IMP

Process View

Mus musculus

1 genes annotated in mouse

semicircular canal formation

The developmental process pertaining to the initial formation of the semicircular canal from the otic vesicle. This process begins with the regionalization of the vesicle that specifies the area where the vesicles will form and continues through the process of fusion which forms the initial tubes.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "semicircular canal formation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "semicircular canal formation" (in gray)

Name	Description	Probability	Func Analog Organism
Pax2	paired box gene 2	1.000
Eya1	eyes absent 1 homolog (Drosophila)	1.000
Pax3	paired box gene 3	0.999
Fgf10	fibroblast growth factor 10	0.997
Tbx1	T-box 1	0.996
Shh	sonic hedgehog	0.993
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.993
Fgfr2	fibroblast growth factor receptor 2	0.984
Prrx1	paired related homeobox 1	0.983
Dlx5	distal-less homeobox 5	0.983
Gbx2	gastrulation brain homeobox 2	0.975
Jag1	jagged 1	0.973
Chrd	chordin	0.972
Fgf8	fibroblast growth factor 8	0.965
Hand2	heart and neural crest derivatives expressed transcript 2	0.965
Tbx10	T-box 10	0.954
Foxg1	forkhead box G1	0.917
Hoxa1	homeobox A1	0.885	Human
Chd7	chromodomain helicase DNA binding protein 7	0.878
Gli3	GLI-Kruppel family member GLI3	0.870
Foxc1	forkhead box C1	0.801
Tcfap2a	transcription factor AP-2, alpha	0.781
Foxc2	forkhead box C2	0.750
Rarb	retinoic acid receptor, beta	0.746
Lmx1a	LIM homeobox transcription factor 1 alpha	0.729
Ednra	endothelin receptor type A	0.687
Msx1	homeobox, msh-like 1	0.687
Hmx3	H6 homeobox 3	0.669
Tgfb2	transforming growth factor, beta 2	0.630
Bmp4	bone morphogenetic protein 4	0.627
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.625
Zeb1	zinc finger E-box binding homeobox 1	0.608
Fgf3	fibroblast growth factor 3	0.568	Mouse
Gata3	GATA binding protein 3	0.545
Hoxa3	homeobox A3	0.537
Gsc	goosecoid homeobox	0.504
Vangl2	vang-like 2 (van gogh, Drosophila)	0.490
Alx4	aristaless-like homeobox 4	0.483
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.448
Hoxa2	homeobox A2	0.436
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.427
Sox9	SRY-box containing gene 9	0.426
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.421
Sox2	SRY-box containing gene 2	0.417
Hoxd11	homeobox D11	0.413
Hand1	heart and neural crest derivatives expressed transcript 1	0.406
Bdnf	brain derived neurotrophic factor	0.405
Acvr1	activin A receptor, type 1	0.395
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.388
Bmp7	bone morphogenetic protein 7	0.343
Ntf3	neurotrophin 3	0.318
Rarg	retinoic acid receptor, gamma	0.316
Tgfbr2	transforming growth factor, beta receptor II	0.306
Prrx2	paired related homeobox 2	0.296
Gli2	GLI-Kruppel family member GLI2	0.271
Hoxa11	homeobox A11	0.263
Efnb2	ephrin B2	0.240
Nog	noggin	0.222
Otx2	orthodenticle homolog 2 (Drosophila)	0.212
Zfpm2	zinc finger protein, multitype 2	0.209
Pax9	paired box gene 9	0.206
Dlx6	distal-less homeobox 6	0.202
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.197
Pitx2	paired-like homeodomain transcription factor 2	0.187
Pax8	paired box gene 8	0.182
Msx2	homeobox, msh-like 2	0.169
Twist2	twist homolog 2 (Drosophila)	0.169
Tbx3	T-box 3	0.165
Tcf21	transcription factor 21	0.161
Isl1	ISL1 transcription factor, LIM/homeodomain	0.151
Hoxd13	homeobox D13	0.143
Tbx15	T-box 15	0.141
Npr3	natriuretic peptide receptor 3	0.125
Rara	retinoic acid receptor, alpha	0.115
Pbx1	pre B-cell leukemia transcription factor 1	0.114
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.114
Mesp1	mesoderm posterior 1	0.114
Nkx2-1	NK2 homeobox 1	0.110
Vegfa	vascular endothelial growth factor A	0.109
Otx1	orthodenticle homolog 1 (Drosophila)	0.108
Ece1	endothelin converting enzyme 1	0.104
Hoxb1	homeobox B1	0.097
Shc3	src homology 2 domain-containing transforming protein C3	0.096
Smo	smoothened homolog (Drosophila)	0.092
Trp63	transformation related protein 63	0.091
Foxi1	forkhead box I1	0.091
Pitx1	paired-like homeodomain transcription factor 1	0.086
Fgfr3	fibroblast growth factor receptor 3	0.084
Ntrk3	neurotrophic tyrosine kinase, receptor, type 3	0.080
Hmx2	H6 homeobox 2	0.080
Pou4f3	POU domain, class 4, transcription factor 3	0.072
Fgfr1	fibroblast growth factor receptor 1	0.071
Fgf9	fibroblast growth factor 9	0.066	Mouse
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.063
Ar	androgen receptor	0.061
Wnt3a	wingless-related MMTV integration site 3A	0.061
Fgfbp1	fibroblast growth factor binding protein 1	0.060
Epha4	Eph receptor A4	0.057
Rbpjl	recombination signal binding protein for immunoglobulin kappa J region-like	0.057
Hoxa13	homeobox A13	0.056
Wt1	Wilms tumor 1 homolog	0.054
Ldb3	LIM domain binding 3	0.053
Wnt9b	wingless-type MMTV integration site 9B	0.052
Spry4	sprouty homolog 4 (Drosophila)	0.050
Rxra	retinoid X receptor alpha	0.050
Slc26a4	solute carrier family 26, member 4	0.049
Hrc	histidine rich calcium binding protein	0.047
Gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.047
Sgcd	sarcoglycan, delta (dystrophin-associated glycoprotein)	0.046
Tgfbr3	transforming growth factor, beta receptor III	0.044
Wnt5a	wingless-related MMTV integration site 5A	0.041
Dlx2	distal-less homeobox 2	0.041
Kcna1	potassium voltage-gated channel, shaker-related subfamily, member 1	0.040
Bmp5	bone morphogenetic protein 5	0.040
Pou3f3	POU domain, class 3, transcription factor 3	0.040
Kcnj12	potassium inwardly-rectifying channel, subfamily J, member 12	0.040
Cntn4	contactin 4	0.039
Ret	ret proto-oncogene	0.039
Kcne1	potassium voltage-gated channel, Isk-related subfamily, member 1	0.038
Erbb4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.038
Kcnk3	potassium channel, subfamily K, member 3	0.037
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.037
Mgat3	mannoside acetylglucosaminyltransferase 3	0.037
Tcf15	transcription factor 15	0.037
Edn3	endothelin 3	0.036
Hoxd3	homeobox D3	0.036
Slurp1	secreted Ly6/Plaur domain containing 1	0.036
Dlx1	distal-less homeobox 1	0.036
Hoxb3	homeobox B3	0.034
Pou3f4	POU domain, class 3, transcription factor 4	0.034
Emx2	empty spiracles homolog 2 (Drosophila)	0.033
Hoxb2	homeobox B2	0.033
Casq2	calsequestrin 2	0.031
Gata6	GATA binding protein 6	0.031
Gdf11	growth differentiation factor 11	0.030
Plcb1	phospholipase C, beta 1	0.029
Esrrb	estrogen related receptor, beta	0.029
Grem1	gremlin 1	0.028
Rdh10	retinol dehydrogenase 10 (all-trans)	0.028
Gata5	GATA binding protein 5	0.028
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.028
Phox2b	paired-like homeobox 2b	0.027
Fam164c	family with sequence similarity 164, member C	0.027
Phex	phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)	0.027
Mme	membrane metallo endopeptidase	0.027
Rxrg	retinoid X receptor gamma	0.027
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.027
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.026
Krt34	keratin 34	0.026
En1	engrailed 1	0.026
Btbd17	BTB (POZ) domain containing 17	0.025
Atp4b	ATPase, H+/K+ exchanging, beta polypeptide	0.025
Gabrd	gamma-aminobutyric acid (GABA) A receptor, subunit delta	0.025
Gria4	glutamate receptor, ionotropic, AMPA4 (alpha 4)	0.025
Lrp2	low density lipoprotein receptor-related protein 2	0.025
Syt7	synaptotagmin VII	0.024
Foxi3	forkhead box I3	0.024
Dhh	desert hedgehog	0.024
Meox2	mesenchyme homeobox 2	0.024
Gja3	gap junction protein, alpha 3	0.024
Kcna2	potassium voltage-gated channel, shaker-related subfamily, member 2	0.023
Tcap	titin-cap	0.023
Cel	carboxyl ester lipase	0.022
Slc5a11	solute carrier family 5 (sodium/glucose cotransporter), member 11	0.022
Epha1	Eph receptor A1	0.022
Crhr2	corticotropin releasing hormone receptor 2	0.022
Fgfrl1	fibroblast growth factor receptor-like 1	0.022
Gja1	gap junction protein, alpha 1	0.022
Neurog1	neurogenin 1	0.022
Cacna2d1	calcium channel, voltage-dependent, alpha2/delta subunit 1	0.021
Fgf15	fibroblast growth factor 15	0.021
Slc25a48	solute carrier family 25, member 48	0.021
Nppc	natriuretic peptide type C	0.021
Foxf1a	forkhead box F1a	0.021
C77370	expressed sequence C77370	0.021
Grm8	glutamate receptor, metabotropic 8	0.021
Gata4	GATA binding protein 4	0.021
Ppargc1a	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	0.020
Krt84	keratin 84	0.020
Krt77	keratin 77	0.020
Neurog3	neurogenin 3	0.020
Adcy8	adenylate cyclase 8	0.020
Gh	growth hormone	0.020
Egfr	epidermal growth factor receptor	0.020
Hoxa7	homeobox A7	0.020
Kcnj11	potassium inwardly rectifying channel, subfamily J, member 11	0.020
Nkx3-2	NK3 homeobox 2	0.020
Gli1	GLI-Kruppel family member GLI1	0.019
Nrg3	neuregulin 3	0.019
Tbx5	T-box 5	0.019
Mn1	meningioma 1	0.019
Musk	muscle, skeletal, receptor tyrosine kinase	0.019
Pax6	paired box gene 6	0.019
Dmrt1	doublesex and mab-3 related transcription factor 1	0.019
Oprd1	opioid receptor, delta 1	0.019
Nefm	neurofilament, medium polypeptide	0.019
Fgf18	fibroblast growth factor 18	0.019
Acan	aggrecan	0.019
Stx1b	syntaxin 1B	0.018
Sim2	single-minded homolog 2 (Drosophila)	0.018
Angpt1	angiopoietin 1	0.018
Hpcal4	hippocalcin-like 4	0.018
Htr7	5-hydroxytryptamine (serotonin) receptor 7	0.018
Ppara	peroxisome proliferator activated receptor alpha	0.018
Wnt1	wingless-related MMTV integration site 1	0.018
Myl3	myosin, light polypeptide 3	0.017
Tll1	tolloid-like	0.017
Mecom	MDS1 and EVI1 complex locus	0.017
Prkg2	protein kinase, cGMP-dependent, type II	0.017
Rgs4	regulator of G-protein signaling 4	0.017
Socs5	suppressor of cytokine signaling 5	0.017
Esr2	estrogen receptor 2 (beta)	0.017
Mafb	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)	0.017
Lhx1	LIM homeobox protein 1	0.017
Kcnd2	potassium voltage-gated channel, Shal-related family, member 2	0.017
Shox2	short stature homeobox 2	0.017
Vsnl1	visinin-like 1	0.017
Stc2	stanniocalcin 2	0.017
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.017
Wnt2b	wingless related MMTV integration site 2b	0.016
Npas2	neuronal PAS domain protein 2	0.016
Dmc1	DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)	0.016
Phox2a	paired-like homeobox 2a	0.016
Pthlh	parathyroid hormone-like peptide	0.016
Smyd1	SET and MYND domain containing 1	0.016
Hoxd1	homeobox D1	0.016
Hoxb4	homeobox B4	0.016
Wnt3	wingless-related MMTV integration site 3	0.016
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.016
Gjb5	gap junction protein, beta 5	0.016
Alx1	ALX homeobox 1	0.016
Pvalb	parvalbumin	0.016
Myo6	myosin VI	0.016
Htr1f	5-hydroxytryptamine (serotonin) receptor 1F	0.016
Phkg1	phosphorylase kinase gamma 1	0.015
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.015
Grin2a	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	0.015
Lef1	lymphoid enhancer binding factor 1	0.015
Alox12b	arachidonate 12-lipoxygenase, 12R type	0.015
Bdkrb2	bradykinin receptor, beta 2	0.015
Foxn1	forkhead box N1	0.015
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.015
Omp	olfactory marker protein	0.015
Gpc3	glypican 3	0.015
Hs6st3	heparan sulfate 6-O-sulfotransferase 3	0.015
Hoxa5	homeobox A5	0.015
Moxd2	monooxygenase, DBH-like 2	0.015
Nefl	neurofilament, light polypeptide	0.015
Fxyd7	FXYD domain-containing ion transport regulator 7	0.015
Hoxb6	homeobox B6	0.014
Cacnb2	calcium channel, voltage-dependent, beta 2 subunit	0.014
Adra1a	adrenergic receptor, alpha 1a	0.014
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.014
Foxf2	forkhead box F2	0.014
Adrb1	adrenergic receptor, beta 1	0.014
Nf1	neurofibromatosis 1	0.014
Hoxa9	homeobox A9	0.014
Plin4	perilipin 4	0.014
Ucp1	uncoupling protein 1 (mitochondrial, proton carrier)	0.014
Kcnmb1	potassium large conductance calcium-activated channel, subfamily M, beta member 1	0.014
Bmper	BMP-binding endothelial regulator	0.014
Edil3	EGF-like repeats and discoidin I-like domains 3	0.014
Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	0.014
Svs5	seminal vesicle secretory protein 5	0.014
Fut1	fucosyltransferase 1	0.014
Gjb4	gap junction protein, beta 4	0.014
Thrb	thyroid hormone receptor beta	0.014
Per3	period homolog 3 (Drosophila)	0.014
Fgf6	fibroblast growth factor 6	0.014	Mouse
Homer1	homer homolog 1 (Drosophila)	0.014
Ltbp1	latent transforming growth factor beta binding protein 1	0.013
Alx3	aristaless-like homeobox 3	0.013
Sall4	sal-like 4 (Drosophila)	0.013
Prph	peripherin	0.013
Gabra1	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1	0.013
Foxb1	forkhead box B1	0.013
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.013
Hoxa10	homeobox A10	0.013
Ascl2	achaete-scute complex homolog 2 (Drosophila)	0.013
Homer2	homer homolog 2 (Drosophila)	0.013
Lgr5	leucine rich repeat containing G protein coupled receptor 5	0.013
Col12a1	collagen, type XII, alpha 1	0.013
Kcnj3	potassium inwardly-rectifying channel, subfamily J, member 3	0.013
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.013
Agtr2	angiotensin II receptor, type 2	0.013
Clic3	chloride intracellular channel 3	0.013
Kcna4	potassium voltage-gated channel, shaker-related subfamily, member 4	0.013
Tbx4	T-box 4	0.013
Aff2	AF4/FMR2 family, member 2	0.013
Vipr1	vasoactive intestinal peptide receptor 1	0.013
Gal	galanin	0.013
Adora2b	adenosine A2b receptor	0.013
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.013
Mylk2	myosin, light polypeptide kinase 2, skeletal muscle	0.013
Sox10	SRY-box containing gene 10	0.013
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.013
Gpr37	G protein-coupled receptor 37	0.013
Des	desmin	0.013
Htr1d	5-hydroxytryptamine (serotonin) receptor 1D	0.013
Tnfrsf8	tumor necrosis factor receptor superfamily, member 8	0.013
Sult4a1	sulfotransferase family 4A, member 1	0.013
Nr5a2	nuclear receptor subfamily 5, group A, member 2	0.013
Nptx1	neuronal pentraxin 1	0.013
Ptprz1	protein tyrosine phosphatase, receptor type Z, polypeptide 1	0.013
Chrdl2	chordin-like 2	0.012
Tacr1	tachykinin receptor 1	0.012
Adam23	a disintegrin and metallopeptidase domain 23	0.012
Foxb2	forkhead box B2	0.012
Bcan	brevican	0.012
Npy5r	neuropeptide Y receptor Y5	0.012
Kif3a	kinesin family member 3A	0.012
Rln1	relaxin 1	0.012
Pnoc	prepronociceptin	0.012
B3galt1	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1	0.012
Hoxb9	homeobox B9	0.012
P2ry1	purinergic receptor P2Y, G-protein coupled 1	0.012
Bnc1	basonuclin 1	0.012
Htr2c	5-hydroxytryptamine (serotonin) receptor 2C	0.012
Fgf12	fibroblast growth factor 12	0.012	Mouse
Nhedc2	Na+/H+ exchanger domain containing 2	0.012
Sall3	sal-like 3 (Drosophila)	0.012
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.012
Sstr1	somatostatin receptor 1	0.012
Dsc3	desmocollin 3	0.012
Camk2a	calcium/calmodulin-dependent protein kinase II alpha	0.012
Dpysl2	dihydropyrimidinase-like 2	0.012
Tecta	tectorin alpha	0.012
Gja5	gap junction protein, alpha 5	0.012
Large	like-glycosyltransferase	0.012
Efna5	ephrin A5	0.012
Rasgrp1	RAS guanyl releasing protein 1	0.012
Prm1	protamine 1	0.012
Hmx1	H6 homeobox 1	0.012
Mov10l1	Moloney leukemia virus 10-like 1	0.012
Pde3a	phosphodiesterase 3A, cGMP inhibited	0.012
Tmeff2	transmembrane protein with EGF-like and two follistatin-like domains 2	0.012
Zfp185	zinc finger protein 185	0.012
Pyy	peptide YY	0.012
Cacna2d3	calcium channel, voltage-dependent, alpha2/delta subunit 3	0.011
Rgs6	regulator of G-protein signaling 6	0.011
Chrng	cholinergic receptor, nicotinic, gamma polypeptide	0.011
Nkx2-4	NK2 transcription factor related, locus 4 (Drosophila)	0.011
Kcnj5	potassium inwardly-rectifying channel, subfamily J, member 5	0.011
Apba2	amyloid beta (A4) precursor protein-binding, family A, member 2	0.011
Cdh6	cadherin 6	0.011
Tlx1	T-cell leukemia, homeobox 1	0.011
Ugt8a	UDP galactosyltransferase 8A	0.011
Cyp2w1	cytochrome P450, family 2, subfamily w, polypeptide 1	0.011
Wnt11	wingless-related MMTV integration site 11	0.011
Edn2	endothelin 2	0.011
Adig	adipogenin	0.011
Nrg1	neuregulin 1	0.011
Angpt4	angiopoietin 4	0.011
Zic3	zinc finger protein of the cerebellum 3	0.011
Pln	phospholamban	0.011
St8sia5	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5	0.011
Ppp1r14c	protein phosphatase 1, regulatory (inhibitor) subunit 14c	0.011
Sstr5	somatostatin receptor 5	0.011
Barx2	BarH-like homeobox 2	0.011
Cox8b	cytochrome c oxidase, subunit VIIIb	0.011
Fgf17	fibroblast growth factor 17	0.011
BC057022	cDNA sequence BC057022	0.011
Gad2	glutamic acid decarboxylase 2	0.011
Kcnq1	potassium voltage-gated channel, subfamily Q, member 1	0.011
Atp6v0a4	ATPase, H+ transporting, lysosomal V0 subunit A4	0.011
Padi3	peptidyl arginine deiminase, type III	0.011
Grid1	glutamate receptor, ionotropic, delta 1	0.011
Cdh13	cadherin 13	0.011
Sgca	sarcoglycan, alpha (dystrophin-associated glycoprotein)	0.011
Hist1h1t	histone cluster 1, H1t	0.011
Fbln1	fibulin 1	0.011
Cnr1	cannabinoid receptor 1 (brain)	0.011
Myod1	myogenic differentiation 1	0.011
Scn7a	sodium channel, voltage-gated, type VII, alpha	0.011
Npy2r	neuropeptide Y receptor Y2	0.010
Fgf14	fibroblast growth factor 14	0.010	Mouse
Wnt6	wingless-related MMTV integration site 6	0.010
Crhr1	corticotropin releasing hormone receptor 1	0.010
Grid2	glutamate receptor, ionotropic, delta 2	0.010
Itga2	integrin alpha 2	0.010
Lmx1b	LIM homeobox transcription factor 1 beta	0.010
Magix	MAGI family member, X-linked	0.010
Actn2	actinin alpha 2	0.010
Otp	orthopedia homolog (Drosophila)	0.010
Rapgef4	Rap guanine nucleotide exchange factor (GEF) 4	0.010
Vipr2	vasoactive intestinal peptide receptor 2	0.010
3110079O15Rik	RIKEN cDNA 3110079O15 gene	0.010
Calcrl	calcitonin receptor-like	0.010
Has2	hyaluronan synthase 2	0.010
Krt17	keratin 17	0.010