The network for 'nephron tubule morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

nephron tubule morphogenesis

The process in which the anatomical structures of a nephron tubule are generated and organized. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney.

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Pax2 paired box gene 2 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Pax8 paired box gene 8 1.000
Fgf8 fibroblast growth factor 8 1.000
Wt1 Wilms tumor 1 homolog 1.000
Gdnf glial cell line derived neurotrophic factor 1.000
Foxc1 forkhead box C1 1.000
Bmp4 bone morphogenetic protein 4 1.000
Pax3 paired box gene 3 1.000
Bcl2 B-cell leukemia/lymphoma 2 1.000
Pitx2 paired-like homeodomain transcription factor 2 1.000
Lhx1 LIM homeobox protein 1 0.999
Hand2 heart and neural crest derivatives expressed transcript 2 0.999
Ctnnb1 catenin (cadherin associated protein), beta 1 0.999
Otx2 orthodenticle homolog 2 (Drosophila) 0.999
Rarg retinoic acid receptor, gamma 0.999
Hoxd11 homeobox D11 0.999
Hand1 heart and neural crest derivatives expressed transcript 1 0.998
Emx2 empty spiracles homolog 2 (Drosophila) 0.998
Vegfa vascular endothelial growth factor A 0.998
Ret ret proto-oncogene 0.997
Smo smoothened homolog (Drosophila) 0.997
Hoxd3 homeobox D3 0.995
Dlx5 distal-less homeobox 5 0.995
Tcf21 transcription factor 21 0.995
Hoxa11 homeobox A11 0.994
Msx1 homeobox, msh-like 1 0.994
Tbx1 T-box 1 0.994
Hoxb6 homeobox B6 0.993
Fgfr1 fibroblast growth factor receptor 1 0.992
Gli2 GLI-Kruppel family member GLI2 0.992
Foxc2 forkhead box C2 0.992
Nog noggin 0.991
Rara retinoic acid receptor, alpha 0.990
Hoxd9 homeobox D9 0.987
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.987
Smad6 MAD homolog 6 (Drosophila) 0.987
Hoxc8 homeobox C8 0.986
Hoxa2 homeobox A2 0.985
Pbx1 pre B-cell leukemia transcription factor 1 0.984
Isl1 ISL1 transcription factor, LIM/homeodomain 0.984
Sox9 SRY-box containing gene 9 0.981
Tbx2 T-box 2 0.980
Eya1 eyes absent 1 homolog (Drosophila) 0.979
Tcfap2a transcription factor AP-2, alpha 0.977
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.977
Tgfb2 transforming growth factor, beta 2 0.974
Rarb retinoic acid receptor, beta 0.974
Hoxa1 homeobox A1 0.973
Hoxc5 homeobox C5 0.972
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.971
Fgf10 fibroblast growth factor 10 0.968
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.963
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.962
Hoxd4 homeobox D4 0.962
Gbx2 gastrulation brain homeobox 2 0.962
Lmx1b LIM homeobox transcription factor 1 beta 0.961
Rxra retinoid X receptor alpha 0.954
Otx1 orthodenticle homolog 1 (Drosophila) 0.952
Nkx2-1 NK2 homeobox 1 0.949
Hoxb3 homeobox B3 0.947
Nodal nodal 0.941
Hoxa3 homeobox A3 0.941
Hoxa9 homeobox A9 0.941
Pkd1 polycystic kidney disease 1 homolog 0.940
Bmp7 bone morphogenetic protein 7 0.939
Hoxa10 homeobox A10 0.939
Hes1 hairy and enhancer of split 1 (Drosophila) 0.934
Smad3 MAD homolog 3 (Drosophila) 0.932
Wnt6 wingless-related MMTV integration site 6 0.931
Wnt4 wingless-related MMTV integration site 4 0.923
Meox2 mesenchyme homeobox 2 0.922
Prrx1 paired related homeobox 1 0.919
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.919
Ren1 renin 1 structural 0.908
Gata4 GATA binding protein 4 0.908
Lhx3 LIM homeobox protein 3 0.901
Msx2 homeobox, msh-like 2 0.898
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.898
Hoxb5 homeobox B5 0.898
Ednra endothelin receptor type A 0.894
Hoxd13 homeobox D13 0.889
Snai1 snail homolog 1 (Drosophila) 0.889
Bnc1 basonuclin 1 0.885
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.882
Gata6 GATA binding protein 6 0.877
Flt4 FMS-like tyrosine kinase 4 0.877
Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 0.872
Ptk7 PTK7 protein tyrosine kinase 7 0.865
Tbx3 T-box 3 0.862
Lmx1a LIM homeobox transcription factor 1 alpha 0.857
Hoxc6 homeobox C6 0.857
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.853
Wnt5a wingless-related MMTV integration site 5A 0.848
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.847
En1 engrailed 1 0.844
Gsc goosecoid homeobox 0.838
Acvr1 activin A receptor, type 1 0.836
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
osr2 odd-skipped related 2 (Drosophila) 0.987
pax2a paired box gene 2a 0.971
shha sonic hedgehog a 0.960
foxd3 forkhead box D3 0.939
wt1b wilms tumor 1b 0.934
bmp2b bone morphogenetic protein 2b 0.906
wt1a wilms tumor 1a 0.852
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.840
notch3 notch homolog 3 0.836
cdh2 cadherin 2, neuronal 0.824
wnt5b wingless-type MMTV integration site family, member 5b 0.808
tbx1 T-box 1 0.787
bmp2a bone morphogenetic protein 2a 0.772
hoxd4a homeo box D4a 0.772
chd chordin 0.737
hoxa9b homeo box A9b 0.712
bmp4 bone morphogenetic protein 4 0.705
spry1 sprouty homolog 1 (Drosophila) 0.700
myod1 myogenic differentiation 1 0.699
eya1 eyes absent homolog 1 0.692
wnt1 wingless-type MMTV integration site family, member 1 0.678
wnt2ba wingless-type MMTV integration site family, member 2Ba 0.655
fgf10a fibroblast growth factor 10a 0.650
lef1 lymphocyte enhancer binding factor 1 0.647
etv2 ets variant gene 2 0.641
prdm1a PR domain containing 1a, with ZNF domain 0.599
nkx3.2 NK3 homeobox 2 0.598
gyltl1b glycosyltransferase-like 1b 0.597
robo3 roundabout homolog 3 0.596
hoxa9a homeo box A9a 0.588
tbx16 T-box gene 16 0.572
osr1 odd-skipped related 1 (Drosophila) 0.568
hoxd10a homeo box D10a 0.545
hoxa13b homeo box A13b 0.532
gbx2 gastrulation brain homeo box 2 0.530
hmx2 H6 family homeobox 2 0.524
itga3b integrin, alpha 3b 0.510
sesn1 sestrin 1 0.493
lhx1a LIM homeobox 1a 0.484
hoxd11a homeo box D11a 0.483
hoxa10b homeo box A10b 0.479
wnt10a wingless-type MMTV integration site family, member 10a 0.465
fgf8a fibroblast growth factor 8 a 0.460
twist1b twist1b 0.453
sim1a single-minded homolog 1a (Drosophila) 0.452
hhip hedgehog interacting protein 0.424
hoxa11a homeo box A11a 0.418
vegfaa vascular endothelial growth factor Aa 0.417
tbx18 T-box 18 0.408
mecom MDS1 and EVI1 complex locus 0.402
notch1a notch homolog 1a 0.395
itgav integrin, alpha V 0.391
jag2 jagged 2 0.389
twist1a twist1a 0.372
tll1 tolloid-like 1 0.372
hoxd13a homeo box D13a 0.371
gdnf glial cell derived neurotrophic factor 0.363
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.361
pcdh8 protocadherin 8 0.356
fgf3 fibroblast growth factor 3 0.350
hoxd12a homeo box D12a 0.347
six4b sine oculis homeobox homolog 4b 0.346
bmp1a bone morphogenetic protein 1a 0.340
ism1 isthmin 1 0.338
rfx2 regulatory factor X, 2 (influences HLA class II expression) 0.337
hoxa13a homeo box A13a 0.330
lrrc50 leucine rich repeat containing 50 0.328
myf5 myogenic factor 5 0.323
mib mind bomb 0.319
hnf1bb HNF1 homeobox Bb 0.316
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.310
antxr1 anthrax toxin receptor 1 0.309
prrx1b paired related homeobox 1b 0.299
snai1a snail homolog 1a (Drosophila) 0.295
aplnrb apelin receptor b 0.281
nphs2 nephrosis 2, idiopathic, steroid-resistant (podocin) 0.281
jag1b jagged 1b 0.276
ptgs1 prostaglandin-endoperoxide synthase 1 0.275
wnt3a wingless-type MMTV integration site family, member 3A 0.271
eng1a engrailed 1a 0.259
wnt4a wingless-type MMTV integration site family, member 4a 0.258
pea3 ETS-domain transcription factor pea3 0.257
six4a sine oculis homeobox homolog 4a 0.257
twist3 twist3 0.253
hoxd9a homeo box D9a 0.252
flr fleer 0.251
sox10 SRY-box containing gene 10 0.247
evx1 even-skipped homeobox 1 0.234
runx2b runt-related transcription factor 2b 0.228
pcdh17 protocadherin 17 0.222
msxb muscle segment homeobox B 0.221
hmx1 H6 homeo box 1 0.213
igfbp3 insulin-like growth factor binding protein 3 0.210
evx2 even-skipped homeobox 2 0.206
tbx5a T-box 5a 0.206
wnt3 wingless-type MMTV integration site family, member 3 0.206
foxo3b forkhead box O3b 0.202
six2a sine oculis-related homeobox 2a 0.200
per2 period homolog 2 (Drosophila) 0.196
mitfa microphthalmia-associated transcription factor a 0.196
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Drosophila melanogaster
Name Description Probability Func Analog Organism
wg wingless 1.000
ci cubitus interruptus 0.999
hh hedgehog 0.999
hth homothorax 0.974
HLHm7 E(spl) region transcript m7 0.967
en engrailed 0.964
HLHmdelta E(spl) region transcript mdelta 0.949
E(spl) Enhancer of split 0.870
bowl brother of odd with entrails limited 0.858
Ser Serrate 0.854
kni knirps 0.824
ds dachsous 0.809
argos CG4531 gene product from transcript CG4531-RA 0.805
vg vestigial 0.796
Dfd Deformed 0.786
Egfr Epidermal growth factor receptor 0.773
emc extra macrochaetae 0.692
os outstretched 0.604
HLHmgamma E(spl) region transcript mgamma 0.580
fng fringe 0.573
m2 E(spl) region transcript m2 0.536
HLHmbeta E(spl) region transcript mbeta 0.500
odd odd skipped 0.483
bib big brain 0.462
Ubx Ultrabithorax 0.459
Tom Twin of m4 0.453
Dad Daughters against dpp 0.425
pan pangolin 0.403
ato atonal 0.391
HLHm3 E(spl) region transcript m3 0.390
tsh teashirt 0.371
Fas2 Fasciclin 2 0.365
ss spineless 0.357
slp1 sloppy paired 1 0.340
pros prospero 0.339
noc no ocelli 0.337
gt giant 0.333
HLHm5 E(spl) region transcript m5 0.330
Mad Mothers against dpp 0.323
opa odd paired 0.314
ft fat 0.311
tup tailup 0.241
klu klumpfuss 0.240
dpp decapentaplegic 0.230
eya eyes absent 0.225
gcm glial cells missing 0.222
sc scute 0.221
Antp Antennapedia 0.215
brk brinker 0.210
run runt 0.207
sbb scribbler 0.207
sna snail 0.203
al aristaless 0.203
bi bifid 0.200
malpha E(spl) region transcript malpha 0.195
sog short gastrulation 0.189
oc ocelliless 0.181
shn schnurri 0.179
so sine oculis 0.177
Dll Distal-less 0.174
ems empty spiracles 0.172
eg eagle 0.169
put punt 0.165
dac dachshund 0.164
disco disconnected 0.162
18w 18 wheeler 0.162
JIL-1 CG6297 gene product from transcript CG6297-RA 0.160
ara araucan 0.154
nkd naked cuticle 0.151
sgg shaggy 0.150
kuz kuzbanian 0.150
byn brachyenteron 0.147
gbb glass bottom boat 0.139
Nrx-IV Neurexin IV 0.137
wit wishful thinking 0.133
CG3563 CG3563 gene product from transcript CG3563-RA 0.133
btl breathless 0.130
inv invected 0.129
bab2 CG9102 gene product from transcript CG9102-RA 0.129
fj four-jointed 0.129
gro groucho 0.121
aop anterior open 0.116
eve even skipped 0.115
fra frazzled 0.114
por porcupine 0.114
tap target of Poxn 0.111
ex expanded 0.110
tll tailless 0.109
abd-A abdominal A 0.108
hkb huckebein 0.108
tra transformer 0.104
ey eyeless 0.104
mbc myoblast city 0.096
nub nubbin 0.095
dy dusky 0.094
exd extradenticle 0.093
B-H1 BarH1 0.093
lab labial 0.092
twi twist 0.092
l(2)gl lethal (2) giant larvae 0.092
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Homo sapiens
Name Description Probability Func Analog Organism
FGFR2 fibroblast growth factor receptor 2 1.000
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.954
FSTL1 follistatin-like 1 0.876
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.876
EGR1 early growth response 1 0.874
FGF10 fibroblast growth factor 10 0.793
FGF1 fibroblast growth factor 1 (acidic) 0.789
KLHL3 kelch-like 3 (Drosophila) 0.782
VEGFA vascular endothelial growth factor A 0.769
EGR3 early growth response 3 0.717
WNK4 WNK lysine deficient protein kinase 4 0.700
BMPR1A bone morphogenetic protein receptor, type IA 0.688
KLHL12 kelch-like 12 (Drosophila) 0.624
CUL3 cullin 3 0.619
DAPK1 death-associated protein kinase 1 0.601
EGR2 early growth response 2 0.573
MEIS1 Meis homeobox 1 0.567
PKD2 polycystic kidney disease 2 (autosomal dominant) 0.480
MEOX1 mesenchyme homeobox 1 0.425
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.402
MEIS2 Meis homeobox 2 0.398
FGFR1 fibroblast growth factor receptor 1 0.337
FGF8 fibroblast growth factor 8 (androgen-induced) 0.306
NKX2-1 NK2 homeobox 1 0.292
SKIL SKI-like oncogene 0.284
TSC22D4 TSC22 domain family, member 4 0.257
SMAD3 SMAD family member 3 0.221
ADAM17 ADAM metallopeptidase domain 17 0.182
PJA1 praja ring finger 1 0.159
FGF4 fibroblast growth factor 4 0.152
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.146
PGF placental growth factor 0.145
MSN moesin 0.144
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like 0.142
KLHL2 kelch-like 2, Mayven (Drosophila) 0.142
WNT1 wingless-type MMTV integration site family, member 1 0.140
SMAD2 SMAD family member 2 0.140
GLIS2 GLIS family zinc finger 2 0.129
HOXB5 homeobox B5 0.119
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit 0.117
FGF3 fibroblast growth factor 3 0.117
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.109
COL2A1 collagen, type II, alpha 1 0.101
MAGED2 melanoma antigen family D, 2 0.100
FGF18 fibroblast growth factor 18 0.099
HOXA10 homeobox A10 0.097
NRP1 neuropilin 1 0.095
TAOK1 TAO kinase 1 0.094
BCL2L1 BCL2-like 1 0.091
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.087
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.083
BMP7 bone morphogenetic protein 7 0.083
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.074
PAX8 paired box 8 0.073
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.062
FOXC2 forkhead box C2 (MFH-1, mesenchyme forkhead 1) 0.060
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.057
FOS FBJ murine osteosarcoma viral oncogene homolog 0.051
TIMP3 TIMP metallopeptidase inhibitor 3 0.050
TP53 tumor protein p53 0.048
PAX3 paired box 3 0.045
SOX1 SRY (sex determining region Y)-box 1 0.044
TGFBR1 transforming growth factor, beta receptor 1 0.042
SFRP1 secreted frizzled-related protein 1 0.039
NOTCH1 notch 1 0.038
IER2 immediate early response 2 0.038
ENG endoglin 0.037
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.036
FGFR3 fibroblast growth factor receptor 3 0.033
LBX1 ladybird homeobox 1 0.033
MDFI MyoD family inhibitor 0.033
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.031
HES2 hairy and enhancer of split 2 (Drosophila) 0.027
CLDN4 claudin 4 0.027
HOXB6 homeobox B6 0.026
HOXA11 homeobox A11 0.026
TRPC1 transient receptor potential cation channel, subfamily C, member 1 0.026
ZNF331 zinc finger protein 331 0.025
HOXD13 homeobox D13 0.025
HNF1A HNF1 homeobox A 0.025
HMGA2 high mobility group AT-hook 2 0.024
NFE2L2 nuclear factor (erythroid-derived 2)-like 2 0.024
FOXA2 forkhead box A2 0.023
BMP2 bone morphogenetic protein 2 0.023
GDNF glial cell derived neurotrophic factor 0.022
FGF7 fibroblast growth factor 7 0.021
BBS1 Bardet-Biedl syndrome 1 0.021
ZFP36 zinc finger protein 36, C3H type, homolog (mouse) 0.021
TAL1 T-cell acute lymphocytic leukemia 1 0.021
SIM2 single-minded homolog 2 (Drosophila) 0.021
ZFYVE9 zinc finger, FYVE domain containing 9 0.021
INHBB inhibin, beta B 0.021
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.020
PAX7 paired box 7 0.020
FOXL1 forkhead box L1 0.019
SKI v-ski sarcoma viral oncogene homolog (avian) 0.019
PAX2 paired box 2 0.019
BHLHE40 basic helix-loop-helix family, member e40 0.018
SLC3A2 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 0.018
PTPRB protein tyrosine phosphatase, receptor type, B 0.018
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism