The network for 'positive regulation of cardiac muscle cell proliferation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of cardiac muscle cell proliferation

Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation.

Mus musculus
Name Description Probability Func Analog Organism
Fgfr2 fibroblast growth factor receptor 2 1.000
Shh sonic hedgehog 1.000
Fgf8 fibroblast growth factor 8 1.000
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 1.000
Tbx1 T-box 1 1.000
Hand2 heart and neural crest derivatives expressed transcript 2 1.000
Foxc1 forkhead box C1 1.000
Pitx2 paired-like homeodomain transcription factor 2 0.999
Hoxa1 homeobox A1 0.998
Pax2 paired box gene 2 0.996
Tbx3 T-box 3 0.996
Pax3 paired box gene 3 0.996
Bmp4 bone morphogenetic protein 4 0.989
Gli3 GLI-Kruppel family member GLI3 0.986
Jag1 jagged 1 0.985
Foxc2 forkhead box C2 0.984
Gata4 GATA binding protein 4 0.977
Hand1 heart and neural crest derivatives expressed transcript 1 0.977
Ret ret proto-oncogene 0.974
Notch1 Notch gene homolog 1 (Drosophila) 0.966
Nodal nodal 0.964
Chrd chordin 0.957
Sox9 SRY-box containing gene 9 0.936
Ntf3 neurotrophin 3 0.936
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.916
Fgfr1 fibroblast growth factor receptor 1 0.885
Tcfap2a transcription factor AP-2, alpha 0.878
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.874
Gli2 GLI-Kruppel family member GLI2 0.866
Tgfb2 transforming growth factor, beta 2 0.862
Efnb2 ephrin B2 0.831
Isl1 ISL1 transcription factor, LIM/homeodomain 0.790
Wnt3a wingless-related MMTV integration site 3A 0.788
Msx1 homeobox, msh-like 1 0.785
Wt1 Wilms tumor 1 homolog 0.784
Eya1 eyes absent 1 homolog (Drosophila) 0.783
Fgf10 fibroblast growth factor 10 0.779
Chd7 chromodomain helicase DNA binding protein 7 0.779
Bmp7 bone morphogenetic protein 7 0.767
Msx2 homeobox, msh-like 2 0.741
Rarg retinoic acid receptor, gamma 0.730
Tbx2 T-box 2 0.723
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.722
Dlx5 distal-less homeobox 5 0.719
Prrx1 paired related homeobox 1 0.716
Nos3 nitric oxide synthase 3, endothelial cell 0.709
Zfpm2 zinc finger protein, multitype 2 0.709
Gbx2 gastrulation brain homeobox 2 0.707
Hoxa13 homeobox A13 0.678
Rxra retinoid X receptor alpha 0.644
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.590
Fgf18 fibroblast growth factor 18 0.583
Vangl2 vang-like 2 (van gogh, Drosophila) 0.572
Vegfa vascular endothelial growth factor A 0.571
Tbx5 T-box 5 0.566
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.529
Bdnf brain derived neurotrophic factor 0.520
Otx2 orthodenticle homolog 2 (Drosophila) 0.491
Hoxd13 homeobox D13 0.477
Gsc goosecoid homeobox 0.464
Pitx1 paired-like homeodomain transcription factor 1 0.463
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.457
Gata6 GATA binding protein 6 0.445
Gdnf glial cell line derived neurotrophic factor 0.416
Pou5f1 POU domain, class 5, transcription factor 1 0.413
Prrx2 paired related homeobox 2 0.406
Tcf21 transcription factor 21 0.403
Rarb retinoic acid receptor, beta 0.398
Smo smoothened homolog (Drosophila) 0.394
Lhx1 LIM homeobox protein 1 0.384
Sall4 sal-like 4 (Drosophila) 0.374
Hmx3 H6 homeobox 3 0.368
Twist2 twist homolog 2 (Drosophila) 0.367
Lmx1a LIM homeobox transcription factor 1 alpha 0.365
Emx2 empty spiracles homolog 2 (Drosophila) 0.351
Hoxd11 homeobox D11 0.347
Fgfr3 fibroblast growth factor receptor 3 0.338
Meox2 mesenchyme homeobox 2 0.335
Egfr epidermal growth factor receptor 0.316
Hoxa11 homeobox A11 0.310
Smad6 MAD homolog 6 (Drosophila) 0.304
Mesp1 mesoderm posterior 1 0.303
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.296
Pax8 paired box gene 8 0.285
Foxg1 forkhead box G1 0.280
Notch2 Notch gene homolog 2 (Drosophila) 0.260
Hoxa3 homeobox A3 0.258
Dll4 delta-like 4 (Drosophila) 0.257
Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.240
Col13a1 collagen, type XIII, alpha 1 0.238
Tbx15 T-box 15 0.227
Gja3 gap junction protein, alpha 3 0.223
Runx2 runt related transcription factor 2 0.223
Nog noggin 0.222
Gli1 GLI-Kruppel family member GLI1 0.221
Foxf1a forkhead box F1a 0.220
Zeb1 zinc finger E-box binding homeobox 1 0.219
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.217
Fgf15 fibroblast growth factor 15 0.205
Alx4 aristaless-like homeobox 4 0.200
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
FGFR2 fibroblast growth factor receptor 2 1.000
FGF1 fibroblast growth factor 1 (acidic) 1.000
CDK2 cyclin-dependent kinase 2 1.000
FGFR1 fibroblast growth factor receptor 1 1.000
FGF10 fibroblast growth factor 10 1.000
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.999
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.999
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.987
FGF2 fibroblast growth factor 2 (basic) 0.978
JAG1 jagged 1 0.972
PLCG1 phospholipase C, gamma 1 0.972
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.972
CCNA2 cyclin A2 0.947
MAML1 mastermind-like 1 (Drosophila) 0.946
NOTCH1 notch 1 0.945
FGF7 fibroblast growth factor 7 0.939
CKS2 CDC28 protein kinase regulatory subunit 2 0.934
EGFR epidermal growth factor receptor 0.913
CCNE1 cyclin E1 0.902
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.897
CCNB2 cyclin B2 0.850
FRS2 fibroblast growth factor receptor substrate 2 0.835
SPEN spen homolog, transcriptional regulator (Drosophila) 0.803
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.799
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.793
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.782
NOTCH3 notch 3 0.711
CKS1B CDC28 protein kinase regulatory subunit 1B 0.693
FGFR3 fibroblast growth factor receptor 3 0.606
EP300 E1A binding protein p300 0.525
ATXN1L ataxin 1-like 0.486
CDK1 cyclin-dependent kinase 1 0.444
HDAC4 histone deacetylase 4 0.408
NOSTRIN nitric oxide synthase trafficker 0.382
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.365
NCOR2 nuclear receptor corepressor 2 0.284
SKP2 S-phase kinase-associated protein 2 (p45) 0.278
RB1 retinoblastoma 1 0.163
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.142
CTGF connective tissue growth factor 0.138
XIAP X-linked inhibitor of apoptosis 0.114
KLF13 Kruppel-like factor 13 0.101
HDAC9 histone deacetylase 9 0.100
GATA4 GATA binding protein 4 0.085
TRO trophinin 0.083
DLG2 discs, large homolog 2 (Drosophila) 0.083
NOTCH2 notch 2 0.082
TBX5 T-box 5 0.074
ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 0.065
PTK6 PTK6 protein tyrosine kinase 6 0.056
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.050
TCF4 transcription factor 4 0.048
JAG2 jagged 2 0.047
INSR insulin receptor 0.046
DLG3 discs, large homolog 3 (Drosophila) 0.043
EEF2K eukaryotic elongation factor-2 kinase 0.043
CIR1 corepressor interacting with RBPJ, 1 0.042
DLL1 delta-like 1 (Drosophila) 0.040
TNS4 tensin 4 0.037
ATXN1 ataxin 1 0.037
MEF2A myocyte enhancer factor 2A 0.035
GAB2 GRB2-associated binding protein 2 0.033
FGF8 fibroblast growth factor 8 (androgen-induced) 0.033
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 0.033
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.031
GRB7 growth factor receptor-bound protein 7 0.031
SYK spleen tyrosine kinase 0.029
SNW1 SNW domain containing 1 0.027
ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.027
HSPG2 heparan sulfate proteoglycan 2 0.026
CTNNBL1 catenin, beta like 1 0.024
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.024
NEK2 NIMA (never in mitosis gene a)-related kinase 2 0.023
CDKN3 cyclin-dependent kinase inhibitor 3 0.023
KAT2B K(lysine) acetyltransferase 2B 0.022
HTT huntingtin 0.022
KAL1 Kallmann syndrome 1 sequence 0.021
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.021
KCNA1 potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) 0.019
APP amyloid beta (A4) precursor protein 0.018
KIAA0174 KIAA0174 0.018
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 0.017
HAND2 heart and neural crest derivatives expressed 2 0.016
PLK1 polo-like kinase 1 0.016
DDR2 discoidin domain receptor tyrosine kinase 2 0.015
IRS1 insulin receptor substrate 1 0.015
GAB1 GRB2-associated binding protein 1 0.014
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase 0.014
CCND1 cyclin D1 0.014
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.014
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 0.013
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 0.013
EGF epidermal growth factor 0.013
EPAS1 endothelial PAS domain protein 1 0.012
ZHX2 zinc fingers and homeoboxes 2 0.012
VAV3 vav 3 guanine nucleotide exchange factor 0.012
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.011
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) 0.011
FGFBP1 fibroblast growth factor binding protein 1 0.011
TBX1 T-box 1 0.011
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Rattus norvegicus
Name Description Probability Func Analog Organism
Top2a topoisomerase (DNA) II alpha 0.552
Cdkn3 cyclin-dependent kinase inhibitor 3 0.331
Ube2c ubiquitin-conjugating enzyme E2C 0.266
Ccnb2 cyclin B2 0.192
Rrm2 ribonucleotide reductase M2 0.136
Pttg1 pituitary tumor-transforming 1 0.130
Cdca3 cell division cycle associated 3 0.123
Cks2 CDC28 protein kinase regulatory subunit 2 0.109
Cdk1 cyclin-dependent kinase 1 0.097
Prss1 protease, serine, 1 (trypsin 1) 0.092
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.087
LOC689399 hypothetical protein LOC689399 0.081
Spc25 SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) 0.081
Traf4af1 TRAF4 associated factor 1 0.079
Glg1 golgi apparatus protein 1 0.077
Ccnb1 cyclin B1 0.072
Hmgb2 high mobility group box 2 0.063
Ect2 epithelial cell transforming sequence 2 oncogene 0.061
Tgfbr2 transforming growth factor, beta receptor II 0.055
Racgap1 Rac GTPase-activating protein 1 0.054
Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.054
Kifc1 kinesin family member C1 0.051
Smad6 SMAD family member 6 0.050
Gata6 GATA binding protein 6 0.043
Ns5atp9 NS5A (hepatitis C virus) transactivated protein 9 0.043
Fgf5 fibroblast growth factor 5 0.043
Depdc1 DEP domain containing 1 0.036
Akt2 v-akt murine thymoma viral oncogene homolog 2 0.034
Hmmr hyaluronan mediated motility receptor (RHAMM) 0.034
Sdc3 syndecan 3 0.033
Slc13a1 solute carrier family 13 (sodium/sulfate symporters), member 1 0.032
Smad7 SMAD family member 7 0.032
Bub1b budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) 0.032
siat7D alpha-2,6-sialyltransferase ST6GalNAc IV 0.031
Crybb3 crystallin, beta B3 0.030
Slc10a2 solute carrier family 10 (sodium/bile acid cotransporter family), member 2 0.030
Mki67 antigen identified by monoclonal antibody Ki-67 0.030
Gabrg3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 0.029
Unc5b unc-5 homolog B (C. elegans) 0.029
Shox2 short stature homeobox 2 0.029
Nusap1 nucleolar and spindle associated protein 1 0.029
Foxc1 forkhead box C1 0.028
Pdk4 pyruvate dehydrogenase kinase, isozyme 4 0.027
Ucn2 urocortin 2 0.027
Tbr1 T-box, brain, 1 0.027
Gna12 guanine nucleotide binding protein (G protein) alpha 12 0.027
Mcam melanoma cell adhesion molecule 0.026
Lepr leptin receptor 0.026
Ica1l islet cell autoantigen 1-like 0.026
Kif2c kinesin family member 2C 0.026
Tk1 thymidine kinase 1, soluble 0.026
Pde7b phosphodiesterase 7B 0.026
Asf1b ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.025
Hist1h1a histone cluster 1, H1a 0.024
Htr2a 5-hydroxytryptamine (serotonin) receptor 2A 0.024
Gja3 gap junction protein, alpha 3 0.023
RGD1309821 similar to KIAA1161 protein 0.023
RGD1308124 similar to KIAA1357 protein 0.023
Nefl neurofilament, light polypeptide 0.023
Met met proto-oncogene 0.023
Homer3 homer homolog 3 (Drosophila) 0.023
Il7 interleukin 7 0.022
Ehf ets homologous factor 0.022
Slc6a18 solute carrier family 6, member 18 0.022
Fgfr2 fibroblast growth factor receptor 2 0.021
Rcvrn recoverin 0.021
Cdh6 cadherin 6 0.021
Nrg1 neuregulin 1 0.021
Cercam cerebral endothelial cell adhesion molecule 0.021
Prc1 protein regulator of cytokinesis 1 0.020
Kcng2 potassium voltage-gated channel, subfamily G, member 2 0.020
Kcnk15 potassium channel, subfamily K, member 15 0.020
Scn11a sodium channel, voltage-gated, type XI, alpha 0.020
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.019
Sfrp4 secreted frizzled-related protein 4 0.019
Syngr2 synaptogyrin 2 0.019
Stmn1 stathmin 1 0.019
Zic1 Zic family member 1 (odd-paired homolog, Drosophila) 0.019
RGD1566083 similar to hypothetical protein MGC24047 0.019
Impg1 interphotoreceptor matrix proteoglycan 1 0.019
Dag1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.019
Pga5 pepsinogen 5, group I 0.018
Melk maternal embryonic leucine zipper kinase 0.018
Npr3 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) 0.018
Clps colipase, pancreatic 0.018
Mcm3 minichromosome maintenance complex component 3 0.018
Adamts13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 0.018
Gip gastric inhibitory polypeptide 0.018
Dmd dystrophin 0.018
Tubb5 tubulin, beta 5 0.018
Otud1 OTU domain containing 1 0.018
Il11 interleukin 11 0.017
Trim17 tripartite motif-containing 17 0.017
Pbk PDZ binding kinase 0.017
Lims1 LIM and senescent cell antigen-like domains 1 0.017
Adrb1 adrenergic, beta-1-, receptor 0.017
Slc7a9 solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 0.017
Cdkn2b cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.017
Kcnj16 potassium inwardly-rectifying channel, subfamily J, member 16 0.017
Camk4 calcium/calmodulin-dependent protein kinase IV 0.017
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism