IMP

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Homo sapiens

18 genes annotated in human

Multi-species View

b cell receptor signaling pathway

GO:0050853

A series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "b cell receptor signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "b cell receptor signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.984	Human
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.965
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.919
PTK2	PTK2 protein tyrosine kinase 2	0.901
SYK	spleen tyrosine kinase	0.893	Mouse
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.843
MPDZ	multiple PDZ domain protein	0.638
VAV1	vav 1 guanine nucleotide exchange factor	0.619	Human
NCF1	neutrophil cytosolic factor 1	0.550
NCK1	NCK adaptor protein 1	0.542
BAX	BCL2-associated X protein	0.529
BCL2	B-cell CLL/lymphoma 2	0.449
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.428
BTK	Bruton agammaglobulinemia tyrosine kinase	0.415	Human
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.326
NCF4	neutrophil cytosolic factor 4, 40kDa	0.298
CD80	CD80 molecule	0.263
GRB2	growth factor receptor-bound protein 2	0.243
NCK2	NCK adaptor protein 2	0.226
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.225
EGFR	epidermal growth factor receptor	0.218
SPRR2A	small proline-rich protein 2A	0.215
FHL2	four and a half LIM domains 2	0.202
GAS7	growth arrest-specific 7	0.192
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.178
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.178
CD79A	CD79a molecule, immunoglobulin-associated alpha	0.160	Mouse
PRKCA	protein kinase C, alpha	0.156	Human
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.141
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.136
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.132
HCK	hemopoietic cell kinase	0.124	Human
VAV2	vav 2 guanine nucleotide exchange factor	0.123	Human
GRAP2	GRB2-related adaptor protein 2	0.122
BCL2L1	BCL2-like 1	0.116	Human
PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	0.116
SH3KBP1	SH3-domain kinase binding protein 1	0.111
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.105
BLNK	B-cell linker	0.102
GRB7	growth factor receptor-bound protein 7	0.093
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.087	Mouse
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.085	Mouse
TFF1	trefoil factor 1	0.080
CD79B	CD79b molecule, immunoglobulin-associated beta	0.074	Mouse
CD86	CD86 molecule	0.072
PTK6	PTK6 protein tyrosine kinase 6	0.057	Human
NCF2	neutrophil cytosolic factor 2	0.056
LCK	lymphocyte-specific protein tyrosine kinase	0.054	Human Mouse
PRKCB	protein kinase C, beta	0.053	Human Mouse
LPXN	leupaxin	0.047
PIK3R3	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	0.044
CD19	CD19 molecule	0.043	Mouse
CD247	CD247 molecule	0.042
ZNF746	zinc finger protein 746	0.037
CYBA	cytochrome b-245, alpha polypeptide	0.035
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.034
YES1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	0.033	Human
CD22	CD22 molecule	0.032
BAD	BCL2-associated agonist of cell death	0.030
TNS3	tensin 3	0.030
ZAP70	zeta-chain (TCR) associated protein kinase 70kDa	0.029
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.028
WIPF1	WAS/WASL interacting protein family, member 1	0.028
LIMS1	LIM and senescent cell antigen-like domains 1	0.028	Human
VIM	vimentin	0.027
TRIP6	thyroid hormone receptor interactor 6	0.026
HOXA1	homeobox A1	0.025
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.024	Human
SH3BP2	SH3-domain binding protein 2	0.024
PRKCQ	protein kinase C, theta	0.023
PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)	0.023	Mouse
MEST	mesoderm specific transcript homolog (mouse)	0.023
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.023
RABAC1	Rab acceptor 1 (prenylated)	0.022
BAK1	BCL2-antagonist/killer 1	0.022	Human
DDX17	DEAD (Asp-Glu-Ala-Asp) box polypeptide 17	0.022
SLA	Src-like-adaptor	0.021
NCOA3	nuclear receptor coactivator 3	0.021
PTPN13	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	0.020
PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.020
HDAC9	histone deacetylase 9	0.020
HDAC6	histone deacetylase 6	0.020
LRMP	lymphoid-restricted membrane protein	0.020
MUC1	mucin 1, cell surface associated	0.020
BLK	B lymphoid tyrosine kinase	0.019
SH2D3C	SH2 domain containing 3C	0.019
PRKCD	protein kinase C, delta	0.018
PXN	paxillin	0.018	Human
FYN	FYN oncogene related to SRC, FGR, YES	0.018	Human
SHC3	SHC (Src homology 2 domain containing) transforming protein 3	0.018
ABL2	v-abl Abelson murine leukemia viral oncogene homolog 2	0.018
ABI1	abl-interactor 1	0.017
TRIM9	tripartite motif containing 9	0.017
TNS4	tensin 4	0.017
IQGAP1	IQ motif containing GTPase activating protein 1	0.017
MS4A1	membrane-spanning 4-domains, subfamily A, member 1	0.017
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.017
CTLA4	cytotoxic T-lymphocyte-associated protein 4	0.017
EVI2A	ecotropic viral integration site 2A	0.016
ACTB	actin, beta	0.016
ZNF775	zinc finger protein 775	0.015
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.015
NRG1	neuregulin 1	0.015
ILK	integrin-linked kinase	0.014
ADRBK1	adrenergic, beta, receptor kinase 1	0.014
RNF144B	ring finger protein 144B	0.014
SFN	stratifin	0.014
BCAR1	breast cancer anti-estrogen resistance 1	0.014
LAT	linker for activation of T cells	0.013
AR	androgen receptor	0.013
JAK3	Janus kinase 3	0.013
HTR2C	5-hydroxytryptamine (serotonin) receptor 2C	0.013
CTTN	cortactin	0.013
BID	BH3 interacting domain death agonist	0.013
HUWE1	HECT, UBA and WWE domain containing 1	0.012
CD27	CD27 molecule	0.012
RNR2	l-rRNA	0.012
CHN2	chimerin (chimaerin) 2	0.012
EPAS1	endothelial PAS domain protein 1	0.012
CSF3R	colony stimulating factor 3 receptor (granulocyte)	0.012
TGFB1I1	transforming growth factor beta 1 induced transcript 1	0.012	Human
LILRA2	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2	0.012
MAPK3	mitogen-activated protein kinase 3	0.012
PNOC	prepronociceptin	0.012
TENC1	tensin like C1 domain containing phosphatase (tensin 2)	0.012
ITGA4	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	0.012
RPS6KA2	ribosomal protein S6 kinase, 90kDa, polypeptide 2	0.011
IBTK	inhibitor of Bruton agammaglobulinemia tyrosine kinase	0.011
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.011
CISH	cytokine inducible SH2-containing protein	0.011
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.011
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.011
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.011
DPEP2	dipeptidase 2	0.011
ITK	IL2-inducible T-cell kinase	0.010	Human
PTPN23	protein tyrosine phosphatase, non-receptor type 23	0.010
SPIB	Spi-B transcription factor (Spi-1/PU.1 related)	0.010
PHC2	polyhomeotic homolog 2 (Drosophila)	0.010
PTPN7	protein tyrosine phosphatase, non-receptor type 7	0.010
GIT2	G protein-coupled receptor kinase interacting ArfGAP 2	0.010