IMP

Process View

Homo sapiens

22 genes annotated in human

Multi-species View

regulation of double strand break repair

GO:2000779

Any process that modulates the frequency, rate or extent of double-strand break repair.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of double strand break repair"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of double strand break repair" (in gray)

Name	Description	Probability	Func Analog Organism
BRCA1	breast cancer 1, early onset	0.999
RPA1	replication protein A1, 70kDa	0.818
H2AFX	H2A histone family, member X	0.800
CCNE1	cyclin E1	0.596
PRKDC	protein kinase, DNA-activated, catalytic polypeptide	0.591
BRCA2	breast cancer 2, early onset	0.588
MDC1	mediator of DNA-damage checkpoint 1	0.584
MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	0.576
SMEK1	SMEK homolog 1, suppressor of mek1 (Dictyostelium)	0.428
RAD52	RAD52 homolog (S. cerevisiae)	0.421
PALB2	partner and localizer of BRCA2	0.404
WRN	Werner syndrome, RecQ helicase-like	0.355
BLM	Bloom syndrome, RecQ helicase-like	0.324	Fly
CDK2	cyclin-dependent kinase 2	0.323	Yeast
RB1	retinoblastoma 1	0.307
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.271
NBN	nibrin	0.219
SETD8	SET domain containing (lysine methyltransferase) 8	0.194
PARP1	poly (ADP-ribose) polymerase 1	0.191
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.167
TOPBP1	topoisomerase (DNA) II binding protein 1	0.148
MSH6	mutS homolog 6 (E. coli)	0.141
TP53BP1	tumor protein p53 binding protein 1	0.132
PCNA	proliferating cell nuclear antigen	0.125
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.117
REV3L	REV3-like, catalytic subunit of DNA polymerase zeta (yeast)	0.104
FANCD2	Fanconi anemia, complementation group D2	0.103
MSH2	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)	0.102
DAXX	death-domain associated protein	0.092
ATM	ataxia telangiectasia mutated	0.085
PSIP1	PC4 and SFRS1 interacting protein 1	0.084
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.084
POLA1	polymerase (DNA directed), alpha 1, catalytic subunit	0.084
TIMELESS	timeless homolog (Drosophila)	0.077
TMPO	thymopoietin	0.075
CHEK1	CHK1 checkpoint homolog (S. pombe)	0.067
C19orf39	chromosome 19 open reading frame 39	0.065
XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	0.062
E2F1	E2F transcription factor 1	0.059
MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)	0.059
BRIP1	BRCA1 interacting protein C-terminal helicase 1	0.051
EXO1	exonuclease 1	0.051
HIPK2	homeodomain interacting protein kinase 2	0.048
ATR	ataxia telangiectasia and Rad3 related	0.044
CCNA2	cyclin A2	0.043
ANKRD28	ankyrin repeat domain 28	0.043
CLSPN	claspin	0.042
CDC25A	cell division cycle 25 homolog A (S. pombe)	0.039
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.037
RAD50	RAD50 homolog (S. cerevisiae)	0.036
CDK1	cyclin-dependent kinase 1	0.035	Yeast
GATA2	GATA binding protein 2	0.035
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.033
RNF168	ring finger protein 168	0.031	Human
DCK	deoxycytidine kinase	0.030
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.029
CREBBP	CREB binding protein	0.027
SETD7	SET domain containing (lysine methyltransferase) 7	0.027
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.026
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.026
BARD1	BRCA1 associated RING domain 1	0.025
RPA3	replication protein A3, 14kDa	0.025
GATA1	GATA binding protein 1 (globin transcription factor 1)	0.025
DMC1	DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)	0.023
AR	androgen receptor	0.022
DNA2	DNA replication helicase 2 homolog (yeast)	0.022
SMC2	structural maintenance of chromosomes 2	0.022
TK1	thymidine kinase 1, soluble	0.021
HMGB2	high mobility group box 2	0.021
CSNK2A1	casein kinase 2, alpha 1 polypeptide	0.021
UNG	uracil-DNA glycosylase	0.021
PRMT6	protein arginine methyltransferase 6	0.021
CCNE2	cyclin E2	0.020
H3F3C	H3 histone, family 3C	0.019
WDHD1	WD repeat and HMG-box DNA binding protein 1	0.019
PPP2R1A	protein phosphatase 2, regulatory subunit A, alpha	0.019
CCNB2	cyclin B2	0.019
ZRANB1	zinc finger, RAN-binding domain containing 1	0.019
ECT2	epithelial cell transforming sequence 2 oncogene	0.019
TOP2A	topoisomerase (DNA) II alpha 170kDa	0.018
PMS1	PMS1 postmeiotic segregation increased 1 (S. cerevisiae)	0.018
UBXN1	UBX domain protein 1	0.018
KAT5	K(lysine) acetyltransferase 5	0.018
CAB39	calcium binding protein 39	0.018
RNF8	ring finger protein 8	0.018
NMRAL1	NmrA-like family domain containing 1	0.017
LMNB1	lamin B1	0.017
HTT	huntingtin	0.017
RNF11	ring finger protein 11	0.016
PRIM2	primase, DNA, polypeptide 2 (58kDa)	0.016
PBK	PDZ binding kinase	0.016
CCNB1	cyclin B1	0.016
CBFB	core-binding factor, beta subunit	0.016
FBXO5	F-box protein 5	0.016
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.015
TOP2B	topoisomerase (DNA) II beta 180kDa	0.015
POLK	polymerase (DNA directed) kappa	0.015
SKP2	S-phase kinase-associated protein 2 (p45)	0.015
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.015
AARSD1	alanyl-tRNA synthetase domain containing 1	0.014
CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	0.014
RAD51L1	RAD51-like 1 (S. cerevisiae)	0.014
TTK	TTK protein kinase	0.014
MEN1	multiple endocrine neoplasia I	0.014
PIAS2	protein inhibitor of activated STAT, 2	0.014
DNMT1	DNA (cytosine-5-)-methyltransferase 1	0.014
RMI1	RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae)	0.013
XRCC3	X-ray repair complementing defective repair in Chinese hamster cells 3	0.013
TMEM194A	transmembrane protein 194A	0.013
IGF2BP1	insulin-like growth factor 2 mRNA binding protein 1	0.013
ELF5	E74-like factor 5 (ets domain transcription factor)	0.013
DDX42	DEAD (Asp-Glu-Ala-Asp) box polypeptide 42	0.013
NEK2	NIMA (never in mitosis gene a)-related kinase 2	0.013
TAL1	T-cell acute lymphocytic leukemia 1	0.012	Human
KIF14	kinesin family member 14	0.012
RUNX1	runt-related transcription factor 1	0.012
PPP4R2	protein phosphatase 4, regulatory subunit 2	0.012
CENPK	centromere protein K	0.012
SMC4	structural maintenance of chromosomes 4	0.011
PDX1	pancreatic and duodenal homeobox 1	0.011
USP24	ubiquitin specific peptidase 24	0.011
TP53	tumor protein p53	0.011
E2F4	E2F transcription factor 4, p107/p130-binding	0.011
PPP4C	protein phosphatase 4, catalytic subunit	0.011
CENPQ	centromere protein Q	0.011
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.011
NEDD1	neural precursor cell expressed, developmentally down-regulated 1	0.010
GATA4	GATA binding protein 4	0.010
POLI	polymerase (DNA directed) iota	0.010
PPP4R1	protein phosphatase 4, regulatory subunit 1	0.010
SMC1A	structural maintenance of chromosomes 1A	0.010
CCND1	cyclin D1	0.010
PHOX2A	paired-like homeobox 2a	0.010