The network for 'organ formation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

organ formation

The process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ.

Danio rerio
Name Description Probability Func Analog Organism
chd chordin 0.958
shha sonic hedgehog a 0.950
tbx1 T-box 1 0.882
bmp4 bone morphogenetic protein 4 0.880
ndr2 nodal-related 2 0.812
bmp2b bone morphogenetic protein 2b 0.784
fgf8a fibroblast growth factor 8 a 0.717
pax2a paired box gene 2a 0.703
tbx16 T-box gene 16 0.685
dlx5a distal-less homeobox gene 5a 0.673
flh floating head 0.635
spaw southpaw 0.595
slit3 slit (Drosophila) homolog 3 0.572
lft2 lefty2 0.541
pcdh8 protocadherin 8 0.495
etv2 ets variant gene 2 0.491
gli1 GLI-Kruppel family member 1 0.473
foxi1 forkhead box I1 0.460
tbx5a T-box 5a 0.441
notch3 notch homolog 3 0.368
gata4 GATA-binding protein 4 0.336
kdrl kinase insert domain receptor like 0.329
wnt5b wingless-type MMTV integration site family, member 5b 0.329
fgf24 fibroblast growth factor 24 0.325
bmp2a bone morphogenetic protein 2a 0.325
foxg1a forkhead box G1a 0.320
dlx3b distal-less homeobox gene 3b 0.319
dlc deltaC 0.312
hnf1ba HNF1 homeobox Ba 0.307
six3b sine oculis homeobox homolog 3b 0.300
wls wntless homolog (Drosophila) 0.284
dlx1a distal-less homeobox gene 1a 0.276
atoh1b atonal homolog 1b 0.274
wt1a wilms tumor 1a 0.263
lhx1a LIM homeobox 1a 0.223
hmgcrb 3-hydroxy-3-methylglutaryl-Coenzyme A reductase b 0.200
ptch2 patched 2 0.199
emx3 empty spiracles homeobox 3 0.193
tal1 T-cell acute lymphocytic leukemia 1 0.186
jag2 jagged 2 0.173
foxp2 forkhead box P2 0.167
wnt3 wingless-type MMTV integration site family, member 3 0.166
evx1 even-skipped homeobox 1 0.166
her15.1 hairy and enhancer of split-related 15.1 0.163
wnt8b wingless-type MMTV integration site family, member 8b 0.162
nkx2.7 NK2 transcription factor related 7 0.158
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.155
sox9a SRY-box containing gene 9a 0.153
lft1 lefty1 0.151
nkx2.5 NK2 transcription factor related 5 0.144
cdh2 cadherin 2, neuronal 0.139
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.138
tbx24 T-box 24 0.138
her1 hairy-related 1 0.137
wnt11 wingless-type MMTV integration site family, member 11 0.135
gata5 GATA-binding protein 5 0.134
lfng lunatic fringe homolog 0.133
igfbp3 insulin-like growth factor binding protein 3 0.131
dlx2a distal-less homeobox gene 2a 0.127
mll myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.127
fgfrl1b fibroblast growth factor receptor-like 1b 0.126
six3a sine oculis homeobox homolog 3a 0.125
crabp2a cellular retinoic acid binding protein 2, a 0.123
her5 hairy-related 5 0.123
robo1 roundabout homolog 1 0.123
her7 hairy and enhancer of split related-7 0.122
fn1 fibronectin 1 0.121
dharma dharma 0.120
alcamb activated leukocyte cell adhesion molecule b 0.119
tbx20 T-box 20 0.115
etv5b ets variant 5b 0.114
vent ventral expressed homeobox 0.108
fsta follistatin a 0.108
otpb orthopedia homolog b 0.107
runx2b runt-related transcription factor 2b 0.105
tll1 tolloid-like 1 0.102
rx3 retinal homeobox gene 3 0.102
dld deltaD 0.102
jag1b jagged 1b 0.100
rfx2 regulatory factor X, 2 (influences HLA class II expression) 0.098
col15a1b collagen, type XV, alpha 1b 0.097
fgf3 fibroblast growth factor 3 0.097
col2a1a collagen type II, alpha-1a 0.095
tbx2b T-box 2b 0.094
osr2 odd-skipped related 2 (Drosophila) 0.091
wnt4a wingless-type MMTV integration site family, member 4a 0.091
ascl1a achaete-scute complex-like 1a (Drosophila) 0.090
six4b sine oculis homeobox homolog 4b 0.090
atoh1a atonal homolog 1a 0.088
hoxa9a homeo box A9a 0.087
mib mind bomb 0.085
mespa mesoderm posterior a 0.084
dmrt2a doublesex and mab-3 related transcription factor 2a 0.081
fgf4 fibroblast growth factor 4 0.080
arx aristaless related homeobox 0.079
sox17 SRY-box containing gene 17 0.078
pax6b paired box gene 6b 0.077
her12 hairy-related 12 0.076
hoxc6a homeo box C6a 0.074
gata6 GATA-binding protein 6 0.074
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
ci cubitus interruptus 0.998
E(spl) Enhancer of split 0.996
HLHmdelta E(spl) region transcript mdelta 0.993
wg wingless 0.992
Tom Twin of m4 0.979
HLHm5 E(spl) region transcript m5 0.974
HLHm7 E(spl) region transcript m7 0.963
tin tinman 0.959
HLHmbeta E(spl) region transcript mbeta 0.908
en engrailed 0.903
sca scabrous 0.891
malpha E(spl) region transcript malpha 0.888
HLHmgamma E(spl) region transcript mgamma 0.887
hkb huckebein 0.858
dsh dishevelled 0.834
Ser Serrate 0.831
slou slouch 0.789
ato atonal 0.788
eya eyes absent 0.758
sns sticks and stones 0.743
abd-A abdominal A 0.729
sli slit 0.717
pnr pannier 0.716
hh hedgehog 0.712
LanB1 CG7123 gene product from transcript CG7123-RA 0.693
ac achaete 0.673
hth homothorax 0.670
Dl Delta 0.653
aop anterior open 0.614
bab2 CG9102 gene product from transcript CG9102-RA 0.611
ush u-shaped 0.606
HLH54F CG5005 gene product from transcript CG5005-RA 0.585
nub nubbin 0.567
B-H2 BarH2 0.551
stumps CG31317 gene product from transcript CG31317-RC 0.548
NetB Netrin-B 0.523
m4 E(spl) region transcript m4 0.512
robo roundabout 0.500
lea leak 0.496
LanB2 Laminin B2 0.436
dx deltex 0.430
Doc2 Dorsocross2 0.418
emc extra macrochaetae 0.404
wb wing blister 0.401
CG14869 CG14869 gene product from transcript CG14869-RB 0.378
LanA Laminin A 0.358
bnl branchless 0.330
m2 E(spl) region transcript m2 0.323
twi twist 0.323
Mad Mothers against dpp 0.286
numb CG3779 gene product from transcript CG3779-RB 0.285
Lim1 CG11354 gene product from transcript CG11354-RA 0.278
dpp decapentaplegic 0.271
nkd naked cuticle 0.239
amos absent MD neurons and olfactory sensilla 0.230
ed echinoid 0.226
Traf4 TNF-receptor-associated factor 4 0.224
B-H1 BarH1 0.218
bowl brother of odd with entrails limited 0.217
Notum CG13076 gene product from transcript CG13076-RB 0.215
argos CG4531 gene product from transcript CG4531-RA 0.210
fng fringe 0.205
fz2 frizzled 2 0.205
Mef2 Myocyte enhancer factor 2 0.201
HLHm3 E(spl) region transcript m3 0.195
hbs hibris 0.194
shn schnurri 0.186
htl heartless 0.186
ttk tramtrack 0.176
Ubx Ultrabithorax 0.175
H Hairless 0.168
Tollo CG6890 gene product from transcript CG6890-RA 0.160
N Notch 0.157
eyg eyegone 0.154
gcm glial cells missing 0.152
ptc patched 0.149
Abd-B Abdominal B 0.147
Dad Daughters against dpp 0.146
Egfr Epidermal growth factor receptor 0.143
dac dachshund 0.143
mid midline 0.142
C15 CG7937 gene product from transcript CG7937-RA 0.141
Su(H) Suppressor of Hairless 0.133
Akt1 CG4006 gene product from transcript CG4006-RA 0.127
Gsc Goosecoid 0.127
vg vestigial 0.127
hipk homeodomain interacting protein kinase 0.122
jeb jelly belly 0.118
rib ribbon 0.115
zfh2 Zn finger homeodomain 2 0.109
comm commissureless 0.109
BobA Brother of Bearded A 0.109
Poxn Pox neuro 0.107
Med Medea 0.107
sc scute 0.105
ds dachsous 0.099
ham hamlet 0.098
fz frizzled 0.095
mam mastermind 0.094
bab1 bric a brac 1 0.091
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Homo sapiens
Name Description Probability Func Analog Organism
FGFR2 fibroblast growth factor receptor 2 1.000
NOTCH1 notch 1 1.000
JAG1 jagged 1 1.000
FGFR1 fibroblast growth factor receptor 1 1.000
FGF1 fibroblast growth factor 1 (acidic) 0.999
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.999
CSNK1E casein kinase 1, epsilon 0.998
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.997
FHL2 four and a half LIM domains 2 0.992
SOX10 SRY (sex determining region Y)-box 10 0.992
FOXD3 forkhead box D3 0.985
FGF10 fibroblast growth factor 10 0.984
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.979
SUFU suppressor of fused homolog (Drosophila) 0.965
SP1 Sp1 transcription factor 0.960
NKX2-1 NK2 homeobox 1 0.957
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.952
TBX5 T-box 5 0.904
FGF8 fibroblast growth factor 8 (androgen-induced) 0.900
GATA4 GATA binding protein 4 0.896
HOXD13 homeobox D13 0.877
EP300 E1A binding protein p300 0.874
MEOX2 mesenchyme homeobox 2 0.853
POU3F2 POU class 3 homeobox 2 0.844
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 0.844
WT1 Wilms tumor 1 0.841
NCOA2 nuclear receptor coactivator 2 0.834
HDAC4 histone deacetylase 4 0.819
NOG noggin 0.812
FGF2 fibroblast growth factor 2 (basic) 0.806
JAG2 jagged 2 0.784
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.780
TP73 tumor protein p73 0.778
MAML1 mastermind-like 1 (Drosophila) 0.776
TGFB3 transforming growth factor, beta 3 0.774
ITGB4 integrin, beta 4 0.774
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.745
PAX2 paired box 2 0.740
PLCG1 phospholipase C, gamma 1 0.732
LHX3 LIM homeobox 3 0.720
NOTCH3 notch 3 0.715
SIX6 SIX homeobox 6 0.714
SOX2 SRY (sex determining region Y)-box 2 0.700
SMAD1 SMAD family member 1 0.696
FGFR3 fibroblast growth factor receptor 3 0.695
ZNF512B zinc finger protein 512B 0.691
FGF3 fibroblast growth factor 3 0.685
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.677
LBX1 ladybird homeobox 1 0.669
CABLES1 Cdk5 and Abl enzyme substrate 1 0.668
MYOD1 myogenic differentiation 1 0.629
LMX1A LIM homeobox transcription factor 1, alpha 0.620
RAX retina and anterior neural fold homeobox 0.608
OTP orthopedia homeobox 0.607
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.602
FOXE1 forkhead box E1 (thyroid transcription factor 2) 0.578
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.577
HOXD9 homeobox D9 0.562
DLL1 delta-like 1 (Drosophila) 0.555
STK36 serine/threonine kinase 36 0.555
LHX1 LIM homeobox 1 0.553
LRP6 low density lipoprotein receptor-related protein 6 0.544
FSTL1 follistatin-like 1 0.540
CDK11B cyclin-dependent kinase 11B 0.520
TGFB1 transforming growth factor, beta 1 0.516
FOXC2 forkhead box C2 (MFH-1, mesenchyme forkhead 1) 0.505
LHX5 LIM homeobox 5 0.503
BMP7 bone morphogenetic protein 7 0.501
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.493
FOXA2 forkhead box A2 0.487
HOXA10 homeobox A10 0.485
CTBP1 C-terminal binding protein 1 0.482
VAX2 ventral anterior homeobox 2 0.479
FGF7 fibroblast growth factor 7 0.473
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.464
FGF4 fibroblast growth factor 4 0.462
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.456
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.451
PHOX2A paired-like homeobox 2a 0.444
HOXB5 homeobox B5 0.440
SIX2 SIX homeobox 2 0.440
NEUROG3 neurogenin 3 0.440
NCOR2 nuclear receptor corepressor 2 0.438
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.435
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.433
CTNNBIP1 catenin, beta interacting protein 1 0.424
ALX3 ALX homeobox 3 0.421
ATXN1L ataxin 1-like 0.419
TGIF1 TGFB-induced factor homeobox 1 0.416
CPE carboxypeptidase E 0.408
TLX2 T-cell leukemia homeobox 2 0.406
ZIC1 Zic family member 1 (odd-paired homolog, Drosophila) 0.405
SIM2 single-minded homolog 2 (Drosophila) 0.405
SOX1 SRY (sex determining region Y)-box 1 0.403
ALX4 ALX homeobox 4 0.398
HIC1 hypermethylated in cancer 1 0.393
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.386
FOXB1 forkhead box B1 0.386
SOX11 SRY (sex determining region Y)-box 11 0.382
NOVA2 neuro-oncological ventral antigen 2 0.379
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Robo1 roundabout homolog 1 (Drosophila) 0.230
Unc5b unc-5 homolog B (C. elegans) 0.199
F13a1 coagulation factor XIII, A1 polypeptide 0.194
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.168
Olfml2b olfactomedin-like 2B 0.141
Ucn2 urocortin 2 0.134
Kcnq3 potassium voltage-gated channel, KQT-like subfamily, member 3 0.115
Slc5a1 solute carrier family 5 (sodium/glucose cotransporter), member 1 0.113
Bcl2 B-cell CLL/lymphoma 2 0.110
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.102
Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit 0.099
Axin1 axin 1 0.087
Snrk SNF related kinase 0.086
Arnt aryl hydrocarbon receptor nuclear translocator 0.084
Ccl22 chemokine (C-C motif) ligand 22 0.082
Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.081
Igfbp5 insulin-like growth factor binding protein 5 0.080
Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 0.077
Arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.077
Bmp6 bone morphogenetic protein 6 0.074
Synpo synaptopodin 0.070
Gper G protein-coupled estrogen receptor 1 0.069
Hist1h1d histone cluster 1, H1d 0.068
Mpp2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.067
Ugt2a1 UDP glucuronosyltransferase 2 family, polypeptide A1 0.066
Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 0.066
Glg1 golgi apparatus protein 1 0.064
Flt1 FMS-related tyrosine kinase 1 0.063
Gjb4 gap junction protein, beta 4 0.063
Sox13 SRY (sex determining region Y)-box 13 0.062
Syt9 synaptotagmin IX 0.061
Otx1 orthodenticle homeobox 1 0.061
Tgfb2 transforming growth factor, beta 2 0.061
Smad7 SMAD family member 7 0.059
Htr1a 5-hydroxytryptamine (serotonin) receptor 1A 0.058
Fgf5 fibroblast growth factor 5 0.058
Met met proto-oncogene 0.058
Prrx1 paired related homeobox 1 0.057
Apba1 amyloid beta (A4) precursor protein-binding, family A, member 1 0.056
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.055
Accn5 amiloride-sensitive cation channel 5, intestinal 0.055
Irs1 insulin receptor substrate 1 0.055
Efnb1 ephrin B1 0.054
Nfib nuclear factor I/B 0.054
Socs3 suppressor of cytokine signaling 3 0.054
Sdc3 syndecan 3 0.053
Rara retinoic acid receptor, alpha 0.053
Creb1 cAMP responsive element binding protein 1 0.052
Myh9 myosin, heavy chain 9, non-muscle 0.052
Sox17 SRY (sex determining region Y)-box 17 0.051
Ccdc102a coiled-coil domain containing 102A 0.051
Il3 interleukin 3 0.051
RY2G5 potential ligand-binding protein 0.051
Xylt1 xylosyltransferase 1 0.051
LOC64038 sertolin 0.050
Abcb4 ATP-binding cassette, subfamily B (MDR/TAP), member 4 0.050
Nfe2l2 nuclear factor, erythroid derived 2, like 2 0.050
Scn8a sodium channel, voltage gated, type VIII, alpha subunit 0.050
Pdyn prodynorphin 0.050
Prph2 peripherin 2 0.049
Fgfr2 fibroblast growth factor receptor 2 0.049
Foxc2 forkhead box C2 0.049
Gdf11 growth differentiation factor 11 0.048
Fzd2 frizzled homolog 2 (Drosophila) 0.048
Tas2r119 taste receptor, type 2, member 119 0.048
Cd4 Cd4 molecule 0.048
Notch2 Notch homolog 2 (Drosophila) 0.048
Six3 SIX homeobox 3 0.048
Bmp3 bone morphogenetic protein 3 0.048
Fgf11 fibroblast growth factor 11 0.047
Hoxb7 homeo box B7 0.047
Cxxc4 CXXC finger 4 0.047
Foxs1 forkhead box S1 0.047
Hoxc4 homeo box C4 0.046
Man1a2 mannosidase, alpha, class 1A, member 2 0.046
Itga6 integrin, alpha 6 0.045
Crybb3 crystallin, beta B3 0.045
Ednra endothelin receptor type A 0.045
Htr1b 5-hydroxytryptamine (serotonin) receptor 1B 0.045
Syt7 synaptotagmin VII 0.045
Grin2a glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.044
Dcc deleted in colorectal carcinoma 0.044
Pou2f3 POU class 2 homeobox 3 0.044
RGD1309821 similar to KIAA1161 protein 0.044
Foxd4 forkhead box D4 0.044
Tgfbr3 transforming growth factor, beta receptor III 0.043
Lims1 LIM and senescent cell antigen-like domains 1 0.043
Clstn3 calsyntenin 3 0.043
Enpep glutamyl aminopeptidase 0.043
Cpxm2 carboxypeptidase X (M14 family), member 2 0.043
Cngb1 cyclic nucleotide gated channel beta 1 0.043
Cxcr3 chemokine (C-X-C motif) receptor 3 0.042
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.042
Pax8 paired box 8 0.041
Megf6 multiple EGF-like-domains 6 0.041
Glra1 glycine receptor, alpha 1 0.040
P2rx6 purinergic receptor P2X, ligand-gated ion channel, 6 0.040
Foxd1 forkhead box D1 0.040
Tpc1808 tropic 1808 0.040
Ptms parathymosin 0.040
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism