IMP

Process View

Homo sapiens

27 genes annotated in human

cell adhesion mediated by integrin

The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cell adhesion mediated by integrin"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cell adhesion mediated by integrin" (in gray)

Name	Description	Probability	Func Analog Organism
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	1.000
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.991
ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	0.925	Human
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.915
FLNA	filamin A, alpha	0.852
FN1	fibronectin 1	0.807
PLAUR	plasminogen activator, urokinase receptor	0.795
FHL2	four and a half LIM domains 2	0.778
VCAM1	vascular cell adhesion molecule 1	0.768
CCL5	chemokine (C-C motif) ligand 5	0.749
PLAU	plasminogen activator, urokinase	0.685
EPHA2	EPH receptor A2	0.593
PTPRC	protein tyrosine phosphatase, receptor type, C	0.529
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.528
ENG	endoglin	0.513
WASL	Wiskott-Aldrich syndrome-like	0.477
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.414	Human Mouse
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.343
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.296
ICAM1	intercellular adhesion molecule 1	0.286	Mouse
CCL2	chemokine (C-C motif) ligand 2	0.279	Human
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.275
PTK2	PTK2 protein tyrosine kinase 2	0.214
CCR5	chemokine (C-C motif) receptor 5	0.192
PDIA3	protein disulfide isomerase family A, member 3	0.171
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.171
MSN	moesin	0.153
THBS1	thrombospondin 1	0.141	Fly
PXN	paxillin	0.141
IL1B	interleukin 1, beta	0.131
ITGA6	integrin, alpha 6	0.112	Human Mouse Worm
TLN1	talin 1	0.111	Human
IL8	interleukin 8	0.105
NRP2	neuropilin 2	0.103
CXCL9	chemokine (C-X-C motif) ligand 9	0.103
PLEC	plectin	0.101
CCL22	chemokine (C-C motif) ligand 22	0.098
RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	0.092	Human
ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	0.087
ITGB4	integrin, beta 4	0.086	Human
PSEN2	presenilin 2 (Alzheimer disease 4)	0.085
EPHA7	EPH receptor A7	0.076	Human
ZNF746	zinc finger protein 746	0.072
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.071
PECAM1	platelet/endothelial cell adhesion molecule	0.069
ARPC2	actin related protein 2/3 complex, subunit 2, 34kDa	0.068
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.066
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.062
EFNA1	ephrin-A1	0.061
RANBP9	RAN binding protein 9	0.061
IGFBP3	insulin-like growth factor binding protein 3	0.059
PVRL1	poliovirus receptor-related 1 (herpesvirus entry mediator C)	0.058
IL6	interleukin 6 (interferon, beta 2)	0.057
CXCL10	chemokine (C-X-C motif) ligand 10	0.056
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.056
VCL	vinculin	0.056
PFN1	profilin 1	0.055
BCAR1	breast cancer anti-estrogen resistance 1	0.055
OSMR	oncostatin M receptor	0.055
CCL4	chemokine (C-C motif) ligand 4	0.054	Human
TNC	tenascin C	0.054
CD44	CD44 molecule (Indian blood group)	0.053
ABI2	abl-interactor 2	0.053	Fly
ZYX	zyxin	0.052
HMG20A	high mobility group 20A	0.048
NCKAP1	NCK-associated protein 1	0.048
ITGA3	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	0.047	Human Worm
ANGPTL4	angiopoietin-like 4	0.047
CCL8	chemokine (C-C motif) ligand 8	0.045	Human
SNX9	sorting nexin 9	0.045
CYTH1	cytohesin 1	0.044
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.044
PLAT	plasminogen activator, tissue	0.043	Human
CXCL11	chemokine (C-X-C motif) ligand 11	0.043
DLG1	discs, large homolog 1 (Drosophila)	0.043
EFNA5	ephrin-A5	0.042	Human
HCLS1	hematopoietic cell-specific Lyn substrate 1	0.042
MYO10	myosin X	0.041
IL7R	interleukin 7 receptor	0.040
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	0.039
CCL13	chemokine (C-C motif) ligand 13	0.038	Human
PTPN12	protein tyrosine phosphatase, non-receptor type 12	0.038
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.037
CCL11	chemokine (C-C motif) ligand 11	0.037	Human
GAB1	GRB2-associated binding protein 1	0.037
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.036
FXYD5	FXYD domain containing ion transport regulator 5	0.034
FYN	FYN oncogene related to SRC, FGR, YES	0.034
CCL19	chemokine (C-C motif) ligand 19	0.033	Human
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.033
IDE	insulin-degrading enzyme	0.033
ITGA4	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	0.032	Human
LGALS1	lectin, galactoside-binding, soluble, 1	0.032
MAD2L2	MAD2 mitotic arrest deficient-like 2 (yeast)	0.032
INHBA	inhibin, beta A	0.032
COL4A1	collagen, type IV, alpha 1	0.031
LIMS1	LIM and senescent cell antigen-like domains 1	0.031
CALD1	caldesmon 1	0.030
SELPLG	selectin P ligand	0.030
LAMC1	laminin, gamma 1 (formerly LAMB2)	0.030
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.029
PLEK	pleckstrin	0.029
SH3D19	SH3 domain containing 19	0.028
VAV1	vav 1 guanine nucleotide exchange factor	0.027
TCF4	transcription factor 4	0.027
LMNA	lamin A/C	0.027
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.027
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.027	Human
SOCS3	suppressor of cytokine signaling 3	0.027
STK10	serine/threonine kinase 10	0.026
LAMB3	laminin, beta 3	0.026
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.025
COTL1	coactosin-like 1 (Dictyostelium)	0.025
SNX33	sorting nexin 33	0.025
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.024
EPHB2	EPH receptor B2	0.024	Human
TGFBR1	transforming growth factor, beta receptor 1	0.023
TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	0.023
CXCL12	chemokine (C-X-C motif) ligand 12	0.022
CXCL13	chemokine (C-X-C motif) ligand 13	0.022	Mouse
SRGN	serglycin	0.022
NCF4	neutrophil cytosolic factor 4, 40kDa	0.022
CXCL2	chemokine (C-X-C motif) ligand 2	0.021
SLC9A1	solute carrier family 9 (sodium/hydrogen exchanger), member 1	0.021
FMR1	fragile X mental retardation 1	0.021
CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)	0.021
CCR1	chemokine (C-C motif) receptor 1	0.021
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.020
IL2RG	interleukin 2 receptor, gamma	0.020
ANXA5	annexin A5	0.020
LAMC2	laminin, gamma 2	0.019
CCR7	chemokine (C-C motif) receptor 7	0.019
CYFIP1	cytoplasmic FMR1 interacting protein 1	0.019
KNG1	kininogen 1	0.018
PRKCB	protein kinase C, beta	0.018
CCL7	chemokine (C-C motif) ligand 7	0.018	Human
CTGF	connective tissue growth factor	0.018
ARPC3	actin related protein 2/3 complex, subunit 3, 21kDa	0.018
GAS7	growth arrest-specific 7	0.018
EFHD2	EF-hand domain family, member D2	0.018
CD97	CD97 molecule	0.017
CD63	CD63 molecule	0.017
PVRL2	poliovirus receptor-related 2 (herpesvirus entry mediator B)	0.017
SPHK1	sphingosine kinase 1	0.017
STC2	stanniocalcin 2	0.017
EPHA3	EPH receptor A3	0.017	Human
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.016
TGFB1I1	transforming growth factor beta 1 induced transcript 1	0.016
NCF2	neutrophil cytosolic factor 2	0.016
FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	0.016
UBASH3B	ubiquitin associated and SH3 domain containing B	0.016
EGFR	epidermal growth factor receptor	0.016
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.016
TM4SF1	transmembrane 4 L six family member 1	0.015
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.015
CD83	CD83 molecule	0.015
LIF	leukemia inhibitory factor (cholinergic differentiation factor)	0.015
COL17A1	collagen, type XVII, alpha 1	0.015
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.015	Human
EPS8	epidermal growth factor receptor pathway substrate 8	0.015
BMP1	bone morphogenetic protein 1	0.015
TGFB2	transforming growth factor, beta 2	0.015
ADAM10	ADAM metallopeptidase domain 10	0.015
TAPBP	TAP binding protein (tapasin)	0.015
SPRY4	sprouty homolog 4 (Drosophila)	0.014
TNF	tumor necrosis factor	0.014
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.014
TGFB3	transforming growth factor, beta 3	0.014
APOH	apolipoprotein H (beta-2-glycoprotein I)	0.014
VEGFC	vascular endothelial growth factor C	0.014
ADAM15	ADAM metallopeptidase domain 15	0.014	Human
HOXA1	homeobox A1	0.014
LOXL2	lysyl oxidase-like 2	0.014
DPP4	dipeptidyl-peptidase 4	0.014
MATK	megakaryocyte-associated tyrosine kinase	0.014
NNMT	nicotinamide N-methyltransferase	0.013
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.013
PHLDA1	pleckstrin homology-like domain, family A, member 1	0.013
MMP19	matrix metallopeptidase 19	0.013
LAMB1	laminin, beta 1	0.013
ICAM3	intercellular adhesion molecule 3	0.013
FBLIM1	filamin binding LIM protein 1	0.013
RGS1	regulator of G-protein signaling 1	0.013
IL32	interleukin 32	0.013
NRP1	neuropilin 1	0.013
CDH3	cadherin 3, type 1, P-cadherin (placental)	0.013
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.013
COL1A1	collagen, type I, alpha 1	0.013
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.013
FLNB	filamin B, beta	0.013
RHOC	ras homolog gene family, member C	0.013
SH3PXD2A	SH3 and PX domains 2A	0.013
CCL20	chemokine (C-C motif) ligand 20	0.013	Human
ZNF426	zinc finger protein 426	0.013
ITGB5	integrin, beta 5	0.013	Human
FSTL3	follistatin-like 3 (secreted glycoprotein)	0.013
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.012
CD9	CD9 molecule	0.012
CORO1A	coronin, actin binding protein, 1A	0.012
ILK	integrin-linked kinase	0.012
GEM	GTP binding protein overexpressed in skeletal muscle	0.012
TGFB1	transforming growth factor, beta 1	0.012	Human
IL2RA	interleukin 2 receptor, alpha	0.012
SOX9	SRY (sex determining region Y)-box 9	0.012
WISP1	WNT1 inducible signaling pathway protein 1	0.012
ACTN1	actinin, alpha 1	0.012
IL4	interleukin 4	0.012
IRF8	interferon regulatory factor 8	0.012
SELE	selectin E	0.012
SLAMF7	SLAM family member 7	0.011
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.011
LTB	lymphotoxin beta (TNF superfamily, member 3)	0.011
DARC	Duffy blood group, chemokine receptor	0.011
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.011
FMNL1	formin-like 1	0.011
IL1A	interleukin 1, alpha	0.011
PDLIM5	PDZ and LIM domain 5	0.011
F2	coagulation factor II (thrombin)	0.011
SRCIN1	SRC kinase signaling inhibitor 1	0.011
ORM1	orosomucoid 1	0.011
ITGA8	integrin, alpha 8	0.011	Human
STC1	stanniocalcin 1	0.011
ITGAX	integrin, alpha X (complement component 3 receptor 4 subunit)	0.010	Human
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.010
MYH9	myosin, heavy chain 9, non-muscle	0.010
JAG1	jagged 1	0.010
RDX	radixin	0.010
KYNU	kynureninase	0.010
VASP	vasodilator-stimulated phosphoprotein	0.010
SORBS2	sorbin and SH3 domain containing 2	0.010
MMP7	matrix metallopeptidase 7 (matrilysin, uterine)	0.010