The network for 'regulation of interleukin 10 production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of interleukin 10 production

Any process that modulates the frequency, rate, or extent of interleukin-10 production.

Homo sapiens
Name Description Probability Func Analog Organism
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.411
CCR5 chemokine (C-C motif) receptor 5 0.390
BTN3A3 butyrophilin, subfamily 3, member A3 0.344
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.273
PILRA paired immunoglobin-like type 2 receptor alpha 0.206
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.201
CCL4 chemokine (C-C motif) ligand 4 0.189
BTN3A2 butyrophilin, subfamily 3, member A2 0.157
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.144
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.128
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.126
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.112
BTN3A1 butyrophilin, subfamily 3, member A1 0.105
CXCL9 chemokine (C-X-C motif) ligand 9 0.089
CD80 CD80 molecule 0.086
HLA-DRA major histocompatibility complex, class II, DR alpha 0.085
NOTCH3 notch 3 0.085
IL23A interleukin 23, alpha subunit p19 0.079
HLA-DMB major histocompatibility complex, class II, DM beta 0.078
CCR1 chemokine (C-C motif) receptor 1 0.077
SNAP23 synaptosomal-associated protein, 23kDa 0.073
TRAF1 TNF receptor-associated factor 1 0.061
SYK spleen tyrosine kinase 0.056
CCL8 chemokine (C-C motif) ligand 8 0.053
CXCL10 chemokine (C-X-C motif) ligand 10 0.044
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.043
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.039
CCL22 chemokine (C-C motif) ligand 22 0.039
HLA-F major histocompatibility complex, class I, F 0.038
CCL13 chemokine (C-C motif) ligand 13 0.037
TYMP thymidine phosphorylase 0.035
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.034
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.033
IRF9 interferon regulatory factor 9 0.033
MYD88 myeloid differentiation primary response gene (88) 0.032
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.032
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.032
IDE insulin-degrading enzyme 0.030
ATF5 activating transcription factor 5 0.030
CCR7 chemokine (C-C motif) receptor 7 0.030
BTN2A2 butyrophilin, subfamily 2, member A2 0.029
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.028
SOCS3 suppressor of cytokine signaling 3 0.028
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.028
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.028
HK3 hexokinase 3 (white cell) 0.027
UBA7 ubiquitin-like modifier activating enzyme 7 0.026
SPI1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.026
IRF1 interferon regulatory factor 1 0.025
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 0.025
IRF8 interferon regulatory factor 8 0.025
PLEK pleckstrin 0.024
GFI1B growth factor independent 1B transcription repressor 0.024
TRIM21 tripartite motif containing 21 0.024
IL1B interleukin 1, beta 0.023
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.023
IL10 interleukin 10 0.023
CD163 CD163 molecule 0.022
MEFV Mediterranean fever 0.022
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.021
SIGLEC7 sialic acid binding Ig-like lectin 7 0.021
IRAK2 interleukin-1 receptor-associated kinase 2 0.021
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.021
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.021
BIRC3 baculoviral IAP repeat containing 3 0.020
BLNK B-cell linker 0.020
NLRP3 NLR family, pyrin domain containing 3 0.020
SP110 SP110 nuclear body protein 0.019
SLAMF8 SLAM family member 8 0.019
IFNG interferon, gamma 0.019
DPP4 dipeptidyl-peptidase 4 0.018
NLRC4 NLR family, CARD domain containing 4 0.018
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.018
ICAM1 intercellular adhesion molecule 1 0.017
CD40 CD40 molecule, TNF receptor superfamily member 5 0.017
CCL7 chemokine (C-C motif) ligand 7 0.017
TNF tumor necrosis factor 0.016
IL2RG interleukin 2 receptor, gamma 0.016
CXCL13 chemokine (C-X-C motif) ligand 13 0.016
NOTCH1 notch 1 0.016
IL1RN interleukin 1 receptor antagonist 0.015
ADAMDEC1 ADAM-like, decysin 1 0.015
NOTCH2 notch 2 0.015
CXCL11 chemokine (C-X-C motif) ligand 11 0.015
HSPE1 heat shock 10kDa protein 1 (chaperonin 10) 0.015
LY96 lymphocyte antigen 96 0.015
CD33 CD33 molecule 0.014
LY86 lymphocyte antigen 86 0.014
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene) 0.014
CCR4 chemokine (C-C motif) receptor 4 0.014
BTN2A1 butyrophilin, subfamily 2, member A1 0.013
HLA-DMA major histocompatibility complex, class II, DM alpha 0.013
STAT2 signal transducer and activator of transcription 2, 113kDa 0.013
FPR3 formyl peptide receptor 3 0.013
CD83 CD83 molecule 0.013
CCL2 chemokine (C-C motif) ligand 2 0.013
TLR7 toll-like receptor 7 0.012
BATF basic leucine zipper transcription factor, ATF-like 0.012
AIF1 allograft inflammatory factor 1 0.012
CD86 CD86 molecule 0.011
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.975
Tnf tumor necrosis factor 0.970
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.862
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.773
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.675
Il2rg interleukin 2 receptor, gamma chain 0.623
Ptprc protein tyrosine phosphatase, receptor type, C 0.611
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.544
Lyz2 lysozyme 2 0.522
Casp1 caspase 1 0.448
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.423
Ifng interferon gamma 0.387
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.385
Myd88 myeloid differentiation primary response gene 88 0.341
Cd44 CD44 antigen 0.281
Cd40 CD40 antigen 0.274
Fas Fas (TNF receptor superfamily member 6) 0.266
Igh immunoglobulin heavy chain complex 0.201
Btk Bruton agammaglobulinemia tyrosine kinase 0.197
Stat3 signal transducer and activator of transcription 3 0.187
Cd28 CD28 antigen 0.171
Ticam1 toll-like receptor adaptor molecule 1 0.157
Ccr6 chemokine (C-C motif) receptor 6 0.149
Tnip1 TNFAIP3 interacting protein 1 0.148
Ikzf1 IKAROS family zinc finger 1 0.147
Cd19 CD19 antigen 0.146
Socs1 suppressor of cytokine signaling 1 0.145
Pycard PYD and CARD domain containing 0.143
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.135
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.134
Gbp5 guanylate binding protein 5 0.124
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.109
Ccl4 chemokine (C-C motif) ligand 4 0.108
Birc3 baculoviral IAP repeat-containing 3 0.108
Il4 interleukin 4 0.106
Pdcd1 programmed cell death 1 0.101
Bcl6 B-cell leukemia/lymphoma 6 0.093
Bcl3 B-cell leukemia/lymphoma 3 0.091
Pou2af1 POU domain, class 2, associating factor 1 0.089
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.086
Lat linker for activation of T cells 0.084
Inpp5d inositol polyphosphate-5-phosphatase D 0.081
Tnfrsf13b tumor necrosis factor receptor superfamily, member 13b 0.078
Cdkn2d cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) 0.072
Ccr7 chemokine (C-C motif) receptor 7 0.069
Aim2 absent in melanoma 2 0.067
Clec4n C-type lectin domain family 4, member n 0.066
Il10 interleukin 10 0.065
Lta lymphotoxin A 0.059
Vav1 vav 1 oncogene 0.054
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.052
Fasl Fas ligand (TNF superfamily, member 6) 0.050
Cd14 CD14 antigen 0.047
Col11a2 collagen, type XI, alpha 2 0.045
Rag2 recombination activating gene 2 0.045
Gpr132 G protein-coupled receptor 132 0.044
Ldb3 LIM domain binding 3 0.042
Prkcd protein kinase C, delta 0.042
Ebi3 Epstein-Barr virus induced gene 3 0.041
Sfpi1 SFFV proviral integration 1 0.041
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.039
2010106G01Rik RIKEN cDNA 2010106G01 gene 0.038
Traf6 TNF receptor-associated factor 6 0.038
Notch1 Notch gene homolog 1 (Drosophila) 0.037
Il27ra interleukin 27 receptor, alpha 0.035
C1qb complement component 1, q subcomponent, beta polypeptide 0.033
Aire autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) 0.033
Pik3cg phosphoinositide-3-kinase, catalytic, gamma polypeptide 0.032
Elane elastase, neutrophil expressed 0.032
Pdcd1lg2 programmed cell death 1 ligand 2 0.032
Csf1r colony stimulating factor 1 receptor 0.031
Icos inducible T-cell co-stimulator 0.031
Cd4 CD4 antigen 0.030
Cd300ld CD300 molecule-like family member d 0.029
Hspa9 heat shock protein 9 0.028
Ifngr1 interferon gamma receptor 1 0.028
Mefv Mediterranean fever 0.027
Lck lymphocyte protein tyrosine kinase 0.026
Il4ra interleukin 4 receptor, alpha 0.026
Il1b interleukin 1 beta 0.026
Il12b interleukin 12b 0.025
Hbb-y hemoglobin Y, beta-like embryonic chain 0.025
Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 0.025
Cd86 CD86 antigen 0.025
Il1r1 interleukin 1 receptor, type I 0.024
Socs3 suppressor of cytokine signaling 3 0.024
Ccr1 chemokine (C-C motif) receptor 1 0.023
Spp1 secreted phosphoprotein 1 0.023
Psg21 pregnancy-specific glycoprotein 21 0.023
Ms4a6d membrane-spanning 4-domains, subfamily A, member 6D 0.023
Cd47 CD47 antigen (Rh-related antigen, integrin-associated signal transducer) 0.023
F2rl2 coagulation factor II (thrombin) receptor-like 2 0.023
Duox2 dual oxidase 2 0.022
Batf basic leucine zipper transcription factor, ATF-like 0.022
Pard3 par-3 (partitioning defective 3) homolog (C. elegans) 0.022
Junb Jun-B oncogene 0.021
Tlr2 toll-like receptor 2 0.020
Nlrp3 NLR family, pyrin domain containing 3 0.020
Siglece sialic acid binding Ig-like lectin E 0.020
Tlr4 toll-like receptor 4 0.020
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Rattus norvegicus
Name Description Probability Func Analog Organism
Hspe1 heat shock protein 1 (chaperonin 10) 0.014
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism