
Nptx2 neuronal pentraxin 2 0.203
Fosb FBJ osteosarcoma oncogene B 0.200
Htr1d 5-hydroxytryptamine (serotonin) receptor 1D 0.199
Ache acetylcholinesterase 0.198
Mc1r melanocortin 1 receptor 0.192
Dab1 disabled homolog 1 (Drosophila) 0.192
Paip2 polyadenylate-binding protein-interacting protein 2 0.191
Fbxl20 F-box and leucine-rich repeat protein 20 0.190
Adrb2 adrenergic receptor, beta 2 0.189
Nphp4 nephronophthisis 4 (juvenile) homolog (human) 0.186
Rasgrp1 RAS guanyl releasing protein 1 0.185
Gja5 gap junction protein, alpha 5 0.172
Gria1 glutamate receptor, ionotropic, AMPA1 (alpha 1) 0.159
Grm2 glutamate receptor, metabotropic 2 0.158
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Rattus norvegicus
Name Description Probability Func Analog Organism
Fos FBJ osteosarcoma oncogene 0.913
S100a10 S100 calcium binding protein A10 0.883
Egr1 early growth response 1 0.882
S100a6 S100 calcium binding protein A6 0.863
Nr4a1 nuclear receptor subfamily 4, group A, member 1 0.838
Anxa2 annexin A2 0.752
Junb jun B proto-oncogene 0.730
S100a8 S100 calcium binding protein A8 0.511
Gng7 guanine nucleotide binding protein (G protein), gamma 7 0.469
S100a9 S100 calcium binding protein A9 0.467
Prkcg protein kinase C, gamma 0.411
Egr2 early growth response 2 0.334
Lgals3 lectin, galactoside-binding, soluble, 3 0.316
Dusp1 dual specificity phosphatase 1 0.294
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.232
Adora2a adenosine A2a receptor 0.226
Btg2 BTG family, member 2 0.223
Dlgap3 discs, large (Drosophila) homolog-associated protein 3 0.219
Lgals1 lectin, galactoside-binding, soluble, 1 0.204
Anxa1 annexin A1 0.200
Acrv1 acrosomal vesicle protein 1 0.187
S100a4 S100 calcium-binding protein A4 0.182
Hpca hippocalcin 0.176
Anxa5 annexin A5 0.176
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.176
Kcnab2 potassium voltage-gated channel, shaker-related subfamily, beta member 2 0.170
Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) 0.160
Dusp6 dual specificity phosphatase 6 0.155
Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 0.149
B3gat1 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) 0.134
Timp1 TIMP metallopeptidase inhibitor 1 0.131
Aqp2 aquaporin 2 (collecting duct) 0.122
Flt1 FMS-related tyrosine kinase 1 0.120
Mag myelin-associated glycoprotein 0.120
Gja1 gap junction protein, alpha 1 0.116
Tspo translocator protein 0.107
Smgb neonatal submandibular gland protein B 0.106
Vip vasoactive intestinal peptide 0.104
Crhbp corticotropin releasing hormone binding protein 0.094
Plp2 proteolipid protein 2 (colonic epithelium-enriched) 0.093
Ier2 immediate early response 2 0.092
Csf1 colony stimulating factor 1 (macrophage) 0.091
Neurod2 neurogenic differentiation 2 0.090
Nr4a2 nuclear receptor subfamily 4, group A, member 2 0.089
Accn1 amiloride-sensitive cation channel 1, neuronal 0.088
Slc30a2 solute carrier family 30 (zinc transporter), member 2 0.088
Gas7 growth arrest specific 7 0.087
Vegp2 von Ebners gland protein 2 0.085
Dlg4 discs, large homolog 4 (Drosophila) 0.084
Htr5a 5-hydroxytryptamine (serotonin) receptor 5A 0.084
Gria1 glutamate receptor, ionotropic, AMPA 1 0.082
Ncr1 natural cytotoxicity triggering receptor 1 0.080
Bcan brevican 0.077
Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 0.076
Cd9 CD9 molecule 0.075
Drd3 dopamine receptor D3 0.075
Mbp myelin basic protein 0.074
Fgf7 fibroblast growth factor 7 0.072
Nrxn3 neurexin 3 0.071
Camk2a calcium/calmodulin-dependent protein kinase II alpha 0.071
Ncan neurocan 0.070
Stx1a syntaxin 1A (brain) 0.070
Tacr3 tachykinin receptor 3 0.070
Cx3cl1 chemokine (C-X3-C motif) ligand 1 0.069
Oprd1 opioid receptor, delta 1 0.069
Gria2 glutamate receptor, ionotropic, AMPA 2 0.068
Cntn3 contactin 3 (plasmacytoma associated) 0.067
Gabrg3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 0.066
Atp2b3 ATPase, Ca++ transporting, plasma membrane 3 0.064
Gad2 glutamate decarboxylase 2 0.063
Ceacam3 carcinoembryonic antigen-related cell adhesion molecule 3 0.062
Slc1a1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 0.062
Dcc deleted in colorectal carcinoma 0.060
Adra2c adrenergic, alpha-2C-, receptor 0.060
Dgkg diacylglycerol kinase, gamma 0.060
Gjb4 gap junction protein, beta 4 0.060
Ptprz1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.059
Bcl2 B-cell CLL/lymphoma 2 0.057
Cdh6 cadherin 6 0.056
Dlgap1 discs, large (Drosophila) homolog-associated protein 1 0.056
Lep leptin 0.055
S100a11 S100 calcium binding protein A11 (calizzarin) 0.055
Arpp21 cAMP-regulated phosphoprotein 21 0.055
Trpc4 transient receptor potential cation channel, subfamily C, member 4 0.055
Svs4 seminal vesicle secretory protein 4 0.054
Prap1 proline-rich acidic protein 1 0.053
Grin2b glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.052
Sstr2 somatostatin receptor 2 0.052
Scn8a sodium channel, voltage gated, type VIII, alpha subunit 0.050
Slc8a2 solute carrier family 8 (sodium/calcium exchanger), member 2 0.049
Grin2a glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.048
Odf4 outer dense fiber of sperm tails 4 0.047
Cd4 Cd4 molecule 0.047
Kctd13 potassium channel tetramerisation domain containing 13 0.047
Th tyrosine hydroxylase 0.047
Bsn bassoon 0.046
Cd63 Cd63 molecule 0.046
Crip cysteine-rich intestinal protein 0.045
Sstr3 somatostatin receptor 3 0.045
Pebp1 phosphatidylethanolamine binding protein 1 0.045
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism