The network for 'oligodendrocyte development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

oligodendrocyte development

The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Otx2 orthodenticle homolog 2 (Drosophila) 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Sox9 SRY-box containing gene 9 1.000
Fgfr2 fibroblast growth factor receptor 2 0.999
Hand2 heart and neural crest derivatives expressed transcript 2 0.999
Fgf8 fibroblast growth factor 8 0.998
Gli2 GLI-Kruppel family member GLI2 0.998
Isl1 ISL1 transcription factor, LIM/homeodomain 0.997
Fgfr1 fibroblast growth factor receptor 1 0.995
Sox2 SRY-box containing gene 2 0.991
Foxg1 forkhead box G1 0.990
Lef1 lymphoid enhancer binding factor 1 0.989
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.983
Nog noggin 0.983
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.981
Eya1 eyes absent 1 homolog (Drosophila) 0.981
Pax3 paired box gene 3 0.981
Foxc1 forkhead box C1 0.977
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.968
Msx1 homeobox, msh-like 1 0.965
Hes1 hairy and enhancer of split 1 (Drosophila) 0.954
Fgfr3 fibroblast growth factor receptor 3 0.944
Chrd chordin 0.941
Pax6 paired box gene 6 0.940
Emx1 empty spiracles homolog 1 (Drosophila) 0.939
Tcf3 transcription factor 3 0.910
Nkx2-2 NK2 transcription factor related, locus 2 (Drosophila) 0.903
Tcfap2a transcription factor AP-2, alpha 0.899
Bmp4 bone morphogenetic protein 4 0.887
Fgf9 fibroblast growth factor 9 0.880
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.872
Foxc2 forkhead box C2 0.858
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.857
Emx2 empty spiracles homolog 2 (Drosophila) 0.849
Smo smoothened homolog (Drosophila) 0.839
Hand1 heart and neural crest derivatives expressed transcript 1 0.836
Pitx2 paired-like homeodomain transcription factor 2 0.810
Chd7 chromodomain helicase DNA binding protein 7 0.788
Ctnnb1 catenin (cadherin associated protein), beta 1 0.766
Wnt5a wingless-related MMTV integration site 5A 0.764
Dlx5 distal-less homeobox 5 0.722
Pthlh parathyroid hormone-like peptide 0.715
Pten phosphatase and tensin homolog 0.684
Ikzf1 IKAROS family zinc finger 1 0.660
Id4 inhibitor of DNA binding 4 0.654
Tgfb2 transforming growth factor, beta 2 0.626
Pax2 paired box gene 2 0.603
Gsc goosecoid homeobox 0.594
Pdx1 pancreatic and duodenal homeobox 1 0.587
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.573
Sox11 SRY-box containing gene 11 0.568
Bmp2 bone morphogenetic protein 2 0.568
Prrx1 paired related homeobox 1 0.564
Sox4 SRY-box containing gene 4 0.558
Gab1 growth factor receptor bound protein 2-associated protein 1 0.549
Zeb1 zinc finger E-box binding homeobox 1 0.534
Six3 sine oculis-related homeobox 3 homolog (Drosophila) 0.498
Pbx1 pre B-cell leukemia transcription factor 1 0.495
Rarg retinoic acid receptor, gamma 0.481
Nr2f1 nuclear receptor subfamily 2, group F, member 1 0.479
Bmp7 bone morphogenetic protein 7 0.475
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.475
Mog myelin oligodendrocyte glycoprotein 0.451
Ret ret proto-oncogene 0.448
Neurod1 neurogenic differentiation 1 0.437
Ptprz1 protein tyrosine phosphatase, receptor type Z, polypeptide 1 0.429
Fgf10 fibroblast growth factor 10 0.421
Notch1 Notch gene homolog 1 (Drosophila) 0.412
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.396
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.377
Lhx1 LIM homeobox protein 1 0.360
Lhx5 LIM homeobox protein 5 0.354
Tbx1 T-box 1 0.342
Gria4 glutamate receptor, ionotropic, AMPA4 (alpha 4) 0.339
Trp53 transformation related protein 53 0.327
Gbx2 gastrulation brain homeobox 2 0.325
Prox1 prospero-related homeobox 1 0.313
Pou3f3 POU domain, class 3, transcription factor 3 0.299
Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 0.294
Tcf4 transcription factor 4 0.286
Rarb retinoic acid receptor, beta 0.283
Nodal nodal 0.270
Insm1 insulinoma-associated 1 0.262
Npas3 neuronal PAS domain protein 3 0.262
Cckbr cholecystokinin B receptor 0.259
Zic1 zinc finger protein of the cerebellum 1 0.259
Hoxa5 homeobox A5 0.257
Sox1 SRY-box containing gene 1 0.246
Nkx2-9 NK2 transcription factor related, locus 9 (Drosophila) 0.244
Dlx6 distal-less homeobox 6 0.236
Lmx1b LIM homeobox transcription factor 1 beta 0.234
Col2a1 collagen, type II, alpha 1 0.229
Pou3f4 POU domain, class 3, transcription factor 4 0.228
Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 0.226
Bdnf brain derived neurotrophic factor 0.221
Avp arginine vasopressin 0.214
Sall3 sal-like 3 (Drosophila) 0.211
Nf1 neurofibromatosis 1 0.210
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.208
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
ascl1a achaete-scute complex-like 1a (Drosophila) 0.980
sox10 SRY-box containing gene 10 0.816
notch1a notch homolog 1a 0.792
plp1a proteolipid protein 1a 0.720
pax6b paired box gene 6b 0.692
dlc deltaC 0.656
bhlhe22 basic helix-loop-helix family, member e22 0.600
foxa2 forkhead box A2 0.578
sox2 SRY-box containing gene 2 0.537
eya1 eyes absent homolog 1 0.516
cdh2 cadherin 2, neuronal 0.509
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.497
flh floating head 0.453
olig2 oligodendrocyte lineage transcription factor 2 0.440
dla deltaA 0.415
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.411
pax6a paired box gene 6a 0.347
jag1b jagged 1b 0.325
tp53 tumor protein p53 0.302
nkx2.2a NK2 transcription factor related 2a 0.295
neurod neurogenic differentiation 0.288
tfe3b transcription factor binding to IGHM enhancer 3b 0.284
mib mind bomb 0.252
sox19a SRY-box containing gene 19a 0.247
foxi3a forkhead box I3a 0.245
shha sonic hedgehog a 0.221
tfap2a transcription factor AP-2 alpha 0.193
gbx2 gastrulation brain homeo box 2 0.151
gli2a GLI-Kruppel family member GLI2a 0.149
fzd8a frizzled homolog 8a 0.141
hmx4 H6 family homeobox 4 0.135
mab21l2 mab-21-like 2 0.127
sox3 SRY-box containing gene 3 0.118
cdx4 caudal type homeo box transcription factor 4 0.109
tbx1 T-box 1 0.105
fn1 fibronectin 1 0.102
neurod4 neurogenic differentiation 4 0.096
dnmt4 DNA (cytosine-5-)-methyltransferase 4 0.095
sox21b SRY-box containing gene 21 b 0.092
hnf1ba HNF1 homeobox Ba 0.086
zic6 zic family member 6 0.083
hlxb9la homeo box HB9 like a 0.074
vsx2 visual system homeobox 2 0.072
fgf8a fibroblast growth factor 8 a 0.070
col15a1b collagen, type XV, alpha 1b 0.064
foxi3b forkhead box I3b 0.064
notch3 notch homolog 3 0.063
prdm1a PR domain containing 1a, with ZNF domain 0.062
gli1 GLI-Kruppel family member 1 0.061
dld deltaD 0.059
mnx1 motor neuron and pancreas homeobox 1 0.057
otx2 orthodenticle homolog 2 0.057
her8a hairy-related 8a 0.055
isl1 islet1 0.051
ascl1b achaete-scute complex-like 1b (Drosophila) 0.050
fsta follistatin a 0.049
bmp2b bone morphogenetic protein 2b 0.048
sox19b SRY-box containing gene 19b 0.041
gata6 GATA-binding protein 6 0.041
pitx2 paired-like homeodomain transcription factor 2 0.041
gata3 GATA-binding protein 3 0.040
sfrp5 secreted frizzled-related protein 5 0.040
crabp2a cellular retinoic acid binding protein 2, a 0.039
lhx1a LIM homeobox 1a 0.039
emx2 empty spiracles homeobox 2 0.038
fgfr2 fibroblast growth factor receptor 2 0.038
neurog1 neurogenin 1 0.038
hgfa hepatocyte growth factor a 0.038
irx1a iroquois homeobox protein 1, a 0.037
nkx6.1 NK6 transcription factor related, locus 1 (Drosophila) 0.036
her12 hairy-related 12 0.035
olig1 oligodendrocyte lineage transcription factor 1 0.033
tgfb3 transforming growth factor, beta 3 0.033
nkx2.2b NK2 transcription factor related 2b 0.033
irx1b iroquois homeobox protein 1, b 0.031
nr2f5 nuclear receptor subfamily 2, group F, member 5 0.031
gdf6a growth differentiation factor 6a 0.031
barhl2 BarH-like 2 0.030
hmx3 homeo box (H6 family) 3 0.030
foxc1a forkhead box C1a 0.029
mdka midkine-related growth factor 0.029
gyltl1b glycosyltransferase-like 1b 0.028
im:7164961 im:7164961 0.028
cldnk claudin k 0.028
pcdh18b protocadherin 18b 0.027
slc4a1b solute carrier family 4, anion exchanger, member 1b 0.025
pwp2h PWP2 periodic tryptophan protein homolog (yeast) 0.025
rfx2 regulatory factor X, 2 (influences HLA class II expression) 0.024
pax2a paired box gene 2a 0.022
smad7 MAD, mothers against decapentaplegic homolog 7 (Drosophila) 0.022
rx3 retinal homeobox gene 3 0.021
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.021
irx4a iroquois homeobox protein 4a 0.021
gata2a GATA-binding protein 2a 0.020
six3b sine oculis homeobox homolog 3b 0.020
olig3 oligodendrocyte transcription factor 3 0.019
mpz myelin protein zero 0.019
atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.019
sox1a SRY-box containing gene 1a 0.019
kctd15a potassium channel tetramerisation domain containing 15a 0.018
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa 0.990
JAG1 jagged 1 0.955
NOTCH1 notch 1 0.865
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa 0.794
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.539
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.518
FGF1 fibroblast growth factor 1 (acidic) 0.499
PTCH1 patched 1 0.436
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa 0.398
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa 0.382
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.205
TCF4 transcription factor 4 0.191
PTPRJ protein tyrosine phosphatase, receptor type, J 0.187
CD81 CD81 molecule 0.181
BCL2L1 BCL2-like 1 0.164
CD63 CD63 molecule 0.159
RANBP9 RAN binding protein 9 0.120
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa 0.104
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 0.082
MED29 mediator complex subunit 29 0.074
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.072
CDK19 cyclin-dependent kinase 19 0.064
PSEN1 presenilin 1 0.055
FBLN1 fibulin 1 0.053
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.051
MED24 mediator complex subunit 24 0.051
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.048
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa 0.044
CAV1 caveolin 1, caveolae protein, 22kDa 0.041
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.038
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.034
MED16 mediator complex subunit 16 0.031
BCS1L BCS1-like (S. cerevisiae) 0.029
ADRB2 adrenergic, beta-2-, receptor, surface 0.029
SRP68 signal recognition particle 68kDa 0.025
HARS histidyl-tRNA synthetase 0.024
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.024
HIC1 hypermethylated in cancer 1 0.024
SOX10 SRY (sex determining region Y)-box 10 0.023
FTSJ3 FtsJ homolog 3 (E. coli) 0.021
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.021
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.020
C22orf28 chromosome 22 open reading frame 28 0.017
POU3F2 POU class 3 homeobox 2 0.016
NMT1 N-myristoyltransferase 1 0.016
TNIK TRAF2 and NCK interacting kinase 0.015
ANAPC5 anaphase promoting complex subunit 5 0.015
EMG1 EMG1 nucleolar protein homolog (S. cerevisiae) 0.015
NCOR2 nuclear receptor corepressor 2 0.015
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.014
OLIG2 oligodendrocyte lineage transcription factor 2 0.012
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.012
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Rattus norvegicus
Name Description Probability Func Analog Organism
Mgst1 microsomal glutathione S-transferase 1 0.145
Inpp5d inositol polyphosphate-5-phosphatase D 0.030
Gstm1 glutathione S-transferase mu 1 0.026
Arpc1b actin related protein 2/3 complex, subunit 1B 0.018
Itm2b integral membrane protein 2B 0.012
Fgfr2 fibroblast growth factor receptor 2 0.010
Il18 interleukin 18 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism