IMP

Process View

Homo sapiens

36 genes annotated in human

gastrointestinal system disease

DOID:77

A disease of anatomical entity that is located in the gastrointestinal tract.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "gastrointestinal system disease"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "gastrointestinal system disease" (in gray)

Name	Description	Probability	Func Analog Organism
NOTCH1	notch 1	1.000	Human
TJP1	tight junction protein 1 (zona occludens 1)	1.000	Human
NOTCH3	notch 3	1.000	Human
STRADA	STE20-related kinase adaptor alpha	0.947
NOTCH2	notch 2	0.721
OCLN	occludin	0.705
JAG1	jagged 1	0.682
TNIP2	TNFAIP3 interacting protein 2	0.660
UNC45A	unc-45 homolog A (C. elegans)	0.489
IL10	interleukin 10	0.443
ABCG5	ATP-binding cassette, sub-family G (WHITE), member 5	0.442	Human
RIPK2	receptor-interacting serine-threonine kinase 2	0.394
EDAR	ectodysplasin A receptor	0.360
NOTCH2NL	notch 2 N-terminal like	0.347
CSNK1E	casein kinase 1, epsilon	0.291
ATG12	ATG12 autophagy related 12 homolog (S. cerevisiae)	0.268
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.249
IL6R	interleukin 6 receptor	0.192
STRADB	STE20-related kinase adaptor beta	0.174
DLL1	delta-like 1 (Drosophila)	0.160	Human
SCRIB	scribbled homolog (Drosophila)	0.158
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.149
MSX2	msh homeobox 2	0.122	Human
MAML1	mastermind-like 1 (Drosophila)	0.112
KIAA1671	KIAA1671	0.107
HAB1	B1 for mucin	0.104
GJA1	gap junction protein, alpha 1, 43kDa	0.079
YAP1	Yes-associated protein 1	0.076
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.065
TBC1D17	TBC1 domain family, member 17	0.063
CDC42BPB	CDC42 binding protein kinase beta (DMPK-like)	0.060
TMEM30B	transmembrane protein 30B	0.058
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.054
WWTR1	WW domain containing transcription regulator 1	0.054
MPRIP	myosin phosphatase Rho interacting protein	0.052
CGN	cingulin	0.052
DVL2	dishevelled, dsh homolog 2 (Drosophila)	0.048
SMAD1	SMAD family member 1	0.048
MXD4	MAX dimerization protein 4	0.043
IL8	interleukin 8	0.039
EFNB2	ephrin-B2	0.037
VMP1	vacuole membrane protein 1	0.035
FBXW12	F-box and WD repeat domain containing 12	0.032
ULK1	unc-51-like kinase 1 (C. elegans)	0.032
CXCL2	chemokine (C-X-C motif) ligand 2	0.031
MARK4	MAP/microtubule affinity-regulating kinase 4	0.031
ZNF611	zinc finger protein 611	0.029
MCC	mutated in colorectal cancers	0.029
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.026
NBPF10	neuroblastoma breakpoint family, member 10	0.025
PILRA	paired immunoglobin-like type 2 receptor alpha	0.025
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.025
HES1	hairy and enhancer of split 1, (Drosophila)	0.023
LAMB2	laminin, beta 2 (laminin S)	0.023
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.023
C1orf38	chromosome 1 open reading frame 38	0.023
COL6A2	collagen, type VI, alpha 2	0.022
COTL1	coactosin-like 1 (Dictyostelium)	0.022
PLCG1	phospholipase C, gamma 1	0.022
TMEM59	transmembrane protein 59	0.022
HSPA1B	heat shock 70kDa protein 1B	0.022
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.022
ABCB4	ATP-binding cassette, sub-family B (MDR/TAP), member 4	0.021
EPB41L3	erythrocyte membrane protein band 4.1-like 3	0.021
ARPC2	actin related protein 2/3 complex, subunit 2, 34kDa	0.021
ZNF160	zinc finger protein 160	0.020
FAM83D	family with sequence similarity 83, member D	0.020
ADAM17	ADAM metallopeptidase domain 17	0.020
CAB39	calcium binding protein 39	0.020
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.019
ZNF721	zinc finger protein 721	0.019
TAOK1	TAO kinase 1	0.019
CXCL3	chemokine (C-X-C motif) ligand 3	0.019
IFNGR2	interferon gamma receptor 2 (interferon gamma transducer 1)	0.019
SMARCD1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.018
NOD1	nucleotide-binding oligomerization domain containing 1	0.018
ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1	0.018
CCL20	chemokine (C-C motif) ligand 20	0.018
HOXC8	homeobox C8	0.018
BRAF	v-raf murine sarcoma viral oncogene homolog B1	0.017
SPRY2	sprouty homolog 2 (Drosophila)	0.017
HRH1	histamine receptor H1	0.017
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.017
WDR6	WD repeat domain 6	0.017
DLX2	distal-less homeobox 2	0.017	Human
BHLHE23	basic helix-loop-helix family, member e23	0.017
FAM110A	family with sequence similarity 110, member A	0.017
LY6D	lymphocyte antigen 6 complex, locus D	0.016
TYMP	thymidine phosphorylase	0.016
SPRY4	sprouty homolog 4 (Drosophila)	0.016
GFRA1	GDNF family receptor alpha 1	0.016
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.016
LHX2	LIM homeobox 2	0.016
CECR1	cat eye syndrome chromosome region, candidate 1	0.016
LTBP4	latent transforming growth factor beta binding protein 4	0.016	Human
CRIP2	cysteine-rich protein 2	0.016
PBXIP1	pre-B-cell leukemia homeobox interacting protein 1	0.016
EML3	echinoderm microtubule associated protein like 3	0.015
CD48	CD48 molecule	0.015
HEXB	hexosaminidase B (beta polypeptide)	0.015
ARPC1B	actin related protein 2/3 complex, subunit 1B, 41kDa	0.015
CCL8	chemokine (C-C motif) ligand 8	0.014
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.014
CD83	CD83 molecule	0.014
ARID1B	AT rich interactive domain 1B (SWI1-like)	0.014
RAI14	retinoic acid induced 14	0.014
GJD3	gap junction protein, delta 3, 31.9kDa	0.014
COL18A1	collagen, type XVIII, alpha 1	0.014
PYY	peptide YY	0.014
TMSB4Y	thymosin beta 4, Y-linked	0.014
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.014
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.014
CST7	cystatin F (leukocystatin)	0.014
SNRK	SNF related kinase	0.014
ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2	0.013
FAM82A2	family with sequence similarity 82, member A2	0.013
XIAP	X-linked inhibitor of apoptosis	0.013
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.013
IFNGR1	interferon gamma receptor 1	0.013
GTF2H3	general transcription factor IIH, polypeptide 3, 34kDa	0.013
CTSS	cathepsin S	0.013
MR1	major histocompatibility complex, class I-related	0.013
FAM110C	family with sequence similarity 110, member C	0.013
CCL4	chemokine (C-C motif) ligand 4	0.013
SYK	spleen tyrosine kinase	0.013
PLD3	phospholipase D family, member 3	0.013
CCL2	chemokine (C-C motif) ligand 2	0.013
VRTN	vertebrae development homolog (pig)	0.013
CTSF	cathepsin F	0.013
DEDD2	death effector domain containing 2	0.013
OSBPL3	oxysterol binding protein-like 3	0.012
HDAC4	histone deacetylase 4	0.012
SHBG	sex hormone-binding globulin	0.012
DLX5	distal-less homeobox 5	0.012	Human
PTX3	pentraxin 3, long	0.012
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.012
MAN1B1	mannosidase, alpha, class 1B, member 1	0.012
NR1I2	nuclear receptor subfamily 1, group I, member 2	0.012
IL2RA	interleukin 2 receptor, alpha	0.012
BCR	breakpoint cluster region	0.012
CH25H	cholesterol 25-hydroxylase	0.012
TLE2	transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)	0.012
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.012
KIAA0930	KIAA0930	0.012
MAP1LC3C	microtubule-associated protein 1 light chain 3 gamma	0.012
TLR2	toll-like receptor 2	0.011
CC2D1A	coiled-coil and C2 domain containing 1A	0.011
CCL5	chemokine (C-C motif) ligand 5	0.011
HLA-DPA1	major histocompatibility complex, class II, DP alpha 1	0.011
CAV2	caveolin 2	0.011
CD86	CD86 molecule	0.011
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.011
GTPBP1	GTP binding protein 1	0.011
IFNAR1	interferon (alpha, beta and omega) receptor 1	0.011
CD81	CD81 molecule	0.011
IL13RA1	interleukin 13 receptor, alpha 1	0.011
BIRC3	baculoviral IAP repeat containing 3	0.011
PAX3	paired box 3	0.011
IFNAR2	interferon (alpha, beta and omega) receptor 2	0.011
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.011
IL18R1	interleukin 18 receptor 1	0.011
ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.011
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.011
SH2B2	SH2B adaptor protein 2	0.011
LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	0.011
GPR1	G protein-coupled receptor 1	0.011
C10orf26	chromosome 10 open reading frame 26	0.011
KRT8	keratin 8	0.011
GAB2	GRB2-associated binding protein 2	0.011
NPDC1	neural proliferation, differentiation and control, 1	0.011
IL1B	interleukin 1, beta	0.011
RB1CC1	RB1-inducible coiled-coil 1	0.011
SKAP2	src kinase associated phosphoprotein 2	0.011
CREG1	cellular repressor of E1A-stimulated genes 1	0.010
F3	coagulation factor III (thromboplastin, tissue factor)	0.010
JAK1	Janus kinase 1	0.010
SNAPC4	small nuclear RNA activating complex, polypeptide 4, 190kDa	0.010
STC1	stanniocalcin 1	0.010
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.010
VEGFB	vascular endothelial growth factor B	0.010
PLAUR	plasminogen activator, urokinase receptor	0.010
ZMYND8	zinc finger, MYND-type containing 8	0.010
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.010
IKBIP	IKBKB interacting protein	0.010
FGF18	fibroblast growth factor 18	0.010
TBX2	T-box 2	0.010
BCL2A1	BCL2-related protein A1	0.010
PROCR	protein C receptor, endothelial	0.010
CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	0.010
AXIN1	axin 1	0.010
HDAC7	histone deacetylase 7	0.010
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.010
ONECUT1	one cut homeobox 1	0.010
IL15RA	interleukin 15 receptor, alpha	0.010
TLX1	T-cell leukemia homeobox 1	0.010
DSPP	dentin sialophosphoprotein	0.009
DLX3	distal-less homeobox 3	0.008
PAX9	paired box 9	0.008
NOD2	nucleotide-binding oligomerization domain containing 2	0.008
ABCB11	ATP-binding cassette, sub-family B (MDR/TAP), member 11	0.007
WNT10A	wingless-type MMTV integration site family, member 10A	0.007
IL10RB	interleukin 10 receptor, beta	0.007
KLK4	kallikrein-related peptidase 4	0.007
EDN3	endothelin 3	0.006
MSX1	msh homeobox 1	0.006
IL10RA	interleukin 10 receptor, alpha	0.006
ATG16L1	ATG16 autophagy related 16-like 1 (S. cerevisiae)	0.006
EDNRB	endothelin receptor type B	0.006
AMELX	amelogenin, X-linked	0.006
MMP20	matrix metallopeptidase 20	0.006
IL23R	interleukin 23 receptor	0.006
ENAM	enamelin	0.006
WDR72	WD repeat domain 72	0.005
ATP7B	ATPase, Cu++ transporting, beta polypeptide	0.005
GDNF	glial cell derived neurotrophic factor	0.005
ATP8B1	ATPase, aminophospholipid transporter, class I, type 8B, member 1	0.005
IRF5	interferon regulatory factor 5	0.005
EDA	ectodysplasin A	0.004
ABCG8	ATP-binding cassette, sub-family G (WHITE), member 8	0.004
RET	ret proto-oncogene	0.004
IRGM	immunity-related GTPase family, M	0.004
FAM83H	family with sequence similarity 83, member H	0.004
CTSC	cathepsin C	0.004
TJP2	tight junction protein 2 (zona occludens 2)	0.003
LTBP3	latent transforming growth factor beta binding protein 3	0.003
IL6	interleukin 6 (interferon, beta 2)	0.002
STK11	serine/threonine kinase 11	0.002