The network for 'regulation of transcription initiation from rna polymerase ii promoter' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of transcription initiation from rna polymerase ii promoter

Any process that modulates the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter.

Homo sapiens
Name Description Probability Func Analog Organism
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.553
TBP TATA box binding protein 0.519
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.474
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.449
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 0.376
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 0.368
SMAD4 SMAD family member 4 0.337
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.276
RXRA retinoid X receptor, alpha 0.205
NCOA6 nuclear receptor coactivator 6 0.183
SKIL SKI-like oncogene 0.123
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 0.118
NCOR2 nuclear receptor corepressor 2 0.113
SP1 Sp1 transcription factor 0.100
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.099
TBX5 T-box 5 0.098
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.087
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 0.084
DCP1A DCP1 decapping enzyme homolog A (S. cerevisiae) 0.081
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.070
NCOR1 nuclear receptor corepressor 1 0.053
DCP1B DCP1 decapping enzyme homolog B (S. cerevisiae) 0.053
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa 0.052
NCOA1 nuclear receptor coactivator 1 0.050
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.049
HMGB2 high mobility group box 2 0.049
MED25 mediator complex subunit 25 0.047
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.047
SSRP1 structure specific recognition protein 1 0.047
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.045
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 0.041
SUZ12 suppressor of zeste 12 homolog (Drosophila) 0.035
ARNT aryl hydrocarbon receptor nuclear translocator 0.035
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.033
KAT2B K(lysine) acetyltransferase 2B 0.032
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 0.027
SMAD2 SMAD family member 2 0.026
SMAD9 SMAD family member 9 0.024
TRIM33 tripartite motif containing 33 0.023
CREBBP CREB binding protein 0.023
HMGA1 high mobility group AT-hook 1 0.021
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 0.021
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.021
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.020
SIRT1 sirtuin 1 0.020
EP300 E1A binding protein p300 0.019
PPARA peroxisome proliferator-activated receptor alpha 0.019
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.019
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa 0.019
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa 0.017
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa 0.017
NCOA3 nuclear receptor coactivator 3 0.016
NBN nibrin 0.015
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) 0.015
RB1 retinoblastoma 1 0.015
MKL1 megakaryoblastic leukemia (translocation) 1 0.014
THUMPD1 THUMP domain containing 1 0.014
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.013
WAPAL wings apart-like homolog (Drosophila) 0.013
HDGF hepatoma-derived growth factor 0.013
AR androgen receptor 0.012
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.012
TP53BP1 tumor protein p53 binding protein 1 0.012
MED1 mediator complex subunit 1 0.011
KLHL24 kelch-like 24 (Drosophila) 0.011
SMAD3 SMAD family member 3 0.011
MDC1 mediator of DNA-damage checkpoint 1 0.011
HMGB1 high mobility group box 1 0.011
HNF4A hepatocyte nuclear factor 4, alpha 0.011
E2F1 E2F transcription factor 1 0.011
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.010
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.010
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 0.010
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Fgf8 fibroblast growth factor 8 0.862
Shh sonic hedgehog 0.685
Sox9 SRY-box containing gene 9 0.479
Gli2 GLI-Kruppel family member GLI2 0.441
Fgfr2 fibroblast growth factor receptor 2 0.349
Gli3 GLI-Kruppel family member GLI3 0.275
Pax2 paired box gene 2 0.239
Pax8 paired box gene 8 0.230
Psmd4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.198
Hand1 heart and neural crest derivatives expressed transcript 1 0.171
Foxc1 forkhead box C1 0.119
Gata4 GATA binding protein 4 0.114
Ctnnb1 catenin (cadherin associated protein), beta 1 0.082
Hand2 heart and neural crest derivatives expressed transcript 2 0.080
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.079
Rarb retinoic acid receptor, beta 0.078
Trp53 transformation related protein 53 0.064
Vax1 ventral anterior homeobox containing gene 1 0.062
Trp63 transformation related protein 63 0.059
Stat2 signal transducer and activator of transcription 2 0.052
Lhx1 LIM homeobox protein 1 0.050
Tbx1 T-box 1 0.047
Hmx3 H6 homeobox 3 0.045
Rxra retinoid X receptor alpha 0.045
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.044
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.042
Hoxd11 homeobox D11 0.041
Nkx6-1 NK6 homeobox 1 0.040
Cct3 chaperonin containing Tcp1, subunit 3 (gamma) 0.040
Bmp7 bone morphogenetic protein 7 0.039
Nog noggin 0.038
Fgfr1 fibroblast growth factor receptor 1 0.033
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.033
Ptch1 patched homolog 1 0.033
Ntf3 neurotrophin 3 0.032
Efnb2 ephrin B2 0.032
Foxa2 forkhead box A2 0.031
Rarg retinoic acid receptor, gamma 0.031
Hoxa13 homeobox A13 0.031
Hoxd13 homeobox D13 0.030
Tgfb2 transforming growth factor, beta 2 0.030
Pthlh parathyroid hormone-like peptide 0.029
Gdnf glial cell line derived neurotrophic factor 0.029
Cct7 chaperonin containing Tcp1, subunit 7 (eta) 0.027
Wnt6 wingless-related MMTV integration site 6 0.027
Wnt3a wingless-related MMTV integration site 3A 0.027
Twist2 twist homolog 2 (Drosophila) 0.026
Lhx3 LIM homeobox protein 3 0.026
Rara retinoic acid receptor, alpha 0.026
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.025
Stat3 signal transducer and activator of transcription 3 0.025
Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.025
Dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.024
Pax1 paired box gene 1 0.024
Foxc2 forkhead box C2 0.023
Pitx1 paired-like homeodomain transcription factor 1 0.023
Pitx2 paired-like homeodomain transcription factor 2 0.023
Psmc3 proteasome (prosome, macropain) 26S subunit, ATPase 3 0.023
Esr1 estrogen receptor 1 (alpha) 0.023
Msx1 homeobox, msh-like 1 0.022
Ar androgen receptor 0.021
Zeb1 zinc finger E-box binding homeobox 1 0.021
Ikzf1 IKAROS family zinc finger 1 0.021
Socs1 suppressor of cytokine signaling 1 0.021
Fgfr3 fibroblast growth factor receptor 3 0.021
Foxn1 forkhead box N1 0.021
Otx2 orthodenticle homolog 2 (Drosophila) 0.021
Mesp1 mesoderm posterior 1 0.020
Barx2 BarH-like homeobox 2 0.020
Nos3 nitric oxide synthase 3, endothelial cell 0.019
Fgf10 fibroblast growth factor 10 0.019
Kl klotho 0.018
Sfpi1 SFFV proviral integration 1 0.018
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.018
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.018
Fzd10 frizzled homolog 10 (Drosophila) 0.017
Ret ret proto-oncogene 0.017
Hoxa2 homeobox A2 0.017
Bmpr1a bone morphogenetic protein receptor, type 1A 0.017
Emx2 empty spiracles homolog 2 (Drosophila) 0.017
Col2a1 collagen, type II, alpha 1 0.017
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.016
Pten phosphatase and tensin homolog 0.016
Bcl3 B-cell leukemia/lymphoma 3 0.016
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.016
Hoxd3 homeobox D3 0.016
Ihh Indian hedgehog 0.016
T brachyury 0.016
Wnt10b wingless related MMTV integration site 10b 0.016
Psmc5 protease (prosome, macropain) 26S subunit, ATPase 5 0.016
Ghr growth hormone receptor 0.016
Hoxa11 homeobox A11 0.015
Foxd2 forkhead box D2 0.015
Prop1 paired like homeodomain factor 1 0.015
Pdx1 pancreatic and duodenal homeobox 1 0.015
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.014
Tbx2 T-box 2 0.014
Adra2b adrenergic receptor, alpha 2b 0.014
Apc adenomatosis polyposis coli 0.014
Lef1 lymphoid enhancer binding factor 1 0.014
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Rattus norvegicus
Name Description Probability Func Analog Organism
Psmc1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.988
Psmd2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.408
Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.398
Psmd4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.333
Vcp valosin-containing protein 0.327
Psmc4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.253
Psmc5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.226
Cct3 chaperonin containing Tcp1, subunit 3 (gamma) 0.194
Psmc3 proteasome (prosome, macropain) 26S subunit, ATPase 3 0.190
Psmd13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.104
Csnk2b casein kinase 2, beta polypeptide 0.087
Psmd7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 0.077
Nsfl1c NSFL1 (p97) cofactor (p47) 0.076
Nup153 nucleoporin 153 0.064
Dhx15 DEAH (Asp-Glu-Ala-His) box polypeptide 15 0.057
Prmt1 protein arginine methyltransferase 1 0.042
Psmb5 proteasome (prosome, macropain) subunit, beta type 5 0.037
Phb prohibitin 0.032
Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 0.030
Pfdn2 prefoldin subunit 2 0.025
Psmd11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.022
Kars lysyl-tRNA synthetase 0.019
Nudc nuclear distribution gene C homolog (A. nidulans) 0.018
Arnt aryl hydrocarbon receptor nuclear translocator 0.017
Psmd1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.017
Baz1a bromodomain adjacent to zinc finger domain, 1A 0.017
Racgap1 Rac GTPase-activating protein 1 0.017
Lin7c lin-7 homolog C (C. elegans) 0.015
Tcp11 t-complex protein 11 0.015
Stip1 stress-induced phosphoprotein 1 0.014
Taf6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor 0.013
Cct5 chaperonin containing Tcp1, subunit 5 (epsilon) 0.013
Rara retinoic acid receptor, alpha 0.013
LOC293989 cytochrome P450-like 0.013
Etf1 eukaryotic translation termination factor 1 0.012
Hnrnpu heterogeneous nuclear ribonucleoprotein U 0.012
Sfrs3 splicing factor, arginine/serine-rich 3 0.012
Aimp1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 0.011
Plrg1 pleiotropic regulator 1, PRL1 homolog (Arabidopsis) 0.011
Crybb3 crystallin, beta B3 0.011
Dbh dopamine beta-hydroxylase (dopamine beta-monooxygenase) 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
SPT16 Spt16p 0.984
SPT5 Spt5p 0.868
RPT6 Rpt6p 0.409
TAF5 Taf5p 0.408
TAF6 Taf6p 0.381
RPT2 Rpt2p 0.365
RPN1 Rpn1p 0.362
TAF12 Taf12p 0.335
CTR9 Ctr9p 0.299
CHD1 Chd1p 0.292
TAF10 Taf10p 0.276
RTF1 Rtf1p 0.275
RPT5 Rpt5p 0.241
NGG1 Ngg1p 0.234
RPN2 Rpn2p 0.193
SPT6 Spt6p 0.187
LEO1 Leo1p 0.174
TFG1 Tfg1p 0.174
MOT1 Mot1p 0.172
RSC4 Rsc4p 0.163
SPT8 Spt8p 0.145
RPT1 Rpt1p 0.139
SUS1 Sus1p 0.131
TRA1 Tra1p 0.120
TFG2 Tfg2p 0.120
SEM1 Sem1p 0.119
SET2 Set2p 0.101
TAF4 Taf4p 0.097
RPN9 Rpn9p 0.094
RPN6 Rpn6p 0.091
RAD23 Rad23p 0.084
TAF8 Taf8p 0.079
ADA2 Ada2p 0.076
RPN7 Rpn7p 0.065
SKI3 Ski3p 0.061
RPT4 Rpt4p 0.059
TIF4632 Tif4632p 0.058
RPT3 Rpt3p 0.052
SPT7 Spt7p 0.050
HDA2 Hda2p 0.048
INO80 Ino80p 0.043
SPN1 Spn1p 0.042
TAF7 Taf7p 0.039
RPN3 Rpn3p 0.038
ISW1 Isw1p 0.038
HHT1 Hht1p 0.038
RPO21 Rpo21p 0.037
TFA1 Tfa1p 0.037
BUR6 Bur6p 0.036
SRD1 Srd1p 0.036
SWI1 Swi1p 0.035
RSC8 Rsc8p 0.034
TAF9 Taf9p 0.034
WWM1 Wwm1p 0.034
RPN13 Rpn13p 0.033
CKA1 Cka1p 0.033
YLR264C-A hypothetical protein 0.033
LEU2 Leu2p 0.031
POB3 Pob3p 0.031
YLR162W hypothetical protein 0.030
YIL151C hypothetical protein 0.029
REB1 Reb1p 0.029
YOL038C-A hypothetical protein 0.028
HXT3 Hxt3p 0.028
STH1 Sth1p 0.027
ARG8 Arg8p 0.027
MER1 Mer1p 0.026
SPT20 Spt20p 0.026
DLS1 Dls1p 0.026
IOC4 Ioc4p 0.026
TAE2 Tae2p 0.026
ARP10 Arp10p 0.026
YPR157W hypothetical protein 0.025
RPN10 Rpn10p 0.024
URA3 Ura3p 0.024
YGR017W hypothetical protein 0.024
HO Hop 0.024
ECM29 Ecm29p 0.024
YAR068W hypothetical protein 0.024
CHA1 Cha1p 0.024
PRS2 Prs2p 0.023
YLR042C hypothetical protein 0.023
ATP6 Atp6p 0.023
HPF1 Hpf1p 0.022
CUP1-1 Cup1-1p 0.022
SPL2 Spl2p 0.022
IOC2 Ioc2p 0.022
SWC7 Swc7p 0.022
NUP49 Nup49p 0.021
UFO1 Ufo1p 0.021
AUA1 Aua1p 0.021
AQY2 Aqy2p 0.021
TAF3 Taf3p 0.021
FMT1 Fmt1p 0.020
YBR013C hypothetical protein 0.020
SCM4 Scm4p 0.020
YOL013W-A hypothetical protein 0.020
ADH2 Adh2p 0.020
SUA7 Sua7p 0.020
SCD6 Scd6p 0.019