IMP

Process View

Homo sapiens

25 genes annotated in human

hypersensitivity reaction disease

DOID:0060056

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "hypersensitivity reaction disease"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "hypersensitivity reaction disease" (in gray)

Name	Description	Probability	Func Analog Organism
CASP8	caspase 8, apoptosis-related cysteine peptidase	1.000	Human
FASLG	Fas ligand (TNF superfamily, member 6)	0.996
CD74	CD74 molecule, major histocompatibility complex, class II invariant chain	0.960
HLA-DRA	major histocompatibility complex, class II, DR alpha	0.956	Human
HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	0.941
HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	0.885
FAS	Fas (TNF receptor superfamily, member 6)	0.847
FADD	Fas (TNFRSF6)-associated via death domain	0.841
HLA-DMA	major histocompatibility complex, class II, DM alpha	0.836	Human
CD80	CD80 molecule	0.804
HLA-DRB5	major histocompatibility complex, class II, DR beta 5	0.781	Human
HLA-DPA1	major histocompatibility complex, class II, DP alpha 1	0.721
HLA-DRB1	major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1	0.576
ZAP70	zeta-chain (TCR) associated protein kinase 70kDa	0.518
HLA-DMB	major histocompatibility complex, class II, DM beta	0.463
CFLAR	CASP8 and FADD-like apoptosis regulator	0.411
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.374
HLA-DPB1	major histocompatibility complex, class II, DP beta 1	0.307
CD247	CD247 molecule	0.276
CD86	CD86 molecule	0.262	Human
RIPK2	receptor-interacting serine-threonine kinase 2	0.251
LCK	lymphocyte-specific protein tyrosine kinase	0.218
PYCARD	PYD and CARD domain containing	0.207
LAT	linker for activation of T cells	0.165
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.159
HLA-DRB4	major histocompatibility complex, class II, DR beta 4	0.137
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.119
PACSIN1	protein kinase C and casein kinase substrate in neurons 1	0.104
FNBP1	formin binding protein 1	0.090
ITK	IL2-inducible T-cell kinase	0.071
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.065
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.065
PACSIN2	protein kinase C and casein kinase substrate in neurons 2	0.063
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.059
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.054
PILRA	paired immunoglobin-like type 2 receptor alpha	0.046
ARHGEF1	Rho guanine nucleotide exchange factor (GEF) 1	0.039
MS4A1	membrane-spanning 4-domains, subfamily A, member 1	0.038
VAV1	vav 1 guanine nucleotide exchange factor	0.038
PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	0.036
LRRC41	leucine rich repeat containing 41	0.031
CLEC4M	C-type lectin domain family 4, member M	0.029
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.028	Human
CSF1R	colony stimulating factor 1 receptor	0.028
PTPN13	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	0.027
FCGR2C	Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)	0.025
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.023
SRGAP2	SLIT-ROBO Rho GTPase activating protein 2	0.023
CXCR6	chemokine (C-X-C motif) receptor 6	0.023
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.022	Human
CXCR4	chemokine (C-X-C motif) receptor 4	0.020
HLA-DQA2	major histocompatibility complex, class II, DQ alpha 2	0.020
SYK	spleen tyrosine kinase	0.020
SNX33	sorting nexin 33	0.019
CD2	CD2 molecule	0.019
TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	0.019	Human
KIAA1539	KIAA1539	0.018
SBNO2	strawberry notch homolog 2 (Drosophila)	0.018
EPOR	erythropoietin receptor	0.018
PTPN18	protein tyrosine phosphatase, non-receptor type 18 (brain-derived)	0.017	Human
PTPRC	protein tyrosine phosphatase, receptor type, C	0.017
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.017
PACSIN3	protein kinase C and casein kinase substrate in neurons 3	0.017
NOD1	nucleotide-binding oligomerization domain containing 1	0.017
SLAMF1	signaling lymphocytic activation molecule family member 1	0.017
CCL22	chemokine (C-C motif) ligand 22	0.016
CNOT3	CCR4-NOT transcription complex, subunit 3	0.016
HLA-DQB2	major histocompatibility complex, class II, DQ beta 2	0.015
TAPBPL	TAP binding protein-like	0.015
PTPRA	protein tyrosine phosphatase, receptor type, A	0.014
NLRC4	NLR family, CARD domain containing 4	0.014
GADD45A	growth arrest and DNA-damage-inducible, alpha	0.014
ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	0.014
TNKS	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	0.013
BID	BH3 interacting domain death agonist	0.013
TRAT1	T cell receptor associated transmembrane adaptor 1	0.013
MAPK7	mitogen-activated protein kinase 7	0.013
TRIP10	thyroid hormone receptor interactor 10	0.012
CD33	CD33 molecule	0.012
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.012
CD72	CD72 molecule	0.012
PLEKHM2	pleckstrin homology domain containing, family M (with RUN domain) member 2	0.012
IRF8	interferon regulatory factor 8	0.012	Human
SLC15A3	solute carrier family 15, member 3	0.012
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.012
BANP	BTG3 associated nuclear protein	0.011
PLEC	plectin	0.011
MPP4	membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)	0.011
FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)	0.011
NCF4	neutrophil cytosolic factor 4, 40kDa	0.011
GAB2	GRB2-associated binding protein 2	0.011
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.011
IFNG	interferon, gamma	0.011
NCKAP1L	NCK-associated protein 1-like	0.011
SPTA1	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	0.011
KLRK1	killer cell lectin-like receptor subfamily K, member 1	0.011
AXL	AXL receptor tyrosine kinase	0.011
TYK2	tyrosine kinase 2	0.011
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.011
MARCH1	membrane-associated ring finger (C3HC4) 1	0.011
PML	promyelocytic leukemia	0.010
FGL2	fibrinogen-like 2	0.010
DOK3	docking protein 3	0.010
RIOK3	RIO kinase 3 (yeast)	0.010
IRF5	interferon regulatory factor 5	0.008
BANK1	B-cell scaffold protein with ankyrin repeats 1	0.005
PTH	parathyroid hormone	0.005
DNASE1L3	deoxyribonuclease I-like 3	0.004
CR2	complement component (3d/Epstein Barr virus) receptor 2	0.004
CTLA4	cytotoxic T-lymphocyte-associated protein 4	0.004
TLR5	toll-like receptor 5	0.004
DNASE1	deoxyribonuclease I	0.003
MEFV	Mediterranean fever	0.003
TREX1	three prime repair exonuclease 1	0.002
NOD2	nucleotide-binding oligomerization domain containing 2	0.002
GCM2	glial cells missing homolog 2 (Drosophila)	0.002
PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.002
PMP22	peripheral myelin protein 22	0.002
FCGR2B	Fc fragment of IgG, low affinity IIb, receptor (CD32)	0.002
ITGAM	integrin, alpha M (complement component 3 receptor 3 subunit)	0.002
PDCD1	programmed cell death 1	0.001
MYO9B	myosin IXB	0.001
BTNL2	butyrophilin-like 2 (MHC class II associated)	0.001