IMP
Process View
The network for 'keratinocyte proliferation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
keratinocyte proliferation
The multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. Keratinocytes are epidermal cells which synthesize keratin and undergo a characteristic change as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Shh | sonic hedgehog | 0.999 | |
| Pten | phosphatase and tensin homolog | 0.993 | |
| Gli3 | GLI-Kruppel family member GLI3 | 0.986 | |
| Fgfr2 | fibroblast growth factor receptor 2 | 0.982 | |
| Gli2 | GLI-Kruppel family member GLI2 | 0.980 | |
| Trp63 | transformation related protein 63 | 0.970 | |
| Csf1 | colony stimulating factor 1 (macrophage) | 0.963 | |
| Ascl1 | achaete-scute complex homolog 1 (Drosophila) | 0.935 | |
| Neurod1 | neurogenic differentiation 1 | 0.929 | |
| Klk1 | kallikrein 1 | 0.888 | |
| Klk1b11 | kallikrein 1-related peptidase b11 | 0.861 | |
| Sfn | stratifin | 0.860 | |
| Yap1 | yes-associated protein 1 | 0.840 | |
| Pthlh | parathyroid hormone-like peptide | 0.816 | |
| Pax6 | paired box gene 6 | 0.786 | |
| Klk1b5 | kallikrein 1-related peptidase b5 | 0.773 | |
| Sox9 | SRY-box containing gene 9 | 0.771 | |
| Gata4 | GATA binding protein 4 | 0.738 | |
| Klk1b8 | kallikrein 1-related peptidase b8 | 0.669 | |
| Klk1b26 | kallikrein 1-related petidase b26 | 0.659 | |
| Klk1b21 | kallikrein 1-related peptidase b21 | 0.634 | |
| Isl1 | ISL1 transcription factor, LIM/homeodomain | 0.597 | |
| Otx2 | orthodenticle homolog 2 (Drosophila) | 0.591 | |
| Zg16 | zymogen granule protein 16 | 0.586 | |
| Runx2 | runt related transcription factor 2 | 0.573 | |
| Hoxa13 | homeobox A13 | 0.570 | |
| Irf6 | interferon regulatory factor 6 | 0.558 | |
| Klk1b3 | kallikrein 1-related peptidase b3 | 0.552 | |
| Hoxd11 | homeobox D11 | 0.530 | |
| Hoxd13 | homeobox D13 | 0.515 | |
| Reg2 | regenerating islet-derived 2 | 0.488 | |
| Bmp4 | bone morphogenetic protein 4 | 0.483 | |
| Twist2 | twist homolog 2 (Drosophila) | 0.472 | |
| Trp53 | transformation related protein 53 | 0.462 | |
| Tlx3 | T-cell leukemia, homeobox 3 | 0.457 | |
| Lhx3 | LIM homeobox protein 3 | 0.449 | |
| Klk1b24 | kallikrein 1-related peptidase b24 | 0.437 | |
| Tbx3 | T-box 3 | 0.430 | |
| Ror2 | receptor tyrosine kinase-like orphan receptor 2 | 0.425 | |
| Ywhaz | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 0.416 | |
| Neurog3 | neurogenin 3 | 0.408 | |
| Pax3 | paired box gene 3 | 0.404 | |
| Ptf1a | pancreas specific transcription factor, 1a | 0.387 | |
| Tbx15 | T-box 15 | 0.386 | |
| Ywhae | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | 0.386 | |
| Msx2 | homeobox, msh-like 2 | 0.365 | |
| Rpgrip1l | Rpgrip1-like | 0.350 | |
| Klk1b1 | kallikrein 1-related peptidase b1 | 0.326 | |
| Fgf5 | fibroblast growth factor 5 | 0.323 | |
| Kitl | kit ligand | 0.322 | |
| Gata6 | GATA binding protein 6 | 0.317 | |
| Zfpm2 | zinc finger protein, multitype 2 | 0.309 | |
| Klk1b16 | kallikrein 1-related peptidase b16 | 0.306 | |
| Fgfr3 | fibroblast growth factor receptor 3 | 0.301 | |
| Pitx2 | paired-like homeodomain transcription factor 2 | 0.286 | |
| Meox2 | mesenchyme homeobox 2 | 0.274 | |
| Foxc1 | forkhead box C1 | 0.274 | |
| Smo | smoothened homolog (Drosophila) | 0.271 | |
| 2210010C04Rik | RIKEN cDNA 2210010C04 gene | 0.271 | |
| Ctrb1 | chymotrypsinogen B1 | 0.267 | |
| Klk1b4 | kallikrein 1-related pepidase b4 | 0.262 | |
| Klk1b9 | kallikrein 1-related peptidase b9 | 0.260 | |
| Mycn | v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) | 0.259 | |
| Clps | colipase, pancreatic | 0.256 | |
| Prrx1 | paired related homeobox 1 | 0.249 | |
| Snai1 | snail homolog 1 (Drosophila) | 0.249 | |
| Egfr | epidermal growth factor receptor | 0.245 | |
| Mmp14 | matrix metallopeptidase 14 (membrane-inserted) | 0.222 | |
| Pitx1 | paired-like homeodomain transcription factor 1 | 0.213 | |
| Mecom | MDS1 and EVI1 complex locus | 0.207 | |
| Pax9 | paired box gene 9 | 0.193 | |
| Stat2 | signal transducer and activator of transcription 2 | 0.192 | |
| Gpr50 | G-protein-coupled receptor 50 | 0.191 | |
| Ywhab | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide | 0.183 | |
| Hif1a | hypoxia inducible factor 1, alpha subunit | 0.183 | |
| Dmbt1 | deleted in malignant brain tumors 1 | 0.175 | |
| Foxc2 | forkhead box C2 | 0.175 | |
| Ntf3 | neurotrophin 3 | 0.166 | |
| Cel | carboxyl ester lipase | 0.163 | |
| Nck2 | non-catalytic region of tyrosine kinase adaptor protein 2 | 0.159 | |
| Epha4 | Eph receptor A4 | 0.158 | |
| Stat1 | signal transducer and activator of transcription 1 | 0.157 | |
| Nkx2-5 | NK2 transcription factor related, locus 5 (Drosophila) | 0.149 | |
| Ifnar2 | interferon (alpha and beta) receptor 2 | 0.149 | |
| Uba7 | ubiquitin-like modifier activating enzyme 7 | 0.145 | |
| Reg3a | regenerating islet-derived 3 alpha | 0.141 | |
| Ikzf1 | IKAROS family zinc finger 1 | 0.137 | |
| Nr0b2 | nuclear receptor subfamily 0, group B, member 2 | 0.136 | |
| Crb2 | crumbs homolog 2 (Drosophila) | 0.134 | |
| Insm1 | insulinoma-associated 1 | 0.134 | |
| Ghr | growth hormone receptor | 0.134 | |
| Cdx2 | caudal type homeobox 2 | 0.134 | |
| 5430421N21Rik | RIKEN cDNA 5430421N21 gene | 0.131 | |
| Fgf9 | fibroblast growth factor 9 | 0.126 | |
| Grip1 | glutamate receptor interacting protein 1 | 0.124 | |
| Rnase1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.122 | |
| Ptpn11 | protein tyrosine phosphatase, non-receptor type 11 | 0.120 | |
| Rxrg | retinoid X receptor gamma | 0.120 | |
| Tgfb2 | transforming growth factor, beta 2 | 0.120 | |
| Tcfap2a | transcription factor AP-2, alpha | 0.118 |
Loading network...
Homo sapiens
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.998 | |
| FGFR2 | fibroblast growth factor receptor 2 | 0.996 | |
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) | 0.970 | |
| KRT15 | keratin 15 | 0.896 | |
| TP63 | tumor protein p63 | 0.729 | |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.699 | |
| PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | 0.678 | |
| KRT17 | keratin 17 | 0.670 | |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.665 | |
| BTRC | beta-transducin repeat containing | 0.583 | |
| FGFR1 | fibroblast growth factor receptor 1 | 0.574 | |
| KRT19 | keratin 19 | 0.570 | |
| TCF4 | transcription factor 4 | 0.484 | |
| LATS2 | LATS, large tumor suppressor, homolog 2 (Drosophila) | 0.473 | |
| YAP1 | Yes-associated protein 1 | 0.467 | |
| NCOR2 | nuclear receptor corepressor 2 | 0.456 | |
| KRT14 | keratin 14 | 0.449 | |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide | 0.318 | |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide | 0.271 | |
| JUP | junction plakoglobin | 0.268 | |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.255 | |
| CDH3 | cadherin 3, type 1, P-cadherin (placental) | 0.248 | |
| SRSF6 | serine/arginine-rich splicing factor 6 | 0.223 | |
| PKP1 | plakophilin 1 (ectodermal dysplasia/skin fragility syndrome) | 0.209 | |
| KRT18 | keratin 18 | 0.205 | |
| PPL | periplakin | 0.203 | |
| KRT6A | keratin 6A | 0.200 | |
| HR | hairless homolog (mouse) | 0.189 | |
| INADL | InaD-like (Drosophila) | 0.187 | |
| SRSF4 | serine/arginine-rich splicing factor 4 | 0.167 | |
| KRT5 | keratin 5 | 0.166 | |
| KRT6B | keratin 6B | 0.161 | |
| RXRA | retinoid X receptor, alpha | 0.160 | |
| PKP3 | plakophilin 3 | 0.133 | |
| TRIM29 | tripartite motif containing 29 | 0.132 | |
| KRT6C | keratin 6C | 0.118 | |
| FGF10 | fibroblast growth factor 10 | 0.117 | |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.113 | |
| HNF4A | hepatocyte nuclear factor 4, alpha | 0.110 | |
| FGF1 | fibroblast growth factor 1 (acidic) | 0.108 | |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 0.099 | |
| RARA | retinoic acid receptor, alpha | 0.097 | |
| ESR1 | estrogen receptor 1 | 0.082 | |
| KRT1 | keratin 1 | 0.082 | |
| KLK10 | kallikrein-related peptidase 10 | 0.079 | |
| DSP | desmoplakin | 0.067 | |
| PSEN1 | presenilin 1 | 0.066 | |
| LIN7A | lin-7 homolog A (C. elegans) | 0.065 | |
| SDC2 | syndecan 2 | 0.065 | |
| FBXW11 | F-box and WD repeat domain containing 11 | 0.063 | |
| GSK3B | glycogen synthase kinase 3 beta | 0.063 | |
| AR | androgen receptor | 0.060 | |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.056 | |
| C19orf50 | chromosome 19 open reading frame 50 | 0.053 | |
| S100A2 | S100 calcium binding protein A2 | 0.051 | |
| GJB3 | gap junction protein, beta 3, 31kDa | 0.050 | |
| ESRRG | estrogen-related receptor gamma | 0.050 | |
| ITGA2B | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) | 0.049 | |
| INHBA | inhibin, beta A | 0.047 | |
| FGF7 | fibroblast growth factor 7 | 0.046 | |
| SPRR1A | small proline-rich protein 1A | 0.045 | |
| PARD3 | par-3 partitioning defective 3 homolog (C. elegans) | 0.045 | |
| KRT34 | keratin 34 | 0.044 | |
| KRT75 | keratin 75 | 0.044 | |
| FGF8 | fibroblast growth factor 8 (androgen-induced) | 0.044 | |
| GLIS2 | GLIS family zinc finger 2 | 0.042 | |
| ALOX12 | arachidonate 12-lipoxygenase | 0.041 | |
| FGFR3 | fibroblast growth factor receptor 3 | 0.040 | |
| HAP1 | huntingtin-associated protein 1 | 0.039 | |
| SPRR1B | small proline-rich protein 1B | 0.039 | |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | 0.039 | |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.039 | |
| FGFBP1 | fibroblast growth factor binding protein 1 | 0.038 | |
| SATB2 | SATB homeobox 2 | 0.037 | |
| AMOTL2 | angiomotin like 2 | 0.034 | |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.032 | |
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | 0.032 | |
| EGFR | epidermal growth factor receptor | 0.031 | |
| NCOR1 | nuclear receptor corepressor 1 | 0.030 | |
| F11R | F11 receptor | 0.029 | |
| LYPD3 | LY6/PLAUR domain containing 3 | 0.029 | |
| APC | adenomatous polyposis coli | 0.029 | |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.029 | |
| GYPC | glycophorin C (Gerbich blood group) | 0.028 | |
| FGF4 | fibroblast growth factor 4 | 0.027 | |
| SIN3A | SIN3 homolog A, transcription regulator (yeast) | 0.027 | |
| HDAC1 | histone deacetylase 1 | 0.026 | |
| PGR | progesterone receptor | 0.026 | |
| KRT33B | keratin 33B | 0.025 | |
| KDM1A | lysine (K)-specific demethylase 1A | 0.025 | |
| SFN | stratifin | 0.025 | |
| KRT9 | keratin 9 | 0.024 | |
| KRT16 | keratin 16 | 0.024 | |
| S1PR5 | sphingosine-1-phosphate receptor 5 | 0.024 | |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 0.024 | |
| BNC1 | basonuclin 1 | 0.024 | |
| DSG3 | desmoglein 3 | 0.023 | |
| FGF18 | fibroblast growth factor 18 | 0.023 | |
| UBR1 | ubiquitin protein ligase E3 component n-recognin 1 | 0.023 | |
| GJB5 | gap junction protein, beta 5, 31.1kDa | 0.023 |