IMP

Process View

Homo sapiens

4 genes annotated in human

t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell

The change in morphology and behavior of a mature or immature T cell resulting from exposure to an antigen for which its T cell receptor is specific bound to an MHC molecule on an antigen presenting cell, leading to the initiation or perpetuation of an immune response.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell" (in gray)

Name	Description	Probability	Func Analog Organism
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	1.000
LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	0.987
FHL2	four and a half LIM domains 2	0.978
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.782
PILRA	paired immunoglobin-like type 2 receptor alpha	0.626
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.567
ENG	endoglin	0.442
LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	0.407	Human
LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	0.323	Human
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.273
LILRA2	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2	0.235
ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	0.209
SIGLEC7	sialic acid binding Ig-like lectin 7	0.190
PTAFR	platelet-activating factor receptor	0.166
HLA-DRA	major histocompatibility complex, class II, DR alpha	0.164
LILRB3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.151	Human
HLA-DMA	major histocompatibility complex, class II, DM alpha	0.109
FCN1	ficolin (collagen/fibrinogen domain containing) 1	0.109
PECAM1	platelet/endothelial cell adhesion molecule	0.098
HK3	hexokinase 3 (white cell)	0.089
CSK	c-src tyrosine kinase	0.078
HLA-DRB1	major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1	0.075
AOAH	acyloxyacyl hydrolase (neutrophil)	0.062
TLN1	talin 1	0.062
CCR1	chemokine (C-C motif) receptor 1	0.060
FHL3	four and a half LIM domains 3	0.057
MICA	MHC class I polypeptide-related sequence A	0.056
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.053
TYMP	thymidine phosphorylase	0.051
PTPRC	protein tyrosine phosphatase, receptor type, C	0.049
HCK	hemopoietic cell kinase	0.047
FN1	fibronectin 1	0.045
SELPLG	selectin P ligand	0.043
AIF1	allograft inflammatory factor 1	0.039
NCF4	neutrophil cytosolic factor 4, 40kDa	0.036
FLNA	filamin A, alpha	0.035
SPI1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.035
CLEC4M	C-type lectin domain family 4, member M	0.035
LST1	leukocyte specific transcript 1	0.034
SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.034
SIRPB1	signal-regulatory protein beta 1	0.034
EMR1	egf-like module containing, mucin-like, hormone receptor-like 1	0.033
TREM1	triggering receptor expressed on myeloid cells 1	0.031
GMFG	glia maturation factor, gamma	0.031
FCGR2C	Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)	0.031
NLRP3	NLR family, pyrin domain containing 3	0.031
DPEP2	dipeptidase 2	0.030
CSF3R	colony stimulating factor 3 receptor (granulocyte)	0.029
CYTH4	cytohesin 4	0.028
PXN	paxillin	0.027
FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	0.027
SLC15A3	solute carrier family 15, member 3	0.025
IGSF6	immunoglobulin superfamily, member 6	0.025
SIGLEC9	sialic acid binding Ig-like lectin 9	0.024
SIRPA	signal-regulatory protein alpha	0.024
ACVRL1	activin A receptor type II-like 1	0.023
ITGAX	integrin, alpha X (complement component 3 receptor 4 subunit)	0.023	Human
CD300A	CD300a molecule	0.023
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	0.023
CYBB	cytochrome b-245, beta polypeptide	0.023
FPR1	formyl peptide receptor 1	0.023
PLEK	pleckstrin	0.022
NOD2	nucleotide-binding oligomerization domain containing 2	0.022
PSEN2	presenilin 2 (Alzheimer disease 4)	0.021
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.021
CD86	CD86 molecule	0.021
VSIG4	V-set and immunoglobulin domain containing 4	0.021
LY86	lymphocyte antigen 86	0.020
PDIA3	protein disulfide isomerase family A, member 3	0.020
TLR8	toll-like receptor 8	0.020
HSD3B7	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	0.020
ITGA6	integrin, alpha 6	0.020
ITGB4	integrin, beta 4	0.019
NCKAP1L	NCK-associated protein 1-like	0.019
THBS1	thrombospondin 1	0.019
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.019
LILRA3	leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3	0.018	Human
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	0.018
FCAR	Fc fragment of IgA, receptor for	0.018	Human
CR1	complement component (3b/4b) receptor 1 (Knops blood group)	0.018
LILRA5	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5	0.018	Human
IL2RA	interleukin 2 receptor, alpha	0.018
CD22	CD22 molecule	0.018
CD14	CD14 molecule	0.018
RASSF4	Ras association (RalGDS/AF-6) domain family member 4	0.017
MARCO	macrophage receptor with collagenous structure	0.017
PTPN2	protein tyrosine phosphatase, non-receptor type 2	0.017
CD163	CD163 molecule	0.017
VCAM1	vascular cell adhesion molecule 1	0.017
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.016	Human
SHARPIN	SHANK-associated RH domain interactor	0.016
CD1D	CD1d molecule	0.016
CD63	CD63 molecule	0.016
PIK3R5	phosphoinositide-3-kinase, regulatory subunit 5	0.016
BIN2	bridging integrator 2	0.016
HLA-G	major histocompatibility complex, class I, G	0.016
LCP1	lymphocyte cytosolic protein 1 (L-plastin)	0.016
CASP5	caspase 5, apoptosis-related cysteine peptidase	0.016
LILRB4	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	0.016	Human
CD52	CD52 molecule	0.016
S100A9	S100 calcium binding protein A9	0.015
CD180	CD180 molecule	0.015
AQP9	aquaporin 9	0.015
C3AR1	complement component 3a receptor 1	0.015
CMKLR1	chemokine-like receptor 1	0.015
BCL3	B-cell CLL/lymphoma 3	0.015
RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	0.015
FMNL1	formin-like 1	0.015
TGFB1	transforming growth factor, beta 1	0.014
CD300C	CD300c molecule	0.014
LGALS1	lectin, galactoside-binding, soluble, 1	0.014
PLAUR	plasminogen activator, urokinase receptor	0.014
ITGA3	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	0.014	Human
FPR2	formyl peptide receptor 2	0.014
MS4A4A	membrane-spanning 4-domains, subfamily A, member 4	0.014
ITGA7	integrin, alpha 7	0.014	Human
S100A12	S100 calcium binding protein A12	0.014
VNN2	vanin 2	0.014
CFP	complement factor properdin	0.014
ITGAM	integrin, alpha M (complement component 3 receptor 3 subunit)	0.014	Human
FOLR3	folate receptor 3 (gamma)	0.014
NCF2	neutrophil cytosolic factor 2	0.013
BEST1	bestrophin 1	0.013
CD33	CD33 molecule	0.013
CSF1R	colony stimulating factor 1 receptor	0.013
ASGR2	asialoglycoprotein receptor 2	0.013
SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	0.013
HLA-DRB5	major histocompatibility complex, class II, DR beta 5	0.013
ICAM1	intercellular adhesion molecule 1	0.013
CD37	CD37 molecule	0.013
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.013
APOBR	apolipoprotein B receptor	0.013
SLC7A7	solute carrier family 7 (cationic amino acid transporter, y+ system), member 7	0.013
HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	0.012
IL1RN	interleukin 1 receptor antagonist	0.012
IL1B	interleukin 1, beta	0.012
STAB1	stabilin 1	0.012
SIGLEC5	sialic acid binding Ig-like lectin 5	0.012
SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	0.012
ARHGAP25	Rho GTPase activating protein 25	0.012
CD72	CD72 molecule	0.012
AR	androgen receptor	0.012
TMSB4X	thymosin beta 4, X-linked	0.012
C1orf38	chromosome 1 open reading frame 38	0.012
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.012
IL16	interleukin 16 (lymphocyte chemoattractant factor)	0.012
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.012
HLA-DRB4	major histocompatibility complex, class II, DR beta 4	0.012
ITGB7	integrin, beta 7	0.012
NFE2	nuclear factor (erythroid-derived 2), 45kDa	0.012
LRMP	lymphoid-restricted membrane protein	0.012
TMC8	transmembrane channel-like 8	0.012
CD68	CD68 molecule	0.012
SLAMF7	SLAM family member 7	0.012
CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	0.012
NPNT	nephronectin	0.011
P2RX1	purinergic receptor P2X, ligand-gated ion channel, 1	0.011
IFNGR2	interferon gamma receptor 2 (interferon gamma transducer 1)	0.011
SLAMF8	SLAM family member 8	0.011
C17orf60	chromosome 17 open reading frame 60	0.011
CYTH1	cytohesin 1	0.011
HAMP	hepcidin antimicrobial peptide	0.011
VNN1	vanin 1	0.011
TBXAS1	thromboxane A synthase 1 (platelet)	0.011
CLEC5A	C-type lectin domain family 5, member A	0.011
ICAM2	intercellular adhesion molecule 2	0.011	Human
CLEC10A	C-type lectin domain family 10, member A	0.011
GPR132	G protein-coupled receptor 132	0.011
EPOR	erythropoietin receptor	0.011
CTGF	connective tissue growth factor	0.011
EVI2A	ecotropic viral integration site 2A	0.010
IKZF1	IKAROS family zinc finger 1 (Ikaros)	0.010
CFD	complement factor D (adipsin)	0.010
FES	feline sarcoma oncogene	0.010
HLA-DPB1	major histocompatibility complex, class II, DP beta 1	0.010
SPHK1	sphingosine kinase 1	0.010
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.010
TLR6	toll-like receptor 6	0.010
CD80	CD80 molecule	0.010
TFEB	transcription factor EB	0.010
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.010
RNASE3	ribonuclease, RNase A family, 3	0.010
MMP19	matrix metallopeptidase 19	0.010
SIPA1	signal-induced proliferation-associated 1	0.010
F5	coagulation factor V (proaccelerin, labile factor)	0.010