IMP

Process View

Homo sapiens

19 genes annotated in human

Multi-species View

regulation of leukocyte mediated cytotoxicity

GO:0001910

Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of leukocyte mediated cytotoxicity"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of leukocyte mediated cytotoxicity" (in gray)

Name	Description	Probability	Func Analog Organism
HLA-A	major histocompatibility complex, class I, A	0.998
B2M	beta-2-microglobulin	0.998	Mouse
HLA-G	major histocompatibility complex, class I, G	0.916	Human
HLA-C	major histocompatibility complex, class I, C	0.901	Human
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.878
HLA-F	major histocompatibility complex, class I, F	0.878	Human
HLA-B	major histocompatibility complex, class I, B	0.742
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.559
IL8	interleukin 8	0.549
CXCL3	chemokine (C-X-C motif) ligand 3	0.475	Mouse
LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	0.470
TAPBP	TAP binding protein (tapasin)	0.445
HLA-E	major histocompatibility complex, class I, E	0.435
IL2RB	interleukin 2 receptor, beta	0.397
CXCL2	chemokine (C-X-C motif) ligand 2	0.378	Mouse
CCR5	chemokine (C-C motif) receptor 5	0.309
TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.293	Rat
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.268
SLAMF1	signaling lymphocytic activation molecule family member 1	0.256
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.230	Mouse
CCL5	chemokine (C-C motif) ligand 5	0.230	Human
CD84	CD84 molecule	0.213
CAV1	caveolin 1, caveolae protein, 22kDa	0.161
IL1B	interleukin 1, beta	0.159
CCR1	chemokine (C-C motif) receptor 1	0.144
LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	0.142	Human
ARRB1	arrestin, beta 1	0.139	Human
CCL4	chemokine (C-C motif) ligand 4	0.137	Human
KLRD1	killer cell lectin-like receptor subfamily D, member 1	0.135	Human
CXCL9	chemokine (C-X-C motif) ligand 9	0.128
CCL13	chemokine (C-C motif) ligand 13	0.109	Human
IFNG	interferon, gamma	0.106
IL6	interleukin 6 (interferon, beta 2)	0.100
GBA	glucosidase, beta, acid	0.100
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.097	Human
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.092
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.087
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.080
IDE	insulin-degrading enzyme	0.079
DPP4	dipeptidyl-peptidase 4	0.074
IL23A	interleukin 23, alpha subunit p19	0.069	Mouse
CCR7	chemokine (C-C motif) receptor 7	0.069
ITM2B	integral membrane protein 2B	0.065
TAP2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0.063	Mouse Rat
CCL8	chemokine (C-C motif) ligand 8	0.058	Human
CCL2	chemokine (C-C motif) ligand 2	0.057	Human
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.055
CCL20	chemokine (C-C motif) ligand 20	0.054	Human
CCL7	chemokine (C-C motif) ligand 7	0.054	Human
RAB14	RAB14, member RAS oncogene family	0.054
PVRL4	poliovirus receptor-related 4	0.046
KLRK1	killer cell lectin-like receptor subfamily K, member 1	0.046
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.045
LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	0.037	Human
BCL2A1	BCL2-related protein A1	0.032
FASLG	Fas ligand (TNF superfamily, member 6)	0.032
CCR4	chemokine (C-C motif) receptor 4	0.029
INSR	insulin receptor	0.029
CXCL5	chemokine (C-X-C motif) ligand 5	0.029	Mouse
GZMK	granzyme K (granzyme 3; tryptase II)	0.028
KLRC3	killer cell lectin-like receptor subfamily C, member 3	0.028	Human
GPR171	G protein-coupled receptor 171	0.028
CH25H	cholesterol 25-hydroxylase	0.027
CD163	CD163 molecule	0.026
TNF	tumor necrosis factor	0.026
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.023
TLR2	toll-like receptor 2	0.023
IL10	interleukin 10	0.023
CXCL10	chemokine (C-X-C motif) ligand 10	0.022
PILRA	paired immunoglobin-like type 2 receptor alpha	0.022
FPR3	formyl peptide receptor 3	0.022
NLRP3	NLR family, pyrin domain containing 3	0.020
VCAM1	vascular cell adhesion molecule 1	0.020
HK3	hexokinase 3 (white cell)	0.020
CCR2	chemokine (C-C motif) receptor 2	0.020
CD8A	CD8a molecule	0.019
KLRC2	killer cell lectin-like receptor subfamily C, member 2	0.019	Human
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.019
CXCL13	chemokine (C-X-C motif) ligand 13	0.018
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.018
GNS	glucosamine (N-acetyl)-6-sulfatase	0.018
CD22	CD22 molecule	0.018
ASAH1	N-acylsphingosine amidohydrolase (acid ceramidase) 1	0.018
SIGLEC7	sialic acid binding Ig-like lectin 7	0.017
CD3G	CD3g molecule, gamma (CD3-TCR complex)	0.017
VAMP4	vesicle-associated membrane protein 4	0.017
CCL19	chemokine (C-C motif) ligand 19	0.016	Human
IL7R	interleukin 7 receptor	0.016	Mouse
TRAF1	TNF receptor-associated factor 1	0.016
BIRC3	baculoviral IAP repeat containing 3	0.016
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.016
STAP2	signal transducing adaptor family member 2	0.016
SLAMF8	SLAM family member 8	0.015
CXCL11	chemokine (C-X-C motif) ligand 11	0.015
LILRB3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.015	Human
SELE	selectin E	0.015
TREM1	triggering receptor expressed on myeloid cells 1	0.015
IL18RAP	interleukin 18 receptor accessory protein	0.015
NCSTN	nicastrin	0.015
AQP9	aquaporin 9	0.015
CMKLR1	chemokine-like receptor 1	0.014
CLEC10A	C-type lectin domain family 10, member A	0.014
CCL22	chemokine (C-C motif) ligand 22	0.014	Human
IFITM2	interferon induced transmembrane protein 2 (1-8D)	0.014
MAPK10	mitogen-activated protein kinase 10	0.013
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.013
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.013
XCL2	chemokine (C motif) ligand 2	0.013	Human
INHBA	inhibin, beta A	0.012
ARL6IP5	ADP-ribosylation-like factor 6 interacting protein 5	0.012
GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	0.012
PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	0.012
STAT4	signal transducer and activator of transcription 4	0.012
SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	0.012
IGSF6	immunoglobulin superfamily, member 6	0.012
CLEC5A	C-type lectin domain family 5, member A	0.012
PTAFR	platelet-activating factor receptor	0.012
ICOS	inducible T-cell co-stimulator	0.012
IRF2	interferon regulatory factor 2	0.012
LILRA3	leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3	0.012	Human
ADAMDEC1	ADAM-like, decysin 1	0.011
DNASE1L3	deoxyribonuclease I-like 3	0.011
GPR65	G protein-coupled receptor 65	0.011
SNX3	sorting nexin 3	0.011
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.011
LILRA2	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2	0.011
KLRF1	killer cell lectin-like receptor subfamily F, member 1	0.011
C3AR1	complement component 3a receptor 1	0.010
FCGR2B	Fc fragment of IgG, low affinity IIb, receptor (CD32)	0.010
MAP2K4	mitogen-activated protein kinase kinase 4	0.010
CD48	CD48 molecule	0.010
FCN1	ficolin (collagen/fibrinogen domain containing) 1	0.010
FAS	Fas (TNF receptor superfamily, member 6)	0.010
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.010
CCR3	chemokine (C-C motif) receptor 3	0.010
CD160	CD160 molecule	0.010
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.010