The network for 'notochord development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

notochord development

The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column.

Mus musculus
Name Description Probability Func Analog Organism
Efnb2 ephrin B2 0.993
Gli3 GLI-Kruppel family member GLI3 0.988
Nodal nodal 0.940
Tbx3 T-box 3 0.913
Ephb2 Eph receptor B2 0.896
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.895
Col1a1 collagen, type I, alpha 1 0.882
Jag1 jagged 1 0.875
Zic3 zinc finger protein of the cerebellum 3 0.874
Shh sonic hedgehog 0.844
Fgfr2 fibroblast growth factor receptor 2 0.818
Bmp4 bone morphogenetic protein 4 0.817
Pax3 paired box gene 3 0.778
Col2a1 collagen, type II, alpha 1 0.744
Gli2 GLI-Kruppel family member GLI2 0.707
Id3 inhibitor of DNA binding 3 0.705
Wt1 Wilms tumor 1 homolog 0.685
Smad6 MAD homolog 6 (Drosophila) 0.663
Gata4 GATA binding protein 4 0.641
Pitx2 paired-like homeodomain transcription factor 2 0.634
Yap1 yes-associated protein 1 0.590
Epha4 Eph receptor A4 0.523
Foxh1 forkhead box H1 0.514
Sall4 sal-like 4 (Drosophila) 0.474
Crb2 crumbs homolog 2 (Drosophila) 0.471
Vangl2 vang-like 2 (van gogh, Drosophila) 0.398
Pax2 paired box gene 2 0.395
Col5a2 collagen, type V, alpha 2 0.389
Foxc2 forkhead box C2 0.385
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.376
Prrx1 paired related homeobox 1 0.342
Ptrf polymerase I and transcript release factor 0.336
Wwtr1 WW domain containing transcription regulator 1 0.332
Hand1 heart and neural crest derivatives expressed transcript 1 0.328
Fstl1 follistatin-like 1 0.327
Fgfr3 fibroblast growth factor receptor 3 0.323
Vegfa vascular endothelial growth factor A 0.321
Pitx1 paired-like homeodomain transcription factor 1 0.318
Fgfr1 fibroblast growth factor receptor 1 0.318
Efnb1 ephrin B1 0.313
Sox2 SRY-box containing gene 2 0.308
Nos3 nitric oxide synthase 3, endothelial cell 0.308
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.299
Col3a1 collagen, type III, alpha 1 0.295
Foxg1 forkhead box G1 0.273
T brachyury 0.269
Tgfb2 transforming growth factor, beta 2 0.268
Id1 inhibitor of DNA binding 1 0.263
Notch1 Notch gene homolog 1 (Drosophila) 0.253
Col1a2 collagen, type I, alpha 2 0.235
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.234
Ephb3 Eph receptor B3 0.225
Tead1 TEA domain family member 1 0.219
Alx4 aristaless-like homeobox 4 0.205
Foxc1 forkhead box C1 0.202
Pthlh parathyroid hormone-like peptide 0.200
Hes1 hairy and enhancer of split 1 (Drosophila) 0.191
Ntf3 neurotrophin 3 0.190
Grb10 growth factor receptor bound protein 10 0.185
Fgf10 fibroblast growth factor 10 0.175
Nog noggin 0.171
Lamb1 laminin B1 0.170
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.168
Runx1t1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.161
Col6a1 collagen, type VI, alpha 1 0.153
Six2 sine oculis-related homeobox 2 homolog (Drosophila) 0.136
Gdf1 growth differentiation factor 1 0.133
Chd7 chromodomain helicase DNA binding protein 7 0.128
Ren1 renin 1 structural 0.125
Copb1 coatomer protein complex, subunit beta 1 0.120
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.120
Fgf8 fibroblast growth factor 8 0.119
Col4a1 collagen, type IV, alpha 1 0.117
Efs embryonal Fyn-associated substrate 0.116
Sox9 SRY-box containing gene 9 0.115
Hcn4 hyperpolarization-activated, cyclic nucleotide-gated K+ 4 0.115
Capn6 calpain 6 0.114
Lox lysyl oxidase 0.113
Pou5f1 POU domain, class 5, transcription factor 1 0.110
Gata5 GATA binding protein 5 0.106
Tead2 TEA domain family member 2 0.106
Nid1 nidogen 1 0.105
Ptk7 PTK7 protein tyrosine kinase 7 0.105
Dll4 delta-like 4 (Drosophila) 0.104
Hoxa1 homeobox A1 0.096
Fbn2 fibrillin 2 0.094
Rnf2 ring finger protein 2 0.094
Atoh7 atonal homolog 7 (Drosophila) 0.093
Col11a1 collagen, type XI, alpha 1 0.089
Efna4 ephrin A4 0.088
Meox2 mesenchyme homeobox 2 0.088
Col5a1 collagen, type V, alpha 1 0.088
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.086
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.085
Eln elastin 0.082
Col13a1 collagen, type XIII, alpha 1 0.081
Hey1 hairy/enhancer-of-split related with YRPW motif 1 0.081
Gdnf glial cell line derived neurotrophic factor 0.080
Tcf3 transcription factor 3 0.079
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.076
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
flh floating head 0.999
lamc1 laminin, gamma 1 0.998
shha sonic hedgehog a 0.992
ntla no tail a 0.988
chd chordin 0.983
col8a1a collagen, type VIII, alpha 1a 0.973
tbx2b T-box 2b 0.970
fgf17 fibroblast growth factor 17 0.968
hnf1ba HNF1 homeobox Ba 0.951
tbx1 T-box 1 0.947
dharma dharma 0.939
lamb1a laminin, beta 1a 0.931
col27a1a collagen, type XXVII, alpha 1a 0.925
col1a1a collagen, type I, alpha 1a 0.921
lft1 lefty1 0.921
col11a2 collagen type XI alpha-2 0.921
gli2a GLI-Kruppel family member GLI2a 0.908
bmp2a bone morphogenetic protein 2a 0.878
ndr2 nodal-related 2 0.864
bmp2b bone morphogenetic protein 2b 0.851
lft2 lefty2 0.846
col5a2l collagen, type V, alpha 2-like 0.829
col5a1 procollagen, type V, alpha 1 0.813
sox10 SRY-box containing gene 10 0.770
ptch2 patched 2 0.766
pou5f1 POU domain, class 5, transcription factor 1 0.760
wnt5b wingless-type MMTV integration site family, member 5b 0.729
gli1 GLI-Kruppel family member 1 0.695
admp anti-dorsalizing morphogenic protein 0.682
wnt9a wingless-type MMTV integration site family, member 9A 0.678
col1a2 collagen, type I, alpha 2 0.677
unc45b unc-45 homolog B (C. elegans) 0.662
foxh1 forkhead box H1 0.647
col2a1a collagen type II, alpha-1a 0.623
eve1 even-skipped-like1 0.616
notch2 notch homolog 2 0.614
foxa2 forkhead box A2 0.605
sparc secreted acidic cysteine rich glycoprotein 0.577
fbn2b fibrillin 2b 0.577
wnt11 wingless-type MMTV integration site family, member 11 0.571
cdh2 cadherin 2, neuronal 0.549
myod1 myogenic differentiation 1 0.543
frzb frizzled-related protein 0.542
wnt2 wingless-type MMTV integration site family member 2 0.509
foxa3 forkhead box A3 0.494
ccm2 cerebral cavernous malformation 2 0.494
neo1 neogenin 1 0.486
rbp4 retinol binding protein 4, plasma 0.474
cdx4 caudal type homeo box transcription factor 4 0.472
zgc:85866 zgc:85866 0.459
nanos3 nanos homolog 3 0.452
runx2b runt-related transcription factor 2b 0.446
bmp4 bone morphogenetic protein 4 0.438
copb1 coatomer protein complex, subunit beta 1 0.423
vent ventral expressed homeobox 0.423
bmp1a bone morphogenetic protein 1a 0.418
dlx5a distal-less homeobox gene 5a 0.407
osr2 odd-skipped related 2 (Drosophila) 0.407
foxd5 forkhead box D5 0.406
col9a2 procollagen, type IX, alpha 2 0.403
mib mind bomb 0.393
wnt8b wingless-type MMTV integration site family, member 8b 0.381
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.358
sox9b SRY-box containing gene 9b 0.356
kita kit receptor a 0.346
twist2 twist2 0.337
nog3 noggin 3 0.336
zgc:111821 zgc:111821 0.332
ndr1 nodal-related 1 0.332
tbx16 T-box gene 16 0.325
fgf3 fibroblast growth factor 3 0.320
tll1 tolloid-like 1 0.319
smyd1b SET and MYND domain containing 1b 0.317
wnt9b wingless-type MMTV integration site family, member 9B 0.316
dkk1b dickkopf 1b 0.313
pdzrn3 PDZ domain containing RING finger 3 and PDZ domain containing ring finger 3 0.304
tbx24 T-box 24 0.286
plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 0.278
fzd7a frizzled homolog 7a 0.278
ltbp3 latent transforming growth factor beta binding protein 3 0.276
cdh6 cadherin 6 0.273
wnt4a wingless-type MMTV integration site family, member 4a 0.273
sox32 SRY-box containing gene 32 0.271
fn1 fibronectin 1 0.267
copa coatomer protein complex, subunit alpha 0.266
ier2 immediate early response 2 0.259
wnt10b wingless-type MMTV integration site family, member 10b 0.255
dcn decorin 0.254
hand2 heart and neural crest derivatives expressed transcript 2 0.254
hhip hedgehog interacting protein 0.253
dld deltaD 0.247
plod2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.241
mmp14a matrix metalloproteinase 14a (membrane-inserted) 0.239
slc45a2 solute carrier family 45, member 2 0.238
atp6v0d1 ATPase, H+ transporting, V0 subunit D isoform 1 0.235
tgfb3 transforming growth factor, beta 3 0.232
pax7a paired box gene 7a 0.230
si:xx-bac7cse.2 si:xx-bac7cse.2 0.223
lhx5 LIM homeobox 5 0.213
dlx2a distal-less homeobox gene 2a 0.207
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism