The network for 'mesenchymal cell development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

mesenchymal cell development

The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.

Danio rerio
Name Description Probability Func Analog Organism
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.988
shha sonic hedgehog a 0.986
cdh2 cadherin 2, neuronal 0.966
foxd3 forkhead box D3 0.963
tbx1 T-box 1 0.948
foxa3 forkhead box A3 0.940
gsc goosecoid 0.920
erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog 0.910
crestin crestin 0.884
bmp2b bone morphogenetic protein 2b 0.859
mib mind bomb 0.851
mecom MDS1 and EVI1 complex locus 0.849
tgfb3 transforming growth factor, beta 3 0.838
tfap2a transcription factor AP-2 alpha 0.833
lef1 lymphocyte enhancer binding factor 1 0.830
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.813
eya1 eyes absent homolog 1 0.809
sox10 SRY-box containing gene 10 0.805
dlc deltaC 0.781
sox2 SRY-box containing gene 2 0.751
notch3 notch homolog 3 0.723
mitfa microphthalmia-associated transcription factor a 0.721
foxi1 forkhead box I1 0.721
osr2 odd-skipped related 2 (Drosophila) 0.721
pax6b paired box gene 6b 0.715
zic2a zic family member 2 (odd-paired homolog, Drosophila), a 0.712
shhb sonic hedgehog b 0.710
wu:fv91b12 wu:fv91b12 0.709
eomesa eomesodermin homolog a 0.697
her6 hairy-related 6 0.681
grem2 gremlin 2, cysteine knot superfamily 0.668
cdh6 cadherin 6 0.648
emx3 empty spiracles homeobox 3 0.615
pax2a paired box gene 2a 0.615
kita kit receptor a 0.602
wnt11 wingless-type MMTV integration site family, member 11 0.587
rspo3 R-spondin 3 homolog (Xenopus laevis) 0.577
gpr126 G protein-coupled receptor 126 0.546
dld deltaD 0.543
traf4a tnf receptor-associated factor 4a 0.537
fgf8a fibroblast growth factor 8 a 0.536
lhx5 LIM homeobox 5 0.529
cdx4 caudal type homeo box transcription factor 4 0.518
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.504
msxe muscle segment homeobox E 0.489
cxcr4a chemokine (C-X-C motif) receptor 4a 0.485
gata3 GATA-binding protein 3 0.480
six3a sine oculis homeobox homolog 3a 0.465
tll1 tolloid-like 1 0.461
gyltl1b glycosyltransferase-like 1b 0.444
gro1 groucho 1 0.443
ndr2 nodal-related 2 0.440
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.437
rarga retinoic acid receptor gamma a 0.435
crabp2a cellular retinoic acid binding protein 2, a 0.432
plod2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.429
pax6a paired box gene 6a 0.425
twist1a twist1a 0.425
prdm5 PR domain containing 5 0.424
neurod neurogenic differentiation 0.423
her1 hairy-related 1 0.417
sox1a SRY-box containing gene 1a 0.415
otx2 orthodenticle homolog 2 0.413
tp53 tumor protein p53 0.413
fzd7b frizzled homolog 7b 0.409
dbx1a developing brain homeobox 1a 0.399
supt6h suppressor of Ty 6 homolog 0.390
hnf1ba HNF1 homeobox Ba 0.385
pcdh18b protocadherin 18b 0.384
flh floating head 0.380
tfec transcription factor EC 0.371
smad1 MAD homolog 1 (Drosophila) 0.371
gria1a glutamate receptor, ionotropic, AMPA 1a 0.355
fgf10a fibroblast growth factor 10a 0.354
notch1b notch homolog 1b 0.349
pitx3 paired-like homeodomain transcription factor 3 0.343
gdf6a growth differentiation factor 6a 0.342
gria3b glutamate receptor, ionotrophic, AMPA 3b 0.336
pax7a paired box gene 7a 0.336
col15a1b collagen, type XV, alpha 1b 0.333
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.329
nrp1a neuropilin 1a 0.326
igf1rb insulin-like growth factor 1b receptor 0.321
pitx2 paired-like homeodomain transcription factor 2 0.312
gria4b glutamate receptor, ionotropic, AMPA 4b 0.312
ascl1a achaete-scute complex-like 1a (Drosophila) 0.309
twist3 twist3 0.307
bmp4 bone morphogenetic protein 4 0.307
oep one-eyed pinhead 0.305
zic3 zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila) 0.297
tp63 tumor protein p63 0.293
sema3d semaphorin 3d 0.293
zic1 zic family member 1 (odd-paired homolog, Drosophila) 0.290
rx2 retinal homeobox gene 2 0.289
zeb2a zinc finger E-box binding homeobox 2a 0.285
fzd7a frizzled homolog 7a 0.276
six3b sine oculis homeobox homolog 3b 0.273
dct dopachrome tautomerase 0.272
dlx3b distal-less homeobox gene 3b 0.271
fgf3 fibroblast growth factor 3 0.267
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
N Notch 0.446
hth homothorax 0.393
Ras85D Ras oncogene at 85D 0.338
nkd naked cuticle 0.327
ttv tout-velu 0.326
ci cubitus interruptus 0.305
wg wingless 0.299
Mad Mothers against dpp 0.267
ush u-shaped 0.230
gcm glial cells missing 0.184
Egfr Epidermal growth factor receptor 0.184
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.178
baz bazooka 0.178
rap retina aberrant in pattern 0.166
Stat92E Signal-transducer and activator of transcription protein at 92E 0.160
hh hedgehog 0.156
shg shotgun 0.155
Eip74EF Ecdysone-induced protein 74EF 0.154
shn schnurri 0.149
dm diminutive 0.131
dsh dishevelled 0.126
hpo hippo 0.120
slou slouch 0.119
klu klumpfuss 0.116
put punt 0.113
insc inscuteable 0.109
en engrailed 0.109
dpp decapentaplegic 0.106
Mef2 Myocyte enhancer factor 2 0.100
numb CG3779 gene product from transcript CG3779-RB 0.097
Smox Smad on X 0.096
Kr Kruppel 0.095
pnr pannier 0.093
CG11347 CG11347 gene product from transcript CG11347-RE 0.091
LanB2 Laminin B2 0.087
emc extra macrochaetae 0.085
ex expanded 0.084
ap apterous 0.083
myoglianin CG1838 gene product from transcript CG1838-RD 0.083
SoxN SoxNeuro 0.081
Antp Antennapedia 0.080
osa CG7467 gene product from transcript CG7467-RD 0.079
Akt1 CG4006 gene product from transcript CG4006-RA 0.079
bowl brother of odd with entrails limited 0.078
slp1 sloppy paired 1 0.077
eya eyes absent 0.077
crb crumbs 0.073
babo baboon 0.071
pxb CG33207 gene product from transcript CG33207-RB 0.069
noc no ocelli 0.069
wts warts 0.068
jing CG9397 gene product from transcript CG9397-RI 0.068
Sema-1a CG18405 gene product from transcript CG18405-RD 0.067
fas faint sausage 0.067
tin tinman 0.067
Gsc Goosecoid 0.066
eyg eyegone 0.063
MED19 Mediator complex subunit 19 0.061
Dad Daughters against dpp 0.060
ash2 absent, small, or homeotic discs 2 0.060
CG8765 CG8765 gene product from transcript CG8765-RA 0.059
nab CG33545 gene product from transcript CG33545-RC 0.058
eIF3-S8 CG4954 gene product from transcript CG4954-RA 0.058
grn grain 0.058
sd scalloped 0.057
l(2)gd1 lethal (2) giant discs 1 0.057
dlg1 discs large 1 0.057
cwo clockwork orange 0.056
tld tolloid 0.056
CG12424 CG12424 gene product from transcript CG12424-RC 0.054
kibra kibra ortholog 0.054
E(z) Enhancer of zeste 0.053
gro groucho 0.053
E(spl) Enhancer of split 0.053
lbl ladybird late 0.052
pr-set7 CG3307 gene product from transcript CG3307-RC 0.052
lbe ladybird early 0.051
gcm2 CG3858 gene product from transcript CG3858-RA 0.050
Fs Follistatin 0.050
stumps CG31317 gene product from transcript CG31317-RC 0.050
ecd ecdysoneless 0.049
eve even skipped 0.049
slp2 sloppy paired 2 0.048
Tsc1 CG6147 gene product from transcript CG6147-RA 0.048
sna snail 0.048
tws twins 0.048
RhoGAP100F CG1976 gene product from transcript CG1976-RB 0.046
trbl tribbles 0.046
m miniature 0.046
nau nautilus 0.045
cnc cap-n-collar 0.045
Pka-C1 cAMP-dependent protein kinase 1 0.044
byn brachyenteron 0.044
fng fringe 0.043
twi twist 0.043
Hr4 CG16902 gene product from transcript CG16902-RC 0.043
Ubx Ultrabithorax 0.043
CG13349 CG13349 gene product from transcript CG13349-RA 0.042
lab labial 0.042
slmb supernumerary limbs 0.042
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Homo sapiens
Name Description Probability Func Analog Organism
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.000
NOTCH1 notch 1 0.999
SMAD3 SMAD family member 3 0.999
JAG1 jagged 1 0.999
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.999
COL1A1 collagen, type I, alpha 1 0.998
SMAD1 SMAD family member 1 0.996
SMAD4 SMAD family member 4 0.996
TGFB1 transforming growth factor, beta 1 0.991
EGFR epidermal growth factor receptor 0.991
SMAD7 SMAD family member 7 0.988
TP53 tumor protein p53 0.987
EP300 E1A binding protein p300 0.982
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.979
SMAD2 SMAD family member 2 0.972
PAX3 paired box 3 0.970
AR androgen receptor 0.970
CREBBP CREB binding protein 0.968
SOX10 SRY (sex determining region Y)-box 10 0.950
SKIL SKI-like oncogene 0.948
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.944
COL5A1 collagen, type V, alpha 1 0.916
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.878
FKBP1A FK506 binding protein 1A, 12kDa 0.876
NOTCH3 notch 3 0.874
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.869
POU3F2 POU class 3 homeobox 2 0.868
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.862
POU5F1 POU class 5 homeobox 1 0.844
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.833
FN1 fibronectin 1 0.819
GATA4 GATA binding protein 4 0.818
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.808
COL4A1 collagen, type IV, alpha 1 0.805
PTK2 PTK2 protein tyrosine kinase 2 0.792
FSTL1 follistatin-like 1 0.788
ENG endoglin 0.781
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.758
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.741
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.740
BMP2 bone morphogenetic protein 2 0.720
NRP1 neuropilin 1 0.689
SMAD5 SMAD family member 5 0.680
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.647
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.615
COL3A1 collagen, type III, alpha 1 0.606
RBPMS RNA binding protein with multiple splicing 0.606
COL4A2 collagen, type IV, alpha 2 0.602
GRB7 growth factor receptor-bound protein 7 0.594
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.563
COL5A2 collagen, type V, alpha 2 0.558
FHL2 four and a half LIM domains 2 0.554
LTBP2 latent transforming growth factor beta binding protein 2 0.544
CXXC5 CXXC finger protein 5 0.541
TBX5 T-box 5 0.529
COL1A2 collagen, type I, alpha 2 0.525
FGF3 fibroblast growth factor 3 0.519
FZD1 frizzled homolog 1 (Drosophila) 0.508
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.491
ZFYVE9 zinc finger, FYVE domain containing 9 0.487
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.487
RUNX1 runt-related transcription factor 1 0.479
THBS1 thrombospondin 1 0.467
GSK3B glycogen synthase kinase 3 beta 0.458
COL2A1 collagen, type II, alpha 1 0.454
TGFB3 transforming growth factor, beta 3 0.453
QKI quaking homolog, KH domain RNA binding (mouse) 0.446
BMP7 bone morphogenetic protein 7 0.438
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.432
AXIN1 axin 1 0.417
MYOD1 myogenic differentiation 1 0.408
NCOR1 nuclear receptor corepressor 1 0.401
COL6A1 collagen, type VI, alpha 1 0.400
SOX1 SRY (sex determining region Y)-box 1 0.399
WNT1 wingless-type MMTV integration site family, member 1 0.392
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.381
POSTN periostin, osteoblast specific factor 0.371
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.370
TP73 tumor protein p73 0.370
BMPR1A bone morphogenetic protein receptor, type IA 0.369
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.368
SMAD9 SMAD family member 9 0.361
LIMS1 LIM and senescent cell antigen-like domains 1 0.359
APC adenomatous polyposis coli 0.354
FOXF2 forkhead box F2 0.353
PAX8 paired box 8 0.351
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.350
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.346
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.338
NCK2 NCK adaptor protein 2 0.332
FZD8 frizzled homolog 8 (Drosophila) 0.329
FGF1 fibroblast growth factor 1 (acidic) 0.325
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 0.321
TCF4 transcription factor 4 0.312
SETD8 SET domain containing (lysine methyltransferase) 8 0.310
HIPK2 homeodomain interacting protein kinase 2 0.309
HIC1 hypermethylated in cancer 1 0.299
PTBP1 polypyrimidine tract binding protein 1 0.298
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.295
ACVR1 activin A receptor, type I 0.293
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Mus musculus
Name Description Probability Func Analog Organism
Foxc1 forkhead box C1 1.000
Shh sonic hedgehog 1.000
Pax3 paired box gene 3 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Bmp4 bone morphogenetic protein 4 1.000
Pax2 paired box gene 2 1.000
Pax6 paired box gene 6 1.000
Tgfb2 transforming growth factor, beta 2 1.000
Tcfap2a transcription factor AP-2, alpha 1.000
Otx2 orthodenticle homolog 2 (Drosophila) 0.999
Pitx2 paired-like homeodomain transcription factor 2 0.999
Hand1 heart and neural crest derivatives expressed transcript 1 0.999
Fgf8 fibroblast growth factor 8 0.999
Jag1 jagged 1 0.999
Vegfa vascular endothelial growth factor A 0.998
Fgfr1 fibroblast growth factor receptor 1 0.998
Nodal nodal 0.998
Rarg retinoic acid receptor, gamma 0.997
Eya1 eyes absent 1 homolog (Drosophila) 0.997
Hoxa1 homeobox A1 0.997
Hand2 heart and neural crest derivatives expressed transcript 2 0.997
Dlx5 distal-less homeobox 5 0.994
Bcl2 B-cell leukemia/lymphoma 2 0.994
Prrx1 paired related homeobox 1 0.994
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.993
Foxc2 forkhead box C2 0.992
Msx2 homeobox, msh-like 2 0.992
Efnb2 ephrin B2 0.992
Chrd chordin 0.991
Lhx1 LIM homeobox protein 1 0.990
Sox9 SRY-box containing gene 9 0.990
Ret ret proto-oncogene 0.988
Isl1 ISL1 transcription factor, LIM/homeodomain 0.986
Nog noggin 0.984
Snai1 snail homolog 1 (Drosophila) 0.982
Runx2 runt related transcription factor 2 0.982
Ednra endothelin receptor type A 0.981
Msx1 homeobox, msh-like 1 0.981
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.980
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.979
Smo smoothened homolog (Drosophila) 0.978
Gli2 GLI-Kruppel family member GLI2 0.977
Acvr1 activin A receptor, type 1 0.977
Lmx1a LIM homeobox transcription factor 1 alpha 0.976
Foxg1 forkhead box G1 0.973
Notch1 Notch gene homolog 1 (Drosophila) 0.970
Gata4 GATA binding protein 4 0.968
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.967
Bmp7 bone morphogenetic protein 7 0.965
Prrx2 paired related homeobox 2 0.962
Fgf10 fibroblast growth factor 10 0.958
Zic3 zinc finger protein of the cerebellum 3 0.954
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.953
Lef1 lymphoid enhancer binding factor 1 0.951
Pitx1 paired-like homeodomain transcription factor 1 0.950
Tlx3 T-cell leukemia, homeobox 3 0.948
Alx4 aristaless-like homeobox 4 0.948
Hoxd13 homeobox D13 0.940
Tgfbr2 transforming growth factor, beta receptor II 0.938
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.933
Gdnf glial cell line derived neurotrophic factor 0.924
Gbx2 gastrulation brain homeobox 2 0.922
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.919
Smad3 MAD homolog 3 (Drosophila) 0.919
Rarb retinoic acid receptor, beta 0.918
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.916
Ntf3 neurotrophin 3 0.909
Tbx1 T-box 1 0.908
Meox2 mesenchyme homeobox 2 0.905
Pax9 paired box gene 9 0.891
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.883
Atoh7 atonal homolog 7 (Drosophila) 0.881
Twist2 twist homolog 2 (Drosophila) 0.870
Pou3f3 POU domain, class 3, transcription factor 3 0.866
Chd7 chromodomain helicase DNA binding protein 7 0.864
Emx1 empty spiracles homolog 1 (Drosophila) 0.859
Pbx1 pre B-cell leukemia transcription factor 1 0.848
Hoxd11 homeobox D11 0.845
Tbx3 T-box 3 0.835
Ece1 endothelin converting enzyme 1 0.831
Pthlh parathyroid hormone-like peptide 0.831
Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 0.831
Rxra retinoid X receptor alpha 0.830
Hes1 hairy and enhancer of split 1 (Drosophila) 0.829
Gdf11 growth differentiation factor 11 0.827
Axin1 axin 1 0.827
Gata6 GATA binding protein 6 0.822
Col2a1 collagen, type II, alpha 1 0.819
Ptf1a pancreas specific transcription factor, 1a 0.800
Wnt6 wingless-related MMTV integration site 6 0.783
Hes5 hairy and enhancer of split 5 (Drosophila) 0.780
Sox2 SRY-box containing gene 2 0.778
Sox3 SRY-box containing gene 3 0.778
En1 engrailed 1 0.763
Smad4 MAD homolog 4 (Drosophila) 0.754
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.749
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.746
Ctnnb1 catenin (cadherin associated protein), beta 1 0.737
Bnc1 basonuclin 1 0.732
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Rattus norvegicus
Name Description Probability Func Analog Organism
Met met proto-oncogene 0.013
Dchs1 dachsous 1 (Drosophila) 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism