The network for 'mesenchymal cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

mesenchymal cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types.

Mus musculus
Name Description Probability Func Analog Organism
Gli3 GLI-Kruppel family member GLI3 1.000
Bmp4 bone morphogenetic protein 4 1.000
Shh sonic hedgehog 1.000
Pitx2 paired-like homeodomain transcription factor 2 1.000
Foxc1 forkhead box C1 1.000
Pax3 paired box gene 3 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Tgfb2 transforming growth factor, beta 2 1.000
Ctnnb1 catenin (cadherin associated protein), beta 1 0.999
Nodal nodal 0.999
Fgf8 fibroblast growth factor 8 0.998
Msx1 homeobox, msh-like 1 0.998
Pax6 paired box gene 6 0.998
Sox9 SRY-box containing gene 9 0.997
Acvr1 activin A receptor, type 1 0.997
Fgfr1 fibroblast growth factor receptor 1 0.997
Otx2 orthodenticle homolog 2 (Drosophila) 0.997
Hand2 heart and neural crest derivatives expressed transcript 2 0.997
Bcl2 B-cell leukemia/lymphoma 2 0.996
Hand1 heart and neural crest derivatives expressed transcript 1 0.995
Vegfa vascular endothelial growth factor A 0.993
Hoxa1 homeobox A1 0.993
Gata4 GATA binding protein 4 0.993
Isl1 ISL1 transcription factor, LIM/homeodomain 0.992
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.990
Lhx1 LIM homeobox protein 1 0.989
Gdnf glial cell line derived neurotrophic factor 0.989
Tbx1 T-box 1 0.988
Prrx1 paired related homeobox 1 0.985
Efnb2 ephrin B2 0.984
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.977
Prrx2 paired related homeobox 2 0.976
Gli2 GLI-Kruppel family member GLI2 0.974
Zic3 zinc finger protein of the cerebellum 3 0.973
Notch1 Notch gene homolog 1 (Drosophila) 0.973
Runx2 runt related transcription factor 2 0.971
Rarg retinoic acid receptor, gamma 0.968
Chrd chordin 0.968
Dlx5 distal-less homeobox 5 0.968
Tcfap2a transcription factor AP-2, alpha 0.965
Ednra endothelin receptor type A 0.962
Gbx2 gastrulation brain homeobox 2 0.956
Bmpr1a bone morphogenetic protein receptor, type 1A 0.952
Ret ret proto-oncogene 0.952
Foxc2 forkhead box C2 0.951
Sox2 SRY-box containing gene 2 0.951
Msx2 homeobox, msh-like 2 0.950
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.947
Sox10 SRY-box containing gene 10 0.947
Nog noggin 0.945
Fgfr3 fibroblast growth factor receptor 3 0.945
Crb2 crumbs homolog 2 (Drosophila) 0.944
Rarb retinoic acid receptor, beta 0.942
Pou3f3 POU domain, class 3, transcription factor 3 0.938
Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 0.938
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.938
Twist2 twist homolog 2 (Drosophila) 0.931
Gata6 GATA binding protein 6 0.929
Snai1 snail homolog 1 (Drosophila) 0.927
Foxg1 forkhead box G1 0.926
Fgf10 fibroblast growth factor 10 0.918
Eya1 eyes absent 1 homolog (Drosophila) 0.918
Gpc3 glypican 3 0.917
Tcf21 transcription factor 21 0.913
Pten phosphatase and tensin homolog 0.906
Gsc goosecoid homeobox 0.903
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.903
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.898
Lef1 lymphoid enhancer binding factor 1 0.892
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.891
Atoh7 atonal homolog 7 (Drosophila) 0.890
Notch2 Notch gene homolog 2 (Drosophila) 0.876
Vangl2 vang-like 2 (van gogh, Drosophila) 0.871
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.869
Wt1 Wilms tumor 1 homolog 0.869
Tlx3 T-cell leukemia, homeobox 3 0.868
Smad4 MAD homolog 4 (Drosophila) 0.860
Pbx1 pre B-cell leukemia transcription factor 1 0.856
Emx1 empty spiracles homolog 1 (Drosophila) 0.849
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.847
Meox2 mesenchyme homeobox 2 0.840
Pax2 paired box gene 2 0.839
Col2a1 collagen, type II, alpha 1 0.833
Hes1 hairy and enhancer of split 1 (Drosophila) 0.830
Hic1 hypermethylated in cancer 1 0.812
Wnt3a wingless-related MMTV integration site 3A 0.788
Smad3 MAD homolog 3 (Drosophila) 0.782
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.781
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.779
Hoxb1 homeobox B1 0.777
Smad6 MAD homolog 6 (Drosophila) 0.770
Tbx3 T-box 3 0.768
Lhx3 LIM homeobox protein 3 0.763
Neurog2 neurogenin 2 0.752
Efnb1 ephrin B1 0.751
Tbx15 T-box 15 0.740
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.729
Ror1 receptor tyrosine kinase-like orphan receptor 1 0.727
Efna2 ephrin A2 0.723
Pitx1 paired-like homeodomain transcription factor 1 0.716
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
foxd3 forkhead box D3 0.996
wu:fv91b12 wu:fv91b12 0.985
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.976
foxi1 forkhead box I1 0.971
sox10 SRY-box containing gene 10 0.951
foxa3 forkhead box A3 0.949
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.938
tbx1 T-box 1 0.935
shha sonic hedgehog a 0.917
gsc goosecoid 0.901
lef1 lymphocyte enhancer binding factor 1 0.868
mib mind bomb 0.854
rarga retinoic acid receptor gamma a 0.843
erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog 0.829
pax6a paired box gene 6a 0.814
pax2a paired box gene 2a 0.799
cdh2 cadherin 2, neuronal 0.776
rest RE1-silencing transcription factor 0.771
bmp4 bone morphogenetic protein 4 0.767
gata3 GATA-binding protein 3 0.767
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.756
sox2 SRY-box containing gene 2 0.743
tp53 tumor protein p53 0.741
snai1b snail homolog 1b (Drosophila) 0.729
emx3 empty spiracles homeobox 3 0.726
eya1 eyes absent homolog 1 0.704
bmp2b bone morphogenetic protein 2b 0.699
dla deltaA 0.682
kita kit receptor a 0.673
mitfa microphthalmia-associated transcription factor a 0.666
dlx2a distal-less homeobox gene 2a 0.663
notch1a notch homolog 1a 0.661
crestin crestin 0.650
cdx4 caudal type homeo box transcription factor 4 0.634
ndr2 nodal-related 2 0.630
wnt5b wingless-type MMTV integration site family, member 5b 0.620
mecom MDS1 and EVI1 complex locus 0.619
pax7a paired box gene 7a 0.613
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.610
pea3 ETS-domain transcription factor pea3 0.600
otx2 orthodenticle homolog 2 0.593
col15a1b collagen, type XV, alpha 1b 0.590
osr1 odd-skipped related 1 (Drosophila) 0.555
tfap2a transcription factor AP-2 alpha 0.551
her6 hairy-related 6 0.550
prdm5 PR domain containing 5 0.545
gpr126 G protein-coupled receptor 126 0.544
jag1b jagged 1b 0.542
ascl1a achaete-scute complex-like 1a (Drosophila) 0.527
zic2a zic family member 2 (odd-paired homolog, Drosophila), a 0.524
spns2 spinster homolog 2 (Drosophila) 0.521
gria4a glutamate receptor, ionotropic, AMPA 4a 0.516
pax6b paired box gene 6b 0.512
tgfbi transforming growth factor, beta-induced 0.511
cdh6 cadherin 6 0.491
tll1 tolloid-like 1 0.487
dld deltaD 0.483
supt6h suppressor of Ty 6 homolog 0.478
fzd7b frizzled homolog 7b 0.472
tfec transcription factor EC 0.469
twist1a twist1a 0.467
her1 hairy-related 1 0.466
twist1b twist1b 0.437
hoxb1b homeo box B1b 0.435
rx2 retinal homeobox gene 2 0.434
zic3 zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila) 0.434
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.433
raraa retinoic acid receptor, alpha a 0.421
dct dopachrome tautomerase 0.407
tgfb3 transforming growth factor, beta 3 0.399
dlc deltaC 0.391
tmem2 transmembrane protein 2 0.376
tnfsf10l tumor necrosis factor (ligand) superfamily, member 10 like 0.363
fli1a friend leukemia integration 1a 0.362
traf4a tnf receptor-associated factor 4a 0.352
alcama activated leukocyte cell adhesion molecule a 0.349
twist3 twist3 0.349
bmp2a bone morphogenetic protein 2a 0.339
spry4 sprouty (Drosophila) homolog 4 0.338
znf503 zinc finger protein 503 0.336
notch3 notch homolog 3 0.326
sox1a SRY-box containing gene 1a 0.318
dhrs3a dehydrogenase/reductase (SDR family) member 3a 0.314
gria1a glutamate receptor, ionotropic, AMPA 1a 0.313
dlb deltaB 0.311
lamc1 laminin, gamma 1 0.308
tp63 tumor protein p63 0.306
gria4b glutamate receptor, ionotropic, AMPA 4b 0.305
fsta follistatin a 0.303
zic5 zic family member 5 (odd-paired homolog, Drosophila) 0.299
pax9 paired box gene 9 0.299
has2 hyaluronan synthase 2 0.293
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.289
wnt11 wingless-type MMTV integration site family, member 11 0.287
nrp1b neuropilin 1b 0.287
crabp2a cellular retinoic acid binding protein 2, a 0.285
msxc muscle segment homeobox C 0.282
barhl1.2 BarH-like 1.2 0.271
id3 inhibitor of DNA binding 3 0.270
dnmt7 DNA (cytosine-5-)-methyltransferase 7 0.269
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Drosophila melanogaster
Name Description Probability Func Analog Organism
ci cubitus interruptus 0.935
hth homothorax 0.886
Egfr Epidermal growth factor receptor 0.810
Mad Mothers against dpp 0.675
hh hedgehog 0.662
shn schnurri 0.649
tkv thickveins 0.556
en engrailed 0.539
dpp decapentaplegic 0.533
slp1 sloppy paired 1 0.520
wg wingless 0.497
arm armadillo 0.454
ttv tout-velu 0.442
Ras85D Ras oncogene at 85D 0.431
bowl brother of odd with entrails limited 0.429
Smox Smad on X 0.387
baz bazooka 0.386
ush u-shaped 0.363
put punt 0.362
fas faint sausage 0.361
dsh dishevelled 0.337
pnr pannier 0.312
LanB2 Laminin B2 0.309
Su(H) Suppressor of Hairless 0.297
ik2 IkappaB kinase-like 2 0.292
dac dachshund 0.287
nkd naked cuticle 0.283
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.281
smo smoothened 0.281
pho pleiohomeotic 0.278
slou slouch 0.261
eya eyes absent 0.258
emc extra macrochaetae 0.257
tld tolloid 0.247
klu klumpfuss 0.247
ap apterous 0.236
numb CG3779 gene product from transcript CG3779-RB 0.233
gcm glial cells missing 0.233
Mef2 Myocyte enhancer factor 2 0.232
osa CG7467 gene product from transcript CG7467-RD 0.228
crb crumbs 0.227
grn grain 0.214
slmb supernumerary limbs 0.212
gsb gooseberry 0.208
ey eyeless 0.191
rap retina aberrant in pattern 0.191
Nrx-IV Neurexin IV 0.189
ecd ecdysoneless 0.189
Tollo CG6890 gene product from transcript CG6890-RA 0.187
cwo clockwork orange 0.185
cact cactus 0.183
scb scab 0.180
odd odd skipped 0.175
Eip74EF Ecdysone-induced protein 74EF 0.175
twi twist 0.175
CG32354 CG32354 gene product from transcript CG32354-RA 0.173
neur neuralized 0.173
por porcupine 0.168
E(spl) Enhancer of split 0.158
Kr Kruppel 0.158
rictor rapamycin-insensitive companion of Tor 0.152
Stat92E Signal-transducer and activator of transcription protein at 92E 0.151
Phm Peptidylglycine-alpha-hydroxylating monooxygenase 0.151
stumps CG31317 gene product from transcript CG31317-RC 0.148
prd paired 0.148
ex expanded 0.147
cnc cap-n-collar 0.142
Akt1 CG4006 gene product from transcript CG4006-RA 0.141
eve even skipped 0.136
spi spitz 0.136
pan pangolin 0.132
hpo hippo 0.132
sog short gastrulation 0.132
CG11347 CG11347 gene product from transcript CG11347-RE 0.128
kuz kuzbanian 0.127
l(2)gd1 lethal (2) giant discs 1 0.125
ftz-f1 ftz transcription factor 1 0.124
brk brinker 0.123
bsk basket 0.117
SoxN SoxNeuro 0.115
trx trithorax 0.114
Wnt2 Wnt oncogene analog 2 0.113
Cp190 Centrosomal protein 190kD 0.109
kibra kibra ortholog 0.109
dm diminutive 0.106
Chro Chromator 0.105
N Notch 0.104
sim single-minded 0.103
spdo sanpodo 0.101
hyx hyrax 0.101
mnd minidiscs 0.100
insc inscuteable 0.100
sna snail 0.099
vg vestigial 0.098
Optix CG18455 gene product from transcript CG18455-RA 0.098
retn retained 0.096
arr arrow 0.095
ash2 absent, small, or homeotic discs 2 0.092
Med Medea 0.091
lab labial 0.090
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Homo sapiens
Name Description Probability Func Analog Organism
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.999
SMAD3 SMAD family member 3 0.996
COL1A1 collagen, type I, alpha 1 0.995
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.994
BBS10 Bardet-Biedl syndrome 10 0.993
JAG1 jagged 1 0.990
NOTCH1 notch 1 0.989
COL6A1 collagen, type VI, alpha 1 0.987
SMAD4 SMAD family member 4 0.982
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.978
TGFB1 transforming growth factor, beta 1 0.972
SMAD1 SMAD family member 1 0.950
SMAD2 SMAD family member 2 0.937
EGFR epidermal growth factor receptor 0.935
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.930
BMP2 bone morphogenetic protein 2 0.918
SMAD7 SMAD family member 7 0.906
SIRT1 sirtuin 1 0.898
COL1A2 collagen, type I, alpha 2 0.888
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.876
SKIL SKI-like oncogene 0.874
EP300 E1A binding protein p300 0.832
COL2A1 collagen, type II, alpha 1 0.827
NOTCH3 notch 3 0.823
COL6A2 collagen, type VI, alpha 2 0.814
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.801
FHL2 four and a half LIM domains 2 0.762
COL4A1 collagen, type IV, alpha 1 0.738
POU3F2 POU class 3 homeobox 2 0.722
POU5F1 POU class 5 homeobox 1 0.706
COL4A2 collagen, type IV, alpha 2 0.689
BMPR1A bone morphogenetic protein receptor, type IA 0.686
AR androgen receptor 0.683
SOX10 SRY (sex determining region Y)-box 10 0.675
PAX3 paired box 3 0.648
DDR2 discoidin domain receptor tyrosine kinase 2 0.622
COL3A1 collagen, type III, alpha 1 0.592
RUNX1 runt-related transcription factor 1 0.567
SMAD6 SMAD family member 6 0.554
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.549
SMAD9 SMAD family member 9 0.546
SOX1 SRY (sex determining region Y)-box 1 0.535
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.534
FSTL1 follistatin-like 1 0.531
FKBP1A FK506 binding protein 1A, 12kDa 0.530
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.511
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.491
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.483
PTK2 PTK2 protein tyrosine kinase 2 0.481
TBX5 T-box 5 0.473
PTBP1 polypyrimidine tract binding protein 1 0.446
COL5A1 collagen, type V, alpha 1 0.431
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.428
NRP1 neuropilin 1 0.416
ENG endoglin 0.412
BMP4 bone morphogenetic protein 4 0.411
CREBBP CREB binding protein 0.396
FOXF2 forkhead box F2 0.392
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.388
COL5A2 collagen, type V, alpha 2 0.374
TGFB3 transforming growth factor, beta 3 0.370
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.359
FZD1 frizzled homolog 1 (Drosophila) 0.354
EIF2C2 eukaryotic translation initiation factor 2C, 2 0.349
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.348
YAP1 Yes-associated protein 1 0.342
GSK3B glycogen synthase kinase 3 beta 0.336
TP53 tumor protein p53 0.336
BGN biglycan 0.333
HIC1 hypermethylated in cancer 1 0.333
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.333
GATA4 GATA binding protein 4 0.328
APC adenomatous polyposis coli 0.322
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.315
FGF1 fibroblast growth factor 1 (acidic) 0.304
LRP6 low density lipoprotein receptor-related protein 6 0.300
SFRP1 secreted frizzled-related protein 1 0.292
FZD8 frizzled homolog 8 (Drosophila) 0.292
COL18A1 collagen, type XVIII, alpha 1 0.292
FOXF1 forkhead box F1 0.292
TCF4 transcription factor 4 0.286
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.278
WNT3A wingless-type MMTV integration site family, member 3A 0.265
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.259
GATA2 GATA binding protein 2 0.257
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.250
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.237
ZFYVE9 zinc finger, FYVE domain containing 9 0.234
FN1 fibronectin 1 0.232
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.230
GRB7 growth factor receptor-bound protein 7 0.227
AXIN1 axin 1 0.212
PDX1 pancreatic and duodenal homeobox 1 0.210
PTCH1 patched 1 0.206
THBS1 thrombospondin 1 0.202
SOX11 SRY (sex determining region Y)-box 11 0.196
MSX1 msh homeobox 1 0.191
FBLN2 fibulin 2 0.187
PIAS1 protein inhibitor of activated STAT, 1 0.183
CAV1 caveolin 1, caveolae protein, 22kDa 0.182
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Rattus norvegicus
Name Description Probability Func Analog Organism
Tgfbr2 transforming growth factor, beta receptor II 0.036
Col12a1 collagen, type XII, alpha 1 0.023
Igfbp5 insulin-like growth factor binding protein 5 0.020
Pfn1 profilin 1 0.016
Unc5b unc-5 homolog B (C. elegans) 0.015
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.015
Smad7 SMAD family member 7 0.014
Dchs1 dachsous 1 (Drosophila) 0.014
Prrx1 paired related homeobox 1 0.013
Fzd2 frizzled homolog 2 (Drosophila) 0.013
Gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting 2 0.012
Lamc1 laminin, gamma 1 0.011
Met met proto-oncogene 0.011
Gata6 GATA binding protein 6 0.011
Slco2a1 solute carrier organic anion transporter family, member 2a1 0.011
Pxdn peroxidasin homolog (Drosophila) 0.011
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.011
Irf2 interferon regulatory factor 2 0.010
Nab1 Ngfi-A binding protein 1 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism