IMP

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Homo sapiens

29 genes annotated in human

Multi-species View

defense response to gram positive bacterium

GO:0050830

Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "defense response to gram positive bacterium"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "defense response to gram positive bacterium" (in gray)

Name	Description	Probability	Func Analog Organism
HIST1H2BD	histone cluster 1, H2bd	0.998	Human
HIST1H2BE	histone cluster 1, H2be	0.988
HIST1H2BF	histone cluster 1, H2bf	0.980
HIST1H1C	histone cluster 1, H1c	0.978
HIST1H2AC	histone cluster 1, H2ac	0.950
HIST1H2BC	histone cluster 1, H2bc	0.948
HIST1H2BH	histone cluster 1, H2bh	0.914	Human
HIST1H2BI	histone cluster 1, H2bi	0.882
HIST2H2AA4	histone cluster 2, H2aa4	0.871
MYD88	myeloid differentiation primary response gene (88)	0.840	Mouse Fly
HIST1H2BK	histone cluster 1, H2bk	0.667
FTL	ferritin, light polypeptide	0.635	Worm
HIST1H3D	histone cluster 1, H3d	0.532
FTH1	ferritin, heavy polypeptide 1	0.399	Worm
TPT1	tumor protein, translationally-controlled 1	0.391
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.376
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.340
BIRC3	baculoviral IAP repeat containing 3	0.308
HIST1H2BG	histone cluster 1, H2bg	0.295
HIST1H2AE	histone cluster 1, H2ae	0.225
HIST2H2BE	histone cluster 2, H2be	0.212
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.203
GABARAPL1	GABA(A) receptor-associated protein like 1	0.192
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.187
TRAF1	TNF receptor-associated factor 1	0.167
IRAK2	interleukin-1 receptor-associated kinase 2	0.163
SNTA1	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	0.160
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.158
DGCR8	DiGeorge syndrome critical region gene 8	0.140
GBP1	guanylate binding protein 1, interferon-inducible	0.134
GABARAPL2	GABA(A) receptor-associated protein-like 2	0.134
RIPK2	receptor-interacting serine-threonine kinase 2	0.121	Mouse
OPTN	optineurin	0.117
HIST1H2AG	histone cluster 1, H2ag	0.117
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.109	Mouse
TRAF3	TNF receptor-associated factor 3	0.109
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.109
MPO	myeloperoxidase	0.106
SOCS3	suppressor of cytokine signaling 3	0.106
ELANE	elastase, neutrophil expressed	0.100
TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.100
MAPK14	mitogen-activated protein kinase 14	0.090	Worm
RPL41	ribosomal protein L41	0.089
BNIP3L	BCL2/adenovirus E1B 19kDa interacting protein 3-like	0.087
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.086
NBR1	neighbor of BRCA1 gene 1	0.078
ZFP36L1	zinc finger protein 36, C3H type-like 1	0.076
IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	0.073
BTK	Bruton agammaglobulinemia tyrosine kinase	0.072
ATG5	ATG5 autophagy related 5 homolog (S. cerevisiae)	0.069
HIST1H3H	histone cluster 1, H3h	0.069
DMBT1	deleted in malignant brain tumors 1	0.066
ATG12	ATG12 autophagy related 12 homolog (S. cerevisiae)	0.065
TICAM2	toll-like receptor adaptor molecule 2	0.063
LRRK2	leucine-rich repeat kinase 2	0.061
MAPKAPK3	mitogen-activated protein kinase-activated protein kinase 3	0.061
DUSP9	dual specificity phosphatase 9	0.061
IL6R	interleukin 6 receptor	0.060
HIST1H4H	histone cluster 1, H4h	0.060
TLR4	toll-like receptor 4	0.055
TRAF2	TNF receptor-associated factor 2	0.050
CYBB	cytochrome b-245, beta polypeptide	0.050
BCL3	B-cell CLL/lymphoma 3	0.050
IL6	interleukin 6 (interferon, beta 2)	0.048
APOE	apolipoprotein E	0.046
NOD2	nucleotide-binding oligomerization domain containing 2	0.046
CD14	CD14 molecule	0.046
MAPK3	mitogen-activated protein kinase 3	0.046
HDAC7	histone deacetylase 7	0.045
PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	0.044
TRAF5	TNF receptor-associated factor 5	0.044
ATF2	activating transcription factor 2	0.043
HIST1H2AJ	histone cluster 1, H2aj	0.040
PKN1	protein kinase N1	0.040
RPS29	ribosomal protein S29	0.039
RPS27	ribosomal protein S27	0.039
HIST1H2AI	histone cluster 1, H2ai	0.039
BIRC2	baculoviral IAP repeat containing 2	0.037
DUSP7	dual specificity phosphatase 7	0.036
GBP4	guanylate binding protein 4	0.036	Mouse
MAP1LC3B	microtubule-associated protein 1 light chain 3 beta	0.035	Worm
LCN2	lipocalin 2	0.035
HIST1H2BO	histone cluster 1, H2bo	0.034	Human
IRAK4	interleukin-1 receptor-associated kinase 4	0.033
MAP1LC3A	microtubule-associated protein 1 light chain 3 alpha	0.032	Worm
MS4A3	membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)	0.032
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.031
ATG3	ATG3 autophagy related 3 homolog (S. cerevisiae)	0.031
NLRC5	NLR family, CARD domain containing 5	0.031
IRF7	interferon regulatory factor 7	0.031
RXRA	retinoid X receptor, alpha	0.030
AZU1	azurocidin 1	0.030
MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	0.029
ATG7	ATG7 autophagy related 7 homolog (S. cerevisiae)	0.029
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.029
NCF4	neutrophil cytosolic factor 4, 40kDa	0.027
MKNK1	MAP kinase interacting serine/threonine kinase 1	0.027
ICAM1	intercellular adhesion molecule 1	0.027
MKNK2	MAP kinase interacting serine/threonine kinase 2	0.027
LTF	lactotransferrin	0.026
IRF1	interferon regulatory factor 1	0.026
HCST	hematopoietic cell signal transducer	0.025
BNIP3	BCL2/adenovirus E1B 19kDa interacting protein 3	0.024
EHD1	EH-domain containing 1	0.024
NOD1	nucleotide-binding oligomerization domain containing 1	0.024	Mouse
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	0.023
RNASE2	ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)	0.023	Human
HIST1H2BM	histone cluster 1, H2bm	0.023	Human
SNRNP70	small nuclear ribonucleoprotein 70kDa (U1)	0.022
IRF9	interferon regulatory factor 9	0.022
PRTN3	proteinase 3	0.021
CD40	CD40 molecule, TNF receptor superfamily member 5	0.021
DEFA1B	defensin, alpha 1B	0.021
FADS1	fatty acid desaturase 1	0.020
RNASE3	ribonuclease, RNase A family, 3	0.020
HIST1H2AM	histone cluster 1, H2am	0.020
DUSP1	dual specificity phosphatase 1	0.019
PKN3	protein kinase N3	0.019
GBP2	guanylate binding protein 2, interferon-inducible	0.019	Mouse
DHCR7	7-dehydrocholesterol reductase	0.019
IRAK1	interleukin-1 receptor-associated kinase 1	0.019
SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.019
MAPK15	mitogen-activated protein kinase 15	0.019
C4BPA	complement component 4 binding protein, alpha	0.019
CYBA	cytochrome b-245, alpha polypeptide	0.019
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.019
MAP3K4	mitogen-activated protein kinase kinase kinase 4	0.019
CEACAM8	carcinoembryonic antigen-related cell adhesion molecule 8	0.018
TNFSF14	tumor necrosis factor (ligand) superfamily, member 14	0.018
MAP2K3	mitogen-activated protein kinase kinase 3	0.018	Worm
HP	haptoglobin	0.017
WIPF1	WAS/WASL interacting protein family, member 1	0.017
MAP2K6	mitogen-activated protein kinase kinase 6	0.017	Worm
CXCL2	chemokine (C-X-C motif) ligand 2	0.017
AQP9	aquaporin 9	0.017
IL18RAP	interleukin 18 receptor accessory protein	0.017
GAS7	growth arrest-specific 7	0.017
HIST1H2BB	histone cluster 1, H2bb	0.017	Human
TLR2	toll-like receptor 2	0.017
CPNE6	copine VI (neuronal)	0.017
RRBP1	ribosome binding protein 1 homolog 180kDa (dog)	0.016
CMA1	chymase 1, mast cell	0.016
S100A9	S100 calcium binding protein A9	0.016
FGL2	fibrinogen-like 2	0.016
HIST1H3G	histone cluster 1, H3g	0.016
RPS6KA4	ribosomal protein S6 kinase, 90kDa, polypeptide 4	0.016
EGR2	early growth response 2	0.016
CST7	cystatin F (leukocystatin)	0.015
ATG4B	ATG4 autophagy related 4 homolog B (S. cerevisiae)	0.015
CHI3L1	chitinase 3-like 1 (cartilage glycoprotein-39)	0.015
MAX	MYC associated factor X	0.015
SESN2	sestrin 2	0.015
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.015
RPS15	ribosomal protein S15	0.015
SLPI	secretory leukocyte peptidase inhibitor	0.015
CSF3R	colony stimulating factor 3 receptor (granulocyte)	0.015
NPC2	Niemann-Pick disease, type C2	0.015
RPS6KA1	ribosomal protein S6 kinase, 90kDa, polypeptide 1	0.015
NAMPT	nicotinamide phosphoribosyltransferase	0.015
CLEC7A	C-type lectin domain family 7, member A	0.015
MAP1S	microtubule-associated protein 1S	0.015
ALOX5	arachidonate 5-lipoxygenase	0.014
RPS18	ribosomal protein S18	0.014
JAK1	Janus kinase 1	0.014
CFP	complement factor properdin	0.014
PADI4	peptidyl arginine deiminase, type IV	0.014
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.014
TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	0.014
SAMSN1	SAM domain, SH3 domain and nuclear localization signals 1	0.013
DUSP16	dual specificity phosphatase 16	0.013
ELMO1	engulfment and cell motility 1	0.013
HMOX1	heme oxygenase (decycling) 1	0.013
SFTPD	surfactant protein D	0.013	Human
TRADD	TNFRSF1A-associated via death domain	0.013
HIST1H4D	histone cluster 1, H4d	0.013
HK3	hexokinase 3 (white cell)	0.013
TCN2	transcobalamin II	0.013
A2M	alpha-2-macroglobulin	0.012
FPR1	formyl peptide receptor 1	0.012
SERPINB10	serpin peptidase inhibitor, clade B (ovalbumin), member 10	0.012
HDAC5	histone deacetylase 5	0.012
SERPINB9	serpin peptidase inhibitor, clade B (ovalbumin), member 9	0.012
TCN1	transcobalamin I (vitamin B12 binding protein, R binder family)	0.012
C2orf18	chromosome 2 open reading frame 18	0.012
ELF4	E74-like factor 4 (ets domain transcription factor)	0.012
SOD2	superoxide dismutase 2, mitochondrial	0.012
IL15	interleukin 15	0.012
SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	0.012
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.012
EMR1	egf-like module containing, mucin-like, hormone receptor-like 1	0.011
RNH1	ribonuclease/angiogenin inhibitor 1	0.011
RGS14	regulator of G-protein signaling 14	0.011
S100A12	S100 calcium binding protein A12	0.011
CEACAM4	carcinoembryonic antigen-related cell adhesion molecule 4	0.011
SFTPA1	surfactant protein A1	0.011	Human
ZBTB48	zinc finger and BTB domain containing 48	0.011
CTSG	cathepsin G	0.011	Mouse
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.011
SAMHD1	SAM domain and HD domain 1	0.011
NCF2	neutrophil cytosolic factor 2	0.011
TNIP2	TNFAIP3 interacting protein 2	0.011
HIST1H2BJ	histone cluster 1, H2bj	0.011
FPR2	formyl peptide receptor 2	0.011
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.011
SMAD3	SMAD family member 3	0.011
FES	feline sarcoma oncogene	0.011
MAN2B1	mannosidase, alpha, class 2B, member 1	0.011
EFHD2	EF-hand domain family, member D2	0.011
ELL3	elongation factor RNA polymerase II-like 3	0.011
RPL34	ribosomal protein L34	0.011
CAMKK2	calcium/calmodulin-dependent protein kinase kinase 2, beta	0.011
TLR5	toll-like receptor 5	0.010
SQLE	squalene epoxidase	0.010
BTN3A1	butyrophilin, subfamily 3, member A1	0.010
CASP4	caspase 4, apoptosis-related cysteine peptidase	0.010
GPR97	G protein-coupled receptor 97	0.010
DEFA3	defensin, alpha 3, neutrophil-specific	0.010
TNIP1	TNFAIP3 interacting protein 1	0.010
TAOK2	TAO kinase 2	0.010
APOC1	apolipoprotein C-I	0.010