IMP

Process View

Homo sapiens

18 genes annotated in human

mitotic spindle checkpoint

A mitotic cell cycle checkpoint that originates from the spindle and delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and oriented, the completion of anaphase until chromosomes are attached to the spindle, or mitotic exit and cytokinesis when the spindle does not form.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "mitotic spindle checkpoint"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "mitotic spindle checkpoint" (in gray)

Name	Description	Probability	Func Analog Organism
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	0.691	Fly
ANAPC4	anaphase promoting complex subunit 4	0.500
CDC20	cell division cycle 20 homolog (S. cerevisiae)	0.415	Yeast
BUB3	budding uninhibited by benzimidazoles 3 homolog (yeast)	0.366	Worm Fly
CDC27	cell division cycle 27 homolog (S. cerevisiae)	0.361
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.271	Yeast
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.256	Yeast
NDC80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.168
CDK2	cyclin-dependent kinase 2	0.145
MAD2L1	MAD2 mitotic arrest deficient-like 1 (yeast)	0.141
CCT8	chaperonin containing TCP1, subunit 8 (theta)	0.122
CCNA2	cyclin A2	0.094
AURKB	aurora kinase B	0.089
CCNB1	cyclin B1	0.084
ANAPC5	anaphase promoting complex subunit 5	0.074
DOT1L	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	0.071
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.069	Yeast
CASC5	cancer susceptibility candidate 5	0.066
BUB1	budding uninhibited by benzimidazoles 1 homolog (yeast)	0.065	Mouse Fly
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.060
TP53BP1	tumor protein p53 binding protein 1	0.055
CSNK2B	casein kinase 2, beta polypeptide	0.054
MDC1	mediator of DNA-damage checkpoint 1	0.049
CKS2	CDC28 protein kinase regulatory subunit 2	0.047
BRCA2	breast cancer 2, early onset	0.045
CENPJ	centromere protein J	0.045
FXR2	fragile X mental retardation, autosomal homolog 2	0.045
MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	0.044
PLK4	polo-like kinase 4	0.039
SASS6	spindle assembly 6 homolog (C. elegans)	0.039
TINF2	TERF1 (TRF1)-interacting nuclear factor 2	0.039
SKA2	spindle and kinetochore associated complex subunit 2	0.038
CDC23	cell division cycle 23 homolog (S. cerevisiae)	0.034
H2AFX	H2A histone family, member X	0.034
SKA3	spindle and kinetochore associated complex subunit 3	0.034
ATMIN	ATM interactor	0.031
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.029
PTTG1	pituitary tumor-transforming 1	0.028
FANCD2	Fanconi anemia, complementation group D2	0.027
TOP2A	topoisomerase (DNA) II alpha 170kDa	0.027
CEP135	centrosomal protein 135kDa	0.026
SMC4	structural maintenance of chromosomes 4	0.026
MAPRE1	microtubule-associated protein, RP/EB family, member 1	0.026
CBX5	chromobox homolog 5	0.025
C13orf34	chromosome 13 open reading frame 34	0.025
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.025
PRC1	protein regulator of cytokinesis 1	0.024
LMNA	lamin A/C	0.024
ZWINT	ZW10 interactor	0.024
SKA1	spindle and kinetochore associated complex subunit 1	0.023
HMMR	hyaluronan-mediated motility receptor (RHAMM)	0.023
TNKS	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	0.023
KIF11	kinesin family member 11	0.022
CENPF	centromere protein F, 350/400kDa (mitosin)	0.021
TTK	TTK protein kinase	0.020	Yeast
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.019
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.019
FBXO5	F-box protein 5	0.019
PPME1	protein phosphatase methylesterase 1	0.019
HNRNPM	heterogeneous nuclear ribonucleoprotein M	0.019
CENPE	centromere protein E, 312kDa	0.018	Mouse
CKS1B	CDC28 protein kinase regulatory subunit 1B	0.018
TERF2IP	telomeric repeat binding factor 2, interacting protein	0.018
ANAPC11	anaphase promoting complex subunit 11	0.017
SGOL1	shugoshin-like 1 (S. pombe)	0.017
CDKN3	cyclin-dependent kinase inhibitor 3	0.017
PARP3	poly (ADP-ribose) polymerase family, member 3	0.017
PPP2R5D	protein phosphatase 2, regulatory subunit B', delta	0.016
NUF2	NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.016
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.016
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.016
SMC6	structural maintenance of chromosomes 6	0.015
MAD2L2	MAD2 mitotic arrest deficient-like 2 (yeast)	0.015
PRNP	prion protein	0.015
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.015
PINX1	PIN2/TERF1 interacting, telomerase inhibitor 1	0.015
HIST1H4A	histone cluster 1, H4a	0.015
RAD52	RAD52 homolog (S. cerevisiae)	0.015
ASPM	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	0.014
TRIP13	thyroid hormone receptor interactor 13	0.014
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.014
PAXIP1	PAX interacting (with transcription-activation domain) protein 1	0.014
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.014
SMC3	structural maintenance of chromosomes 3	0.014
KIF18A	kinesin family member 18A	0.014
MAD1L1	MAD1 mitotic arrest deficient-like 1 (yeast)	0.014
KIF14	kinesin family member 14	0.013
KIF5B	kinesin family member 5B	0.013
CDK1	cyclin-dependent kinase 1	0.013
MAD2L1BP	MAD2L1 binding protein	0.012
SFN	stratifin	0.012	Yeast
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.012
SGOL2	shugoshin-like 2 (S. pombe)	0.012
KDM4A	lysine (K)-specific demethylase 4A	0.012
OR5AR1	olfactory receptor, family 5, subfamily AR, member 1	0.012
DLGAP5	discs, large (Drosophila) homolog-associated protein 5	0.011
HIST1H3A	histone cluster 1, H3a	0.011	Yeast
HIST1H1E	histone cluster 1, H1e	0.011
MYST1	MYST histone acetyltransferase 1	0.011
CREBBP	CREB binding protein	0.011
HIST1H2AL	histone cluster 1, H2al	0.011
HIST1H3B	histone cluster 1, H3b	0.011	Yeast
FANCI	Fanconi anemia, complementation group I	0.010
LBR	lamin B receptor	0.010
EPM2A	epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)	0.010
C19orf39	chromosome 19 open reading frame 39	0.010
OTUB1	OTU domain, ubiquitin aldehyde binding 1	0.010
APC	adenomatous polyposis coli	0.010