The network for 'neural crest cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

neural crest cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell.

Mus musculus
Name Description Probability Func Analog Organism
Fgfr2 fibroblast growth factor receptor 2 1.000
Shh sonic hedgehog 0.999
Otx2 orthodenticle homolog 2 (Drosophila) 0.998
Pax3 paired box gene 3 0.995
Foxg1 forkhead box G1 0.995
Fgf8 fibroblast growth factor 8 0.991
Tbx3 T-box 3 0.990
Hand2 heart and neural crest derivatives expressed transcript 2 0.990
Pitx2 paired-like homeodomain transcription factor 2 0.987
Isl1 ISL1 transcription factor, LIM/homeodomain 0.987
Gli3 GLI-Kruppel family member GLI3 0.987
Vegfa vascular endothelial growth factor A 0.985
Msx1 homeobox, msh-like 1 0.982
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.979
Bmp4 bone morphogenetic protein 4 0.974
Tbx1 T-box 1 0.970
Hand1 heart and neural crest derivatives expressed transcript 1 0.968
Tcfap2a transcription factor AP-2, alpha 0.967
Tgfb2 transforming growth factor, beta 2 0.960
Hoxa1 homeobox A1 0.946
Acvr1 activin A receptor, type 1 0.943
Neurog2 neurogenin 2 0.941
Hoxa2 homeobox A2 0.934
Eya1 eyes absent 1 homolog (Drosophila) 0.931
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.915
Gata4 GATA binding protein 4 0.908
Dlx5 distal-less homeobox 5 0.904
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.904
Gata6 GATA binding protein 6 0.901
Chrd chordin 0.901
Neurod1 neurogenic differentiation 1 0.898
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.893
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.893
En1 engrailed 1 0.874
Gdnf glial cell line derived neurotrophic factor 0.870
Tlx3 T-cell leukemia, homeobox 3 0.865
Bdnf brain derived neurotrophic factor 0.857
Gbx2 gastrulation brain homeobox 2 0.837
Zic3 zinc finger protein of the cerebellum 3 0.831
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.824
Nodal nodal 0.822
Pax2 paired box gene 2 0.822
Sox2 SRY-box containing gene 2 0.807
Prrx1 paired related homeobox 1 0.797
Foxc1 forkhead box C1 0.779
Meox2 mesenchyme homeobox 2 0.765
Gsc goosecoid homeobox 0.761
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.756
Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 0.740
Pax6 paired box gene 6 0.727
Runx2 runt related transcription factor 2 0.727
Jag1 jagged 1 0.726
Phox2b paired-like homeobox 2b 0.723
Smad6 MAD homolog 6 (Drosophila) 0.687
Snai1 snail homolog 1 (Drosophila) 0.666
Vangl2 vang-like 2 (van gogh, Drosophila) 0.662
Prrx2 paired related homeobox 2 0.657
Lhx3 LIM homeobox protein 3 0.650
Nog noggin 0.635
Efnb2 ephrin B2 0.622
Sox3 SRY-box containing gene 3 0.620
Sema3f sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 0.608
Hes5 hairy and enhancer of split 5 (Drosophila) 0.584
Fgf10 fibroblast growth factor 10 0.582
Efna2 ephrin A2 0.578
Sox10 SRY-box containing gene 10 0.576
Smad4 MAD homolog 4 (Drosophila) 0.570
Hmx3 H6 homeobox 3 0.559
Cer1 cerberus 1 homolog (Xenopus laevis) 0.547
Wnt6 wingless-related MMTV integration site 6 0.532
Ednra endothelin receptor type A 0.527
Axin1 axin 1 0.514
Ptf1a pancreas specific transcription factor, 1a 0.509
Tbx2 T-box 2 0.503
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.500
Ctnnb1 catenin (cadherin associated protein), beta 1 0.495
Chd7 chromodomain helicase DNA binding protein 7 0.487
Pax9 paired box gene 9 0.482
Uncx UNC homeobox 0.466
Foxc2 forkhead box C2 0.464
Tgfbr2 transforming growth factor, beta receptor II 0.464
Wnt5a wingless-related MMTV integration site 5A 0.462
Sox4 SRY-box containing gene 4 0.448
T brachyury 0.446
Fgfr1 fibroblast growth factor receptor 1 0.440
Emx1 empty spiracles homolog 1 (Drosophila) 0.439
Bmpr1a bone morphogenetic protein receptor, type 1A 0.426
Notch2 Notch gene homolog 2 (Drosophila) 0.424
She src homology 2 domain-containing transforming protein E 0.419
Wnt3a wingless-related MMTV integration site 3A 0.414
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.403
Mecom MDS1 and EVI1 complex locus 0.394
Msx2 homeobox, msh-like 2 0.390
Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 0.387
Hoxd13 homeobox D13 0.382
Sox9 SRY-box containing gene 9 0.379
Nhlh1 nescient helix loop helix 1 0.375
Fzd1 frizzled homolog 1 (Drosophila) 0.369
Wnt7a wingless-related MMTV integration site 7A 0.369
Wt1 Wilms tumor 1 homolog 0.367
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
tbx1 T-box 1 0.997
foxi1 forkhead box I1 0.997
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.997
sox10 SRY-box containing gene 10 0.981
notch1a notch homolog 1a 0.948
pax2a paired box gene 2a 0.942
mib mind bomb 0.936
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.922
dla deltaA 0.922
zic2a zic family member 2 (odd-paired homolog, Drosophila), a 0.921
shha sonic hedgehog a 0.892
dlx2a distal-less homeobox gene 2a 0.884
dld deltaD 0.858
eya1 eyes absent homolog 1 0.844
pax6b paired box gene 6b 0.834
foxa3 forkhead box A3 0.829
tll1 tolloid-like 1 0.818
twist1a twist1a 0.796
wu:fv91b12 wu:fv91b12 0.785
gsc goosecoid 0.779
bmp2b bone morphogenetic protein 2b 0.765
her1 hairy-related 1 0.747
lef1 lymphocyte enhancer binding factor 1 0.743
hnf1ba HNF1 homeobox Ba 0.693
crabp2a cellular retinoic acid binding protein 2, a 0.675
crestin crestin 0.650
fgf8a fibroblast growth factor 8 a 0.647
bmp4 bone morphogenetic protein 4 0.643
mitfa microphthalmia-associated transcription factor a 0.630
dlb deltaB 0.581
erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog 0.577
jag1b jagged 1b 0.554
oep one-eyed pinhead 0.541
flh floating head 0.521
sox2 SRY-box containing gene 2 0.511
gata3 GATA-binding protein 3 0.510
myf5 myogenic factor 5 0.506
wnt11 wingless-type MMTV integration site family, member 11 0.503
otx1b orthodenticle homolog 1b 0.501
tp63 tumor protein p63 0.489
rerea arginine-glutamic acid dipeptide (RE) repeats a 0.486
hand2 heart and neural crest derivatives expressed transcript 2 0.484
tfap2a transcription factor AP-2 alpha 0.481
msxe muscle segment homeobox E 0.478
sox9a SRY-box containing gene 9a 0.466
pitx2 paired-like homeodomain transcription factor 2 0.464
rest RE1-silencing transcription factor 0.464
gata5 GATA-binding protein 5 0.462
fgf3 fibroblast growth factor 3 0.455
celsr1a cadherin EGF LAG seven-pass G-type receptor 1a 0.443
cdx4 caudal type homeo box transcription factor 4 0.436
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.434
spns2 spinster homolog 2 (Drosophila) 0.434
sema3aa semaphorin 3aa 0.429
prdm1a PR domain containing 1a, with ZNF domain 0.426
kita kit receptor a 0.411
gpr126 G protein-coupled receptor 126 0.407
six3b sine oculis homeobox homolog 3b 0.405
mecom MDS1 and EVI1 complex locus 0.397
pax9 paired box gene 9 0.391
bmper BMP binding endothelial regulator 0.382
egr2b early growth response 2b 0.378
cdh6 cadherin 6 0.376
rarga retinoic acid receptor gamma a 0.354
foxc1a forkhead box C1a 0.351
otx2 orthodenticle homolog 2 0.341
dlc deltaC 0.326
tgfb3 transforming growth factor, beta 3 0.324
cxcr4a chemokine (C-X-C motif) receptor 4a 0.321
tfeb transcription factor EB 0.312
irx3a iroquois homeobox protein 3a 0.310
myod1 myogenic differentiation 1 0.307
snai1b snail homolog 1b (Drosophila) 0.302
pax7a paired box gene 7a 0.301
sox1a SRY-box containing gene 1a 0.291
rx3 retinal homeobox gene 3 0.281
foxd3 forkhead box D3 0.280
col15a1b collagen, type XV, alpha 1b 0.280
dct dopachrome tautomerase 0.277
six3a sine oculis homeobox homolog 3a 0.273
sema3fa semaphorin 3fa 0.273
dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.272
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.271
tmem2 transmembrane protein 2 0.270
fn1 fibronectin 1 0.266
emx3 empty spiracles homeobox 3 0.264
pea3 ETS-domain transcription factor pea3 0.264
tbx16 T-box gene 16 0.258
neurod neurogenic differentiation 0.257
gria1a glutamate receptor, ionotropic, AMPA 1a 0.253
nrg1 neuregulin 1 0.251
her6 hairy-related 6 0.251
ntla no tail a 0.248
cdh2 cadherin 2, neuronal 0.241
mef2cb myocyte enhancer factor 2cb 0.236
rx2 retinal homeobox gene 2 0.236
ndr2 nodal-related 2 0.235
tfec transcription factor EC 0.233
fzd7b frizzled homolog 7b 0.231
tp53 tumor protein p53 0.229
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
EGFR epidermal growth factor receptor 0.939
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.909
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.463
POU5F1 POU class 5 homeobox 1 0.250
BBS10 Bardet-Biedl syndrome 10 0.160
PAX3 paired box 3 0.146
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.088
NOTCH3 notch 3 0.066
POU3F2 POU class 3 homeobox 2 0.063
SMAD3 SMAD family member 3 0.058
EP300 E1A binding protein p300 0.056
NOTCH1 notch 1 0.052
BMP2 bone morphogenetic protein 2 0.050
MEF2A myocyte enhancer factor 2A 0.050
SOX10 SRY (sex determining region Y)-box 10 0.047
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.043
MEOX2 mesenchyme homeobox 2 0.039
ESR1 estrogen receptor 1 0.038
SKIL SKI-like oncogene 0.037
SETD8 SET domain containing (lysine methyltransferase) 8 0.036
EIF2C2 eukaryotic translation initiation factor 2C, 2 0.030
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.029
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.029
APP amyloid beta (A4) precursor protein 0.024
EPAS1 endothelial PAS domain protein 1 0.021
HIPK2 homeodomain interacting protein kinase 2 0.021
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.020
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.020
PIAS1 protein inhibitor of activated STAT, 1 0.020
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.020
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.020
VEGFA vascular endothelial growth factor A 0.018
TNRC6A trinucleotide repeat containing 6A 0.018
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.017
JAG1 jagged 1 0.017
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.015
AR androgen receptor 0.014
PTCH1 patched 1 0.013
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.013
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.012
TECPR1 tectonin beta-propeller repeat containing 1 0.012
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.011
DKK1 dickkopf homolog 1 (Xenopus laevis) 0.011
SOX2 SRY (sex determining region Y)-box 2 0.011
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.011
NOTCH2 notch 2 0.010
SIRT1 sirtuin 1 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Igfbp5 insulin-like growth factor binding protein 5 0.231
Marcks myristoylated alanine rich protein kinase C substrate 0.179
Slc4a4 solute carrier family 4, sodium bicarbonate cotransporter, member 4 0.165
Prelid1 PRELI domain containing 1 0.163
Gata6 GATA binding protein 6 0.136
Fgfr2 fibroblast growth factor receptor 2 0.114
Itga1 integrin, alpha 1 0.105
Lepr leptin receptor 0.098
Slc1a3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.083
Ptprz1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.074
Col9a1 collagen, type IX, alpha 1 0.072
Cald1 caldesmon 1 0.064
Rbm42 RNA binding motif protein 42 0.064
Fgf1 fibroblast growth factor 1 0.064
Foxi2 forkhead box I2 0.063
Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 0.063
Ednra endothelin receptor type A 0.062
Grip1 glutamate receptor interacting protein 1 0.061
Slc6a6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 0.057
Lphn2 latrophilin 2 0.056
Aqp4 aquaporin 4 0.054
Dab2 disabled homolog 2 (Drosophila) 0.053
Calcrl calcitonin receptor-like 0.051
Slco2a1 solute carrier organic anion transporter family, member 2a1 0.051
Wdr1 WD repeat domain 1 0.050
Irs1 insulin receptor substrate 1 0.050
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.048
Cpxm2 carboxypeptidase X (M14 family), member 2 0.047
Tgfbr2 transforming growth factor, beta receptor II 0.046
Ehf ets homologous factor 0.046
Add3 adducin 3 (gamma) 0.046
Ddr2 discoidin domain receptor tyrosine kinase 2 0.046
Pde5a phosphodiesterase 5A, cGMP-specific 0.044
Ceacam1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.044
Dchs1 dachsous 1 (Drosophila) 0.044
Tuba1c tubulin, alpha 1C 0.044
Hrh1 histamine receptor H 1 0.043
Ddr1 discoidin domain receptor tyrosine kinase 1 0.043
Nradd neurotrophin receptor associated death domain 0.043
S1pr2 sphingosine-1-phosphate receptor 2 0.043
Ap2m1 adaptor-related protein complex 2, mu 1 subunit 0.042
Fgd4 FYVE, RhoGEF and PH domain containing 4 0.041
Ddah1 dimethylarginine dimethylaminohydrolase 1 0.041
Map2 microtubule-associated protein 2 0.040
Pdha2 pyruvate dehydrogenase (lipoamide) alpha 2 0.040
F13a1 coagulation factor XIII, A1 polypeptide 0.039
Kcnj16 potassium inwardly-rectifying channel, subfamily J, member 16 0.039
Col12a1 collagen, type XII, alpha 1 0.039
Bmp4 bone morphogenetic protein 4 0.038
Hand2 heart and neural crest derivatives expressed 2 0.038
Grk1 G protein-coupled receptor kinase 1 0.038
Arhgap23 Rho GTPase activating protein 23 0.036
Nfia nuclear factor I/A 0.036
Pick1 protein interacting with PRKCA 1 0.036
Six1 SIX homeobox 1 0.035
Cd8b CD8b molecule 0.034
Htr1b 5-hydroxytryptamine (serotonin) receptor 1B 0.034
Gpc3 glypican 3 0.034
Yars tyrosyl-tRNA synthetase 0.033
Grb7 growth factor receptor bound protein 7 0.033
Sptbn1 spectrin, beta, non-erythrocytic 1 0.033
Bmpr1a bone morphogenetic protein receptor, type IA 0.033
Cdc2l5 cell division cycle 2-like 5 (cholinesterase-related cell division controller) 0.033
Vhl von Hippel-Lindau tumor suppressor 0.033
Insr insulin receptor 0.033
Slc4a2 solute carrier family 4 (anion exchanger), member 2 0.033
Plcb1 phospholipase C, beta 1 (phosphoinositide-specific) 0.032
Cadm1 cell adhesion molecule 1 0.032
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.031
Rfc1 replication factor C (activator 1) 1 0.031
Gast gastrin 0.031
Slc7a2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.031
Trove2 TROVE domain family, member 2 0.031
Chrnb2 cholinergic receptor, nicotinic, beta 2 (neuronal) 0.031
Thbs4 thrombospondin 4 0.031
Col4a5 collagen, type IV, alpha 5 0.031
Pde4b phosphodiesterase 4B, cAMP specific 0.030
Prrx1 paired related homeobox 1 0.030
Fam63b family with sequence similarity 63, member B 0.030
Pld2 phospholipase D2 0.030
Vdr vitamin D (1,25- dihydroxyvitamin D3) receptor 0.029
Tnni1 troponin I type 1 (skeletal, slow) 0.029
Ptprf protein tyrosine phosphatase, receptor type, F 0.029
Atp7a ATPase, Cu++ transporting, alpha polypeptide 0.029
Npy5r neuropeptide Y receptor Y5 0.028
Grb10 growth factor receptor bound protein 10 0.028
Kif1b kinesin family member 1B 0.028
Dcaf17 DDB1 and CUL4 associated factor 17 0.028
Klc3 kinesin light chain 3 0.028
Fzd2 frizzled homolog 2 (Drosophila) 0.028
Sema3a sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.028
Gja1 gap junction protein, alpha 1 0.028
Itpr1 inositol 1,4,5-triphosphate receptor, type 1 0.027
Aqp5 aquaporin 5 0.027
Pld1 phospholipase D1 0.027
Trmt61a tRNA methyltransferase 61 homolog A (S. cerevisiae) 0.027
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.027
Hist1h2ba histone cluster 1, H2ba 0.027
Rara retinoic acid receptor, alpha 0.027
Spink3 serine peptidase inhibitor, Kazal type 3 0.027
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism