IMP

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Homo sapiens

26 genes annotated in human

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lamellipodium assembly

GO:0030032

Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "lamellipodium assembly"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "lamellipodium assembly" (in gray)

Name	Description	Probability	Func Analog Organism
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.990
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.982	Human Fly
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.916
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.865
ILK	integrin-linked kinase	0.844
BAIAP2	BAI1-associated protein 2	0.648
GRB7	growth factor receptor-bound protein 7	0.637
ZNF746	zinc finger protein 746	0.618
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.377
GAS7	growth arrest-specific 7	0.323
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.323
PRKCZ	protein kinase C, zeta	0.303
VAV1	vav 1 guanine nucleotide exchange factor	0.265
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.226
SPTAN1	spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)	0.210
NCKAP1	NCK-associated protein 1	0.202
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.196
JUP	junction plakoglobin	0.171
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.170
ARPC3	actin related protein 2/3 complex, subunit 3, 21kDa	0.169
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.166
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.163	Fly
ARPC1B	actin related protein 2/3 complex, subunit 1B, 41kDa	0.156
SH3GL3	SH3-domain GRB2-like 3	0.119
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.117
TWF2	twinfilin, actin-binding protein, homolog 2 (Drosophila)	0.116
PLCG1	phospholipase C, gamma 1	0.110
LRRK2	leucine-rich repeat kinase 2	0.109
CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)	0.098
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	0.098
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.097
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.096	Human
CD2AP	CD2-associated protein	0.089
ATN1	atrophin 1	0.086
MAPK8	mitogen-activated protein kinase 8	0.084
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.083	Fly
CAPZB	capping protein (actin filament) muscle Z-line, beta	0.081	Fly
LIMS1	LIM and senescent cell antigen-like domains 1	0.074
ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	0.070
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.060
NUMB	numb homolog (Drosophila)	0.060
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.059
EPS8	epidermal growth factor receptor pathway substrate 8	0.054
PAK2	p21 protein (Cdc42/Rac)-activated kinase 2	0.051
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.050
ACTR2	ARP2 actin-related protein 2 homolog (yeast)	0.046
SORBS3	sorbin and SH3 domain containing 3	0.045
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.044	Fly
PFN1	profilin 1	0.043
LDOC1	leucine zipper, down-regulated in cancer 1	0.043
HCK	hemopoietic cell kinase	0.042
PARD6A	par-6 partitioning defective 6 homolog alpha (C. elegans)	0.042	Fly
PFDN1	prefoldin subunit 1	0.039
LLGL1	lethal giant larvae homolog 1 (Drosophila)	0.037
EFNA5	ephrin-A5	0.037
ABI2	abl-interactor 2	0.037	Fly
ARPC5	actin related protein 2/3 complex, subunit 5, 16kDa	0.036
EFNA1	ephrin-A1	0.036
PACSIN1	protein kinase C and casein kinase substrate in neurons 1	0.034
DOCK1	dedicator of cytokinesis 1	0.034
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	0.033
TRIP6	thyroid hormone receptor interactor 6	0.032
WASF1	WAS protein family, member 1	0.031	Human Fly
CDC42EP3	CDC42 effector protein (Rho GTPase binding) 3	0.031
RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	0.031
PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	0.030
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.029
GRB10	growth factor receptor-bound protein 10	0.029	Worm
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.029	Fly
TRIP10	thyroid hormone receptor interactor 10	0.027
FYB	FYN binding protein	0.027
CBLB	Cas-Br-M (murine) ecotropic retroviral transforming sequence b	0.026
FASLG	Fas ligand (TNF superfamily, member 6)	0.025
PRKCI	protein kinase C, iota	0.025
WASL	Wiskott-Aldrich syndrome-like	0.025
DSG2	desmoglein 2	0.024
NCKIPSD	NCK interacting protein with SH3 domain	0.024
TCF4	transcription factor 4	0.024
FAT1	FAT tumor suppressor homolog 1 (Drosophila)	0.023
KITLG	KIT ligand	0.023
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.023
PKP3	plakophilin 3	0.023
SH2D1A	SH2 domain containing 1A	0.022
DEF6	differentially expressed in FDCP 6 homolog (mouse)	0.022
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.022
LRP6	low density lipoprotein receptor-related protein 6	0.022
CTNND1	catenin (cadherin-associated protein), delta 1	0.022
LLGL2	lethal giant larvae homolog 2 (Drosophila)	0.022
NPTN	neuroplastin	0.021
FERMT2	fermitin family member 2	0.021
FZD1	frizzled homolog 1 (Drosophila)	0.020
CHRD	chordin	0.020
ZNF71	zinc finger protein 71	0.020
IRS1	insulin receptor substrate 1	0.019
PARVA	parvin, alpha	0.019	Human
PTK6	PTK6 protein tyrosine kinase 6	0.019
SNAI1	snail homolog 1 (Drosophila)	0.019
RICTOR	RPTOR independent companion of MTOR, complex 2	0.018
MOBKL1B	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.018
COTL1	coactosin-like 1 (Dictyostelium)	0.018
MEF2A	myocyte enhancer factor 2A	0.018
RPTOR	regulatory associated protein of MTOR, complex 1	0.018
TNS4	tensin 4	0.017
HOOK2	hook homolog 2 (Drosophila)	0.017
GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	0.017
CYFIP2	cytoplasmic FMR1 interacting protein 2	0.017
SH3BP2	SH3-domain binding protein 2	0.017
ABI1	abl-interactor 1	0.017	Fly
CCDC115	coiled-coil domain containing 115	0.016
CSNK1E	casein kinase 1, epsilon	0.016
MSN	moesin	0.016
PARK2	parkinson protein 2, E3 ubiquitin protein ligase (parkin)	0.016
PARVB	parvin, beta	0.016
INSR	insulin receptor	0.015
EFNB2	ephrin-B2	0.015
FMNL1	formin-like 1	0.015
GLIS2	GLIS family zinc finger 2	0.014
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.014
GSK3B	glycogen synthase kinase 3 beta	0.014
FKBP1A	FK506 binding protein 1A, 12kDa	0.014
MEF2C	myocyte enhancer factor 2C	0.014
WIPF1	WAS/WASL interacting protein family, member 1	0.014
GRB2	growth factor receptor-bound protein 2	0.014
FGF18	fibroblast growth factor 18	0.014
RSU1	Ras suppressor protein 1	0.014
PPP1CB	protein phosphatase 1, catalytic subunit, beta isozyme	0.014
GNB1	guanine nucleotide binding protein (G protein), beta polypeptide 1	0.014
PRKAA1	protein kinase, AMP-activated, alpha 1 catalytic subunit	0.014
WASF2	WAS protein family, member 2	0.014
SFRP1	secreted frizzled-related protein 1	0.013
DOK1	docking protein 1, 62kDa (downstream of tyrosine kinase 1)	0.013
PIK3R3	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	0.013
HIPK2	homeodomain interacting protein kinase 2	0.013
SH3KBP1	SH3-domain kinase binding protein 1	0.013
SH3BGRL3	SH3 domain binding glutamic acid-rich protein like 3	0.013
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.013
KIAA1949	KIAA1949	0.013
PKP1	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	0.013
SORBS2	sorbin and SH3 domain containing 2	0.012
SH3RF3	SH3 domain containing ring finger 3	0.012
CDH3	cadherin 3, type 1, P-cadherin (placental)	0.012	Human
MAP1B	microtubule-associated protein 1B	0.012
TRIM29	tripartite motif containing 29	0.012
AXIN1	axin 1	0.012
ZYX	zyxin	0.012
DDX24	DEAD (Asp-Glu-Ala-Asp) box polypeptide 24	0.012
IRS2	insulin receptor substrate 2	0.012
CORO1A	coronin, actin binding protein, 1A	0.012
MAP7D1	MAP7 domain containing 1	0.012
PLCB3	phospholipase C, beta 3 (phosphatidylinositol-specific)	0.012
TLN1	talin 1	0.012
PTOV1	prostate tumor overexpressed 1	0.012
CD164	CD164 molecule, sialomucin	0.012
EPHB1	EPH receptor B1	0.012	Human
CMPK1	cytidine monophosphate (UMP-CMP) kinase 1, cytosolic	0.012
CDH5	cadherin 5, type 2 (vascular endothelium)	0.012
CEP164	centrosomal protein 164kDa	0.012
MAP3K11	mitogen-activated protein kinase kinase kinase 11	0.012
EFHD2	EF-hand domain family, member D2	0.012
RIN1	Ras and Rab interactor 1	0.012
WNT1	wingless-type MMTV integration site family, member 1	0.012
DSG1	desmoglein 1	0.011
NCF2	neutrophil cytosolic factor 2	0.011
EGFR	epidermal growth factor receptor	0.011
PREX1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	0.011
ZNF775	zinc finger protein 775	0.011
WNT7A	wingless-type MMTV integration site family, member 7A	0.011	Human
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.011
JAG2	jagged 2	0.011
FZD8	frizzled homolog 8 (Drosophila)	0.011
WT1	Wilms tumor 1	0.011
SPTBN1	spectrin, beta, non-erythrocytic 1	0.011
FN1	fibronectin 1	0.011
CDC42BPG	CDC42 binding protein kinase gamma (DMPK-like)	0.010
FNBP1	formin binding protein 1	0.010
APC	adenomatous polyposis coli	0.010
MCC	mutated in colorectal cancers	0.010
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.010
VHL	von Hippel-Lindau tumor suppressor	0.010
ACTN1	actinin, alpha 1	0.010
TGFB2	transforming growth factor, beta 2	0.010
SOCS6	suppressor of cytokine signaling 6	0.010