IMP
Process View
The network for 'positive regulation of type i interferon mediated signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
positive regulation of type i interferon mediated signaling pathway
Any process that increases the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Psmb9 | proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) | 0.912 | |
| Irf9 | interferon regulatory factor 9 | 0.877 | |
| Stat1 | signal transducer and activator of transcription 1 | 0.791 | |
| Ifit3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.784 | |
| Usp18 | ubiquitin specific peptidase 18 | 0.763 | |
| Stat2 | signal transducer and activator of transcription 2 | 0.690 | |
| Igtp | interferon gamma induced GTPase | 0.672 | |
| Irgm2 | immunity-related GTPase family M member 2 | 0.668 | |
| Uba7 | ubiquitin-like modifier activating enzyme 7 | 0.660 | |
| Irgm1 | immunity-related GTPase family M member 1 | 0.599 | |
| Trim21 | tripartite motif-containing 21 | 0.535 | |
| Isg15 | ISG15 ubiquitin-like modifier | 0.502 | |
| Ifit1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.435 | |
| Oasl2 | 2'-5' oligoadenylate synthetase-like 2 | 0.403 | |
| Gbp7 | guanylate binding protein 7 | 0.307 | |
| Rtp4 | receptor transporter protein 4 | 0.299 | |
| Bcl3 | B-cell leukemia/lymphoma 3 | 0.284 | |
| Dhx58 | DEXH (Asp-Glu-X-His) box polypeptide 58 | 0.275 | |
| Ifi47 | interferon gamma inducible protein 47 | 0.269 | |
| Parp14 | poly (ADP-ribose) polymerase family, member 14 | 0.266 | |
| Trim30a | tripartite motif-containing 30A | 0.255 | |
| Rsad2 | radical S-adenosyl methionine domain containing 2 | 0.240 | |
| Map3k8 | mitogen-activated protein kinase kinase kinase 8 | 0.239 | |
| Ifi44 | interferon-induced protein 44 | 0.232 | |
| Unc93b1 | unc-93 homolog B1 (C. elegans) | 0.199 | |
| Gbp2 | guanylate binding protein 2 | 0.162 | |
| Nfkb1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 | 0.147 | |
| Irf7 | interferon regulatory factor 7 | 0.143 | |
| Irf8 | interferon regulatory factor 8 | 0.141 | |
| Tor3a | torsin family 3, member A | 0.124 | |
| Traf3 | TNF receptor-associated factor 3 | 0.120 | |
| Sfpi1 | SFFV proviral integration 1 | 0.118 | |
| Gbp3 | guanylate binding protein 3 | 0.116 | |
| Ifi35 | interferon-induced protein 35 | 0.111 | |
| Iigp1 | interferon inducible GTPase 1 | 0.110 | |
| Casp8 | caspase 8 | 0.107 | |
| Parp10 | poly (ADP-ribose) polymerase family, member 10 | 0.107 | |
| Myd88 | myeloid differentiation primary response gene 88 | 0.104 | |
| Ifih1 | interferon induced with helicase C domain 1 | 0.101 | |
| Oas1a | 2'-5' oligoadenylate synthetase 1A | 0.100 | |
| BC006779 | cDNA sequence BC006779 | 0.094 | |
| Tgtp2 | T-cell specific GTPase 2 | 0.091 | |
| Ifi27l2a | interferon, alpha-inducible protein 27 like 2A | 0.090 | |
| Ptpn6 | protein tyrosine phosphatase, non-receptor type 6 | 0.089 | |
| Ror2 | receptor tyrosine kinase-like orphan receptor 2 | 0.089 | |
| 1810019J16Rik | RIKEN cDNA 1810019J16 gene | 0.086 | |
| Tnfaip3 | tumor necrosis factor, alpha-induced protein 3 | 0.082 | |
| Fas | Fas (TNF receptor superfamily member 6) | 0.076 | |
| Relb | avian reticuloendotheliosis viral (v-rel) oncogene related B | 0.072 | |
| Lyn | Yamaguchi sarcoma viral (v-yes-1) oncogene homolog | 0.071 | |
| Sp100 | nuclear antigen Sp100 | 0.067 | |
| Ifnar2 | interferon (alpha and beta) receptor 2 | 0.067 | |
| Pml | promyelocytic leukemia | 0.065 | |
| Nfkb2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 | 0.065 | |
| Plcg2 | phospholipase C, gamma 2 | 0.063 | |
| Tap2 | transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) | 0.063 | |
| Cmpk2 | cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial | 0.062 | |
| Traf2 | TNF receptor-associated factor 2 | 0.060 | |
| Ikzf1 | IKAROS family zinc finger 1 | 0.059 | |
| Oas2 | 2'-5' oligoadenylate synthetase 2 | 0.059 | |
| Mx1 | myxovirus (influenza virus) resistance 1 | 0.058 | |
| Ddx58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | 0.058 | |
| Eif2ak2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.058 | |
| Cd72 | CD72 antigen | 0.053 | |
| Cxcl10 | chemokine (C-X-C motif) ligand 10 | 0.051 | |
| Trim30d | tripartite motif-containing 30D | 0.050 | |
| Znfx1 | zinc finger, NFX1-type containing 1 | 0.049 | |
| Irf5 | interferon regulatory factor 5 | 0.048 | |
| Ddx60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.047 | |
| Ms4a4c | membrane-spanning 4-domains, subfamily A, member 4C | 0.047 | |
| H2-DMb2 | histocompatibility 2, class II, locus Mb2 | 0.046 | |
| Batf | basic leucine zipper transcription factor, ATF-like | 0.046 | |
| Tapbp | TAP binding protein | 0.046 | |
| Nfkbia | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.044 | |
| Irf1 | interferon regulatory factor 1 | 0.043 | |
| Ccl5 | chemokine (C-C motif) ligand 5 | 0.041 | |
| Zbp1 | Z-DNA binding protein 1 | 0.041 | |
| AW112010 | expressed sequence AW112010 | 0.041 | |
| Oas1b | 2'-5' oligoadenylate synthetase 1B | 0.040 | |
| Samhd1 | SAM domain and HD domain, 1 | 0.039 | |
| Cxcl9 | chemokine (C-X-C motif) ligand 9 | 0.037 | |
| Tnfrsf1b | tumor necrosis factor receptor superfamily, member 1b | 0.037 | |
| Parp12 | poly (ADP-ribose) polymerase family, member 12 | 0.037 | |
| Cd74 | CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) | 0.036 | |
| Parp9 | poly (ADP-ribose) polymerase family, member 9 | 0.036 | |
| Oasl1 | 2'-5' oligoadenylate synthetase-like 1 | 0.036 | |
| Cd7 | CD7 antigen | 0.035 | |
| Ifnar1 | interferon (alpha and beta) receptor 1 | 0.035 | |
| Rnf31 | ring finger protein 31 | 0.035 | |
| Rela | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 0.035 | |
| Ube2l6 | ubiquitin-conjugating enzyme E2L 6 | 0.035 | |
| Prkcd | protein kinase C, delta | 0.035 | |
| Cd79b | CD79B antigen | 0.034 | |
| Cd274 | CD274 antigen | 0.034 | |
| Spib | Spi-B transcription factor (Spi-1/PU.1 related) | 0.034 | |
| Dock2 | dedicator of cyto-kinesis 2 | 0.034 | |
| Tnfrsf13b | tumor necrosis factor receptor superfamily, member 13b | 0.032 | |
| Stat3 | signal transducer and activator of transcription 3 | 0.032 | |
| Ripk1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.031 | |
| Ticam1 | toll-like receptor adaptor molecule 1 | 0.031 |
Loading network...
Homo sapiens
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| TNFRSF10A | tumor necrosis factor receptor superfamily, member 10a | 0.804 | |
| CASP8 | caspase 8, apoptosis-related cysteine peptidase | 0.552 | |
| CREBBP | CREB binding protein | 0.203 | |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 0.188 | |
| IKBKB | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 0.175 | |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 0.133 | |
| PIAS4 | protein inhibitor of activated STAT, 4 | 0.120 | |
| FAS | Fas (TNF receptor superfamily, member 6) | 0.100 | |
| HTT | huntingtin | 0.063 | |
| IRAK1 | interleukin-1 receptor-associated kinase 1 | 0.058 | |
| TMEM173 | transmembrane protein 173 | 0.054 | |
| IRF3 | interferon regulatory factor 3 | 0.051 | |
| FASLG | Fas ligand (TNF superfamily, member 6) | 0.051 | |
| IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 0.051 | |
| MYD88 | myeloid differentiation primary response gene (88) | 0.048 | |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.032 | |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.031 | |
| TRADD | TNFRSF1A-associated via death domain | 0.028 | |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.022 | |
| TRAF2 | TNF receptor-associated factor 2 | 0.022 | |
| CALCOCO2 | calcium binding and coiled-coil domain 2 | 0.022 | |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | 0.022 | |
| TBK1 | TANK-binding kinase 1 | 0.020 | |
| MAVS | mitochondrial antiviral signaling protein | 0.019 | |
| FZD1 | frizzled homolog 1 (Drosophila) | 0.019 | |
| SGTA | small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha | 0.018 | |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.017 | |
| TIRAP | toll-interleukin 1 receptor (TIR) domain containing adaptor protein | 0.015 | |
| STAT6 | signal transducer and activator of transcription 6, interleukin-4 induced | 0.014 | |
| IRF7 | interferon regulatory factor 7 | 0.013 | |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.013 | |
| AZI2 | 5-azacytidine induced 2 | 0.013 | |
| DAXX | death-domain associated protein | 0.012 | |
| LRP6 | low density lipoprotein receptor-related protein 6 | 0.012 | |
| ABL1 | c-abl oncogene 1, non-receptor tyrosine kinase | 0.011 | |
| TADA3 | transcriptional adaptor 3 | 0.011 | |
| TRAF3 | TNF receptor-associated factor 3 | 0.010 | |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.010 |