The network for 'positive regulation of myeloid leukocyte differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of myeloid leukocyte differentiation

Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation.

Homo sapiens
Name Description Probability Func Analog Organism
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.000
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.999
BIRC3 baculoviral IAP repeat containing 3 0.998
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.998
RIPK2 receptor-interacting serine-threonine kinase 2 0.997
XIAP X-linked inhibitor of apoptosis 0.996
BIRC2 baculoviral IAP repeat containing 2 0.995
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.992
CFLAR CASP8 and FADD-like apoptosis regulator 0.972
TRAF1 TNF receptor-associated factor 1 0.960
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.922
FAS Fas (TNF receptor superfamily, member 6) 0.903
CCR5 chemokine (C-C motif) receptor 5 0.867
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.835
TRAF3 TNF receptor-associated factor 3 0.762
SH2D4A SH2 domain containing 4A 0.757
CCR2 chemokine (C-C motif) receptor 2 0.705
FASLG Fas ligand (TNF superfamily, member 6) 0.693
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.676
EP300 E1A binding protein p300 0.663
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.592
CCL4 chemokine (C-C motif) ligand 4 0.529
IFNG interferon, gamma 0.515
CXCL10 chemokine (C-X-C motif) ligand 10 0.464
CCL5 chemokine (C-C motif) ligand 5 0.439
NOTCH1 notch 1 0.425
IL2RB interleukin 2 receptor, beta 0.417
APAF1 apoptotic peptidase activating factor 1 0.399
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.369
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.363
CXCL9 chemokine (C-X-C motif) ligand 9 0.360
IL8 interleukin 8 0.359
CXCL2 chemokine (C-X-C motif) ligand 2 0.358
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.354
IL10 interleukin 10 0.338
CXCR3 chemokine (C-X-C motif) receptor 3 0.336
CXCL11 chemokine (C-X-C motif) ligand 11 0.332
IL23A interleukin 23, alpha subunit p19 0.324
CASP7 caspase 7, apoptosis-related cysteine peptidase 0.309
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.284
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.274
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.266
CXCL5 chemokine (C-X-C motif) ligand 5 0.264
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.236
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.223
CCR7 chemokine (C-C motif) receptor 7 0.220
HDAC6 histone deacetylase 6 0.205
IL1B interleukin 1, beta 0.182
CXCL6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.177
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.159
CCL8 chemokine (C-C motif) ligand 8 0.158
IRF4 interferon regulatory factor 4 0.155
CTBP1 C-terminal binding protein 1 0.155
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.154
RBL1 retinoblastoma-like 1 (p107) 0.145
BBS10 Bardet-Biedl syndrome 10 0.133
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.132
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.131
RIPK3 receptor-interacting serine-threonine kinase 3 0.126
ZMYND11 zinc finger, MYND-type containing 11 0.124
CXCL13 chemokine (C-X-C motif) ligand 13 0.124
CCR4 chemokine (C-C motif) receptor 4 0.121
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.121
ATF2 activating transcription factor 2 0.120
JUND jun D proto-oncogene 0.116
NLRC4 NLR family, CARD domain containing 4 0.113
NUMBL numb homolog (Drosophila)-like 0.111
IDE insulin-degrading enzyme 0.097
LRDD leucine-rich repeats and death domain containing 0.093
CXCR6 chemokine (C-X-C motif) receptor 6 0.089
CCL20 chemokine (C-C motif) ligand 20 0.086
CCL7 chemokine (C-C motif) ligand 7 0.083
CCR1 chemokine (C-C motif) receptor 1 0.081
IL16 interleukin 16 (lymphocyte chemoattractant factor) 0.081
WIPF1 WAS/WASL interacting protein family, member 1 0.080
JAG1 jagged 1 0.079
CYBB cytochrome b-245, beta polypeptide 0.077
RUNX3 runt-related transcription factor 3 0.075
ING2 inhibitor of growth family, member 2 0.074
CCL3 chemokine (C-C motif) ligand 3 0.070
CCL22 chemokine (C-C motif) ligand 22 0.068
FADD Fas (TNFRSF6)-associated via death domain 0.067
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 0.066
RAI1 retinoic acid induced 1 0.064
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.064
ZNRD1 zinc ribbon domain containing 1 0.064
IL6 interleukin 6 (interferon, beta 2) 0.063
DIABLO diablo, IAP-binding mitochondrial protein 0.062
CD40 CD40 molecule, TNF receptor superfamily member 5 0.061
HIPK2 homeodomain interacting protein kinase 2 0.061
LTA lymphotoxin alpha (TNF superfamily, member 1) 0.060
MGEA5 meningioma expressed antigen 5 (hyaluronidase) 0.059
ELF4 E74-like factor 4 (ets domain transcription factor) 0.059
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 0.057
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.057
CCL2 chemokine (C-C motif) ligand 2 0.056
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 0.054
CXCL3 chemokine (C-X-C motif) ligand 3 0.052
TNF tumor necrosis factor 0.050
TCF4 transcription factor 4 0.050
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
junbl jun B proto-oncogene, like 0.176
mpx myeloid-specific peroxidase 0.066
ltk leukocyte tyrosine kinase 0.048
mitfa microphthalmia-associated transcription factor a 0.043
cmyb transcription factor cmyb 0.041
socs3a suppressor of cytokine signaling 3a 0.035
LOC100331484 hypothetical protein LOC100331484 0.034
atp6v0d1 ATPase, H+ transporting, V0 subunit D isoform 1 0.029
tal1 T-cell acute lymphocytic leukemia 1 0.028
gadd45ba growth arrest and DNA-damage-inducible, beta a 0.028
cx43 connexin 43 0.025
spi1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.024
junb jun B proto-oncogene 0.024
wu:fv91b12 wu:fv91b12 0.023
atf3 activating transcription factor 3 0.020
csf1ra colony stimulating factor 1 receptor, a 0.017
tgfbi transforming growth factor, beta-induced 0.016
si:dkey-181m9.9 si:dkey-181m9.9 0.016
zgc:63523 zgc:63523 0.016
coro1a coronin, actin binding protein, 1A 0.015
clic2 chloride intracellular channel 2 0.015
pnp4a purine nucleoside phosphorylase 4a 0.014
krml2.2 Kreisler (mouse) maf-related leucine zipper homolog 2.2 0.014
hhip hedgehog interacting protein 0.014
phlda2 pleckstrin homology-like domain, family A, member 2 0.013
kita kit receptor a 0.013
zgc:92851 zgc:92851 0.013
atp6v0ca ATPase, H+ transporting, lysosomal, V0 subunit c, a 0.013
ldha lactate dehydrogenase A4 0.013
slc4a1a solute carrier family 4, anion exchanger, member 1a 0.012
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.012
safb scaffold attachment factor B 0.012
sltm SAFB-like, transcription modulator 0.011
LOC100000332 e3 ubiquitin-protein ligase RNF182-like 0.011
mmrn2a multimerin 2a 0.011
igf1 insulin-like growth factor 1 0.011
sf3b1 splicing factor 3b, subunit 1 0.010
snai1a snail homolog 1a (Drosophila) 0.010
rarga retinoic acid receptor gamma a 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Notch1 Notch gene homolog 1 (Drosophila) 0.981
Tnf tumor necrosis factor 0.955
Jun Jun oncogene 0.912
Tgfb1 transforming growth factor, beta 1 0.818
Ptgs2 prostaglandin-endoperoxide synthase 2 0.810
Lepr leptin receptor 0.793
Id1 inhibitor of DNA binding 1 0.770
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.765
Fos FBJ osteosarcoma oncogene 0.759
Ikzf1 IKAROS family zinc finger 1 0.745
Ctnnb1 catenin (cadherin associated protein), beta 1 0.730
Stat3 signal transducer and activator of transcription 3 0.728
Trp53 transformation related protein 53 0.689
Id3 inhibitor of DNA binding 3 0.677
Psen1 presenilin 1 0.665
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.662
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.648
Egr1 early growth response 1 0.631
Stat5a signal transducer and activator of transcription 5A 0.603
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.593
Smad3 MAD homolog 3 (Drosophila) 0.559
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.554
Dll1 delta-like 1 (Drosophila) 0.538
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.528
Btk Bruton agammaglobulinemia tyrosine kinase 0.522
Csf1 colony stimulating factor 1 (macrophage) 0.485
Pten phosphatase and tensin homolog 0.403
Col1a1 collagen, type I, alpha 1 0.391
Igh immunoglobulin heavy chain complex 0.390
Cav1 caveolin 1, caveolae protein 0.371
Notch2 Notch gene homolog 2 (Drosophila) 0.366
Hif1a hypoxia inducible factor 1, alpha subunit 0.331
Gata1 GATA binding protein 1 0.329
Zfp36 zinc finger protein 36 0.314
Ncoa3 nuclear receptor coactivator 3 0.311
Cyld cylindromatosis (turban tumor syndrome) 0.308
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.287
Tcf4 transcription factor 4 0.277
Irf9 interferon regulatory factor 9 0.277
Ldb3 LIM domain binding 3 0.263
Hes1 hairy and enhancer of split 1 (Drosophila) 0.256
Kit kit oncogene 0.253
Tcf3 transcription factor 3 0.249
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.246
Id2 inhibitor of DNA binding 2 0.246
Fas Fas (TNF receptor superfamily member 6) 0.245
Casp8 caspase 8 0.243
Junb Jun-B oncogene 0.215
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.208
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.197
Nckap1l NCK associated protein 1 like 0.194
Klf4 Kruppel-like factor 4 (gut) 0.193
Cd44 CD44 antigen 0.193
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.192
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.191
Rbl2 retinoblastoma-like 2 0.180
Gata3 GATA binding protein 3 0.179
Pparg peroxisome proliferator activated receptor gamma 0.169
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.169
Itgb3 integrin beta 3 0.156
Dusp1 dual specificity phosphatase 1 0.154
Fgfr2 fibroblast growth factor receptor 2 0.151
Ltb lymphotoxin B 0.151
Klf6 Kruppel-like factor 6 0.150
Atf3 activating transcription factor 3 0.149
Mcl1 myeloid cell leukemia sequence 1 0.143
Nfil3 nuclear factor, interleukin 3, regulated 0.139
Fgd1 FYVE, RhoGEF and PH domain containing 1 0.138
Ccl4 chemokine (C-C motif) ligand 4 0.136
Cd40 CD40 antigen 0.135
Skil SKI-like 0.134
Il6st interleukin 6 signal transducer 0.129
Ets1 E26 avian leukemia oncogene 1, 5' domain 0.128
Btg2 B-cell translocation gene 2, anti-proliferative 0.122
Msx2 homeobox, msh-like 2 0.121
P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 0.121
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.119
Stat5b signal transducer and activator of transcription 5B 0.117
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.117
Il10 interleukin 10 0.116
Ikbkb inhibitor of kappaB kinase beta 0.115
Smad1 MAD homolog 1 (Drosophila) 0.110
Jak3 Janus kinase 3 0.110
Psen2 presenilin 2 0.108
Myd88 myeloid differentiation primary response gene 88 0.106
Src Rous sarcoma oncogene 0.105
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.105
Fadd Fas (TNFRSF6)-associated via death domain 0.104
Apaf1 apoptotic peptidase activating factor 1 0.103
Nos2 nitric oxide synthase 2, inducible 0.103
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.101
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.099
Egr2 early growth response 2 0.098
Smad4 MAD homolog 4 (Drosophila) 0.095
Ahr aryl-hydrocarbon receptor 0.093
Grap2 GRB2-related adaptor protein 2 0.093
Il12b interleukin 12b 0.092
Runx2 runt related transcription factor 2 0.091
Twsg1 twisted gastrulation homolog 1 (Drosophila) 0.089
Tcirg1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 0.089
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Rattus norvegicus
Name Description Probability Func Analog Organism
Dusp1 dual specificity phosphatase 1 0.830
Klf4 Kruppel-like factor 4 (gut) 0.512
Fcn1 ficolin (collagen/fibrinogen domain containing) 1 0.379
Egr1 early growth response 1 0.352
Prf1 perforin 1 (pore forming protein) 0.197
Ier2 immediate early response 2 0.171
Ddx17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 0.125
Cd247 Cd247 molecule 0.104
Il2rb interleukin 2 receptor, beta 0.096
Casp2 caspase 2 0.091
Fos FBJ osteosarcoma oncogene 0.090
Btg2 BTG family, member 2 0.087
Mag myelin-associated glycoprotein 0.081
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.076
Il1b interleukin 1 beta 0.063
Junb jun B proto-oncogene 0.062
Cd2 Cd2 molecule 0.057
Cd3e CD3 molecule, epsilon 0.053
Gfra2 GDNF family receptor alpha 2 0.051
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.048
Ccl4 chemokine (C-C motif) ligand 4 0.047
Atf3 activating transcription factor 3 0.046
Xcl1 chemokine (C motif) ligand 1 0.043
Axl Axl receptor tyrosine kinase 0.041
Nr4a1 nuclear receptor subfamily 4, group A, member 1 0.038
Plek pleckstrin 0.037
Cd8a CD8a molecule 0.036
RGD1359529 similar to chromosome 1 open reading frame 63 0.036
Egr2 early growth response 2 0.035
C4b complement component 4B (Chido blood group) 0.032
Myd88 myeloid differentiation primary response gene 88 0.031
Errfi1 ERBB receptor feedback inhibitor 1 0.031
Mmp3 matrix metallopeptidase 3 0.030
Cfp complement factor properdin 0.030
Reg3b regenerating islet-derived 3 beta 0.030
Acacb acetyl-Coenzyme A carboxylase beta 0.029
Cela1 chymotrypsin-like elastase family, member 1 0.028
Zfp36 zinc finger protein 36 0.027
Mrc1 mannose receptor, C type 1 0.027
Cst7 cystatin F (leukocystatin) 0.027
Fgfr2 fibroblast growth factor receptor 2 0.026
Ppp1r15a protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.026
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.026
Stx11 syntaxin 11 0.024
Ccl19 chemokine (C-C motif) ligand 19 0.023
Il1a interleukin 1 alpha 0.023
Ivl involucrin 0.023
Gzmk granzyme K 0.022
Guca2a guanylate cyclase activator 2a (guanylin) 0.021
Jun Jun oncogene 0.021
Inmt indolethylamine N-methyltransferase 0.020
Dnase1l3 deoxyribonuclease 1-like 3 0.020
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.019
Calcrl calcitonin receptor-like 0.019
Kdr kinase insert domain receptor 0.019
Adora2a adenosine A2a receptor 0.018
Erp27 endoplasmic reticulum protein 27 0.018
Ccl7 chemokine (C-C motif) ligand 7 0.018
Tcrb T-cell receptor beta chain 0.018
Ccl3 chemokine (C-C motif) ligand 3 0.017
F13a1 coagulation factor XIII, A1 polypeptide 0.016
Dusp6 dual specificity phosphatase 6 0.016
Ctsw cathepsin W 0.016
Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.016
Cd86 CD86 molecule 0.016
Ccl6 chemokine (C-C motif) ligand 6 0.016
Lst1 leukocyte specific transcript 1 0.016
Pla2g2a phospholipase A2, group IIA (platelets, synovial fluid) 0.015
Nos3 nitric oxide synthase 3, endothelial cell 0.015
Cd40 CD40 molecule, TNF receptor superfamily member 5 0.015
Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 0.015
Il8rb interleukin 8 receptor, beta 0.014
Klk6 kallikrein related-peptidase 6 0.014
Clph casein-like phosphoprotein 0.014
Nkd1 naked cuticle homolog 1 (Drosophila) 0.014
Nkg7 natural killer cell group 7 sequence 0.014
Mycbp2 MYC binding protein 2 0.014
Notch2 Notch homolog 2 (Drosophila) 0.014
Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 0.013
Icam2 intercellular adhesion molecule 2 0.013
Tfec transcription factor EC 0.013
S100a8 S100 calcium binding protein A8 0.013
Gfi1 growth factor independent 1 transcription repressor 0.013
Tgm1 transglutaminase 1, K polypeptide 0.013
Gm2a GM2 ganglioside activator 0.012
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.012
Fut2 fucosyltransferase 2 (secretor status included) 0.011
Rassf1 Ras association (RalGDS/AF-6) domain family member 1 0.011
Gp5 glycoprotein V (platelet) 0.011
Ces1d carboxylesterase 1D 0.011
P2ry14 purinergic receptor P2Y, G-protein coupled, 14 0.011
Mobp myelin-associated oligodendrocyte basic protein 0.011
Gzma granzyme A 0.011
Tcf12 transcription factor 12 0.011
Nfib nuclear factor I/B 0.011
Smad1 SMAD family member 1 0.010
Psgb1 pregnancy-specific beta 1-glycoprotein 0.010
Igsf6 immunoglobulin superfamily, member 6 0.010
Trem2 triggering receptor expressed on myeloid cells 2 0.010
RT1-A3 RT1 class I, locus A3 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism