The network for 'mesangial cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

mesangial cell differentiation

The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesangial cells of the kidney as it progresses from its formation to the mature state.

Mus musculus
Name Description Probability Func Analog Organism
Pax2 paired box gene 2 0.999
Pax3 paired box gene 3 0.999
Shh sonic hedgehog 0.998
Foxc1 forkhead box C1 0.998
Bmp4 bone morphogenetic protein 4 0.997
Tbx1 T-box 1 0.993
Fgfr2 fibroblast growth factor receptor 2 0.993
Fgf8 fibroblast growth factor 8 0.992
Jag1 jagged 1 0.976
Foxc2 forkhead box C2 0.971
Gli3 GLI-Kruppel family member GLI3 0.969
Wt1 Wilms tumor 1 homolog 0.965
Fgfr1 fibroblast growth factor receptor 1 0.964
Eya1 eyes absent 1 homolog (Drosophila) 0.955
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.933
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.933
Chd7 chromodomain helicase DNA binding protein 7 0.923
Psen1 presenilin 1 0.909
Hoxa1 homeobox A1 0.887
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.874
Pitx2 paired-like homeodomain transcription factor 2 0.874
Emx2 empty spiracles homolog 2 (Drosophila) 0.870
Hmx3 H6 homeobox 3 0.867
Lhx1 LIM homeobox protein 1 0.862
Hand2 heart and neural crest derivatives expressed transcript 2 0.848
Tgfb2 transforming growth factor, beta 2 0.836
Foxa2 forkhead box A2 0.813
Rarg retinoic acid receptor, gamma 0.804
Pax8 paired box gene 8 0.789
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.771
Otx2 orthodenticle homolog 2 (Drosophila) 0.770
Notch1 Notch gene homolog 1 (Drosophila) 0.761
Nos3 nitric oxide synthase 3, endothelial cell 0.754
Vegfa vascular endothelial growth factor A 0.730
Rxra retinoid X receptor alpha 0.721
Flt4 FMS-like tyrosine kinase 4 0.687
Otx1 orthodenticle homolog 1 (Drosophila) 0.661
Efnb2 ephrin B2 0.629
Gdnf glial cell line derived neurotrophic factor 0.624
Msx1 homeobox, msh-like 1 0.604
Nkx2-1 NK2 homeobox 1 0.602
Chrd chordin 0.593
Gbx2 gastrulation brain homeobox 2 0.589
Tcfap2a transcription factor AP-2, alpha 0.582
Prrx1 paired related homeobox 1 0.568
Bcl2 B-cell leukemia/lymphoma 2 0.561
Notch2 Notch gene homolog 2 (Drosophila) 0.560
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.558
Meox2 mesenchyme homeobox 2 0.540
Lmx1a LIM homeobox transcription factor 1 alpha 0.530
Hes1 hairy and enhancer of split 1 (Drosophila) 0.495
Ctnnb1 catenin (cadherin associated protein), beta 1 0.490
Pbx1 pre B-cell leukemia transcription factor 1 0.472
Itga3 integrin alpha 3 0.471
Tcf21 transcription factor 21 0.466
Hoxd11 homeobox D11 0.454
Rarb retinoic acid receptor, beta 0.446
Pax9 paired box gene 9 0.433
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.432
Foxg1 forkhead box G1 0.432
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.427
Dll1 delta-like 1 (Drosophila) 0.403
Hoxa3 homeobox A3 0.372
Dlx5 distal-less homeobox 5 0.365
Gata6 GATA binding protein 6 0.355
Rara retinoic acid receptor, alpha 0.350
Nog noggin 0.349
Lmx1b LIM homeobox transcription factor 1 beta 0.330
Gsc goosecoid homeobox 0.328
Vangl2 vang-like 2 (van gogh, Drosophila) 0.321
Foxe3 forkhead box E3 0.313
Lama5 laminin, alpha 5 0.310
Foxa1 forkhead box A1 0.309
Smo smoothened homolog (Drosophila) 0.305
Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 0.295
Kdr kinase insert domain protein receptor 0.294
Gata4 GATA binding protein 4 0.283
Gli2 GLI-Kruppel family member GLI2 0.282
Sox9 SRY-box containing gene 9 0.279
Hoxa2 homeobox A2 0.275
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.265
Hoxd3 homeobox D3 0.258
Tbx2 T-box 2 0.252
Snai1 snail homolog 1 (Drosophila) 0.248
Ednra endothelin receptor type A 0.246
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.241
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.234
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.233
Egfl7 EGF-like domain 7 0.227
Pax6 paired box gene 6 0.226
Runx2 runt related transcription factor 2 0.226
Hand1 heart and neural crest derivatives expressed transcript 1 0.209
Gata3 GATA binding protein 3 0.207
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.202
Cdx1 caudal type homeobox 1 0.200
Neurog1 neurogenin 1 0.191
Hoxc6 homeobox C6 0.181
Sox7 SRY-box containing gene 7 0.178
Sox2 SRY-box containing gene 2 0.176
Hoxd9 homeobox D9 0.173
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.472
TUBA1B tubulin, alpha 1b 0.301
CFL1 cofilin 1 (non-muscle) 0.120
CFL2 cofilin 2 (muscle) 0.024
PFN1 profilin 1 0.024
JAG1 jagged 1 0.021
TRIM63 tripartite motif containing 63 0.019
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.018
MYH11 myosin, heavy chain 11, smooth muscle 0.014
NOTCH3 notch 3 0.014
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.012
COL4A1 collagen, type IV, alpha 1 0.010
ACTC1 actin, alpha, cardiac muscle 1 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism