The network for 'embryonic skeletal system development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

embryonic skeletal system development

The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure.

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Pitx2 paired-like homeodomain transcription factor 2 1.000
Foxc1 forkhead box C1 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Pax3 paired box gene 3 1.000
Hand1 heart and neural crest derivatives expressed transcript 1 1.000
Otx2 orthodenticle homolog 2 (Drosophila) 1.000
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 1.000
Dlx5 distal-less homeobox 5 1.000
Msx1 homeobox, msh-like 1 1.000
Hand2 heart and neural crest derivatives expressed transcript 2 1.000
Ctnnb1 catenin (cadherin associated protein), beta 1 1.000
Bmp7 bone morphogenetic protein 7 1.000
Bmp4 bone morphogenetic protein 4 1.000
Sox9 SRY-box containing gene 9 1.000
Prrx1 paired related homeobox 1 1.000
Eya1 eyes absent 1 homolog (Drosophila) 1.000
Foxc2 forkhead box C2 1.000
Pdgfra platelet derived growth factor receptor, alpha polypeptide 1.000
Pbx1 pre B-cell leukemia transcription factor 1 1.000
Gli2 GLI-Kruppel family member GLI2 1.000
Tgfb2 transforming growth factor, beta 2 1.000
Hoxa1 homeobox A1 1.000
Pax6 paired box gene 6 1.000
Tcfap2a transcription factor AP-2, alpha 1.000
Fgf8 fibroblast growth factor 8 1.000
Tbx1 T-box 1 1.000
Tbx3 T-box 3 1.000
Fgf10 fibroblast growth factor 10 1.000
Fgfr3 fibroblast growth factor receptor 3 1.000
Fgfr1 fibroblast growth factor receptor 1 0.999
Runx2 runt related transcription factor 2 0.999
Hoxa10 homeobox A10 0.999
Zeb1 zinc finger E-box binding homeobox 1 0.999
Isl1 ISL1 transcription factor, LIM/homeodomain 0.999
Hoxa13 homeobox A13 0.999
Pitx1 paired-like homeodomain transcription factor 1 0.999
Pax2 paired box gene 2 0.999
Apc adenomatosis polyposis coli 0.998
Nodal nodal 0.997
Pax9 paired box gene 9 0.997
Prrx2 paired related homeobox 2 0.997
Hoxd13 homeobox D13 0.997
Msx2 homeobox, msh-like 2 0.996
Gbx2 gastrulation brain homeobox 2 0.996
Chrd chordin 0.996
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.996
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.994
Col1a1 collagen, type I, alpha 1 0.994
Meox2 mesenchyme homeobox 2 0.993
Nkx2-1 NK2 homeobox 1 0.992
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.992
Zic3 zinc finger protein of the cerebellum 3 0.992
Gata4 GATA binding protein 4 0.992
Hoxa2 homeobox A2 0.991
Smad4 MAD homolog 4 (Drosophila) 0.990
Hoxa9 homeobox A9 0.990
Dlx2 distal-less homeobox 2 0.990
Jag1 jagged 1 0.989
Tgfbr2 transforming growth factor, beta receptor II 0.989
Hoxd11 homeobox D11 0.988
Rarb retinoic acid receptor, beta 0.986
Rybp RING1 and YY1 binding protein 0.984
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.984
Hoxa5 homeobox A5 0.983
Hoxa11 homeobox A11 0.982
Alx4 aristaless-like homeobox 4 0.981
Pten phosphatase and tensin homolog 0.979
Foxg1 forkhead box G1 0.979
Rnf2 ring finger protein 2 0.978
Rarg retinoic acid receptor, gamma 0.978
Fgf3 fibroblast growth factor 3 0.977
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.977
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.976
Twist2 twist homolog 2 (Drosophila) 0.975
Bmpr1a bone morphogenetic protein receptor, type 1A 0.974
Hoxb4 homeobox B4 0.974
Sox2 SRY-box containing gene 2 0.972
Tcf21 transcription factor 21 0.971
Acvr1 activin A receptor, type 1 0.966
Lef1 lymphoid enhancer binding factor 1 0.966
Ptch1 patched homolog 1 0.966
Tbx15 T-box 15 0.965
Efnb2 ephrin B2 0.965
Trp63 transformation related protein 63 0.964
Wnt3a wingless-related MMTV integration site 3A 0.962
Amhr2 anti-Mullerian hormone type 2 receptor 0.961
Vegfa vascular endothelial growth factor A 0.961
Foxh1 forkhead box H1 0.959
Lmx1a LIM homeobox transcription factor 1 alpha 0.959
Notch1 Notch gene homolog 1 (Drosophila) 0.959
Col2a1 collagen, type II, alpha 1 0.958
Ptf1a pancreas specific transcription factor, 1a 0.957
Pthlh parathyroid hormone-like peptide 0.954
Emx2 empty spiracles homolog 2 (Drosophila) 0.954
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.953
Pax8 paired box gene 8 0.953
Trp53 transformation related protein 53 0.947
Smad6 MAD homolog 6 (Drosophila) 0.947
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
dlx2a distal-less homeobox gene 2a 0.993
barx1 BarH-like homeobox 1 0.991
sox9a SRY-box containing gene 9a 0.990
wu:fv91b12 wu:fv91b12 0.987
myod1 myogenic differentiation 1 0.985
jag1b jagged 1b 0.985
col2a1a collagen type II, alpha-1a 0.985
edn1 endothelin 1 0.978
twist1a twist1a 0.975
egr2b early growth response 2b 0.967
twist3 twist3 0.962
fgf8a fibroblast growth factor 8 a 0.959
twist1b twist1b 0.956
foxd3 forkhead box D3 0.955
plcb3 phospholipase C, beta 3 (phosphatidylinositol-specific) 0.946
hoxb5b homeo box B5b 0.943
disp1 dispatched homolog 1 (Drosophila) 0.932
foxi1 forkhead box I1 0.923
pax6a paired box gene 6a 0.914
cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 0.910
brpf1 bromodomain and PHD finger containing, 1 0.905
hoxa2b homeo box A2b 0.905
tfap2a transcription factor AP-2 alpha 0.897
prdm16 PR domain containing 16 0.891
hoxa4a homeo box A4a 0.891
hoxb6a homeo box B6a 0.883
hoxb1b homeo box B1b 0.873
fzd10 frizzled homolog 10 0.863
gata3 GATA-binding protein 3 0.854
col5a1 procollagen, type V, alpha 1 0.846
egr1 early growth response 1 0.844
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.842
foxa2 forkhead box A2 0.842
prdm1a PR domain containing 1a, with ZNF domain 0.840
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.837
tbx1 T-box 1 0.835
hoxb3a homeo box B3a 0.830
pitx2 paired-like homeodomain transcription factor 2 0.829
mef2ca myocyte enhancer factor 2ca 0.810
shha sonic hedgehog a 0.787
fn1 fibronectin 1 0.782
crabp2a cellular retinoic acid binding protein 2, a 0.780
bmp2a bone morphogenetic protein 2a 0.731
mab21l2 mab-21-like 2 0.728
tgfbi transforming growth factor, beta-induced 0.721
hoxb5a homeo box B5a 0.721
fgf4 fibroblast growth factor 4 0.721
runx2b runt-related transcription factor 2b 0.719
dlx3b distal-less homeobox gene 3b 0.697
pax7a paired box gene 7a 0.697
sec24d SEC24 family, member D (S. cerevisiae) 0.694
snai1b snail homolog 1b (Drosophila) 0.691
hoxb2a homeo box B2a 0.689
gli1 GLI-Kruppel family member 1 0.682
uxs1 UDP-glucuronic acid decarboxylase 1 0.681
gli2a GLI-Kruppel family member GLI2a 0.676
wnt11 wingless-type MMTV integration site family, member 11 0.673
pthlh parathyroid hormone-like hormone 0.673
hoxb6b homeo box B6b 0.667
tp63 tumor protein p63 0.665
xylt1 xylosyltransferase 1 0.664
epb4.1l4 erythrocyte protein band 4.1-like 4 0.664
dlx5a distal-less homeobox gene 5a 0.658
gria4a glutamate receptor, ionotropic, AMPA 4a 0.655
lhx5 LIM homeobox 5 0.651
runx2a runt-related transcription factor 2a 0.646
pwp2h PWP2 periodic tryptophan protein homolog (yeast) 0.625
pcsk5b proprotein convertase subtilisin/kexin type 5b 0.623
fgf3 fibroblast growth factor 3 0.622
raraa retinoic acid receptor, alpha a 0.617
pax8 paired box gene 8 0.616
hoxd11a homeo box D11a 0.614
frem2a Fras1 related extracellular matrix protein 2a 0.608
zgc:85942 zgc:85942 0.607
zgc:158603 zgc:158603 0.606
mecom MDS1 and EVI1 complex locus 0.595
dlx4b distal-less homeobox gene 4b 0.575
csnk1a1 casein kinase 1, alpha 1 0.559
tmem2 transmembrane protein 2 0.545
myf5 myogenic factor 5 0.541
six4b sine oculis homeobox homolog 4b 0.531
hoxc4a homeo box C4a 0.528
hoxa3a homeo box A3a 0.517
nkx2.3 NK2 transcription factor related 3 0.517
disc1 disrupted in schizophrenia 1 0.508
eya1 eyes absent homolog 1 0.506
zic5 zic family member 5 (odd-paired homolog, Drosophila) 0.502
sox2 SRY-box containing gene 2 0.500
eng2a engrailed 2a 0.496
pax9 paired box gene 9 0.487
msxe muscle segment homeobox E 0.483
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.482
zgc:171495 zgc:171495 0.478
tp53 tumor protein p53 0.477
ptch1 patched 1 0.477
sox32 SRY-box containing gene 32 0.468
shhb sonic hedgehog b 0.466
wnt11r wingless-type MMTV integration site family, member 11, related 0.459
unc45b unc-45 homolog B (C. elegans) 0.451
nog1 noggin 1 0.451
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
COL1A1 collagen, type I, alpha 1 0.909
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.885
HOXB5 homeobox B5 0.881
FGF1 fibroblast growth factor 1 (acidic) 0.849
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.797
MEIS1 Meis homeobox 1 0.611
TGFB1 transforming growth factor, beta 1 0.587
SMAD3 SMAD family member 3 0.570
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.512
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.498
PBX1 pre-B-cell leukemia homeobox 1 0.493
CREBBP CREB binding protein 0.473
COL1A2 collagen, type I, alpha 2 0.437
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.396
HOXA10 homeobox A10 0.375
SMAD2 SMAD family member 2 0.348
EP300 E1A binding protein p300 0.337
GABPA GA binding protein transcription factor, alpha subunit 60kDa 0.333
HOXA5 homeobox A5 0.327
SMAD7 SMAD family member 7 0.302
HOXA11 homeobox A11 0.297
RUNX1 runt-related transcription factor 1 0.278
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.225
HOXC8 homeobox C8 0.215
COL6A1 collagen, type VI, alpha 1 0.203
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.202
HOXB3 homeobox B3 0.186
HOXB9 homeobox B9 0.180
TAL1 T-cell acute lymphocytic leukemia 1 0.180
FSTL1 follistatin-like 1 0.174
HOXB6 homeobox B6 0.167
TRIP6 thyroid hormone receptor interactor 6 0.167
HOXA4 homeobox A4 0.163
COL2A1 collagen, type II, alpha 1 0.157
ATN1 atrophin 1 0.152
TP53 tumor protein p53 0.122
HOXC6 homeobox C6 0.120
LOX lysyl oxidase 0.114
HOXA7 homeobox A7 0.109
HOXA6 homeobox A6 0.107
HOXD9 homeobox D9 0.106
HOXC11 homeobox C11 0.098
SIRT1 sirtuin 1 0.095
FZD1 frizzled homolog 1 (Drosophila) 0.095
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.094
MDFI MyoD family inhibitor 0.091
PTCH1 patched 1 0.089
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.089
GATA4 GATA binding protein 4 0.083
POSTN periostin, osteoblast specific factor 0.079
MEF2A myocyte enhancer factor 2A 0.079
TGFB3 transforming growth factor, beta 3 0.076
COL3A1 collagen, type III, alpha 1 0.075
COL11A1 collagen, type XI, alpha 1 0.074
MEIS2 Meis homeobox 2 0.072
CBX8 chromobox homolog 8 0.070
TJP1 tight junction protein 1 (zona occludens 1) 0.069
CABP1 calcium binding protein 1 0.064
MYOD1 myogenic differentiation 1 0.064
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 0.063
HOXC10 homeobox C10 0.061
PDX1 pancreatic and duodenal homeobox 1 0.060
HOXD13 homeobox D13 0.059
HDAC4 histone deacetylase 4 0.059
NCOA1 nuclear receptor coactivator 1 0.057
HOXB7 homeobox B7 0.057
HOXA9 homeobox A9 0.056
ADAM12 ADAM metallopeptidase domain 12 0.051
FEV FEV (ETS oncogene family) 0.051
GATA2 GATA binding protein 2 0.051
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit 0.051
CDK6 cyclin-dependent kinase 6 0.050
YAP1 Yes-associated protein 1 0.050
DLX4 distal-less homeobox 4 0.050
ADAM17 ADAM metallopeptidase domain 17 0.048
SMAD1 SMAD family member 1 0.047
NCOR1 nuclear receptor corepressor 1 0.047
PLCG1 phospholipase C, gamma 1 0.046
HOXA3 homeobox A3 0.046
FGF18 fibroblast growth factor 18 0.046
MYCN v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.046
NCK2 NCK adaptor protein 2 0.046
HOXB13 homeobox B13 0.045
PAX2 paired box 2 0.044
FOXF2 forkhead box F2 0.044
COL5A1 collagen, type V, alpha 1 0.044
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.042
PIAS1 protein inhibitor of activated STAT, 1 0.041
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.041
TWIST1 twist homolog 1 (Drosophila) 0.041
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 0.040
AR androgen receptor 0.039
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.038
SETD8 SET domain containing (lysine methyltransferase) 8 0.037
PRRX2 paired related homeobox 2 0.037
FGF3 fibroblast growth factor 3 0.036
HOXA2 homeobox A2 0.036
DAXX death-domain associated protein 0.036
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.036
BARX1 BARX homeobox 1 0.035
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Rattus norvegicus
Name Description Probability Func Analog Organism
Col3a1 collagen, type III, alpha 1 0.994
Bgn biglycan 0.985
Col12a1 collagen, type XII, alpha 1 0.944
Col1a2 collagen, type I, alpha 2 0.941
Col5a1 collagen, type V, alpha 1 0.935
Lamc1 laminin, gamma 1 0.870
Fn1 fibronectin 1 0.778
Col1a1 collagen, type I, alpha 1 0.774
Aebp1 AE binding protein 1 0.750
Nfya nuclear transcription factor-Y alpha 0.690
Pcolce procollagen C-endopeptidase enhancer 0.663
Col5a2 collagen, type V, alpha 2 0.550
Egr2 early growth response 2 0.541
Lox lysyl oxidase 0.537
Dab2 disabled homolog 2 (Drosophila) 0.502
Igfbp5 insulin-like growth factor binding protein 5 0.406
Fstl1 follistatin-like 1 0.400
Loxl1 lysyl oxidase-like 1 0.370
Tcf12 transcription factor 12 0.290
Ptpn14 protein tyrosine phosphatase, non-receptor type 14 0.275
Arnt aryl hydrocarbon receptor nuclear translocator 0.267
Tgfbr2 transforming growth factor, beta receptor II 0.264
Dnah8 dynein, axonemal, heavy chain 8 0.232
Kctd15 potassium channel tetramerisation domain containing 15 0.225
Rnf138 ring finger protein 138 0.203
Fmod fibromodulin 0.187
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.182
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.179
Sfrp4 secreted frizzled-related protein 4 0.178
Tcfe2a transcription factor E2a 0.170
Bmp6 bone morphogenetic protein 6 0.170
Add3 adducin 3 (gamma) 0.167
Gdf11 growth differentiation factor 11 0.167
Hoxc4 homeo box C4 0.165
Col9a1 collagen, type IX, alpha 1 0.165
Galr3 galanin receptor 3 0.163
Znf503 zinc finger protein 503 0.154
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.152
Mapk8 mitogen-activated protein kinase 8 0.152
Prrx1 paired related homeobox 1 0.150
Hist1h1d histone cluster 1, H1d 0.143
Mybpc2 myosin binding protein C, fast-type 0.139
Postn periostin, osteoblast specific factor 0.134
Capn5 calpain 5 0.134
Tgfbr1 transforming growth factor, beta receptor 1 0.130
Rest RE1-silencing transcription factor 0.129
Kif1b kinesin family member 1B 0.123
Sod3 superoxide dismutase 3, extracellular 0.118
Six1 SIX homeobox 1 0.118
Nppc natriuretic peptide precursor C 0.116
Pnliprp1 pancreatic lipase-related protein 1 0.116
Col15a1 collagen, type XV, alpha 1 0.116
Colec12 collectin sub-family member 12 0.114
Cp ceruloplasmin 0.114
Mmp2 matrix metallopeptidase 2 0.112
Efna5 ephrin A5 0.111
Col6a2 collagen, type VI, alpha 2 0.107
Ube2d4 ubiquitin-conjugating enzyme E2D 4 0.107
Homer3 homer homolog 3 (Drosophila) 0.106
Baiap2 BAI1-associated protein 2 0.106
Ctsk cathepsin K 0.104
Gria4 glutamate receptor, ionotrophic, AMPA 4 0.102
Bmp3 bone morphogenetic protein 3 0.102
Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.100
Tgfb2 transforming growth factor, beta 2 0.099
Col8a1 collagen, type VIII, alpha 1 0.098
Htr2b 5-hydroxytryptamine (serotonin) receptor 2B 0.097
Gria1 glutamate receptor, ionotropic, AMPA 1 0.097
Sema3a sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.097
Pik3r3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.095
Twist2 twist homolog 2 (Drosophila) 0.095
Crtap cartilage associated protein 0.095
Cpz carboxypeptidase Z 0.093
Plagl1 pleiomorphic adenoma gene-like 1 0.092
Atxn1 ataxin 1 0.092
Fos FBJ osteosarcoma oncogene 0.091
F13a1 coagulation factor XIII, A1 polypeptide 0.090
Cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase 0.089
Ephb3 Eph receptor B3 0.089
C1r complement component 1, r subcomponent 0.089
Shox2 short stature homeobox 2 0.087
Slk STE20-like kinase (yeast) 0.086
Myh3 myosin, heavy chain 3, skeletal muscle, embryonic 0.085
Isl1 ISL LIM homeobox 1 0.084
Slit3 slit homolog 3 (Drosophila) 0.084
Fbn1 fibrillin 1 0.082
Ddr2 discoidin domain receptor tyrosine kinase 2 0.082
Col14a1 collagen, type XIV, alpha 1 0.081
Hoxa5 homeo box A5 0.080
Hoxb7 homeo box B7 0.080
Lef1 lymphoid enhancer binding factor 1 0.079
Robo2 roundabout homolog 2 (Drosophila) 0.079
Grip1 glutamate receptor interacting protein 1 0.078
Dusp1 dual specificity phosphatase 1 0.076
Agtr1a angiotensin II receptor, type 1a 0.075
Gpc3 glypican 3 0.073
Fut4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 0.073
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.073
Mllt4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.072
Gabra1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 0.072
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism