The network for 'regulation of skeletal muscle cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of skeletal muscle cell differentiation

Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation.

Mus musculus
Name Description Probability Func Analog Organism
Fgfr2 fibroblast growth factor receptor 2 0.997
Eya1 eyes absent 1 homolog (Drosophila) 0.991
Prrx1 paired related homeobox 1 0.972
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.961
Pitx2 paired-like homeodomain transcription factor 2 0.951
Tbx3 T-box 3 0.927
Sox9 SRY-box containing gene 9 0.918
Tbx1 T-box 1 0.903
Msx1 homeobox, msh-like 1 0.900
Dlx5 distal-less homeobox 5 0.898
Bmp4 bone morphogenetic protein 4 0.888
Shh sonic hedgehog 0.876
Gli3 GLI-Kruppel family member GLI3 0.788
Tcfap2a transcription factor AP-2, alpha 0.739
Pax2 paired box gene 2 0.737
Pax3 paired box gene 3 0.715
Rarg retinoic acid receptor, gamma 0.709
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.645
Otx2 orthodenticle homolog 2 (Drosophila) 0.638
Foxc1 forkhead box C1 0.614
Hand1 heart and neural crest derivatives expressed transcript 1 0.608
Hand2 heart and neural crest derivatives expressed transcript 2 0.557
Rarb retinoic acid receptor, beta 0.554
Pitx1 paired-like homeodomain transcription factor 1 0.547
Pbx1 pre B-cell leukemia transcription factor 1 0.508
Bmp7 bone morphogenetic protein 7 0.464
Fgfr1 fibroblast growth factor receptor 1 0.459
Hoxa1 homeobox A1 0.430
Prrx2 paired related homeobox 2 0.369
Fgf8 fibroblast growth factor 8 0.364
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.340
Tgfb2 transforming growth factor, beta 2 0.337
Fgf10 fibroblast growth factor 10 0.313
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.282
Msx2 homeobox, msh-like 2 0.271
Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 0.265
Ednra endothelin receptor type A 0.261
Pax8 paired box gene 8 0.256
Runx2 runt related transcription factor 2 0.240
Alx1 ALX homeobox 1 0.229
Foxg1 forkhead box G1 0.227
Hoxa2 homeobox A2 0.217
Gsc goosecoid homeobox 0.204
Gli2 GLI-Kruppel family member GLI2 0.190
Dlx2 distal-less homeobox 2 0.189
Fgfr3 fibroblast growth factor receptor 3 0.168
Cry1 cryptochrome 1 (photolyase-like) 0.153
Foxc2 forkhead box C2 0.149
Smo smoothened homolog (Drosophila) 0.138
Alx4 aristaless-like homeobox 4 0.136
Zeb1 zinc finger E-box binding homeobox 1 0.132
Chrd chordin 0.131
Sox2 SRY-box containing gene 2 0.131
Tbx5 T-box 5 0.118
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.102
Emx2 empty spiracles homolog 2 (Drosophila) 0.100
Jag1 jagged 1 0.088
Rxra retinoid X receptor alpha 0.087
Ece1 endothelin converting enzyme 1 0.087
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.086
Acvr1 activin A receptor, type 1 0.079
Hcn4 hyperpolarization-activated, cyclic nucleotide-gated K+ 4 0.075
Isl1 ISL1 transcription factor, LIM/homeodomain 0.072
Dlx6 distal-less homeobox 6 0.067
Alx3 aristaless-like homeobox 3 0.066
Wt1 Wilms tumor 1 homolog 0.065
Thra thyroid hormone receptor alpha 0.065
Bmp5 bone morphogenetic protein 5 0.063
Per2 period homolog 2 (Drosophila) 0.063
Ptch1 patched homolog 1 0.056
Tceb2 transcription elongation factor B (SIII), polypeptide 2 0.055
Sim1 single-minded homolog 1 (Drosophila) 0.054
Chd7 chromodomain helicase DNA binding protein 7 0.052
Lhx1 LIM homeobox protein 1 0.052
Gbx2 gastrulation brain homeobox 2 0.049
Hoxa3 homeobox A3 0.047
Nog noggin 0.047
Lef1 lymphoid enhancer binding factor 1 0.047
Gata6 GATA binding protein 6 0.044
Scn5a sodium channel, voltage-gated, type V, alpha 0.044
Gata4 GATA binding protein 4 0.043
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.042
Smad6 MAD homolog 6 (Drosophila) 0.041
Pax9 paired box gene 9 0.040
Dlx1 distal-less homeobox 1 0.039
Wnt5a wingless-related MMTV integration site 5A 0.039
Tbx15 T-box 15 0.037
Gata3 GATA binding protein 3 0.035
Zic3 zinc finger protein of the cerebellum 3 0.034
Vegfa vascular endothelial growth factor A 0.034
Cry2 cryptochrome 2 (photolyase-like) 0.033
Cyp26c1 cytochrome P450, family 26, subfamily c, polypeptide 1 0.033
Tcf21 transcription factor 21 0.031
Bmp2 bone morphogenetic protein 2 0.031
Bcl2 B-cell leukemia/lymphoma 2 0.030
Foxd1 forkhead box D1 0.030
Hoxb3 homeobox B3 0.030
Gja5 gap junction protein, alpha 5 0.030
Hoxa11 homeobox A11 0.029
Sall4 sal-like 4 (Drosophila) 0.028
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
mef2ca myocyte enhancer factor 2ca 0.565
tbx5a T-box 5a 0.266
tnnt2a troponin T2a, cardiac 0.205
eya1 eyes absent homolog 1 0.124
ttna titin a 0.095
edn1 endothelin 1 0.081
smyd1b SET and MYND domain containing 1b 0.078
mef2d myocyte enhancer factor 2d 0.071
crestin crestin 0.069
foxd3 forkhead box D3 0.067
rbm24a RNA binding motif protein 24a 0.065
unc45b unc-45 homolog B (C. elegans) 0.063
cbfb core-binding factor, beta subunit 0.058
mef2cb myocyte enhancer factor 2cb 0.054
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.046
klf4 Kruppel-like factor 4 0.044
prrx1b paired related homeobox 1b 0.041
hand2 heart and neural crest derivatives expressed transcript 2 0.039
sema3aa semaphorin 3aa 0.036
chrna1 cholinergic receptor, nicotinic, alpha polypeptide 1 0.035
flncb filamin C, gamma b (actin binding protein 280) 0.034
dzip1 DAZ interacting protein 1 0.032
tef thyrotroph embryonic factor 0.030
six2a sine oculis-related homeobox 2a 0.028
fgf10a fibroblast growth factor 10a 0.027
fn1 fibronectin 1 0.027
hoxb3a homeo box B3a 0.024
atp2a2a ATPase, Ca++ transporting, cardiac muscle, slow twitch 2a 0.023
dmrta2 doublesex and mab-3 related transcription factor like family A2 0.023
ptch1 patched 1 0.022
myod1 myogenic differentiation 1 0.021
hsp90a.1 heat shock protein 90-alpha 1 0.021
dlx5a distal-less homeobox gene 5a 0.021
nkx2.3 NK2 transcription factor related 3 0.021
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.020
ednra endothelin receptor type A 0.019
six4a sine oculis homeobox homolog 4a 0.019
hoxa3a homeo box A3a 0.019
six1a sine oculis homeobox homolog 1a 0.018
cmlc1 cardiac myosin light chain-1 0.018
si:ch211-212m21.5 si:ch211-212m21.5 0.018
tp53bp2 tumor protein p53 binding protein, 2 0.018
cry1a cryptochrome 1a 0.017
eif1b eukaryotic translation initiation factor 1B 0.017
robo2 roundabout homolog 2 0.017
plekhh1 pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 0.016
flot1 flotillin 1 0.016
LOC556647 GDNF family receptor alpha-4-like 0.016
jam2a junctional adhesion molecule 2a 0.016
gch2 GTP cyclohydrolase 2 0.016
fli1a friend leukemia integration 1a 0.016
zgc:110298 zgc:110298 0.015
pitx3 paired-like homeodomain transcription factor 3 0.015
flt4 fms-related tyrosine kinase 4 0.015
rerea arginine-glutamic acid dipeptide (RE) repeats a 0.014
hsf2 heat shock factor 2 0.014
rbfox2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.014
smo smoothened homolog (Drosophila) 0.014
acvrl1 activin A receptor type II-like 1 0.013
barx1 BarH-like homeobox 1 0.013
znf395b zinc finger protein 395b 0.013
mef2a myocyte enhancer factor 2a 0.013
spns2 spinster homolog 2 (Drosophila) 0.013
gdnf glial cell derived neurotrophic factor 0.013
trnau1apl tRNA selenocysteine 1 associated protein 1, like 0.013
tnnt1 troponin T1, skeletal, slow 0.013
foxp2 forkhead box P2 0.013
s100t S100 calcium binding protein T 0.013
satb2 SATB homeobox 2 0.012
tfap2c transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.012
cry3 cryptochrome 3 0.012
xirp1 xin actin-binding repeat containing 1 0.012
crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.012
hoxc9a homeo box C9a 0.012
hoxa2b homeo box A2b 0.012
foxo3b forkhead box O3b 0.012
tgfb3 transforming growth factor, beta 3 0.012
vasp vasodilator-stimulated phosphoprotein 0.012
antxr1 anthrax toxin receptor 1 0.012
dlx4b distal-less homeobox gene 4b 0.012
tlx2 T-cell leukemia, homeobox 2 0.012
bmp3 bone morphogenetic protein 3 0.012
boc brother of CDO 0.012
esama endothelial cell adhesion molecule a 0.011
skia nuclear oncoprotein skia 0.011
si:dkey-19p15.7 si:dkey-19p15.7 0.011
plxnb2a plexin b2a 0.011
ndrg4 N-myc downstream regulated gene 4 0.011
barx2 BarH-like homeobox 2 0.011
dlx6a distal-less homeobox gene 6a 0.011
cart1 cartilage paired-class homeoprotein 1 0.011
dkk2 dickkopf homolog 2 (Xenopus laevis) 0.011
bnip3lb BCL2/adenovirus E1B interacting protein 3-like b 0.011
vangl2 vang-like 2 (van gogh, Drosophila) 0.011
alg1 asparagine-linked glycosylation 1 homolog (yeast, beta-1,4-mannosyltransferase) 0.011
hoxb5a homeo box B5a 0.011
dedd1 death effector domain-containing 1 0.011
hoxb4a homeo box B4a 0.010
actn2 actinin, alpha 2 0.010
foxc1b forkhead box C1b 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.945
DDX5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 0.827
HDAC4 histone deacetylase 4 0.792
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 0.630
DDX17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 0.397
SF1 splicing factor 1 0.369
NCOA3 nuclear receptor coactivator 3 0.197
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.173
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.150
RBM4 RNA binding motif protein 4 0.120
EP300 E1A binding protein p300 0.110
NCOA2 nuclear receptor coactivator 2 0.076
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H') 0.057
ESR1 estrogen receptor 1 0.043
CLOCK clock homolog (mouse) 0.041
HDAC9 histone deacetylase 9 0.032
SMAD1 SMAD family member 1 0.022
MDFI MyoD family inhibitor 0.022
SIRT1 sirtuin 1 0.021
NCOA1 nuclear receptor coactivator 1 0.018
EPAS1 endothelial PAS domain protein 1 0.016
AHR aryl hydrocarbon receptor 0.015
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.014
MEF2C myocyte enhancer factor 2C 0.013
MKL1 megakaryoblastic leukemia (translocation) 1 0.013
U2AF2 U2 small nuclear RNA auxiliary factor 2 0.012
MBNL1 muscleblind-like (Drosophila) 0.012
AR androgen receptor 0.010
MKL2 MKL/myocardin-like 2 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
S100a6 S100 calcium binding protein A6 0.997
Lgals3 lectin, galactoside-binding, soluble, 3 0.843
Anxa2 annexin A2 0.823
Timp1 TIMP metallopeptidase inhibitor 1 0.697
S100a10 S100 calcium binding protein A10 0.581
Lgals1 lectin, galactoside-binding, soluble, 1 0.566
Anxa1 annexin A1 0.517
S100a11 S100 calcium binding protein A11 (calizzarin) 0.385
S100a4 S100 calcium-binding protein A4 0.336
Tspo translocator protein 0.332
Anxa5 annexin A5 0.241
Plp2 proteolipid protein 2 (colonic epithelium-enriched) 0.218
RGD1309537 similar to Myosin regulatory light chain 2-A, smooth muscle isoform (Myosin RLC-A) 0.186
Crip cysteine-rich intestinal protein 0.172
Cstb cystatin B (stefin B) 0.133
Vim vimentin 0.130
Clic1 chloride intracellular channel 1 0.119
Capg capping protein (actin filament), gelsolin-like 0.112
Mgp matrix Gla protein 0.102
Rhoc ras homolog gene family, member C 0.101
Cd63 Cd63 molecule 0.090
Cd151 CD151 molecule (Raph blood group) 0.088
Mbp myelin basic protein 0.081
Tagln2 transgelin 2 0.067
Prr13 proline rich 13 0.057
Ahnak AHNAK nucleoprotein 0.032
Tmsb4x thymosin beta 4, X-linked 0.028
Tax1bp3 Tax1 (human T-cell leukemia virus type I) binding protein 3 0.024
Capn2 calpain 2 0.020
Serpinb6a serine (or cysteine) peptidase inhibitor, clade B, member 6a 0.018
Spp1 secreted phosphoprotein 1 0.018
Akr1b8 aldo-keto reductase family 1, member B8 0.017
Arpc3 actin related protein 2/3 complex, subunit 3 0.017
Fxyd1 FXYD domain-containing ion transport regulator 1 0.015
Ifitm3 interferon induced transmembrane protein 3 0.015
Adm adrenomedullin 0.015
Ccl2 chemokine (C-C motif) ligand 2 0.014
Kdelr3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 0.013
Gstm5 glutathione S-transferase, mu 5 0.013
Pdlim1 PDZ and LIM domain 1 0.013
Dynlt1 dynein light chain Tctex-type 1 0.013
Cryab crystallin, alpha B 0.012
Sncg synuclein, gamma (breast cancer-specific protein 1) 0.012
Ppm1a protein phosphatase 1A, magnesium dependent, alpha isoform 0.012
Tmbim1 transmembrane BAX inhibitor motif containing 1 0.012
LOC691259 hypothetical protein LOC691259 0.011
G6pd glucose-6-phosphate dehydrogenase 0.011
Tagln transgelin 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism