The network for 'positive regulation of fibroblast growth factor receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of fibroblast growth factor receptor signaling pathway

Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.

Mus musculus
Name Description Probability Func Analog Organism
Fgfr2 fibroblast growth factor receptor 2 0.964
Shh sonic hedgehog 0.912
Nos3 nitric oxide synthase 3, endothelial cell 0.845
Gli3 GLI-Kruppel family member GLI3 0.791
Flt4 FMS-like tyrosine kinase 4 0.638
Nr0b1 nuclear receptor subfamily 0, group B, member 1 0.455
Pten phosphatase and tensin homolog 0.427
Notch2 Notch gene homolog 2 (Drosophila) 0.385
Usp8 ubiquitin specific peptidase 8 0.352
Bmp4 bone morphogenetic protein 4 0.352
Itga3 integrin alpha 3 0.344
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.340
Kdr kinase insert domain protein receptor 0.323
Lama5 laminin, alpha 5 0.322
Pou5f1 POU domain, class 5, transcription factor 1 0.292
Sox9 SRY-box containing gene 9 0.266
Sall1 sal-like 1 (Drosophila) 0.233
Gaa glucosidase, alpha, acid 0.230
Rxra retinoid X receptor alpha 0.210
Tcfcp2l1 transcription factor CP2-like 1 0.198
Fgf8 fibroblast growth factor 8 0.179
Nanog Nanog homeobox 0.169
Hbegf heparin-binding EGF-like growth factor 0.151
Slc9a3r2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 0.150
Ctnnb1 catenin (cadherin associated protein), beta 1 0.148
Apc adenomatosis polyposis coli 0.137
Hes1 hairy and enhancer of split 1 (Drosophila) 0.136
Samd4b sterile alpha motif domain containing 4B 0.135
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.129
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.128
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.126
Esrrb estrogen related receptor, beta 0.121
Otx2 orthodenticle homolog 2 (Drosophila) 0.119
Tbx3 T-box 3 0.116
Sox13 SRY-box containing gene 13 0.115
Sh3bgrl SH3-binding domain glutamic acid-rich protein like 0.114
Stam2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 0.114
Lrp6 low density lipoprotein receptor-related protein 6 0.110
Pkd1 polycystic kidney disease 1 homolog 0.103
Ar androgen receptor 0.099
Trp53 transformation related protein 53 0.097
Flt1 FMS-like tyrosine kinase 1 0.096
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.095
Efnb1 ephrin B1 0.094
Fbrs fibrosin 0.092
Tcf21 transcription factor 21 0.089
Notch1 Notch gene homolog 1 (Drosophila) 0.088
Apln apelin 0.080
Serinc1 serine incorporator 1 0.079
Sox7 SRY-box containing gene 7 0.075
Ptms parathymosin 0.074
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.071
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.068
Spry4 sprouty homolog 4 (Drosophila) 0.068
Wt1 Wilms tumor 1 homolog 0.067
Fam83h family with sequence similarity 83, member H 0.067
Wnt5a wingless-related MMTV integration site 5A 0.066
Plxnd1 plexin D1 0.063
Itfg1 integrin alpha FG-GAP repeat containing 1 0.062
Ptpn14 protein tyrosine phosphatase, non-receptor type 14 0.062
Gng12 guanine nucleotide binding protein (G protein), gamma 12 0.060
Vhl von Hippel-Lindau tumor suppressor 0.059
Smpd3 sphingomyelin phosphodiesterase 3, neutral 0.058
Fstl3 follistatin-like 3 0.057
Tsc2 tuberous sclerosis 2 0.057
Wbp2 WW domain binding protein 2 0.057
Pitx2 paired-like homeodomain transcription factor 2 0.056
Sfn stratifin 0.056
Epn1 epsin 1 0.055
Fgf9 fibroblast growth factor 9 0.054
Foxa2 forkhead box A2 0.053
Ndfip1 Nedd4 family interacting protein 1 0.053
Gata6 GATA binding protein 6 0.053
Col1a1 collagen, type I, alpha 1 0.053
Vegfa vascular endothelial growth factor A 0.053
Tmem30a transmembrane protein 30A 0.052
Epas1 endothelial PAS domain protein 1 0.051
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.051
Abl1 c-abl oncogene 1, non-receptor tyrosine kinase 0.051
Eng endoglin 0.051
Col4a3 collagen, type IV, alpha 3 0.051
Nacc1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing 0.049
Rab5a RAB5A, member RAS oncogene family 0.049
Hoxd11 homeobox D11 0.047
Sox4 SRY-box containing gene 4 0.046
Nrp1 neuropilin 1 0.046
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.046
Smtn smoothelin 0.045
Rb1 retinoblastoma 1 0.045
Stk40 serine/threonine kinase 40 0.045
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.045
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.044
Egln1 EGL nine homolog 1 (C. elegans) 0.044
Fgfr3 fibroblast growth factor receptor 3 0.043
Etl4 enhancer trap locus 4 0.043
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.042
Cdk16 cyclin-dependent kinase 16 0.041
Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 0.040
Epha2 Eph receptor A2 0.040
Sox18 SRY-box containing gene 18 0.040
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
wnt10a wingless-type MMTV integration site family, member 10a 0.695
wnt8b wingless-type MMTV integration site family, member 8b 0.650
gli1 GLI-Kruppel family member 1 0.556
tbx1 T-box 1 0.499
lef1 lymphocyte enhancer binding factor 1 0.472
dharma dharma 0.439
wnt1 wingless-type MMTV integration site family, member 1 0.420
ptch2 patched 2 0.402
robo3 roundabout homolog 3 0.388
prdm1a PR domain containing 1a, with ZNF domain 0.383
ndr2 nodal-related 2 0.357
wnt5b wingless-type MMTV integration site family, member 5b 0.355
bmp2a bone morphogenetic protein 2a 0.346
wnt4a wingless-type MMTV integration site family, member 4a 0.326
bmp4 bone morphogenetic protein 4 0.262
wnt2 wingless-type MMTV integration site family member 2 0.231
wnt9b wingless-type MMTV integration site family, member 9B 0.229
fgf17 fibroblast growth factor 17 0.217
lft1 lefty1 0.203
wnt3 wingless-type MMTV integration site family, member 3 0.183
wnt9a wingless-type MMTV integration site family, member 9A 0.171
fgf8a fibroblast growth factor 8 a 0.170
wnt10b wingless-type MMTV integration site family, member 10b 0.163
ndr1 nodal-related 1 0.142
fgf3 fibroblast growth factor 3 0.128
wnt7aa wingless-type MMTV integration site family, member 7Aa 0.127
zfyve26 zinc finger, FYVE domain containing 26 0.127
twist3 twist3 0.123
smad9 MAD homolog 9 (Drosophila) 0.116
ippk inositol 1,3,4,5,6-pentakisphosphate 2-kinase 0.112
osr2 odd-skipped related 2 (Drosophila) 0.111
smo smoothened homolog (Drosophila) 0.109
flh floating head 0.106
map2k4a mitogen-activated protein kinase kinase 4a 0.104
wnt3a wingless-type MMTV integration site family, member 3A 0.097
wnt7bb wingless-type MMTV integration site family, member 7Bb 0.091
lhx2b LIM homeobox 2b 0.090
zic3 zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila) 0.085
hoxd4a homeo box D4a 0.082
shha sonic hedgehog a 0.080
fgf4 fibroblast growth factor 4 0.078
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.071
sp8a sp8 transcription factor a 0.066
pou5f1 POU domain, class 5, transcription factor 1 0.057
dkk1b dickkopf 1b 0.055
brd4 bromodomain containing 4 0.052
col11a2 collagen type XI alpha-2 0.052
sec24d SEC24 family, member D (S. cerevisiae) 0.050
ephb4b eph receptor B4b 0.047
wnt16 wingless-type MMTV integration site family, member 16 0.045
mapk3 mitogen-activated protein kinase 3 0.044
wnt7ba wingless-type MMTV integration site family, member 7Ba 0.044
mpped2 metallophosphoesterase domain containing 2 0.043
msxb muscle segment homeobox B 0.043
hoxa13b homeo box A13b 0.042
ext2 exostoses (multiple) 2 0.040
smad3b MAD, mothers against decapentaplegic homolog 3b (Drosophila) 0.038
zbtb4 zinc finger and BTB domain containing 4 0.037
gro2 groucho 2 0.037
sox32 SRY-box containing gene 32 0.037
ihha Indian hedgehog homolog a 0.036
axin1 axin 1 0.036
uxs1 UDP-glucuronic acid decarboxylase 1 0.036
ptch1 patched 1 0.035
plcb3 phospholipase C, beta 3 (phosphatidylinositol-specific) 0.034
bmp2b bone morphogenetic protein 2b 0.034
amotl2a angiomotin like 2a 0.033
mapk1 mitogen-activated protein kinase 1 0.033
gngt2b guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2b 0.032
frem1a Fras1 related extracellular matrix 1a 0.032
grem1a gremlin 1 homolog a, cysteine knot superfamily (Xenopus laevis) 0.031
il17rd interleukin 17 receptor D 0.031
zgc:158603 zgc:158603 0.030
sall4 sal-like 4 (Drosophila) 0.030
hmx1 H6 homeo box 1 0.029
bmp1a bone morphogenetic protein 1a 0.027
vent ventral expressed homeobox 0.027
extl3 exostoses (multiple)-like 3 0.027
sfrp1a secreted frizzled-related protein 1a 0.026
hoxc1a homeo box C1a 0.026
pcdh8 protocadherin 8 0.025
sox11b SRY-box containing gene 11b 0.025
pdlim7 PDZ and LIM domain 7 0.024
znf711 zinc finger protein 711 0.024
jag2 jagged 2 0.024
bmpr1aa bone morphogenetic protein receptor, type 1aa 0.024
frem2a Fras1 related extracellular matrix protein 2a 0.024
msxd muscle segment homeobox D 0.023
gli2b GLI-Kruppel family member GLI2b 0.023
frzb frizzled-related protein 0.022
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.022
runx2b runt-related transcription factor 2b 0.022
rarab retinoic acid receptor, alpha b 0.022
cdkn1c cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.021
gsc goosecoid 0.020
sult1st4 sulfotransferase family 1, cytosolic sulfotransferase 4 0.020
mapk15 mitogen-activated protein kinase 15 0.019
spry4 sprouty (Drosophila) homolog 4 0.019
rspo3 R-spondin 3 homolog (Xenopus laevis) 0.018
admp anti-dorsalizing morphogenic protein 0.018
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Ext2 CG8433 gene product from transcript CG8433-RA 0.814
ttv tout-velu 0.668
botv brother of tout-velu 0.605
Shc SHC-adaptor protein 0.391
wg wingless 0.260
sgl sugarless 0.255
Ras85D Ras oncogene at 85D 0.189
Egfr Epidermal growth factor receptor 0.148
mib1 mind bomb 1 0.087
crb crumbs 0.084
dsh dishevelled 0.075
dpp decapentaplegic 0.072
smo smoothened 0.069
Hrs Hepatocyte growth factor regulated tyrosine kinase substrate 0.041
pUf68 poly U binding factor 68kD 0.039
eya eyes absent 0.038
Vps35 Vacuolar protein sorting 35 0.038
wls wntless 0.036
dome domeless 0.035
Psn Presenilin 0.028
dve defective proventriculus 0.027
Smr Smrter 0.026
baz bazooka 0.025
EloA Elongin A 0.023
sfl sulfateless 0.021
argos CG4531 gene product from transcript CG4531-RA 0.021
ci cubitus interruptus 0.020
Chc Clathrin heavy chain 0.020
fu fused 0.019
ash2 absent, small, or homeotic discs 2 0.019
Bre1 CG10542 gene product from transcript CG10542-RA 0.019
drk downstream of receptor kinase 0.019
ara araucan 0.018
Wnk CG7177 gene product from transcript CG7177-RA 0.016
Mad Mothers against dpp 0.015
sqh spaghetti squash 0.015
CG9139 CG9139 gene product from transcript CG9139-RA 0.015
Stam Signal transducing adaptor molecule 0.015
l(2)gl lethal (2) giant larvae 0.014
pnt pointed 0.014
Mo25 CG4083 gene product from transcript CG4083-RA 0.014
frc fringe connection 0.013
inv invected 0.013
arr arrow 0.012
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Homo sapiens
Name Description Probability Func Analog Organism
STAMBP STAM binding protein 0.992
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 0.545
HDAC7 histone deacetylase 7 0.526
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.254
TCF4 transcription factor 4 0.190
RNF11 ring finger protein 11 0.175
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 0.175
TSG101 tumor susceptibility gene 101 0.113
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.110
CHMP1B chromatin modifying protein 1B 0.109
RRBP1 ribosome binding protein 1 homolog 180kDa (dog) 0.087
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.084
ACTN4 actinin, alpha 4 0.081
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.064
GORASP1 golgi reassembly stacking protein 1, 65kDa 0.044
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.043
VPS24 vacuolar protein sorting 24 homolog (S. cerevisiae) 0.042
PDGFC platelet derived growth factor C 0.041
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.039
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 0.031
APC adenomatous polyposis coli 0.025
PDGFA platelet-derived growth factor alpha polypeptide 0.025
RXRA retinoid X receptor, alpha 0.024
TNIP2 TNFAIP3 interacting protein 2 0.024
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 0.024
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae) 0.023
JAK1 Janus kinase 1 0.022
GLIS2 GLIS family zinc finger 2 0.022
PDLIM7 PDZ and LIM domain 7 (enigma) 0.022
MDFI MyoD family inhibitor 0.021
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1 0.020
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.019
UBQLN1 ubiquilin 1 0.019
EHMT2 euchromatic histone-lysine N-methyltransferase 2 0.019
SEC24C SEC24 family, member C (S. cerevisiae) 0.018
UBA1 ubiquitin-like modifier activating enzyme 1 0.017
EXOC7 exocyst complex component 7 0.016
GDI1 GDP dissociation inhibitor 1 0.016
COL5A1 collagen, type V, alpha 1 0.016
ZRANB1 zinc finger, RAN-binding domain containing 1 0.015
TOM1 target of myb1 (chicken) 0.015
KLF5 Kruppel-like factor 5 (intestinal) 0.015
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.014
DAZAP2 DAZ associated protein 2 0.014
MORF4L1 mortality factor 4 like 1 0.013
GAK cyclin G associated kinase 0.013
COL6A1 collagen, type VI, alpha 1 0.013
MT2A metallothionein 2A 0.012
UBQLN2 ubiquilin 2 0.012
CHMP5 chromatin modifying protein 5 0.012
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 0.012
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.011
MT1H metallothionein 1H 0.011
AXIN1 axin 1 0.011
EXOC8 exocyst complex component 8 0.011
NCOA1 nuclear receptor coactivator 1 0.010
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 0.010
PSEN1 presenilin 1 0.010
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.010
SIRT7 sirtuin 7 0.010
MTPN myotrophin 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism