IMP
Process View
The network for 'vasoconstriction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
vasoconstriction
A decrease in the diameter of blood vessels, especially arteries, usually causing an increase in blood pressure.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Nos3 | nitric oxide synthase 3, endothelial cell | 0.983 | |
| Ptgs2 | prostaglandin-endoperoxide synthase 2 | 0.971 | |
| Lep | leptin | 0.836 | |
| Ren1 | renin 1 structural | 0.833 | |
| Klk1b5 | kallikrein 1-related peptidase b5 | 0.683 | |
| Pgr | progesterone receptor | 0.644 | |
| Bbs4 | Bardet-Biedl syndrome 4 (human) | 0.574 | |
| Vegfa | vascular endothelial growth factor A | 0.565 | |
| Klk1b21 | kallikrein 1-related peptidase b21 | 0.517 | |
| Sgca | sarcoglycan, alpha (dystrophin-associated glycoprotein) | 0.430 | |
| Tgfbr1 | transforming growth factor, beta receptor I | 0.402 | |
| Acvr1 | activin A receptor, type 1 | 0.401 | |
| Dmd | dystrophin, muscular dystrophy | 0.399 | |
| Tgfbr2 | transforming growth factor, beta receptor II | 0.395 | |
| Ednra | endothelin receptor type A | 0.392 | |
| Efemp2 | epidermal growth factor-containing fibulin-like extracellular matrix protein 2 | 0.386 | |
| Klk1b26 | kallikrein 1-related petidase b26 | 0.382 | |
| Cnn1 | calponin 1 | 0.343 | |
| Kcnma1 | potassium large conductance calcium-activated channel, subfamily M, alpha member 1 | 0.320 | |
| Tacr1 | tachykinin receptor 1 | 0.315 | |
| Ar | androgen receptor | 0.288 | |
| Gpr12 | G-protein coupled receptor 12 | 0.276 | |
| Gabrb2 | gamma-aminobutyric acid (GABA) A receptor, subunit beta 2 | 0.255 | |
| Lmna | lamin A | 0.253 | |
| Acvrl1 | activin A receptor, type II-like 1 | 0.249 | |
| Kcna2 | potassium voltage-gated channel, shaker-related subfamily, member 2 | 0.239 | |
| Klk1b16 | kallikrein 1-related peptidase b16 | 0.231 | |
| Ptrf | polymerase I and transcript release factor | 0.223 | |
| Ece1 | endothelin converting enzyme 1 | 0.222 | |
| Lepr | leptin receptor | 0.199 | |
| Cry2 | cryptochrome 2 (photolyase-like) | 0.193 | |
| Adipoq | adiponectin, C1Q and collagen domain containing | 0.191 | |
| Serpina1c | serine (or cysteine) peptidase inhibitor, clade A, member 1C | 0.183 | |
| Cd44 | CD44 antigen | 0.182 | |
| Klk1b11 | kallikrein 1-related peptidase b11 | 0.178 | |
| Hsd3b4 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 4 | 0.169 | |
| Per1 | period homolog 1 (Drosophila) | 0.168 | |
| Cx3cr1 | chemokine (C-X3-C) receptor 1 | 0.167 | |
| Tagln | transgelin | 0.166 | |
| Crim1 | cysteine rich transmembrane BMP regulator 1 (chordin like) | 0.166 | |
| Kcna1 | potassium voltage-gated channel, shaker-related subfamily, member 1 | 0.160 | |
| Mmp9 | matrix metallopeptidase 9 | 0.153 | |
| Klk1b8 | kallikrein 1-related peptidase b8 | 0.151 | |
| Nos1 | nitric oxide synthase 1, neuronal | 0.149 | |
| Cyp3a11 | cytochrome P450, family 3, subfamily a, polypeptide 11 | 0.149 | |
| Pik3c2g | phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide | 0.142 | |
| Dtna | dystrobrevin alpha | 0.141 | |
| Fzd8 | frizzled homolog 8 (Drosophila) | 0.141 | |
| Umod | uromodulin | 0.141 | |
| Insr | insulin receptor | 0.140 | |
| P2rx7 | purinergic receptor P2X, ligand-gated ion channel, 7 | 0.137 | |
| Serpina6 | serine (or cysteine) peptidase inhibitor, clade A, member 6 | 0.137 | |
| Plcb1 | phospholipase C, beta 1 | 0.135 | |
| Klk1b1 | kallikrein 1-related peptidase b1 | 0.135 | |
| Cav1 | caveolin 1, caveolae protein | 0.131 | |
| Kcnmb1 | potassium large conductance calcium-activated channel, subfamily M, beta member 1 | 0.130 | |
| Klk1 | kallikrein 1 | 0.129 | |
| Per2 | period homolog 2 (Drosophila) | 0.128 | |
| Pcdh12 | protocadherin 12 | 0.128 | |
| Kcnj11 | potassium inwardly rectifying channel, subfamily J, member 11 | 0.125 | |
| Adra1a | adrenergic receptor, alpha 1a | 0.124 | |
| Fbn1 | fibrillin 1 | 0.121 | |
| Cckbr | cholecystokinin B receptor | 0.118 | |
| Col4a3 | collagen, type IV, alpha 3 | 0.115 | |
| Slc27a5 | solute carrier family 27 (fatty acid transporter), member 5 | 0.110 | |
| Klk1b3 | kallikrein 1-related peptidase b3 | 0.109 | |
| Kl | klotho | 0.108 | |
| Mup5 | major urinary protein 5 | 0.107 | |
| Apc | adenomatosis polyposis coli | 0.106 | |
| Krtap6-1 | keratin associated protein 6-1 | 0.101 | |
| Akr1c6 | aldo-keto reductase family 1, member C6 | 0.097 | |
| Cyp2c38 | cytochrome P450, family 2, subfamily c, polypeptide 38 | 0.097 | |
| Pdgfra | platelet derived growth factor receptor, alpha polypeptide | 0.097 | |
| Keg1 | kidney expressed gene 1 | 0.097 | |
| Crp | C-reactive protein, pentraxin-related | 0.096 | |
| Vdr | vitamin D receptor | 0.094 | |
| Hspa5 | heat shock protein 5 | 0.093 | |
| Htr1d | 5-hydroxytryptamine (serotonin) receptor 1D | 0.092 | |
| Ace | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | 0.092 | |
| Agt | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | 0.091 | |
| Fzd4 | frizzled homolog 4 (Drosophila) | 0.090 | |
| Kcnb1 | potassium voltage gated channel, Shab-related subfamily, member 1 | 0.087 | |
| Smad3 | MAD homolog 3 (Drosophila) | 0.086 | |
| Klk1b4 | kallikrein 1-related pepidase b4 | 0.085 | |
| Slc12a1 | solute carrier family 12, member 1 | 0.085 | |
| Mup4 | major urinary protein 4 | 0.083 | |
| Grid2 | glutamate receptor, ionotropic, delta 2 | 0.083 | |
| Plau | plasminogen activator, urokinase | 0.082 | |
| Myl9 | myosin, light polypeptide 9, regulatory | 0.082 | |
| Rasgrf2 | RAS protein-specific guanine nucleotide-releasing factor 2 | 0.081 | |
| Myl2 | myosin, light polypeptide 2, regulatory, cardiac, slow | 0.079 | |
| Tgfbr3 | transforming growth factor, beta receptor III | 0.078 | |
| Vamp2 | vesicle-associated membrane protein 2 | 0.078 | |
| Fxyd2 | FXYD domain-containing ion transport regulator 2 | 0.078 | |
| Nfatc2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.078 | |
| Trpc4 | transient receptor potential cation channel, subfamily C, member 4 | 0.077 | |
| Aloxe3 | arachidonate lipoxygenase 3 | 0.077 | |
| Plat | plasminogen activator, tissue | 0.074 | |
| Slc10a1 | solute carrier family 10 (sodium/bile acid cotransporter family), member 1 | 0.074 | |
| Hsd3b2 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 | 0.072 |
Loading network...
Homo sapiens
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| TEK | TEK tyrosine kinase, endothelial | 0.967 | |
| RAF1 | v-raf-1 murine leukemia viral oncogene homolog 1 | 0.896 | |
| FGA | fibrinogen alpha chain | 0.734 | |
| FGB | fibrinogen beta chain | 0.546 | |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.509 | |
| ACTN2 | actinin, alpha 2 | 0.331 | |
| MPDZ | multiple PDZ domain protein | 0.324 | |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | 0.295 | |
| MAPK12 | mitogen-activated protein kinase 12 | 0.228 | |
| CAV2 | caveolin 2 | 0.210 | |
| FGG | fibrinogen gamma chain | 0.163 | |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.096 | |
| CRP | C-reactive protein, pentraxin-related | 0.078 | |
| PRKG1 | protein kinase, cGMP-dependent, type I | 0.078 | |
| VAC14 | Vac14 homolog (S. cerevisiae) | 0.066 | |
| RLN3 | relaxin 3 | 0.064 | |
| CBL | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 0.060 | |
| PTGIR | prostaglandin I2 (prostacyclin) receptor (IP) | 0.042 | |
| HYOU1 | hypoxia up-regulated 1 | 0.042 | |
| MAPK8 | mitogen-activated protein kinase 8 | 0.034 | |
| PPP1R9B | protein phosphatase 1, regulatory (inhibitor) subunit 9B | 0.034 | |
| SDF2L1 | stromal cell-derived factor 2-like 1 | 0.027 | |
| HSPB1 | heat shock 27kDa protein 1 | 0.025 | |
| ACVR1 | activin A receptor, type I | 0.025 | |
| PRDX4 | peroxiredoxin 4 | 0.024 | |
| THBS1 | thrombospondin 1 | 0.022 | |
| KDR | kinase insert domain receptor (a type III receptor tyrosine kinase) | 0.022 | |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.019 | |
| KAT2B | K(lysine) acetyltransferase 2B | 0.018 | |
| TXNRD1 | thioredoxin reductase 1 | 0.018 | |
| TGFB1 | transforming growth factor, beta 1 | 0.018 | |
| SRC | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 0.018 | |
| MYOZ1 | myozenin 1 | 0.018 | |
| A2M | alpha-2-macroglobulin | 0.018 | |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | 0.017 | |
| ARRDC3 | arrestin domain containing 3 | 0.017 | |
| MYH11 | myosin, heavy chain 11, smooth muscle | 0.017 | |
| CDH5 | cadherin 5, type 2 (vascular endothelium) | 0.016 | |
| IL8 | interleukin 8 | 0.016 | |
| CRELD2 | cysteine-rich with EGF-like domains 2 | 0.015 | |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.015 | |
| PROCR | protein C receptor, endothelial | 0.015 | |
| DLG4 | discs, large homolog 4 (Drosophila) | 0.014 | |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | 0.014 | |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.014 | |
| PTEN | phosphatase and tensin homolog | 0.014 | |
| PEBP4 | phosphatidylethanolamine-binding protein 4 | 0.014 | |
| MAPK1 | mitogen-activated protein kinase 1 | 0.013 | |
| CYSLTR2 | cysteinyl leukotriene receptor 2 | 0.013 | |
| EDNRB | endothelin receptor type B | 0.012 | |
| GAB2 | GRB2-associated binding protein 2 | 0.012 | |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.012 | |
| TKT | transketolase | 0.012 | |
| THBS2 | thrombospondin 2 | 0.011 | |
| CRYAB | crystallin, alpha B | 0.011 | |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.011 | |
| IL6 | interleukin 6 (interferon, beta 2) | 0.011 | |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | 0.011 |
Loading network...
Rattus norvegicus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Olr226 | olfactory receptor 226 | 0.267 | |
| Aqp6 | aquaporin 6, kidney specific | 0.258 | |
| Cyp2a1 | cytochrome P450, family 2, subfamily a, polypeptide 1 | 0.212 | |
| Grin2b | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | 0.133 | |
| Foxd3 | forkhead box D3 | 0.119 | |
| Mrgprf | MAS-related GPR, member F | 0.117 | |
| Mag | myelin-associated glycoprotein | 0.115 | |
| Nrg1 | neuregulin 1 | 0.107 | |
| Hal | histidine ammonia lyase | 0.105 | |
| Serpina3k | serine (or cysteine) peptidase inhibitor, clade A, member 3K | 0.100 | |
| Zp1 | zona pellucida glycoprotein 1 (sperm receptor) | 0.098 | |
| Ugt8 | UDP glycosyltransferase 8 | 0.094 | |
| Il1rn | interleukin 1 receptor antagonist | 0.094 | |
| Abcb11 | ATP-binding cassette, subfamily B (MDR/TAP), member 11 | 0.088 | |
| Sec61a1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.085 | |
| Nmu | neuromedin U | 0.084 | |
| LOC100362824 | caveolin 2-like | 0.081 | |
| Hsph1 | heat shock 105/110 protein 1 | 0.080 | |
| Pnlip | pancreatic lipase | 0.079 | |
| Mmp3 | matrix metallopeptidase 3 | 0.079 | |
| Slc2a3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.078 | |
| Csf3 | colony stimulating factor 3 (granulocyte) | 0.077 | |
| F2rl1 | coagulation factor II (thrombin) receptor-like 1 | 0.077 | |
| LOC100364212 | heterogeneous nuclear ribonucleoprotein K-like | 0.073 | |
| Akr1c18 | aldo-keto reductase family 1, member C18 | 0.073 | |
| Syt8 | synaptotagmin VIII | 0.072 | |
| Scn8a | sodium channel, voltage gated, type VIII, alpha subunit | 0.072 | |
| Cyp21a1 | cytochrome P450, family 21, subfamily a, polypeptide 1 | 0.071 | |
| Lim2 | lens intrinsic membrane protein 2 | 0.070 | |
| Nos3 | nitric oxide synthase 3, endothelial cell | 0.069 | |
| Vip | vasoactive intestinal peptide | 0.069 | |
| Htr7 | 5-hydroxytryptamine (serotonin) receptor 7 | 0.067 | |
| Slc6a3 | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 | 0.063 | |
| Slc6a7 | solute carrier family 6 (neurotransmitter transporter, L-proline), member 7 | 0.062 | |
| Kcnq3 | potassium voltage-gated channel, KQT-like subfamily, member 3 | 0.062 | |
| Cxcl6 | chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) | 0.062 | |
| Folh1 | folate hydrolase 1 | 0.061 | |
| P2rx2 | purinergic receptor P2X, ligand-gated ion channel, 2 | 0.060 | |
| Trhr2 | thyrotropin releasing hormone receptor 2 | 0.059 | |
| Ngf | nerve growth factor (beta polypeptide) | 0.059 | |
| Cpb1 | carboxypeptidase B1 (tissue) | 0.058 | |
| Htr2c | 5-hydroxytryptamine (serotonin) receptor 2C | 0.058 | |
| Agtr2 | angiotensin II receptor, type 2 | 0.058 | |
| Smad3 | SMAD family member 3 | 0.057 | |
| Grm7 | glutamate receptor, metabotropic 7 | 0.056 | |
| Fev | FEV (ETS oncogene family) | 0.056 | |
| Hk1 | hexokinase 1 | 0.055 | |
| C8b | complement component 8, beta polypeptide | 0.054 | |
| Orm1 | orosomucoid 1 | 0.054 | |
| Il4 | interleukin 4 | 0.053 | |
| Cyp4a10 | cytochrome P450, family 4, subfamily a, polypeptide 10 | 0.053 | |
| Ccdc102a | coiled-coil domain containing 102A | 0.053 | |
| Zg16 | zymogen granule protein 16 | 0.052 | |
| Htr6 | 5-hydroxytryptamine (serotonin) receptor 6 | 0.051 | |
| Cyp2c22 | cytochrome P450, family 2, subfamily c, polypeptide 22 | 0.051 | |
| Prl8a7 | prolactin family 8, subfamily a, member 7 | 0.050 | |
| Calcr | calcitonin receptor | 0.049 | |
| Cyp2c13 | cytochrome P450, family 2, subfamily c, polypeptide 13 | 0.049 | |
| Pnliprp2 | pancreatic lipase-related protein 2 | 0.049 | |
| Foxg1 | forkhead box G1 | 0.048 | |
| LOC299282 | Serine protease inhibitor | 0.048 | |
| Bdkrb2 | bradykinin receptor B2 | 0.047 | |
| Cmklr1 | chemokine-like receptor 1 | 0.047 | |
| Pmfbp1 | polyamine modulated factor 1 binding protein 1 | 0.046 | |
| Slc5a1 | solute carrier family 5 (sodium/glucose cotransporter), member 1 | 0.046 | |
| Tff1 | trefoil factor 1 | 0.046 | |
| Kcnab1 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 | 0.046 | |
| Ccr5 | chemokine (C-C motif) receptor 5 | 0.045 | |
| Vom2r27 | vomeronasal 2 receptor, 27 | 0.045 | |
| Cd14 | CD14 molecule | 0.045 | |
| Cacnb1 | calcium channel, voltage-dependent, beta 1 subunit | 0.045 | |
| Tbxa2r | thromboxane A2 receptor | 0.044 | |
| Spp2 | secreted phosphoprotein 2 | 0.044 | |
| Tacr3 | tachykinin receptor 3 | 0.043 | |
| Prl | prolactin | 0.043 | |
| Sult1c3 | sulfotransferase family, cytosolic, 1C, member 3 | 0.043 | |
| Fshb | follicle stimulating hormone, beta polypeptide | 0.043 | |
| Kcnj10 | potassium inwardly-rectifying channel, subfamily J, member 10 | 0.043 | |
| Aqp4 | aquaporin 4 | 0.042 | |
| Tacr2 | tachykinin receptor 2 | 0.042 | |
| Atxn1 | ataxin 1 | 0.042 | |
| Hsp90ab1 | heat shock protein 90 alpha (cytosolic), class B member 1 | 0.042 | |
| Olr416 | olfactory receptor 416 | 0.041 | |
| RGD1565859 | RGD1565859 | 0.041 | |
| Lepr | leptin receptor | 0.041 | |
| Cryba4 | crystallin, beta A4 | 0.040 | |
| Hp | haptoglobin | 0.040 | |
| Mog | myelin oligodendrocyte glycoprotein | 0.040 | |
| Il3 | interleukin 3 | 0.040 | |
| Chrna6 | cholinergic receptor, nicotinic, alpha 6 | 0.040 | |
| Rgs9 | regulator of G-protein signaling 9 | 0.040 | |
| Slc12a1 | solute carrier family 12 (sodium/potassium/chloride transporters), member 1 | 0.039 | |
| Gjb5 | gap junction protein, beta 5 | 0.039 | |
| Cyp2d2 | cytochrome P450, family 2, subfamily d, polypeptide 2 | 0.039 | |
| Pax8 | paired box 8 | 0.039 | |
| Hnmt | histamine N-methyltransferase | 0.039 | |
| Sycn | syncollin | 0.039 | |
| Mmp7 | matrix metallopeptidase 7 | 0.039 | |
| Atp4b | ATPase, H+/K+ exchanging, beta polypeptide | 0.038 | |
| Capn13 | calpain 13 | 0.038 |