The network for 'embryonic appendage morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

embryonic appendage morphogenesis

The process, occurring in the embryo, by which the anatomical structures of the appendage are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch.

Mus musculus
Name Description Probability Func Analog Organism
Gli3 GLI-Kruppel family member GLI3 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Pitx2 paired-like homeodomain transcription factor 2 1.000
Msx1 homeobox, msh-like 1 1.000
Shh sonic hedgehog 1.000
Pax2 paired box gene 2 1.000
Fgfr1 fibroblast growth factor receptor 1 1.000
Bmp7 bone morphogenetic protein 7 1.000
Foxc1 forkhead box C1 0.999
Rarb retinoic acid receptor, beta 0.999
Pax3 paired box gene 3 0.999
Msx2 homeobox, msh-like 2 0.999
Pax6 paired box gene 6 0.999
Hoxd11 homeobox D11 0.999
Lef1 lymphoid enhancer binding factor 1 0.999
Pax8 paired box gene 8 0.998
Chrd chordin 0.997
Wnt3a wingless-related MMTV integration site 3A 0.997
Sall4 sal-like 4 (Drosophila) 0.997
Hoxa10 homeobox A10 0.996
En1 engrailed 1 0.995
Otx2 orthodenticle homolog 2 (Drosophila) 0.995
Fgf8 fibroblast growth factor 8 0.995
Pten phosphatase and tensin homolog 0.995
Hoxa13 homeobox A13 0.994
Sox2 SRY-box containing gene 2 0.994
Pbx1 pre B-cell leukemia transcription factor 1 0.993
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.992
Tgfb2 transforming growth factor, beta 2 0.990
Sox9 SRY-box containing gene 9 0.989
Wnt5a wingless-related MMTV integration site 5A 0.988
Pitx1 paired-like homeodomain transcription factor 1 0.987
Dlx5 distal-less homeobox 5 0.985
Rarg retinoic acid receptor, gamma 0.984
Gli2 GLI-Kruppel family member GLI2 0.984
Twist2 twist homolog 2 (Drosophila) 0.981
Bmp4 bone morphogenetic protein 4 0.979
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.977
Prrx2 paired related homeobox 2 0.974
Gsc goosecoid homeobox 0.971
Hoxa11 homeobox A11 0.971
Lhx1 LIM homeobox protein 1 0.970
Fgf10 fibroblast growth factor 10 0.967
Tbx3 T-box 3 0.965
Hoxd13 homeobox D13 0.965
Hoxa1 homeobox A1 0.965
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.965
Gbx2 gastrulation brain homeobox 2 0.964
Runx2 runt related transcription factor 2 0.960
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.956
Sfrp2 secreted frizzled-related protein 2 0.955
Hand2 heart and neural crest derivatives expressed transcript 2 0.954
Tcfap2a transcription factor AP-2, alpha 0.951
Nodal nodal 0.950
Hand1 heart and neural crest derivatives expressed transcript 1 0.944
Hoxd10 homeobox D10 0.939
Eya1 eyes absent 1 homolog (Drosophila) 0.935
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.934
Trp63 transformation related protein 63 0.928
Foxc2 forkhead box C2 0.925
Fuz fuzzy homolog (Drosophila) 0.922
Rxra retinoid X receptor alpha 0.921
Vangl2 vang-like 2 (van gogh, Drosophila) 0.913
Psen1 presenilin 1 0.910
Gdnf glial cell line derived neurotrophic factor 0.904
Gas1 growth arrest specific 1 0.902
Smo smoothened homolog (Drosophila) 0.897
Tbx15 T-box 15 0.895
Hoxa2 homeobox A2 0.880
Insm1 insulinoma-associated 1 0.879
Alx4 aristaless-like homeobox 4 0.877
Pax9 paired box gene 9 0.865
Pcsk5 proprotein convertase subtilisin/kexin type 5 0.863
Prrx1 paired related homeobox 1 0.859
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.853
Mks1 Meckel syndrome, type 1 0.848
Hoxa9 homeobox A9 0.843
Twist1 twist homolog 1 (Drosophila) 0.840
Emx2 empty spiracles homolog 2 (Drosophila) 0.836
Gpc3 glypican 3 0.835
Wt1 Wilms tumor 1 homolog 0.835
Lmx1b LIM homeobox transcription factor 1 beta 0.826
Fgf15 fibroblast growth factor 15 0.818
Fgf9 fibroblast growth factor 9 0.815
Otx1 orthodenticle homolog 1 (Drosophila) 0.806
Efna2 ephrin A2 0.804
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.790
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.762
Pou3f3 POU domain, class 3, transcription factor 3 0.761
Lmx1a LIM homeobox transcription factor 1 alpha 0.740
Gdf3 growth differentiation factor 3 0.738
Smad6 MAD homolog 6 (Drosophila) 0.737
Neurog1 neurogenin 1 0.732
Hmx3 H6 homeobox 3 0.726
Alx3 aristaless-like homeobox 3 0.725
Efnb1 ephrin B1 0.722
Cdx2 caudal type homeobox 2 0.717
Tcfcp2l1 transcription factor CP2-like 1 0.703
Sin3a transcriptional regulator, SIN3A (yeast) 0.695
Tbx1 T-box 1 0.686
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
hand2 heart and neural crest derivatives expressed transcript 2 0.979
hoxc6a homeo box C6a 0.972
wnt5b wingless-type MMTV integration site family, member 5b 0.964
chd chordin 0.964
bmp2b bone morphogenetic protein 2b 0.927
hoxc4a homeo box C4a 0.910
bmp4 bone morphogenetic protein 4 0.905
shha sonic hedgehog a 0.898
hoxb5b homeo box B5b 0.891
hoxb5a homeo box B5a 0.871
gbx2 gastrulation brain homeo box 2 0.865
bmp1a bone morphogenetic protein 1a 0.856
hoxa9a homeo box A9a 0.831
kdrl kinase insert domain receptor like 0.798
fras1 Fraser syndrome 1 0.792
msxd muscle segment homeobox D 0.779
hoxc8a homeo box C8a 0.758
runx2b runt-related transcription factor 2b 0.757
hnf1ba HNF1 homeobox Ba 0.753
bmp2a bone morphogenetic protein 2a 0.752
eya1 eyes absent homolog 1 0.731
tfap2a transcription factor AP-2 alpha 0.705
snai1a snail homolog 1a (Drosophila) 0.674
hoxd10a homeo box D10a 0.641
gsc goosecoid 0.638
fgf10a fibroblast growth factor 10a 0.636
sox9a SRY-box containing gene 9a 0.614
hoxa13b homeo box A13b 0.603
hoxd13a homeo box D13a 0.601
hoxd11a homeo box D11a 0.596
fgf8a fibroblast growth factor 8 a 0.564
hoxa4a homeo box A4a 0.550
hoxb6b homeo box B6b 0.537
lef1 lymphocyte enhancer binding factor 1 0.512
mib mind bomb 0.505
hoxb8a homeo box B8a 0.504
tbx1 T-box 1 0.496
hoxa9b homeo box A9b 0.493
fgf24 fibroblast growth factor 24 0.482
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.414
crabp2a cellular retinoic acid binding protein 2, a 0.410
dlx3b distal-less homeobox gene 3b 0.394
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.393
tbx18 T-box 18 0.392
wnt11 wingless-type MMTV integration site family, member 11 0.392
pcdh8 protocadherin 8 0.382
dlx2a distal-less homeobox gene 2a 0.348
hoxc9a homeo box C9a 0.323
dkk1b dickkopf 1b 0.322
hoxd4a homeo box D4a 0.311
irx2a iroquois homeobox protein 2, a 0.309
col2a1a collagen type II, alpha-1a 0.307
myod1 myogenic differentiation 1 0.305
her5 hairy-related 5 0.300
dlx5a distal-less homeobox gene 5a 0.298
vent ventral expressed homeobox 0.294
myf5 myogenic factor 5 0.292
gpr126 G protein-coupled receptor 126 0.271
msxb muscle segment homeobox B 0.268
gdf6a growth differentiation factor 6a 0.256
foxa3 forkhead box A3 0.251
fn1 fibronectin 1 0.250
tbx16 T-box gene 16 0.249
frem1a Fras1 related extracellular matrix 1a 0.246
tbx5a T-box 5a 0.245
hgfa hepatocyte growth factor a 0.245
wnt9a wingless-type MMTV integration site family, member 9A 0.242
hoxd9a homeo box D9a 0.242
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.241
hoxc1a homeo box C1a 0.241
jag2 jagged 2 0.233
hoxa11b homeo box A11b 0.227
wnt3a wingless-type MMTV integration site family, member 3A 0.224
cxcl12b chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) 0.221
wnt3 wingless-type MMTV integration site family, member 3 0.219
lbx1a ladybird homeobox 1a 0.210
vcanb versican b 0.206
hoxb6a homeo box B6a 0.205
dcc deleted in colorectal carcinoma 0.202
hoxd12a homeo box D12a 0.200
hmx3 homeo box (H6 family) 3 0.200
dlb deltaB 0.200
frem2a Fras1 related extracellular matrix protein 2a 0.198
msxc muscle segment homeobox C 0.197
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.197
tcf12 transcription factor 12 0.195
tbx2b T-box 2b 0.192
cdx4 caudal type homeo box transcription factor 4 0.187
ptenb phosphatase and tensin homolog B (mutated in multiple advanced cancers 1) 0.181
prtga protogenin homolog a (Gallus gallus) 0.177
meis3 myeloid ecotropic viral integration site 3 0.175
eve1 even-skipped-like1 0.169
has2 hyaluronan synthase 2 0.165
gli2a GLI-Kruppel family member GLI2a 0.165
ptf1a pancreas specific transcription factor, 1a 0.156
apc adenomatosis polyposis coli 0.155
hoxa5a homeo box A5a 0.155
si:ch211-173o4.2 si:ch211-173o4.2 0.153
prdm1a PR domain containing 1a, with ZNF domain 0.143
twist1b twist1b 0.142
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
HDAC1 histone deacetylase 1 0.947
PSEN1 presenilin 1 0.667
HDAC2 histone deacetylase 2 0.648
JAG1 jagged 1 0.563
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.449
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.438
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.409
MEIS1 Meis homeobox 1 0.278
BMP2 bone morphogenetic protein 2 0.270
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.231
SMAD3 SMAD family member 3 0.195
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.172
SETD8 SET domain containing (lysine methyltransferase) 8 0.172
SOX2 SRY (sex determining region Y)-box 2 0.140
ARRB1 arrestin, beta 1 0.120
MSX2 msh homeobox 2 0.119
TJP1 tight junction protein 1 (zona occludens 1) 0.112
HOXD9 homeobox D9 0.105
PML promyelocytic leukemia 0.101
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 0.099
HOXA11 homeobox A11 0.089
MSX1 msh homeobox 1 0.088
BMP7 bone morphogenetic protein 7 0.085
GATA4 GATA binding protein 4 0.080
HOXD13 homeobox D13 0.077
SMAD4 SMAD family member 4 0.069
CHD8 chromodomain helicase DNA binding protein 8 0.069
HOXA10 homeobox A10 0.060
COL2A1 collagen, type II, alpha 1 0.060
BAX BCL2-associated X protein 0.057
YY1 YY1 transcription factor 0.056
MEIS2 Meis homeobox 2 0.054
BAK1 BCL2-antagonist/killer 1 0.046
BCL2L1 BCL2-like 1 0.045
FOXF2 forkhead box F2 0.045
PRRX2 paired related homeobox 2 0.043
AR androgen receptor 0.043
NCOR1 nuclear receptor corepressor 1 0.040
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.039
TRIP6 thyroid hormone receptor interactor 6 0.039
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.039
DLX5 distal-less homeobox 5 0.039
HOXD10 homeobox D10 0.039
GSK3B glycogen synthase kinase 3 beta 0.038
BCL2 B-cell CLL/lymphoma 2 0.038
HOXC8 homeobox C8 0.037
HOXD11 homeobox D11 0.037
BMPR1B bone morphogenetic protein receptor, type IB 0.037
ELL2 elongation factor, RNA polymerase II, 2 0.036
RUNX1 runt-related transcription factor 1 0.036
BAD BCL2-associated agonist of cell death 0.036
FGF18 fibroblast growth factor 18 0.035
BARX1 BARX homeobox 1 0.035
HOXC11 homeobox C11 0.034
TERF2 telomeric repeat binding factor 2 0.034
HUWE1 HECT, UBA and WWE domain containing 1 0.034
LRP6 low density lipoprotein receptor-related protein 6 0.034
PSEN2 presenilin 2 (Alzheimer disease 4) 0.034
CDX2 caudal type homeobox 2 0.032
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.032
ACAN aggrecan 0.032
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.031
NGFR nerve growth factor receptor 0.030
SKIL SKI-like oncogene 0.030
DAXX death-domain associated protein 0.030
DLX4 distal-less homeobox 4 0.028
FOXC1 forkhead box C1 0.028
FGF3 fibroblast growth factor 3 0.028
AFF1 AF4/FMR2 family, member 1 0.028
HIPK2 homeodomain interacting protein kinase 2 0.027
DKK1 dickkopf homolog 1 (Xenopus laevis) 0.027
HOXC6 homeobox C6 0.027
RBBP4 retinoblastoma binding protein 4 0.026
HOXC13 homeobox C13 0.025
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.025
WNT1 wingless-type MMTV integration site family, member 1 0.025
NOG noggin 0.025
MED13 mediator complex subunit 13 0.024
PAX3 paired box 3 0.024
ERBB2IP erbb2 interacting protein 0.024
TBX1 T-box 1 0.024
FOXC2 forkhead box C2 (MFH-1, mesenchyme forkhead 1) 0.024
SMAD6 SMAD family member 6 0.024
CREBBP CREB binding protein 0.024
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 0.023
HES2 hairy and enhancer of split 2 (Drosophila) 0.023
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.022
NOTCH3 notch 3 0.022
FLNB filamin B, beta 0.021
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.021
WNT11 wingless-type MMTV integration site family, member 11 0.021
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 0.020
PDX1 pancreatic and duodenal homeobox 1 0.020
SIX2 SIX homeobox 2 0.020
SMAD1 SMAD family member 1 0.019
NKX3-2 NK3 homeobox 2 0.019
ZFYVE9 zinc finger, FYVE domain containing 9 0.019
NCSTN nicastrin 0.019
ZIC1 Zic family member 1 (odd-paired homolog, Drosophila) 0.019
TP53 tumor protein p53 0.019
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Rattus norvegicus
Name Description Probability Func Analog Organism
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.363
Lef1 lymphoid enhancer binding factor 1 0.356
Mmp13 matrix metallopeptidase 13 0.241
Dpy30 dpy-30 homolog (C. elegans) 0.194
Nkd1 naked cuticle homolog 1 (Drosophila) 0.180
Msx1 msh homeobox 1 0.171
Prrx1 paired related homeobox 1 0.144
Jak1 Janus kinase 1 0.132
Serpine2 serine (or cysteine) peptidase inhibitor, clade E, member 2 0.130
Col12a1 collagen, type XII, alpha 1 0.116
Acvr1 activin A receptor, type I 0.104
Ankrd1 ankyrin repeat domain 1 (cardiac muscle) 0.100
Pip prolactin induced protein 0.099
Fmod fibromodulin 0.096
Myh3 myosin, heavy chain 3, skeletal muscle, embryonic 0.090
Fzd2 frizzled homolog 2 (Drosophila) 0.083
Gal galanin prepropeptide 0.083
Fgf7 fibroblast growth factor 7 0.074
Cald1 caldesmon 1 0.073
Cox6b2 cytochrome c oxidase subunit VIb polypeptide 2 0.073
Timp3 TIMP metallopeptidase inhibitor 3 0.073
Tacr1 tachykinin receptor 1 0.066
Nradd neurotrophin receptor associated death domain 0.065
Capn6 calpain 6 0.062
C1qtnf5 C1q and tumor necrosis factor related protein 5 0.062
Chd4 chromodomain helicase DNA binding protein 4 0.062
Ccl11 chemokine (C-C motif) ligand 11 0.061
Shox2 short stature homeobox 2 0.060
RGD1309414 similar to KIAA0913 protein 0.059
Ibsp integrin-binding sialoprotein 0.058
Nrg1 neuregulin 1 0.058
Fgfr1 Fibroblast growth factor receptor 1 0.057
Slc34a2 solute carrier family 34 (sodium phosphate), member 2 0.055
Crx cone-rod homeobox 0.055
Htr2b 5-hydroxytryptamine (serotonin) receptor 2B 0.054
Serpinb12 serpin peptidase inhibitor, clade B (ovalbumin), member 12 0.054
Hrasls5 HRAS-like suppressor family, member 5 0.053
RGD1305627 hypothetical LOC314467 0.052
Mprip myosin phosphatase Rho interacting protein 0.051
Lect1 leukocyte cell derived chemotaxin 1 0.051
Ccna1 cyclin A1 0.051
S1pr2 sphingosine-1-phosphate receptor 2 0.051
Mmp7 matrix metallopeptidase 7 0.050
Nfix nuclear factor I/X (CCAAT-binding transcription factor) 0.050
Lamc1 laminin, gamma 1 0.049
Elof1 elongation factor 1 homolog (S. cerevisiae) 0.049
Accn3 amiloride-sensitive cation channel 3 0.048
Gemin8 gem (nuclear organelle) associated protein 8 0.048
Plekhg2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 0.048
LOC100364212 heterogeneous nuclear ribonucleoprotein K-like 0.047
Dact1 dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis) 0.046
Hnmt histamine N-methyltransferase 0.046
Cxxc4 CXXC finger 4 0.046
Ptpn14 protein tyrosine phosphatase, non-receptor type 14 0.046
Bmp4 bone morphogenetic protein 4 0.046
Glycam1 glycosylation dependent cell adhesion molecule 1 0.046
Chad chondroadherin 0.044
Gcnt3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.044
Glg1 golgi apparatus protein 1 0.044
Bik BCL2-interacting killer (apoptosis-inducing) 0.044
Phex phosphate regulating endopeptidase homolog, X-linked 0.043
Gja4 gap junction protein, alpha 4 0.042
Nfia nuclear factor I/A 0.042
Aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.042
Sf3b2 splicing factor 3b, subunit 2 0.041
Arsb arylsulfatase B 0.041
Mcpt1 mast cell protease 1 0.040
Abp1 amiloride binding protein 1 (amine oxidase, copper-containing) 0.040
Mmp9 matrix metallopeptidase 9 0.040
Igfbp5 insulin-like growth factor binding protein 5 0.040
Myh9 myosin, heavy chain 9, non-muscle 0.039
Aebp1 AE binding protein 1 0.039
Oas1b 2-5 oligoadenylate synthetase 1B 0.039
Ddr2 discoidin domain receptor tyrosine kinase 2 0.039
Ccl4 chemokine (C-C motif) ligand 4 0.038
Lrpap1 low density lipoprotein receptor-related protein associated protein 1 0.038
Cxcl2 chemokine (C-X-C motif) ligand 2 0.038
Dock6 dedicator of cytokinesis 6 0.038
Actn4 actinin alpha 4 0.037
Smarcb1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 0.037
Sod3 superoxide dismutase 3, extracellular 0.037
Lphn2 latrophilin 2 0.037
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.036
Serpinb2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.036
Ppp1r10 protein phosphatase 1, regulatory subunit 10 0.036
Slit2 slit homolog 2 (Drosophila) 0.036
Ep400 E1A binding protein p400 0.036
Hdac1l histone deacetylase 1-like 0.035
Dmgdh dimethylglycine dehydrogenase 0.035
Zfp423 zinc finger protein 423 0.035
Arl9 ADP-ribosylation factor-like 9 0.035
Vom2r40 vomeronasal 2 receptor, 40 0.035
Igfbp2 insulin-like growth factor binding protein 2 0.035
Pld1 phospholipase D1 0.034
Sycp1 synaptonemal complex protein 1 0.033
Slc12a4 solute carrier family 12 (potassium/chloride transporters), member 4 0.033
Twist2 twist homolog 2 (Drosophila) 0.033
Mybph myosin binding protein H 0.033
Lamb2 laminin, beta 2 0.033
Crisp1 cysteine-rich secretory protein 1 0.033
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism